Abstract：
:Cigarette smoking is a habit that has spread all over the world and is a significant risk factor for many diseases including cardiovascular disease, chronic obstructive pulmonary disease (COPD), asthma and lung cancer. Evaluation and understanding of tobacco health effects are of major interest worldwide and answer to important societal concerns. Identification of new biomarkers of exposure to tobacco smoke potentially implicated in COPD or lung carcinogenesis would allow a better observation of tobacco exposed population, thanks to screening establishment at reversible stages of pathological processes. In this study, we questioned whether cigarette smoking alters miRNA profiles of Extracellular Vesicles (EVs) present in human Broncho Alveolar Lavages (BALs), which could affect surrounding normal bronchial epithelial cells status. To this aim, BALs were carried out on 10 Smokers and 10 Non-Smokers, and EVs were isolated from the supernatants and characterized. We then compared the amount of 10 microRNAs (miRNAs) present in Smokers versus Non-Smokers BAL EVs and performed statistical analysis to discuss the biological significance by the smoking status and to evaluate BAL EV miRNAs as potential biomarkers of tobacco exposure. Finally, we tested the effects of smokers versus non-smokers EVs on human bronchial epithelial cells (BEAS-2B) to compare their influence on the cells status. Our study shows for the first time in human samples that smoking can alter lung EV profile that can influence surrounding bronchial epithelial cells.
journal_name
Int J Hyg Environ Healthauthors
Héliot A,Landkocz Y,Roy Saint-Georges F,Gosset P,Billet S,Shirali P,Courcot D,Martin PJdoi
10.1016/j.ijheh.2016.12.010subject
Has Abstractpub_date
2017-04-01 00:00:00pages
445-454issue
2 Pt Beissn
1438-4639issn
1618-131Xpii
S1438-4639(16)30277-2journal_volume
220pub_type
杂志文章abstract：:A national survey was conducted to determine polychlorinated dibenzo-p-dioxins and dibenofurans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (dl-PCBs) in human milk samples collected from 16 provinces in China to assess current exposure and temporal trends in China. The arithmetic mean concentration of total TE...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
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journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
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journal_title：International journal of hygiene and environmental health
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journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章,meta分析
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journal_title：International journal of hygiene and environmental health
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journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2007.01.028
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journal_title：International journal of hygiene and environmental health
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journal_title：International journal of hygiene and environmental health
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journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
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journal_title：International journal of hygiene and environmental health
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journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2010.05.004
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journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章,评审
doi：10.1016/j.ijheh.2016.04.008
更新日期：2016-07-01 00:00:00
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journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1078/1438-4639-00215
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journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章,评审
doi：10.1016/j.ijheh.2005.11.004
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journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2015.11.005
更新日期：2016-10-01 00:00:00
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journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章,评审
doi：10.1016/j.ijheh.2010.08.009
更新日期：2011-01-01 00:00:00
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journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2016.10.009
更新日期：2017-03-01 00:00:00
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journal_title：International journal of hygiene and environmental health
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journal_title：International journal of hygiene and environmental health
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journal_title：International journal of hygiene and environmental health
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journal_title：International journal of hygiene and environmental health
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journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
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更新日期：2008-07-01 00:00:00
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journal_title：International journal of hygiene and environmental health
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journal_title：International journal of hygiene and environmental health
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abstract：:Brominated flame retardants (BFRs) are a large group of different substances used in numerous products to prevent fire hazards. Some of them are persistent in the environment, accumulate in the food chain and are of toxicological concern, while for others current data are limited. Meanwhile, BFRs have been found in ma...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章,评审
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journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
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journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
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更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Despite increasing concerns about the health effects of climate change, the extent to which workers are affected by hot weather is not well documented. This study aims to investigate the association between high temperatures and work-related injuries using data from a large subtropical city in China. METHOD...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2018.01.005
更新日期：2018-04-01 00:00:00
abstract：:Between January and October 1994, a study of the prevalence, intensity and clinical manifestations of onchocerciasis in nine communities of Toro local government area of Bauchi State, Nigeria was undertaken using the skin-snip method. Of the 1117 inhabitants examined, 188 (16.8%) were positive for microfilariae of Onc...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1078/1438-4639-00052
更新日期：2001-07-01 00:00:00
