Abstract:
BACKGROUND AND AIM:Epidemiological studies linking insecticide exposure to childhood neurodevelopment have been gaining global attention. Despite the rapid development of the central nervous system in early childhood, studies regarding the biological monitoring of insecticide exposure in diapered children are limited. In this study, we aimed to clarify the concentrations of organophosphate (OP) insecticide metabolites in toddler urine extracted from disposable diapers in Japan. METHODS:We recruited diapered children from the Aichi regional subcohort participants of the Japan Environment and Children's Study (JECS) at the time of their 18-month checkup. A total of 116 children wore designated disposable diapers overnight, which were then sent as refrigerated cargo. The urine was extracted from the diapers using acetone and analyzed by ultra-performance liquid chromatography with tandem mass spectrometry (UPLC-MS/MS) to determine the concentrations of six dialkyl phosphates (DAPs) (i.e., dimethyl phosphate [DMP], dimethyl thiophosphate [DMTP], dimethyl dithiophosphate [DMDTP], diethyl phosphate [DEP], diethyl thiophosphate [DETP], and diethyl dithiophosphate [DEDTP]). DAP absorption into the diapers was quantified to calculate the urinary DAP concentrations. RESULTS:The DAP recovery using the developed method yielded between 54.2% (DEDTP) and 101.4% (DEP). Within-run precision expressed as the relative standard deviation was between 2.4% and 14.7%, and the between-run precision was between 3.1% and 8.5%. A Bland-Altman analysis confirmed the agreement between the results obtained by the developed method and by the measurements for the corresponding urine without diaper absorption. The geometric means (GM) of urinary DMP, DMTP, DMDTP, DEP, DETP, and total DAPs (ΣDAP) were 3.6, 3.9, 0.9, 6.0, 0.6μg/L, and 137.6 nmol/L, respectively. The GM of DEDTP was not calculated due to its low detection rate. CONCLUSIONS:We successfully established a method to measure the DAP concentrations in urine extracted from diapers and this is the first report of these pesticide concentrations in diapered children in Japan.
journal_name
Int J Hyg Environ Healthauthors
Oya N,Ito Y,Hioki K,Asai Y,Aoi A,Sugiura Y,Ueyama J,Oguri T,Kato S,Ebara T,Kamijima Mdoi
10.1016/j.ijheh.2016.10.009subject
Has Abstractpub_date
2017-03-01 00:00:00pages
209-216issue
2 Pt Aeissn
1438-4639issn
1618-131Xpii
S1438-4639(16)30127-4journal_volume
220pub_type
杂志文章abstract::High fish consumption and extended breastfeeding are hallmarks of traditional lifestyle in Western Amazonia. We studied sources of mercury exposure, fish-methylmercury (meHg) and dental-amalgam filling, in 75 urban and 82 rural lactating mothers. Total mercury was determined in all samples while meHg concentrations we...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2012.12.011
更新日期:2013-11-01 00:00:00
abstract::Adequate access to water, sanitation, and hygiene (WaSH) in schools impacts health, educational outcomes, and gender disparities. Little multi-country research has been published on WaSH in rural schools in Sub-Saharan Africa. In this multi-national cross-sectional WaSH study, we document WaSH access, continuity, qual...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2017.03.015
更新日期:2017-08-01 00:00:00
abstract:AIM:The focus of our study was the assessment of the effects of spatial relocation on office staff. Our aim was to investigate whether psychosocial or personal factors are better predictors of the occurrence of impaired well-being. METHODS:Before relocation the administration of the university hospital of Ulm (Germany...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2006.03.005
更新日期:2006-07-01 00:00:00
abstract::Cervical cancer (CC) is potentially the most preventable and treatable cancer in human but it is a leading cause for cancer morbidity and mortality in women around the world. Therefore, more innovative prevention and treatment protocols need to be developed and implemented. With better understanding of the etiology of...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章,评审
doi:10.1016/j.ijheh.2006.10.003
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVES:We investigated the role of a stress-sensitive personality on relations between noise, noise annoyance and somatic symptom reporting. First, we investigated the cross-sectional association of road traffic noise exposure and somatic symptoms, and its modification by hostility and vulnerability to stress. Seco...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2015.05.001
更新日期:2015-08-01 00:00:00
abstract:OBJECTIVE:Unprotected sun exposure especially during childhood is a risk factor for skin cancer. A combined use of sun protection measures is recommended to protect children. However, the prevalence and determinants for combined use have been scarcely studied in children. The objective of this study was to identify det...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2013.07.013
更新日期:2014-03-01 00:00:00
abstract::Indoor air quality (IAQ) and exposure to indoor chemicals are widely discussed in terms of personal discomfort and health risks. In contrast to ambient air and working environments, legally binding regulations are only partially established for indoor contaminants, and other available European guidelines are limited. ...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章,评审
doi:10.1016/j.ijheh.2018.12.012
更新日期:2019-04-01 00:00:00
abstract::Researchers are increasingly interested in using human biomonitoring - the measurement of chemicals, their metabolites or specific reaction products in biological specimens/body fluids - for investigating exposure to environmental chemicals. General population human biomonitoring programs are useful for investigating ...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2011.08.014
更新日期:2012-02-01 00:00:00
abstract::Inhalation of ash can be of great concern for affected communities, during and after volcanic eruptions. Governmental and humanitarian agencies recommend and distribute a variety of respiratory protection (RP), most commonly surgical masks. However, there is currently no evidence on how effective such masks are in pro...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2018.03.011
更新日期:2018-07-01 00:00:00
abstract::Organic solvents utilized in various industrial processes may be associated with hepatotoxicity. The hepatotoxicity of some of the solvents was recognized as early as 1887, 1889 and 1904. Factors contributing to the hepatotoxicity of solvents include 1) species differences, 2) liver blood flow, 3) protein binding, 4) ...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章,评审
doi:10.1078/1438-4639-00175
更新日期:2002-10-01 00:00:00
abstract:OBJECTIVES:Although several nosocomial outbreaks with multi-drug resistant Gram-negative bacteria (MRGN) are documented, only few are known about the endemic situation of theses pathogens. Especially cystic fibrosis (CF) patients are known to be at risk for MRGN acquisition. We present surveillance data of endemic MRGN...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2006.03.001
更新日期:2006-07-01 00:00:00
abstract::In an interdisciplinary approach the exposure to lead and cadmium of the population living in the vicinity of a Bulgarian non-ferrous metallurgical plant was studied to determine the routes of exposure. Two exposed villages situated 4 and 6 km SW and W, respectively,--in the plume of the plant's emissions--and a villa...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1078/1438-4639-00194
更新日期:2003-01-01 00:00:00
abstract::This paper reviews the existing literature on human exposure to polybrominated diphenyl ethers (PBDEs), with particular focus on external exposure routes (e.g. dust, diet, and air) and the resulting internal exposure to PBDEs (e.g. breast milk and blood). Being lipophilic and persistent organic compounds, PBDEs accumu...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章,评审
doi:10.1016/j.ijheh.2008.04.005
更新日期:2009-03-01 00:00:00
abstract::Data on inhalational and potential dermal exposures during spray application of liquid biocidal products were generated. On the one hand, model experiments with different spraying devices using fluorescent tracers were carried out to investigate the influence of parameters relevant to the exposure (e.g. spraying equip...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2005.04.006
更新日期:2005-01-01 00:00:00
abstract::Swimming pool attendance and exposure to chlorination by-products showed adverse health effects on children. We assessed whether early swimming pool attendance, especially baby swimming, is related to higher rates of early infections and to the development of allergic diseases. In 2003-2005, 2192 children were analyse...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2007.08.001
更新日期:2008-07-01 00:00:00
abstract::Risk assessments are important components of the decision making process. At hazardous waste sites, they are used as tools to determine appropriate cleanup levels. Therefore, it is critical that the best up-to-date methods, models, and exposure data are available to the exposure and risk assessor to realistically esti...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1078/1438-4639-00142
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVES:Diffuse vascular encephalopathy, parkinsonism and peripheral polyneuropathy (PNP) due to CS(2) exposure are known since long. Data concerning low exposure are sparse. The current study aimed to evaluate whether the decrease of exposure below the threshold limit value (TLV) of 31 mg/m(3) results in an absence...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2005.09.005
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND:The observed deficit of lung cancer in farmers has been partly attributed to exposure to organic dusts and endotoxins based largely on surrogate metrics. To move beyond these surrogates for etiological studies, we characterized task-based and time-weighted average (TWA) exposure to inhalable endotoxin, (1 → ...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2020.113525
更新日期:2020-07-01 00:00:00
abstract::Di(2-ethylhexyl)phthalate (DEHP) is the main plasticizer for polyvinyl chloride (PVC) products. It has become widely spread in our environment and among people. DEHP is suspected to be responsible for endocrine-disruptor-like effects in mankind. Children are probably most susceptible to these endocrine effects. In thi...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1078/1438-4639-00270
更新日期:2004-01-01 00:00:00
abstract:AIM:It has been reported that a great proportion of mental health disorders have an origin in early childhood. In order to evaluate factors possibly associated with children's health, the health monitoring units have been established since 2004 in six study regions in Bavaria, Germany. The second health monitoring surv...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2016.04.012
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:The second to fourth digit ratio (2D:4D) is assumed to be a biomarker of prenatal sex steroid exposure, correlating negatively with prenatal testosterone and positively with prenatal estrogen. The ratio has been suggested to be influenced by endocrine disrupting chemicals (EDCs). However, evidence regarding ...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2020.113639
更新日期:2021-01-01 00:00:00
abstract::To protect groundwater as a drinking water resource from microbiological contamination, protection zones are installed. While travelling through these zones, concentrations of potential pathogens should decline to levels that pose no risks to human health. Removal of viruses during subsurface passage is influenced by ...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2014.06.004
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:The developing fetus and pregnant woman can be exposed to a variety of environmental chemicals that may adversely affect their health. Moreover, environmental exposure and risk disparities are associated with different social determinants, including socioeconomic status (SES) and demographic indicators. Our ...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2017.01.001
更新日期:2017-03-01 00:00:00
abstract::Mental disorders were often reported following hazardous substance exposure. The present study analyses this association in relation to a work-related exposure to PCBs (polychlorinated biphenyls). Specifically, the aim was to investigate (a) the relationship of inner PCB burden and the severity of mental symptoms and ...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2014.04.001
更新日期:2014-09-01 00:00:00
abstract::Dusts are one of the main air pollutants emitted during cement manufacturing. A substantial part of these are breathable particles that are less than 10 μm in diameter (PM10), which represent a potential threat for the health of the exposed population. This study aimed at evaluating the short-term effects of PM10 conc...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2013.07.016
更新日期:2014-03-01 00:00:00
abstract::Though increasing evidence supports significant association between particulate matter (PM) air pollution and stroke, it remains unclear what characteristics, such as particle size and chemical constituents, are responsible for this association. A time-series model with quasi-Poisson function was applied to assess the...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2015.11.002
更新日期:2016-03-01 00:00:00
abstract::A multiparametric analysis of immune components was performed in blood and serum of 61 voluntary persons before and after (1 day, 3 days, 4-6 months, 10-12 months) a professional pest control operation (PCO) using pyrethroids. Following parameters were included in the study (1) immunological parameters of the humoral ...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1078/1438-4639-00201
更新日期:2003-03-01 00:00:00
abstract::Ultimately, the health and quality of life of all human beings depend upon the environment and ecosystems to which we are directly and indirectly connected. The papers in this special edition address a number of the critical environmental health issues on which U.S. government agencies and their collaborating partners...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1078/1438-4639-00221
更新日期:2003-08-01 00:00:00
abstract::Airborne bioaerosols and Microbial Volatile Organic Compounds (MVOC) concentrations were simultaneously monitored at a composting facility and the main determinants of atmospheric concentrations were characterised, in order to help protect workers from potential adverse health effects. Microorganisms and MVOC were sam...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2010.06.001
更新日期:2010-09-01 00:00:00
abstract::Arsenic in drinking water presents a serious public health problem in Serbia, but its relationship with diabetes has not been studied previously. The aim of this study was to explore the association between exposure to arsenic in drinking water and the occurrence of type 2 diabetes in Middle Banat region, Serbia. This...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2012.01.001
更新日期:2013-01-01 00:00:00