Abstract：
:The p53 gene plays a major role in hepatocellular carcinoma (HCC). Acquired mutations may provide clues to etiology, as some carcinogenic agents are associated with specific genetic changes in p53. Our aim was to analyze the spectrum of p53 mutations in tumor tissues from subjects with HCC in Egypt, where there is a rising incidence of HCC due to hepatitis C virus (HCV). We collected tumor tissues from 41 subjects with HCC diagnosed at the National Cancer Institute of Cairo University during 2000-2003. Sequence mutations were analyzed by the Affymetrix GeneChip technique. HCV RNA was detected in the sera of 37 subjects (90%). Only one patient had a current HBV infection. A total of 17 of the 41 subjects (41%) had p53 mutations. Thirteen of these were in exon 7, of which 10 were in codon 249, but only 8 of the 10 were the R249S mutation, previously reported to be associated with aflatoxin exposure. The other three exon 7 mutations were found in codons 232, 242 and 248. A total of three mutations were detected in exon 5 codons 133, 144 and 176. One mutation was detected in exon 8 codon 275. Unlike previous studies, this population is characterized by a high prevalence of chronic HCV infection. The presence of the R249S mutation in exon 7 may indicate that these subjects with HCC have been exposed to aflatoxin (AFB1), and further investigation is in progress to measure AFB1-albumin adducts in the sera of these subjects.
journal_name
Int J Hyg Environ Healthauthors
El-Kafrawy SA,Abdel-Hamid M,El-Daly M,Nada O,Ismail A,Ezzat S,Abdel-Latif S,Abdel-Hamid A,Shields PG,Loffredo Cdoi
10.1016/j.ijheh.2005.02.002keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
263-70issue
4eissn
1438-4639issn
1618-131Xpii
S1438-4639(05)00040-4journal_volume
208pub_type
杂志文章abstract：BACKGROUND:The exposure of children to lead has decreased in recent years, thanks notably to the banning of leaded gasoline. However, lead exposure remains a matter of public health concern, because no toxicity threshold has been observed, cognitive effects having been demonstrated even at low levels. It is therefore i...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
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journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
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abstract：AIM:It has been reported that a great proportion of mental health disorders have an origin in early childhood. In order to evaluate factors possibly associated with children's health, the health monitoring units have been established since 2004 in six study regions in Bavaria, Germany. The second health monitoring surv...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
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abstract：:A component of the ure gene cluster in E. coli, ureC, encodes a subunit of urease. We have investigated the distribution of ureC in 202 Shiga toxin-producing E. coli (STEC) strains from Austria belonging to 61 different serotypes. These strains were of human (n=150), animal (n=38), and food (n=14) origin. ureC was pre...
journal_title：International journal of hygiene and environmental health
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abstract：BACKGROUND:The developing fetus and pregnant woman can be exposed to a variety of environmental chemicals that may adversely affect their health. Moreover, environmental exposure and risk disparities are associated with different social determinants, including socioeconomic status (SES) and demographic indicators. Our ...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
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abstract：:Due to the increased awareness of the ubiquitous contamination of all environmental compartments and of human beings with perfluoroalkyl substances (PFAS), voluntary withdrawals and shifts in products and manufacturing technologies, as well as in regulatory measures, have been made. To investigate whether these activi...
journal_title：International journal of hygiene and environmental health
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journal_title：International journal of hygiene and environmental health
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journal_title：International journal of hygiene and environmental health
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journal_title：International journal of hygiene and environmental health
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journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
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journal_title：International journal of hygiene and environmental health
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journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
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更新日期：2007-03-01 00:00:00
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journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章,评审
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更新日期：2016-07-01 00:00:00
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journal_title：International journal of hygiene and environmental health
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更新日期：2003-08-01 00:00:00
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journal_title：International journal of hygiene and environmental health
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更新日期：2004-09-01 00:00:00
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journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
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journal_title：International journal of hygiene and environmental health
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journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
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更新日期：2016-05-01 00:00:00
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journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
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journal_title：International journal of hygiene and environmental health
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journal_title：International journal of hygiene and environmental health
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更新日期：2018-06-01 00:00:00
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journal_title：International journal of hygiene and environmental health
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