当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH期刊下所有文献 > Nephrotoxicity, neurotoxicity, and mercury exposure among children with and without dental amalgam fillings.

Nephrotoxicity, neurotoxicity, and mercury exposure among children with and without dental amalgam fillings.

Abstract：

PURPOSE:A scientific review panel for the US Food and Drug Administration (FDA) recently identified the need for more data on the health risk of mercury exposure from dental amalgam among susceptible populations. We evaluated impacts of low-level mercury exposure on renal function and neurobehavioral and neuropsychological performance among children. METHODS:Dental histories for 403 children aged 7-11 years in five schools from Xuhui, Shanghai were checked by dentists. Of them, 198 with confirmed amalgam fillings were recruited (exposure group). Reference children (N=205) were those who never had dental amalgam treatment. In May 2004, each child provided a urine sample for measurements of total mercury, N-acetyl-beta-D-glucosaminidase activity, microalbumin, and creatinine (Cr). The Child Behavior Checklist, Eysenck Personality Questionnaire, and an intelligence screening test were administered. RESULTS:The geometric mean urinary mercury concentration was 1.6 microg/g Cr for children with and 1.4 microg/g Cr for children without amalgam fillings. No differences were found between children with and without fillings for either renal function biomarker, or on neurobehavioral, neuropsychological, or intelligence tests. CONCLUSIONS:Although urinary mercury concentration was slightly elevated among children with amalgam fillings, we found no evidence of adverse effects on the outcomes evaluated. These results agree with those from recent trials in developed countries.

journal_name

Int J Hyg Environ Health

journal_title

International journal of hygiene and environmental health

authors

Ye X,Qian H,Xu P,Zhu L,Longnecker MP,Fu H

doi

10.1016/j.ijheh.2008.09.004

subject

Has Abstract

pub_date

2009-07-01 00:00:00

pages

378-86

issue

4

eissn

1438-4639

issn

1618-131X

pii

S1438-4639(08)00080-1

journal_volume

212

pub_type

杂志文章

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