Abstract:
:Several studies have pointed out associations between various metals and cardiovascular disease. Since cardiovascular disease prevalence is different between males and females, we investigated whether circulating levels of metals related differently to coronary risk in men and women. In the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study, coronary risk was assessed by the Framingham Risk Score together with circulating blood levels of 11 different trace and heavy metals in 1016 subjects aged 70 years. Circulating levels of cadmium, copper and manganese were significantly higher in women than in men, while mercury, zinc and lead were significantly lower following adjustment for kidney function (measured by glomerular filtration rate, GFR). No significant differences between women and men were seen regarding levels of aluminium, molybdenum, cobalt, chromium and nickel. When all 11 metals were entered as independent variables together with GFR in multiple models in the Framingham Risk Score as the dependent variable, cadmium was the major determinant of the Framingham Risk Score in women (p<0.0001, followed by zinc p=0.03), while copper was the major determinant of the Framingham Risk Score in men (p<0.0001, followed by inverse relations vs. aluminium p=0.01 and nickel p=0.01). There are gender differences in levels of metals and also regarding the association between metals and coronary risk, with cadmium levels being most important for women and copper levels for men in this elderly population.
journal_name
Int J Hyg Environ Healthauthors
Olsén L,Lind PM,Lind Ldoi
10.1016/j.ijheh.2011.11.004subject
Has Abstractpub_date
2012-04-01 00:00:00pages
411-7issue
3eissn
1438-4639issn
1618-131Xpii
S1438-4639(11)00215-Xjournal_volume
215pub_type
杂志文章abstract:OBJECTIVE:To determine the accuracy of questions in identifying subjects occupationally exposed to high noise level and those with hearing loss using noise dosimeter and pure-tone air conduction audiometry as the gold standards. DESIGN:A cross-sectional study involving 259 noise-exposed workers selected randomly from ...
journal_title:International journal of hygiene and environmental health
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journal_title:International journal of hygiene and environmental health
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journal_title:International journal of hygiene and environmental health
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journal_title:International journal of hygiene and environmental health
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journal_title:International journal of hygiene and environmental health
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journal_title:International journal of hygiene and environmental health
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journal_title:International journal of hygiene and environmental health
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doi:10.1016/j.ijheh.2012.08.004
更新日期:2013-11-01 00:00:00
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doi:10.1016/j.ijheh.2018.03.011
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pub_type: 杂志文章
doi:10.1016/j.ijheh.2006.09.001
更新日期:2007-03-01 00:00:00
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doi:10.1016/j.ijheh.2018.06.008
更新日期:2019-01-01 00:00:00
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doi:10.1078/1438-4639-00231
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journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2013.10.002
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journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章,meta分析
doi:10.1016/j.ijheh.2013.03.006
更新日期:2014-01-01 00:00:00
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journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2016.07.013
更新日期:2016-11-01 00:00:00
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journal_title:International journal of hygiene and environmental health
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更新日期:2018-03-01 00:00:00
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journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2020.113495
更新日期:2020-05-01 00:00:00
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journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2011.01.003
更新日期:2011-06-01 00:00:00
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journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2017.05.009
更新日期:2017-08-01 00:00:00
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journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2012.02.008
更新日期:2013-01-01 00:00:00
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journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2017.11.004
更新日期:2018-03-01 00:00:00
abstract::Prenatal exposure to polybrominated diphenyl ethers (PBDEs) have been reported to impair executive function in children, but little is known whether childhood PBDE exposures play a role. Using the Health Outcomes and Measures of the Environment (HOME) Study, a prospective birth cohort in the greater Cincinnati area, w...
journal_title:International journal of hygiene and environmental health
pub_type: 杂志文章
doi:10.1016/j.ijheh.2017.10.006
更新日期:2018-01-01 00:00:00