当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH期刊下所有文献 > The distribution of blood concentrations of lead (Pb), cadmium (Cd), chromium (Cr) and manganese (Mn) in residents of the German Ruhr area and its potential association with occupational exposure in metal industry and/or other risk factors.

The distribution of blood concentrations of lead (Pb), cadmium (Cd), chromium (Cr) and manganese (Mn) in residents of the German Ruhr area and its potential association with occupational exposure in metal industry and/or other risk factors.

Abstract：

OBJECTIVE:This study investigated the metal distribution in blood samples from the general population and the risk of having high metal concentration for metal workers. METHODS:Metal concentrations were determined in archived blood samples from 1411 men and 1410 women (median age 59 and 57 years, respectively) collected at baseline (2000-2003) of the prospective Heinz Nixdorf Recall Study. Retrospective information on working in metal industry was obtained from previous follow-up survey (2011-2014). Odds ratios (ORs) with 95% confidence intervals (CI) of having a metal concentration >90th percentile (P90) for working in metal industry were calculated using logistic regression with adjustment for covariates. RESULTS:More men than women worked in metal industry (57 vs. 3 at baseline). Male metal workers had increased blood lead (Pb) (OR: 2.86; 95% CI: 1.38-5.91) and manganese (Mn) (OR: 2.92; 95% CI: 1.46-5.81). Smoking (≥30 cigarettes/day) strongly influenced cadmium (Cd) in blood (OR: 168; 95% CI: 55-510). Women had higher Mn (8.92μg/L) and Cd (0.36μg/L) concentrations than men (Mn: 8.11μg/L; Cd: 0.29μg/L). Blood Pb in women (29.2μg/L) was lower than in men (33.2μg/L). None of the studied risk factors was significantly associated with chromium and nickel concentrations above their 90th percentiles. CONCLUSIONS:In this population-based cohort we found evidence that working in metal industry was predictive for having elevated blood Pb and Mn concentrations. However, the 95th percentiles of all investigated metals were not significantly influenced by metal-related occupations. The present study is supportive for gender-specific reference values to limit occupational exposure to Mn and Pb. The strong influence of smoking on blood Cd hinders establishing reference values.

journal_name

Int J Hyg Environ Health

journal_title

International journal of hygiene and environmental health

authors

Bonberg N,Pesch B,Ulrich N,Moebus S,Eisele L,Marr A,Arendt M,Jöckel KH,Brüning T,Weiss T

doi

10.1016/j.ijheh.2017.05.009

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

998-1005

issue

eissn

1438-4639

issn

1618-131X

pii

S1438-4639(17)30106-2

journal_volume

220

pub_type

杂志文章

在线工具

The distribution of blood concentrations of lead (Pb), cadmium (Cd), chromium (Cr) and manganese (Mn) in residents of the German Ruhr area and its potential association with occupational exposure in metal industry and/or other risk factors.