Abstract：
:Non-carcinogenic effects in low-level (< 100 μgL(-1)) arsenic (As)-impacted populations, such as the development and progression of type-2 diabetes mellitus (T2DM), are often neglected given the primary emphasis of public health authorities on As carcinogenicity. We gathered studies reporting urinary biomarkers of As exposure (U-As) and biomarkers associated with T2DM and its complications (U-T2DM), such as renal damage, oxidation stress, low-grade inflammation, and endothelial damage. Studied U-T2DM biomarkers were: 8-hydroxy-2'deoxyguanosine, N-acetyl-β-d-glucosaminidase, β2-microglobulin, and albumin. Data was expressed as: either arithmetic means and standard deviations, or geometric means and geometric standard deviations, or correlation coefficients of U-As and U-T2DM. Urinary As concentrations were consistently associated with the aforementioned biomarkers of T2DM pathologic complications. Despite the limited selectivity of the selected T2DM biomarkers, a per unit change in As exposure level was reflected in the corresponding T2DM biomarker urinary concentrations. Our systematic review provides new evidence on the role of environmental As exposures influencing the T2DM disease process. Additional epidemiologic studies onto the association between As and T2DM should incorporate both urinary As and T2DM biomarkers, as suggested in this study, in order to evaluate subclinical effects of low-level As exposures.
journal_name
Int J Hyg Environ Healthauthors
Andra SS,Makris KC,Christophi CA,Ettinger ASdoi
10.1016/j.ijheh.2012.07.001subject
Has Abstractpub_date
2013-01-01 00:00:00pages
35-49issue
1eissn
1438-4639issn
1618-131Xpii
S1438-4639(12)00089-2journal_volume
216pub_type
杂志文章,meta分析abstract：:A number of prospective cohort studies are ongoing worldwide to investigate the impact of foetal and neonatal exposures to chemical substances on child health. To assess multiple exposure (mixture) effects and low prevalence health outcomes it is useful to pool data from several studies and conduct mega-data-analysis....
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2019.07.005
更新日期：2019-09-01 00:00:00
abstract：:Due to the frequent use of antibiotics and recurring illnesses related to multidrug-resistant (MDR) bacteria in South Africa, we determined if MDR Escherichia coli were present in pit latrine fecal sludge samples obtained from a peri-urban community in KwaZulu-Natal, South Africa. The abundance of E. coli in pit latri...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2017.08.002
更新日期：2017-11-01 00:00:00
abstract：:The body burden of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), dioxin-like (dl-PCBs) and non-dioxin-like (ndl-PCBs) polychlorinated biphenyls, and polybrominated diphenyl ethers (PBDEs) was determined in blood samples from 70 subjects between 4 and 76 years old. The participants of the study were re...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2014.07.004
更新日期：2015-01-01 00:00:00
abstract：:Parabens are widely used as antimicrobial preservatives in personal care and consumer products, food and pharmaceuticals. Due to their ubiquity, humans are constantly exposed to these chemicals. We assessed exposure to nine parabens (methyl-, ethyl-, n- and iso-propyl-, n- and iso-butyl-, benzyl-, pentyl- and heptyl p...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2015.07.005
更新日期：2015-10-01 00:00:00
abstract：:Alongside efforts to improve safe management of feces along the entire sanitation chain, including after the toilet, global sanitation efforts are focusing on universal access 'basic' services: onsite facilities that safely contain excreta away from human contact. Although fecal sludge management is improving in urban...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2019.113433
更新日期：2020-03-01 00:00:00
abstract：:It is a weak point of environmental medicine that health disturbances, e.g. functional affections of the upper respiratory tract, cannot be objectively judged by physicians resp. researchers. In this study, the validity of acoustic rhinometry, a method giving information on cross-sectional areas of the upper airways b...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1078/S1438-4639(04)70008-5
更新日期：2000-03-01 00:00:00
abstract：:Human biomonitoring (HBM) has proven an extremely valuable tool for determining which chemicals are getting into people, detecting trends in population exposures over time, and identifying populations with exposures above background. The potential significance of the HBM data in the context of existing toxicology data...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2011.09.011
更新日期：2012-02-01 00:00:00
abstract：:Among the 3rd Seminar for PhD students working on Water and Health which was held in Cannes on 27–29 June 2011, experts from a number of universities and research institutes took the opportunity to discuss the emergence of Escherichia coli O104:H4 in Europe. Especially, possible threats for European water suppliers we...
journal_title：International journal of hygiene and environmental health
pub_type： 共识发展会议,杂志文章
doi：10.1016/j.ijheh.2011.08.001
更新日期：2011-11-01 00:00:00
abstract：:E-liquids generally contain four main components: nicotine, flavours, water and carrier liquids. The carrier liquid dissolves flavours and nicotine and vaporises at a certain temperature on the atomizer of the e-cigarette. Propylene glycol and glycerol, the principal carriers used in e-liquids, undergo decomposition i...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2016.01.004
更新日期：2016-05-01 00:00:00
abstract：BACKGROUND:Isocyanates are highly reactive chemicals used widely in metal structure coating applications in construction. Isocyanates are potent respiratory and skin sensitizers and a leading cause of occupational asthma. At present, there is no cure for isocyanate asthma and no biomarkers of early disease. Exposure re...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2020.113495
更新日期：2020-05-01 00:00:00
abstract：:Indoor air quality (IAQ) and exposure to indoor chemicals are widely discussed in terms of personal discomfort and health risks. In contrast to ambient air and working environments, legally binding regulations are only partially established for indoor contaminants, and other available European guidelines are limited. ...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章,评审
doi：10.1016/j.ijheh.2018.12.012
更新日期：2019-04-01 00:00:00
abstract：:The beneficial effect of trans-resveratrol (RESV) on health is well documented. Our aim was to study the putative preventive effect of RESV on the cytotoxicity of frequently used herbicides (alachlor, acetochlor). Estrogen receptor positive (ER+) MCF-7 human mammary carcinoma, HepG2 (ER+) human hepatocellular carcinom...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2005.01.021
更新日期：2005-01-01 00:00:00
abstract：:A component of the ure gene cluster in E. coli, ureC, encodes a subunit of urease. We have investigated the distribution of ureC in 202 Shiga toxin-producing E. coli (STEC) strains from Austria belonging to 61 different serotypes. These strains were of human (n=150), animal (n=38), and food (n=14) origin. ureC was pre...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2006.06.003
更新日期：2006-11-01 00:00:00
abstract：:Arsenic in drinking water presents a serious public health problem in Serbia, but its relationship with diabetes has not been studied previously. The aim of this study was to explore the association between exposure to arsenic in drinking water and the occurrence of type 2 diabetes in Middle Banat region, Serbia. This...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2012.01.001
更新日期：2013-01-01 00:00:00
abstract：OBJECTIVES:Diffuse vascular encephalopathy, parkinsonism and peripheral polyneuropathy (PNP) due to CS(2) exposure are known since long. Data concerning low exposure are sparse. The current study aimed to evaluate whether the decrease of exposure below the threshold limit value (TLV) of 31 mg/m(3) results in an absence...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2005.09.005
更新日期：2006-03-01 00:00:00
abstract：:It remains unclear whether exposure to low-level mercury (Hg) is associated with impaired renal function, and whether omega-3 fatty acid (FA) intake could affect the association of interest. The current study examined the association of blood Hg and omega-3 FAs with renal function using data from 1046 subjects aged 40...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2013.09.004
更新日期：2014-04-01 00:00:00
abstract：BACKGROUND:Growing evidence suggests that pesticide exposure may influence respiratory health, but data in young children are very limited. We examined the association of prenatal pesticide exposure with lower respiratory tract infections (LRTIs) and wheeze at one year of age in children from the Infants' Environmental...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2020.113474
更新日期：2020-04-01 00:00:00
abstract：:Swine confinement buildings in eastern Canada are enclosed and equipped with modern production systems to manage waste. Bioaerosols of these swine confinement buildings could be contaminated by human pathogens and antimicrobial resistant bacteria which could colonize exposed workers. We therefore wanted to analyze bio...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2010.09.008
更新日期：2010-11-01 00:00:00
abstract：:Chlorination of seawater is one of the most effective technologies for industrial biofouling control. However, chlorination leads to the formation of halogenated chlorination byproducts (CBPs) associated with potential risks to environmental and human health. The present study investigated the occurrence and distribut...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2018.06.008
更新日期：2019-01-01 00:00:00
abstract：:In this study, the concentrations of disinfection byproducts (DBPs), including trihalomethanes (THMs; chloroform, bromodichloromethane, dibromochloromethane, and bromoform), haloacetic acids (HAAs; dichloroacetic acid and trichloroacetic acid), haloacetonitriles (HANs; dichloroacetonitrile, trichloroacetonitrile, brom...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2010.09.005
更新日期：2010-11-01 00:00:00
abstract：:7-Hydroxy-3,7-dimethyl-1-octanal, also known as 7-hydroxycitronellal (7-HC, CAS No. 107-75-5) is a synthetic fragrance widely used in cosmetic and hygiene products. Due to its large scope, 7-HC was selected for the development of a biomonitoring method suitable for the general population within the frame of the cooper...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2017.10.015
更新日期：2018-03-01 00:00:00
abstract：:Inhalation of ash can be of great concern for affected communities, during and after volcanic eruptions. Governmental and humanitarian agencies recommend and distribute a variety of respiratory protection (RP), most commonly surgical masks. However, there is currently no evidence on how effective such masks are in pro...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2018.03.011
更新日期：2018-07-01 00:00:00
abstract：:Polychlorinated biphenyls (PCBs) and organochlorine pesticides are persistent organic pollutants that have a widespread distribution in the environment. Human biomonitoring is a suitable tool to assess the burden of humans with these substances. Over a time span of 8 years, a free analysis of their milk was offered to...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2008.04.001
更新日期：2008-10-01 00:00:00
abstract：:Asthma is a heterogeneous disease with varying severity and subtypes. Recent reviews of epidemiologic studies have identified cleaning and disinfecting activities (CDAs) as important risk factors for asthma-related outcomes among healthcare workers. However, the complexity of CDAs in healthcare settings has rarely bee...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2019.04.001
更新日期：2019-06-01 00:00:00
abstract：:High fish consumption and extended breastfeeding are hallmarks of traditional lifestyle in Western Amazonia. We studied sources of mercury exposure, fish-methylmercury (meHg) and dental-amalgam filling, in 75 urban and 82 rural lactating mothers. Total mercury was determined in all samples while meHg concentrations we...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2012.12.011
更新日期：2013-11-01 00:00:00
abstract：:This study aimed to evaluate the contamination level of the Peri Lagoon, the main freshwater reservoir of Santa Catarina Island, Southern Brazil, for human adenovirus (HAdV), hepatitis A virus (HAV), rotavirus species A (RVA), and somatic coliphages (SOMCPH). Viruses were also investigated in sediments and their sensi...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2016.07.009
更新日期：2016-10-01 00:00:00
abstract：:Ultimately, the health and quality of life of all human beings depend upon the environment and ecosystems to which we are directly and indirectly connected. The papers in this special edition address a number of the critical environmental health issues on which U.S. government agencies and their collaborating partners...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1078/1438-4639-00221
更新日期：2003-08-01 00:00:00
abstract：:The results of the study demonstrate that the weak estrogenic action of bisphenol A (a daily subcutaneous dose of 200 mg/kg on 4 consecutive days, administered before or after decidual induction that occurs on day 4 of pseudopregnancy) on deciduoma growth in pseudopregnant Sprague-Dawley rats, was functionally associa...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1078/1438-4639-00115
更新日期：2002-02-01 00:00:00
abstract：:The p53 gene plays a major role in hepatocellular carcinoma (HCC). Acquired mutations may provide clues to etiology, as some carcinogenic agents are associated with specific genetic changes in p53. Our aim was to analyze the spectrum of p53 mutations in tumor tissues from subjects with HCC in Egypt, where there is a r...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2005.02.002
更新日期：2005-01-01 00:00:00
abstract：:Biomonitoring of exposure to chemicals has been practiced for over half a century on a regular basis. During the last decade, however, the focus changed from occupational to environmental settings, requiring a different interpretative framework. Under the auspices of the European Centre for Ecology and Ecotoxicology (...
journal_title：International journal of hygiene and environmental health
pub_type： 杂志文章
doi：10.1016/j.ijheh.2007.01.006
更新日期：2007-05-01 00:00:00
