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YAP and TAZ protect against white adipocyte cell death during obesity.

Abstract：

:The expansion of the white adipose tissue (WAT) in obesity goes along with increased mechanical, metabolic and inflammatory stress. How adipocytes resist this stress is still poorly understood. Both in human and mouse adipocytes, the transcriptional co-activators YAP/TAZ and YAP/TAZ target genes become activated during obesity. When fed a high-fat diet (HFD), mice lacking YAP/TAZ in white adipocytes develop severe lipodystrophy with adipocyte cell death. The pro-apoptotic factor BIM, which is downregulated in adipocytes of obese mice and humans, is strongly upregulated in YAP/TAZ-deficient adipocytes under HFD, and suppression of BIM expression reduces adipocyte apoptosis. In differentiated adipocytes, TNFα and IL-1β promote YAP/TAZ nuclear translocation via activation of RhoA-mediated actomyosin contractility and increase YAP/TAZ-mediated transcriptional regulation by activation of c-Jun N-terminal kinase (JNK) and AP-1. Our data indicate that the YAP/TAZ signaling pathway may be a target to control adipocyte cell death and compensatory adipogenesis during obesity.

journal_name

Nat Commun

journal_title

Nature communications

authors

Wang L,Wang S,Shi Y,Li R,Günther S,Ong YT,Potente M,Yuan Z,Liu E,Offermanns S

doi

10.1038/s41467-020-19229-3

subject

Has Abstract

pub_date

2020-10-28 00:00:00

pages

5455

issue

1

issn

2041-1723

pii

10.1038/s41467-020-19229-3

journal_volume

11

pub_type

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