Abstract:
BACKGROUND:Nontuberculous mycobacteria (NTM) are ubiquitous organisms and the incidence of NTM infections has been increasing in recent years. Mycobacteroides abscessus (M. abscessus) is one of the most antimicrobial-resistant NTM; however, no reliable antibiotic regimen can be officially advocated. We evaluated the efficacy of clarithromycin in combination with various antimicrobial agents against the M. abscessus complex. RESULTS:Twenty-nine clinical strains of M. abscessus were isolated from various clinical samples. Of the isolates, 10 (34.5%) were of M. abscessus subsp. abscessus, 18 (62.1%) of M. abscessus subsp. massiliense, and 1 (3.4%) of M. abscessus subsp. bolletii. MICs of three antimicrobial agents (amikacin, imipenem, and moxifloxacin) were measured with or without clarithromycin. The imipenem-clarithromycin combination significantly reduced MICs compared to clarithromycin and imipenem monotherapies, including against resistant strains. The association between susceptibility of the M. abscessus complex and each combination of agents was significant (p = 0.001). Adjusted residuals indicated that the imipenem-clarithromycin combination had the synergistic effect (adjusted residual = 3.1) and suppressed the antagonistic effect (adjusted residual = - 3.1). In subspecies of M. abscessus complex, the association with susceptibility of M. abscessus subsp. massiliense was similarly statistically significant (p = 0.036: adjusted residuals of synergistic and antagonistic effect respectively: 2.6 and - 2.6). The association with susceptibility of M. abscessus subsp. abscessus also showed a similar trend but did not reach statistical significance. CONCLUSION:Our data suggest that the imipenem-clarithromycin combination could be the recommended therapeutic choice for the treatment of M. abscessus complex owing to its ability to restore antimicrobial susceptibility.
journal_name
BMC Microbioljournal_title
BMC microbiologyauthors
Takei S,Ihara H,Togo S,Nakamura A,Fujimoto Y,Watanabe J,Kurokawa K,Shibayama K,Sumiyoshi I,Ochi Y,Iwai M,Okabe T,Chonan M,Misawa S,Ohsaka A,Takahashi Kdoi
10.1186/s12866-020-02000-5subject
Has Abstractpub_date
2020-10-19 00:00:00pages
316issue
1issn
1471-2180pii
10.1186/s12866-020-02000-5journal_volume
20pub_type
杂志文章相关文献
BMC MICROBIOLOGY文献大全abstract:BACKGROUND:Most of the studies evaluating the secular trends of blood isolates come from tertiary hospitals in urban areas. We sought to study the trends of the antimicrobial resistance of blood isolates in patients from a rural population hospitalized in a tertiary hospital in a small city in Greece. METHODS:We retro...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-6-41
更新日期:2006-05-02 00:00:00
abstract:BACKGROUND:Rhodosporidium toruloides is a β-carotenoid accumulating, oleaginous yeast that has great biotechnological potential. The lack of reliable and efficient genetic manipulation tools have been a major hurdle blocking its adoption as a biotechnology platform. RESULTS:We report for the first time the development...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-14-50
更新日期:2014-02-27 00:00:00
abstract:BACKGROUND:Ustilago esculenta, a typical dimorphic fungus could infect Zizania latifolia and induce host stem swollen to form an edible vegetable called Jiaobai in China. The strains differentiation especially in the mating ability and pathogenicity is closely related to different phenotypes of Jiaobai formed in the fi...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1588-2
更新日期:2019-09-05 00:00:00
abstract:BACKGROUND:Sigma factors are one of the components of RNA polymerase holoenzymes, and an essential factor of transcription initiation in bacteria. Corynebacterium glutamicum possesses seven genes coding for sigma factors, most of which have been studied to some detail; however, the role of SigD in transcriptional regul...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-017-1067-6
更新日期:2017-07-12 00:00:00
abstract:BACKGROUND:The increasing availability of whole genome sequences allows the gene or protein content of different organisms to be compared, leading to burgeoning interest in the relatively new subfield of pan-genomics. However, while several studies have analyzed protein content relationships in specific groups of bacte...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-10-258
更新日期:2010-10-13 00:00:00
abstract:BACKGROUND:It is well known that expression of certain bacterial genes responds rapidly to such stimuli as exposure to toxic chemicals and physical agents. It is generally believed that the proteins encoded in these genes are important for successful survival of the organism under the hostile conditions. Analogously, t...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-3-16
更新日期:2003-08-12 00:00:00
abstract:BACKGROUND:The genus Brucella contains highly infectious species that are classified as biological threat agents. The timely detection and identification of the microorganism involved is essential for an effective response not only to biological warfare attacks but also to natural outbreaks. Matrix-assisted laser desor...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-11-267
更新日期:2011-12-23 00:00:00
abstract:BACKGROUND:Bacteria adapted to live within animals can protect their hosts against harmful infections. Beyond antagonism with pathogens, a 'defensive' bacterial symbiont could engage in additional interactions with other colonizing micro-organisms. A single bacterium might thus have cascading ecological impacts on the ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-020-01845-0
更新日期:2020-06-15 00:00:00
abstract:BACKGROUND:Adhesion to surfaces facilitates many crucial functions of microbes in their natural habitats. Thus understanding the mechanism of microbial adhesion is of broad interest to the microbiology research community. RESULTS:We report a study by fluorescence imaging and atomic force microscopy on the growth in si...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-13-139
更新日期:2013-06-19 00:00:00
abstract:BACKGROUND:Salmonella enterica is a causative agent of foodborne gastroenteritis and the systemic disease known as typhoid fever. This bacterium uses two type three secretion systems (T3SSs) to translocate protein effectors into host cells to manipulate cellular function. Salmonella pathogenicity island (SPI)-2 encodes...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-13-221
更新日期:2013-10-04 00:00:00
abstract:BACKGROUND:The influence of the membrane-bound AAA+ protease FtsH on membrane and cytoplasmic proteins of Corynebacterium glutamicum was investigated in this study. For the analysis of the membrane fraction, anion exchange chromatography was combined with SDS-PAGE, while the cytoplasmic protein fraction was studied by ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-7-6
更新日期:2007-01-25 00:00:00
abstract:: ...
journal_title:BMC microbiology
pub_type:
doi:10.1186/s12866-018-1279-4
更新日期:2018-11-23 00:00:00
abstract:BACKGROUND:Pectobacterium carotovorum subsp. carotovorum is a phytopathogenic enterobacterium responsible for soft rot, a disease characterized by extensive maceration of the affected plant tissue. This species also produces two or more antibacterial substances called bacteriocins, which enhance its competitiveness aga...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-9-181
更新日期:2009-08-27 00:00:00
abstract:BACKGROUND:Klebsiella pneumoniae displaying the hypermucoviscosity (HV) phenotype are considered more virulent than HV-negative strains. Nevertheless, the emergence of tissue-abscesses-associated HV-negative isolates motivated us to re-evaluate the role of HV-phenotype. RESULTS:Instead of genetically manipulating the ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-11-50
更新日期:2011-03-08 00:00:00
abstract:BACKGROUND:Thiomonas strains are ubiquitous in arsenic-contaminated environments. Differences between Thiomonas strains in the way they have adapted and respond to arsenic have never been studied in detail. For this purpose, five Thiomonas strains, that are interesting in terms of arsenic metabolism were selected: T. a...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-9-127
更新日期:2009-06-23 00:00:00
abstract:BACKGROUND:Papua New Guinea (PNG) is a high tuberculosis (TB) burden country of the WHO Western Pacific Region, but so far research on drug resistance (DR) and genotypes of Mycobacterium tuberculosis (M. tuberculosis) was only conducted in few provinces in the country. The aim of the present study was to obtain baselin...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-014-0307-2
更新日期:2014-12-05 00:00:00
abstract:BACKGROUND:Microbiome and metagenomic studies have given rise to a new understanding of microbial colonization of various human tissues and their ability to impact our health. One human microbiome growing in notoriety, the vaginal microbiome, stands out given its importance for women's health, and is peculiar in terms ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-020-02027-8
更新日期:2020-11-10 00:00:00
abstract:BACKGROUND:Hepatitis B virus (HBV), because of its error-prone viral polymerase, has a high mutation rate leading to widespread substitutions, deletions, and insertions in the HBV genome. Deletions may significantly change viral biological features complicating the progression of liver diseases. However, the clinical c...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-12-307
更新日期:2012-12-28 00:00:00
abstract:BACKGROUND:Hfq is a widely conserved bacterial RNA-binding protein which generally mediates the global regulatory activities involv ed in physiological process and virulence. The goal of this study was to characterize the biological function of hfq gene in Xanthomonas axonpodis pv. citri (Xac), the causal agent of citr...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1476-9
更新日期:2019-05-22 00:00:00
abstract:BACKGROUND:Similar to Gram-negative bacteria, the outer membrane (OM) of the pathogenic spirochete, Borrelia burgdorferi, contains integral OM-spanning proteins (OMPs), as well as membrane-anchored lipoproteins. Although the mechanism of OMP biogenesis is still not well-understood, recent studies have indicated that a ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-12-60
更新日期:2012-04-20 00:00:00
abstract:BACKGROUND:Streptococcus pseudopneumoniae, is a novel member of the genus Streptococcus, falling close to related members like S. pneumoniae, S. mitis, and S. oralis. Its recent appearance has shed light on streptococcal infections, which has been unclear till recently. In this study, the transcriptome of S. pseudopneu...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-12-77
更新日期:2012-07-06 00:00:00
abstract:BACKGROUND:The infections caused by antibiotic multidrug-resistant bacteria seriously threaten human health. To prevent and cure the infections caused by multidrug-resistant bacteria, new antimicrobial agents are required. Antimicrobial peptides are ideal therapy candidates for antibiotic-resistant pathogens. However, ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-015-0389-5
更新日期:2015-03-03 00:00:00
abstract:BACKGROUND:Alpha-isopropylmalate synthase (alpha-IPMS) is the key enzyme that catalyzes the first committed step in the leucine biosynthetic pathway. The gene encoding alpha-IPMS in Mycobacterium tuberculosis, leuA, is polymorphic due to the insertion of 57-bp repeat units referred to as Variable Number of Tandem Repea...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-9-122
更新日期:2009-06-09 00:00:00
abstract:BACKGROUND:Brucellosis is an important zoonosis caused by the genus Brucella. In addition Brucella represents potential biological warfare agents due to the high contagious rates for humans and animals. Therefore, the strain typing epidemiological tool may be crucial for tracing back source of infection in outbreaks an...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-9-66
更新日期:2009-04-07 00:00:00
abstract:BACKGROUND:The naked mole-rat (NMR, Heterocephalus glaber) is being bred as a novel laboratory animal due to its unique biological characteristics, including longevity, cancer resistance, hypoxia tolerance, and pain insensitivity. It is expected that differences exist between the microbiota of wild NMRs and that of NMR...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-018-1226-4
更新日期:2018-08-22 00:00:00
abstract:BACKGROUND:Fungi constitute an important yet frequently neglected component of the human microbiota with a possible role in health and disease. Fungi and bacteria colonise the infant gastrointestinal tract in parallel, yet most infant microbiome studies have ignored fungi. Milk is a source of diverse and viable bacteri...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-020-01829-0
更新日期:2020-06-05 00:00:00
abstract:BACKGROUND:Many bacterial extracytoplasmic proteins are stabilized by intramolecular disulfide bridges that are formed post-translationally between their cysteine residues. This protein modification plays an important role in bacterial pathogenesis, and is facilitated by the Dsb (disulfide bond) family of the redox pro...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-11-166
更新日期:2011-07-25 00:00:00
abstract:BACKGROUND:The Gram-negative phytopathogenic bacterium Xanthomonas campestris pv. campestris recruits the hrp/T3SS system to inject pathogenicity effector proteins into host cells and uses the rpf/DSF cell-cell signaling system to regulate the expression of virulence factors such as extracellular enzymes and polysaccha...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-018-1233-5
更新日期:2018-09-03 00:00:00
abstract:BACKGROUND:Participation of renal cells in the pathogenesis of staphylococcal enterotoxin B (SEB) is critical for late cleansing and sequestration of the antigens facilitated by CD1d mediated antigen sensing and recognition. This is a noted deviation from the typical antigen recognition process that recruits the major ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-015-0344-5
更新日期:2015-02-04 00:00:00
abstract:BACKGROUND:In the present work, we describe a group of anomalous dose-response (DR) profiles and develop a dynamic model that is able to explain them. Responses were obtained from conventional assays of three antimicrobial agents (nisin, pediocin and phenol) against two microorganisms (Carnobacterium piscicola and Leuc...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/1471-2180-10-220
更新日期:2010-08-19 00:00:00