Association between the serotonin transporter linked polymorphic region and lifelong premature ejaculation: An updated meta-analysis of case-control studies.

Abstract:

:Previous studies on the association between serotonin transporter linked polymorphic region (5-HTTLPR) polymorphism and premature ejaculation (PE) have led to inconsistent results. The purpose of the present meta-analysis was to examine whether 5-HTTLPR polymorphism is associated with PE susceptibility.All eligible studies were searched and acquired from PubMed, Embase, Science Direct, CNKI, and Wanfang databases according to inclusion and exclusion criteria. Odds ratios (ORs) with 95% confidence intervals (CIs) were computed to assess the strength of the association between 5-HTTLPR polymorphism and PE. In addition, heterogeneity test, publication bias and sensitivity analysis were also conducted.Firstly, the association were observed in 8 studies (L vs S: OR = 0.74, 95% CI = 0.63-0.87; LL vs SS: OR = 0.61, 95% CI = 0.44-0.83; SL vs SS: OR = 0.73, 95% CI = 0.55-0.96; LL + SL vs SS: OR = 0.67, 95% CI = 0.52-0.86; LL vs SL + SS: OR = 0.72, 95% CI = 0.55-0.92). When the 2 studies not in Hardy-Weinberg equilibrium (HWE) were omitted, a positive association could only be observed between the 5-HTTLPR polymorphism and PE in allele contrast model (L vs S: OR = 0.81, 95% CI = 0.67-0.98). In the stratified analysis by subgroup, significantly associations were also found between PE and 5-HTTLPR polymorphism in Caucasians but not Asians (L vs S: OR = 0.79, 95% CI = 0.63-0.98; LL + SL vs SS: OR = 0.67, 95% CI = 0.46-0.96).Our meta-analysis demonstrated that the 5-HTTLPR polymorphism was associated with the susceptibility to PE in the Caucasian population. Compared with S allele, L allele is likely to be less susceptible to PE.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Ye N,Huang Y,Zhao H,Li G

doi

10.1097/MD.0000000000022169

subject

Has Abstract

pub_date

2020-10-09 00:00:00

pages

e22169

issue

41

eissn

0025-7974

issn

1536-5964

pii

00005792-202010090-00007

journal_volume

99

pub_type

杂志文章,meta分析

相关文献

MEDICINE文献大全
  • Clinicopathological features and surgical options for synchronous colorectal cancer.

    abstract::This study was conducted to investigate the clinicopathological features of synchronous cancers and treatment options according to their locations.Records of 8368 patients with colorectal cancer treated at our center between July 2003 and December 2010 were analyzed retrospectively. All synchronous colorectal cancer p...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000006224

    authors: Lee BC,Yu CS,Kim J,Lee JL,Kim CW,Yoon YS,Park IJ,Lim SB,Kim JC

    更新日期:2017-03-01 00:00:00

  • A meta-analysis: Internet mindfulness-based interventions for stress management in the general population.

    abstract:BACKGROUND:Psychological stress was an important mental health problem among the general population and warrant research to inform strategies for effective prevention. iMBIs provide a possibility to offer easily accessible, efficacious, convenient, and low-cost interventions on a wide scale. However, the efficacy of iM...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000020493

    authors: Zhang Y,Xue J,Huang Y

    更新日期:2020-07-10 00:00:00

  • Low expression of aging-related NRXN3 is associated with Alzheimer disease: A systematic review and meta-analysis.

    abstract:BACKGROUND:Alzheimer disease (AD) is a common neurodegenerative disorder with distinct pathological features, with aging considered the greatest risk factor. We explored how aging contributes to increased AD risk, and determined concurrent and coordinate changes (including genetic and phenotypic modifications) commonly...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MD.0000000000011343

    authors: Zheng JJ,Li WX,Liu JQ,Guo YC,Wang Q,Li GH,Dai SX,Huang JF

    更新日期:2018-07-01 00:00:00

  • Synchronous Resectable Metastatic Colorectal Cancer: Lymph Node Involvement Predicts Poor Outcome.

    abstract::To evaluate the value of lymph node status of primary tumors in predicting the prognosis of synchronous resectable metastatic colorectal cancer (mCRC).The characteristics of resectable mCRC are substantially different from other cancers, and the prognostic factors of resectable mCRC are still controversial.The data of...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000001215

    authors: Fu J,Jiang M,Tan Y,Yang J,Wu L,Feng L,Zheng S,Yuan Y

    更新日期:2015-07-01 00:00:00

  • Tuberculosis-associated hemophagocytic lymphohistiocytosis with initial presentation of fever of unknown origin in a general hospital: An analysis of 8 clinical cases.

    abstract::The study aimed to investigate the clinical features and prognoses of patients with tuberculosis (TB) who had secondary hemophagocytic lymphohistiocytosis (HLH).Patients first presenting with fever of unknown origin, who were ultimately diagnosed with TB-associated secondary HLH, were assessed retrospectively. We summ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000006575

    authors: Zhang Y,Liang G,Qin H,Li Y,Zeng X

    更新日期:2017-04-01 00:00:00

  • The association between weight fluctuation and all-cause mortality: A systematic review and meta-analysis.

    abstract:BACKGROUND:Many observational studies have reported an association between weight fluctuation and all-cause mortality. However, the conclusions obtained from these studies have been unclear. OBJECTIVE:The current meta-analysis aimed to clarify the association between weight fluctuation and all-cause mortality. DATA S...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000017513

    authors: Zhang Y,Hou F,Li J,Yu H,Li L,Hu S,Shen G,Yatsuya H

    更新日期:2019-10-01 00:00:00

  • Clinical pain management by a multidisciplinary palliative care team: Experience from a tertiary cancer center in China.

    abstract::To investigate the effect of multidisciplinary interventions on pain management in cancer inpatients.Four hundred thirty eight patients with cancer pain, who performed the multidisciplinary intervention were recruited. Before and after intervention, the Brief Pain Inventory (BPI) and the MD Anderson Symptom Inventory ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000023312

    authors: Yang B,Cui Z,Zhu X,Deng M,Pan Y,Li R,Guo M,Lu G,Zhang X,Guo L,Huang Y,Li F

    更新日期:2020-11-25 00:00:00

  • Risk factors associated with hepatic osteopathy in HBV related cirrhosis measured by liver stiffness: An Observational study.

    abstract::To investigate the differences in bone mineral density between patients with liver cirrhosis and healthy control, and to analyze the risk factors of hepatic osteoporosis in patients with HBV related liver cirrhosis.A total of 189 patients with liver cirrhosis and 207 health controls were enrolled. The bone mineral den...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000016628

    authors: Zhang W,Gong H,Su Z,Zhang X,Cao S

    更新日期:2019-08-01 00:00:00

  • Effect of sub-hypothermia blood purification technique in cardiac shock after valvular disease surgery.

    abstract::To observe the effect of sub-hypothermia (HT) blood purification technique in the treatment of cardiac shock after heart valve disease.The patients were randomly divided into normothermic (NT) continuous blood purification (CBP) group (NT group) and HT CBP group (HT group). Observe the cardiac index (CI), the oxygen d...

    journal_title:Medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MD.0000000000019476

    authors: Fang J,Xu M,Liu B,Wang B,Ren H,Yang H,Dong Y,Song L,Xiao H

    更新日期:2020-03-01 00:00:00

  • Comparison of neuroendoscopic surgery and craniotomy for supratentorial hypertensive intracerebral hemorrhage: A meta-analysis.

    abstract:BACKGROUND:In recent years, neuroendoscopy has been used as a method for treating intracerebral hemorrhages (ICHs). However, the efficacy and safety of neuroendoscopic surgery is still controversial compared with that of craniotomy. Our aim was to compare the outcomes of neuroendoscopic surgery and craniotomy in patien...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000007876

    authors: Ye Z,Ai X,Hu X,Fang F,You C

    更新日期:2017-09-01 00:00:00

  • Comparison of the Degree of Exercise Tolerance in Children After Surgical Treatment of Complex Cardiac Defects, Assessed Using Ergospirometry and the Level of Brain Natriuretic Peptide.

    abstract::Children who underwent surgery for complex congenital heart defects present worse exercise capacity than their healthy peers. In adults and adolescents, heart failure is assessed on the basis of clinical symptoms using the New York Heart Association (NYHA) score, while in an infant Ross scale; heart failure can also b...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000002619

    authors: Mazurek B,Szydlowski L,Mazurek M,Markiewicz-Loskot G,Pajak J,Morka A

    更新日期:2016-02-01 00:00:00

  • Cardiac Autonomic Function in Patients With Ankylosing Spondylitis: A Case-Control Study.

    abstract::Ankylosing spondylitis (AS) is a chronic inflammatory disease involing spine and enthesis. The primary aim of this study is to investigate the autonomic nervous system (ANS) function and the association between ANS and the functional status or disease activity in AS.The study included 42 AS patients, all fulfilling th...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000003749

    authors: Wei CY,Kung WM,Chou YS,Wang YC,Tai HC,Wei JC

    更新日期:2016-05-01 00:00:00

  • Volume-Based F-18 FDG PET/CT Imaging Markers Provide Supplemental Prognostic Information to Histologic Grading in Patients With High-Grade Bone or Soft Tissue Sarcoma.

    abstract::The aim of the study is to assess the prognostic value of different volume-based calculations of tumor metabolic activity in the initial assessment of patients with high-grade bone sarcomas (BS) and soft tissue sarcomas (STS) using F-18 FDG PET/CT.A single-site, retrospective study from 2002 to 2012 including 92 patie...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000002319

    authors: Andersen KF,Fuglo HM,Rasmussen SH,Petersen MM,Loft A

    更新日期:2015-12-01 00:00:00

  • Myeloperoxidase-antineutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis developed from ANCA negative renal limited vasculitis: A case report.

    abstract:RATIONALE:The relationship between antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) and ANCA-negative vasculitis has not been elucidated. PATIENT CONCERNS:A 64-year-old female with edema and proteinuria was admitted. A kidney biopsy indicated focal proliferative nephritis with crescents in 25...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000009128

    authors: Li XL,Xu PC,Chen T,Yan TK,Jiang JQ,Jia JY,Wei L,Shang WY,Hu SY

    更新日期:2017-12-01 00:00:00

  • Surgery combined with radio-chemotherapy for esophageal mucoepidermoid carcinoma: A case report.

    abstract:RATIONALE:Primary mucoepidermoid carcinoma (MEC) of the esophagus is a rare type of malignant neoplasm. Its morphology resembles that of MEC of the salivary glands. It is characterized by a diffuse mixture of squamous and mucus-secreting glandular carcinoma cells. Due to the low incidence of esophageal MEC, the biologi...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000011165

    authors: Zheng C,Chen X,Zhang F,Yan L,Zhang X

    更新日期:2018-06-01 00:00:00

  • Efficacy of acid suppression therapy in gastroesophageal reflux disease-related chronic laryngitis.

    abstract:BACKGROUND:This research aims to assess the response to acid suppression therapy in gastroesophageal reflux disease (GERD)-related chronic laryngitis (CL). METHODS:Data were extracted from Web of Knowledge, Embase, and PubMed for English language article published up to March 2016. Pooled overall response rate (ORR) r...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MD.0000000000004868

    authors: Yang Y,Wu H,Zhou J

    更新日期:2016-10-01 00:00:00

  • Renal transplantation in scleroderma.

    abstract::Although the outcome of renal transplantation in patients with systemic lupus erythematosus (SLE) has been studied, there are few reports about the outcome of patients with systemic sclerosis who have undergone renal transplantation. We retrospectively collected data from the United Network for Organ Sharing (UNOS) Sc...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/00005792-199911000-00003

    authors: Chang YJ,Spiera H

    更新日期:1999-11-01 00:00:00

  • Impact of hysterosalpingography after operative treatment for ectopic pregnancy in Taiwan: A 16-year Nationwide Population-Based Analysis.

    abstract::By retrieving records from Taiwan's National Health Insurance (NHI) system's database, the current study aimed to investigate the impacts of hysterosalpingography (HSG) to patients after ectopic pregnancy (EP) operations in Taiwan.In this retrospective cohort study, insurance claims data from 1997 to 2013, derived fro...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000007263

    authors: Chiu NC,Ho CH,Shen SH,Tsuei YC,Lee KL,Huang CY,Li HY,Chen TJ

    更新日期:2017-06-01 00:00:00

  • Correlation Between Bladder Pain Syndrome/Interstitial Cystitis and Pelvic Inflammatory Disease.

    abstract::Pelvic inflammatory disease (PID) has been investigated in Western countries and identified to be associated with chronic pelvic pain and inflammation. Bladder pain syndrome/interstitial cystitis (BPS/IC) is a complex syndrome that is significantly more prevalent in women than in men. Chronic pelvic pain is a main sym...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000001878

    authors: Chung SD,Chang CH,Hung PH,Chung CJ,Muo CH,Huang CY

    更新日期:2015-11-01 00:00:00

  • Failed percutaneous kyphoplasty in treatment of stage 3 Kummell disease: A case report and literature review.

    abstract:RATIONALE:Albeit it is rare, the authors report a stage 3 Kummell disease case. It is diagnosed by dynamic thoracic magnetic resonance imaging (MRI). Because there is no established strategy on stage 3 Kummell disease, we performed percutaneous kyphoplasty at first, but unfortunately made a revision surgery to remove t...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0000000000008895

    authors: Zhang C,Wang G,Liu X,Li Y,Sun J

    更新日期:2017-11-01 00:00:00

  • Assessment of left ventricular function in chronic alcoholics by real-time three-dimensional echocardiography.

    abstract::Chronic alcohol consumption may lead to progressive cardiac dysfunction. The aim of this study was to evaluate the feasibility of using real-time 3-dimensional echocardiography (3DE) on assessing left ventricular (LV) function in chronic alcoholics.We classified 92 male alcoholics into mild, moderate, and severe group...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000006033

    authors: Wang Y,Shan G,Shen J,Zhou Q,Tan B,Liu Y,Luo R,Zhao S,Bi W,Yao F,Li G

    更新日期:2017-02-01 00:00:00

  • Pemetrexed-carboplatin with intercalated icotinib in the treatment of patient with advanced EGFR wild-type lung adenocarcinoma: A case report.

    abstract:RATIONALE:Tyrosine kinase inhibitors (TKIs) are known to have greater efficacy in epidermal growth factor receptor (EGFR) mutation nonsmall cell lung cancer (NSCLC). However, about 10% of EGFR wild-type (wt) patients respond to TKIs. PATIENT CONCERNS:Several strategies to increase the efficacy of TKIs in wt NSCLC are ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000007732

    authors: Xu T,Wu H,Jin S,Min H,Zhang Z,Shu Y,Wen W,Guo R

    更新日期:2017-08-01 00:00:00

  • Efficacy of rabbit anti-thymocyte globulin for steroid-resistant acute rejection after liver transplantation.

    abstract::Acute cellular rejection after liver transplantation (LT) can be treated with steroid pulse therapy, but there is no ideal treatment for steroid-resistant acute rejection (SRAR). We aimed to determine the feasibility and potential complications of rabbit anti-thymocyte globulin (rATG) application to treat SRAR in live...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000003711

    authors: Lee JG,Lee J,Lee JJ,Song SH,Ju MK,Choi GH,Kim MS,Choi JS,Kim SI,Joo DJ

    更新日期:2016-06-01 00:00:00

  • Risk factors of the postoperative 30-day readmission of gastric cancer surgery after discharge: A PRISMA-compliant systematic review and meta-analysis.

    abstract:BACKGROUND:Readmission is a common postoperative adverse event. This study aimed to analyze potential risk factors for the incidence of postoperative 30-day readmission after discharge for gastric cancer patients with surgical treatment. METHODS:Those studies that reported the risk factors of gastric cancer patients w...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000014639

    authors: Wu WW,Zhang WH,Zhang WY,Yang L,Deng XQ,Zhu T

    更新日期:2019-03-01 00:00:00

  • Effectiveness of neuromuscular electrical stimulation combined with rehabilitation training for treatment of post-stroke limb spasticity.

    abstract:BACKGROUND:This study aims to systematically explore the effectiveness of neuromuscular electrical stimulation (NMES) combined with rehabilitation training (RT) for the treatment of post-stroke limb spasticity (PSLS). METHODS:We will search Cochrane Library, MEDILINE, EMBASE, CINAHL, AMED, PsycINFO, WOS, Scopus, OpenG...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000017261

    authors: He YL,Gao Y,Fan BY

    更新日期:2019-09-01 00:00:00

  • Erratum: The Value of U/S to Determine Priority for Upper Gastrointestinal Endoscopy in Emergency Room: Erratum.

    abstract::[This corrects the article DOI: 10.1097/MD.0000000000002241.]. ...

    journal_title:Medicine

    pub_type: 已发布勘误

    doi:10.1097/01.md.0000479433.86506.88

    authors:

    更新日期:2016-01-08 00:00:00

  • Association between miRNA polymorphisms and susceptibility to brain tumors: A meta-analysis.

    abstract:BACKGROUND:Previous studies have demonstrated that single-nucleotide polymorphisms (SNPs) in miRNAs are related to the susceptibility to brain tumors, but the conclusions remain controversial. This study was to perform a meta-analysis to re-assess the associations between miRNA SNPs and brain tumor risk. METHODS:Relev...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000016933

    authors: Gao F,Zhu Y

    更新日期:2019-08-01 00:00:00

  • Endoscopic Findings of Small-Bowel Lesions in Familial Amyloid Polyneuropathy: A Case Report.

    abstract::Familial amyloid polyneuropathy (FAP) is an autosomal dominant disease associated with the mutations in the transthyretin gene. To date, the endoscopic findings of the small-bowel lesions of FAP have never been described. We report a rare case of FAP with gastrointestinal involvement. A 71-year-old woman complaining o...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000002896

    authors: Asakura K,Yanai S,Nakamura S,Kawaski K,Eizuka M,Ishida K,Sugai T,Ueda M,Yamashita T,Ando Y,Matsumoto T

    更新日期:2016-03-01 00:00:00

  • Negative pressure wound therapy combined with skin grafting improves surgical wound healing in the perianal area.

    abstract::Management of large tissue defects resulting from local wide resection of perianal is a clinical challenge for surgeons. The aim of the present study was to investigate the efficacy of negative pressure wound therapy (NPWT) following skin grafting on perianal surgical wound healing.Included in this study were 12 patie...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000004670

    authors: Jia-Zi S,Xiao Z,Jun-Hui L,Chun-Yu X,Hong-da B

    更新日期:2016-08-01 00:00:00

  • Predictors for Reconstruction and Mood Disorder Associated With Reconstruction in Patients With Breast Cancer and Mastectomy: A Retrospective Cohort Study.

    abstract::This study used Taiwan's National Health Insurance medical claims to investigate the predictors for operative modes chosen by early-stage breast cancer patients; as well as to assess whether operative modes are associated with risk of mood disorder. We included 36,377 patients with breast cancer who received surgery b...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000002510

    authors: Pan HH,Chu CH,Wu LF,Hsieh PC,Chang KC,Li CY

    更新日期:2016-01-01 00:00:00