Abstract:
:The aim of the study is to assess the prognostic value of different volume-based calculations of tumor metabolic activity in the initial assessment of patients with high-grade bone sarcomas (BS) and soft tissue sarcomas (STS) using F-18 FDG PET/CT.A single-site, retrospective study from 2002 to 2012 including 92 patients with histologically verified high-grade BS (N = 37) or STS (N = 55). All patients underwent a pretreatment F-18 FDG PET/CT scan. Clinical data were registered. Measurements of the accuracy of metabolic tumor volume with a preset threshold of 40% of the maximum standardized uptake value of primary tumor (MTV40%) and total lesion glycolysis (TLG) as prognostic variables and identification of optimal discriminating cut-off values were performed through ROC curve analysis. Patients were grouped according to the cut-off values. All deaths were considered an event in survival analysis. Kaplan-Meier survival estimates and log-rank test were used to compare the degree of equality of survival distributions. Prognostic variables with related hazard ratios (HR) were assessed using Cox proportional hazards regression analysis.Forty-one of 92 patients died during follow-up (45%; 12 BS and 29 STS). Average survival for included patients was 6.5 years (95% CI 5.8-7.3 years) and probability of 5-year survival was 52%. There was a high-significant accuracy of TLG and MTV40% as prognostic variables when looking on all patients and during subgroup analysis. AUCs were higher for TLG than for MTV40%. TLG above optimal cut-off value was the only variable which was independently prognostic for survival throughout multivariate regression analysis of all included patients (P = 0.01, HR 4.78 [95% CI 1.45-15.87]) and subgroup analysis (BS: P = 0.04, HR 11.11 [95% CI 1.09-111.11]; STS: P < 0.05, HR 3.37 [95% CI 1.02-11.11]). No significant results were demonstrated for MTV40%.Volume-based F-18 FDG PET/CT imaging markers in terms of pretreatment estimation of TLG provide supplemental prognostic information to histologic grading, with significant independent properties for prediction of overall survival in patients with high-grade BS or STS.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Andersen KF,Fuglo HM,Rasmussen SH,Petersen MM,Loft Adoi
10.1097/MD.0000000000002319subject
Has Abstractpub_date
2015-12-01 00:00:00pages
e2319issue
51eissn
0025-7974issn
1536-5964pii
00005792-201512210-00023journal_volume
94pub_type
杂志文章相关文献
MEDICINE文献大全abstract:BACKGROUND:The argument on the clinical effects of previous anterior cruciate ligament (ACL) reconstruction on total knee arthroplasty (TKA) remains to be resolved. The aim of the current study was to compare operative and postoperative outcomes of patients undergoing TKA after ACL reconstruction with a matched cohort ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020767
更新日期:2020-06-19 00:00:00
abstract::The aim of the study was to explore keyhole approach and dura suture in the neuroendoscopic treatment for hydrocephalus.Twelve cases of hydrocephalus patients who were treated with neuroendoscope by this approach were analyzed retrospectively from April 2015 to April 2016 in our department. The basic steps of this pro...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005823
更新日期:2017-01-01 00:00:00
abstract::Chronic postsurgical pain (CPSP) is an important clinic problem. It is assessed that prevalence of chronic pain extends to 30% but it is contended that there are various risk factors. We aimed to evaluate the prevalence of chronic pain after hysterectomy, risk factors of chronicity, neuropathic features of pain, and s...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004484
更新日期:2016-08-01 00:00:00
abstract::Ankylosing spondylitis (AS) is a chronic inflammatory disease involing spine and enthesis. The primary aim of this study is to investigate the autonomic nervous system (ANS) function and the association between ANS and the functional status or disease activity in AS.The study included 42 AS patients, all fulfilling th...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003749
更新日期:2016-05-01 00:00:00
abstract:RATIONALE:Multiorgan/system injury was observed in severely infected coronavirus disease 2019 (COVID-19) patients, in addition to viral pneumonia. Recognizing and correcting the key and immediate dysfunctions may reduce mortality. PATIENT CONCERNS:A 66-year-old previously healthy male patient was referred to the isola...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000023449
更新日期:2020-12-04 00:00:00
abstract::Although the optimal treatment for femur shaft fracture is intramedullary nailing fixation, nonunion still occurs. We determined the oligotrophic nonunion rate among femur fractures managed operatively and identified risk factors for reoperation. This was a retrospective clinical study. The data of the patients betwee...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016559
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:This study aims to systematically explore the effectiveness of neuromuscular electrical stimulation (NMES) combined with rehabilitation training (RT) for the treatment of post-stroke limb spasticity (PSLS). METHODS:We will search Cochrane Library, MEDILINE, EMBASE, CINAHL, AMED, PsycINFO, WOS, Scopus, OpenG...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017261
更新日期:2019-09-01 00:00:00
abstract::There is no known useful clinical parameter that can specifically predict a biliary stricture and differentiate it from other related complications after living donor liver transplantations (LDLT). The aims of this study were to determine whether the changes of liver enzymes can predict postoperative biliary stricture...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006892
更新日期:2017-10-01 00:00:00
abstract::Although both multiple sclerosis (MS) and neuromyelitis optica (NMO) are demyelinating diseases, their psychiatric disturbances may differ given differences in the neurological manifestations. We used subjective and objective measurements to compare the psychiatric disturbances in patients with MS and NMO.Psychiatric ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017184
更新日期:2019-09-01 00:00:00
abstract::To determine the incidence of permanent visual loss (PVL) in giant cell arteritis (GCA) and the GCA relapse rate during glucocorticoid (GC) tapering.This prospective, longitudinal single secondary/tertiary rheumatology centre study was conducted between September 2011 and September 2014 in Slovenia. Predetermined clin...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003210
更新日期:2016-04-01 00:00:00
abstract::It is unclear whether the use of antibiotics is related to the efficacy of gemcitabine plus nab-paclitaxel (GnP). Therefore, we investigated the association between the use of antibiotics and efficacy of GnP.We conducted a retrospective single center study from January 2014 to December 2018 in Hokkaido University Hosp...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022250
更新日期:2020-09-25 00:00:00
abstract:RATIONALE:Apatinib is an oral tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor-2. It has been shown that apatinib is effective and safe for treatment of multiple solid tumors, including gastric cancer, liver cancer, non-small-cell lung cancer, and breast cancer. However, there is currentl...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000018382
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:A carcinoma ex pleomorphic adenoma (CXPA) is an epithelial malignancy arising in or from a benign pleomorphic salivary adenoma. The parotid gland is the most common location of CXPAs. Minor salivary gland CXPAs of the nasal cavity are exceedingly rare, with only 6 documented in the literature. METHODS AND R...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005004
更新日期:2016-09-01 00:00:00
abstract:RATIONALE:Treprostinil, a potent vasodilator, is the treatment of choice for severe pulmonary arterial hypertension (PAH) during pregnancy. Its inhibition of platelet aggregation increases the risk of hemorrhage. In addition, anticoagulation therapy is widely used in pregnancy with PAH due to the hypercoagulable state....
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011810
更新日期:2018-08-01 00:00:00
abstract:RATIONALE:Behçet's disease (BD) is a chronic immune-mediated inflammatory disorder involving multiple organ systems. In BD, intestinal ulcers can present as a refractory lesion capable of perforation, which makes the choice of treatment difficult. PATIENT CONCERNS:A 34-year-old male who was diagnosed with intestinal B...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014624
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:To verify the accuracy of serum dickkopf-1 protein (DKK-1) in the diagnosis of hepatocellular carcinoma (HCC) by an updated meta-analysis. METHODS:We searched potential eligible studies in PubMed and Embase before July 8, 2018. Sensitivity (SN), specificity (SP), positive likelihood ratio (PLR), negative li...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000016725
更新日期:2019-08-01 00:00:00
abstract::The aim of our study was to compare the clinical and surgical characteristics of pregnant and nonpregnant women with surgically verified ovarian torsion, as well as the differences among 3 trimesters during pregnancy.We conducted a retrospective study of patients diagnosed with surgically proven ovarian torsion in our...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020627
更新日期:2020-06-12 00:00:00
abstract::Identification of tumor imaging features associated with metastatic pattern may allow better understanding of cancer dissemination. Here, we investigated how primary tumor F-fluorodeoxyglucose (FDG) avidity influences the first site of breast cancer metastasis.Subjects were 264 patients with advanced breast cancer who...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004266
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Assessing the effectiveness and safety of Chinese medicine for the mastitis in COVID-19 patients is the main purpose of this systematic review protocol. METHODS:The following electronic databases will be searched from inception to April 2020: MEDLINE, Ovid, EMBASE, the Cochrane Library, the Allied and Compl...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021656
更新日期:2020-08-28 00:00:00
abstract:BACKGROUND:Because of aging of population, osteoporotic vertebral compression fracture (OVCF) appears an increasing incidence rate. Conservative therapy (CT) and balloon kyphoplasty (BKP) have been used to treat OVCFs. However, an increase in new vertebral compression fractures at nontreated levels following BKP is of ...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000012666
更新日期:2018-10-01 00:00:00
abstract:RATIONALE:Ectopic variceal bleeding is a rare (2-5%) but fatal gastrointestinal bleed in patients with portal hypertension. Patients with ectopic variceal bleeding manifest melena, hematochezia, or hematemesis, which require urgent managements. Definitive therapeutic modalities of ectopic varices are not yet standardiz...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005860
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Knee osteoarthritis (KOA) is a disabling joint disease with an increasingly prevalence among the older individuals. Tai Chi, one of the ancient meditative movements, has been recognized to have clinical benefits for KOA. We aim to evaluate the efficacy and safety of Tai Chi for patients with KOA through this...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020242
更新日期:2020-05-01 00:00:00
abstract:INTRODUCTION:Kawasaki disease (KD) is a systemic inflammatory disease. Standard imaging features of KD include interstitial and lobular inflammatory lesions in the lungs, while KD shock syndrome (KDSS), complicated with substantial consolidation and atelectasis in the lung, is rarely reported. PATIENTS CONCERNS:Herein...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020998
更新日期:2020-07-17 00:00:00
abstract::Obstructive sleep apnea (OSA) has a high prevalence in patients with obesity. Only patients with clinical symptoms of OSA are admitted to polysomnography; however, many patients with OSA are asymptomatic. We aimed to create and validate a population-based risk score that predicts the severity of OSA in patients with o...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016687
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Pancreas graft quality directly affects morbidity and mortality rates after pancreas transplantation (PTx). The criteria for pancreas graft allocation are restricted, which has decreased the number of available organs. Suitable pancreatic allografts are selected based on donor demographics, medical history, ...
journal_title:Medicine
pub_type: 杂志文章,多中心研究
doi:10.1097/MD.0000000000019335
更新日期:2020-03-01 00:00:00
abstract::Actinic keratoses (AKs) are precancerous epidermal lesions that develop on sensitive, frequently sun-exposed skin surfaces. There are very little data regarding AK prevalance. The aim of this study was to investigate the prevalence of AK and related conditions among patients in a dermatology outpatient clinic.Patients...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016465
更新日期:2019-07-01 00:00:00
abstract::The objective of this work is to verify the relationship between the self-perception of health and the self-concept of physical appearance in adolescents, in order to check their influence on the physical activity they perform with the aim of preventing chronic illnesses. To this end, an observational, cross-sectional...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020884
更新日期:2020-07-10 00:00:00
abstract::For proximal varus osteotomy of the femur in children, a stable fixation, is a concern regarding the safety and the protection of the surgery. The methods of fixation are mostly represented by plating systems; however, the tension band wiring is a simple and eligible option for fixation of proximal femur osteotomy. Th...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000061
更新日期:2014-08-01 00:00:00
abstract:RATIONALE:Acquired vertical diplopia is commonly observed in trochlear nerve palsy, often resulting from blunt head trauma or vascular problems. It is rarely caused by tumorous conditions or space occupying lesion. We report the first case of Onodi cell mucocele causing isolated trochlear nerve palsy. PATIENT CONCERNS...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015475
更新日期:2019-05-01 00:00:00
abstract::Cerebral edema is a frequent and serious complication in traumatic brain injury (TBI) patients. The objective is to study the effect of dexamethasone in patients with brain contusions, and to assess its effect on the vasogenic component of the pericontusional edema.Prospective-observational study to quantify, using ma...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022879
更新日期:2020-10-23 00:00:00