New vertebral fractures after osteoporotic vertebral compression fracture between balloon kyphoplasty and nonsurgical treatment PRISMA.

Abstract:

BACKGROUND:Because of aging of population, osteoporotic vertebral compression fracture (OVCF) appears an increasing incidence rate. Conservative therapy (CT) and balloon kyphoplasty (BKP) have been used to treat OVCFs. However, an increase in new vertebral compression fractures at nontreated levels following BKP is of concern. It is still not clear whether new fractures were a result of BKP and the purpose of this meta-analysis was to evaluate the new fractures risk after BKP compared with CT. METHODS:An exhaustive literature search of PubMed, EMBASE, and the Cochrane Library was conducted to identify randomized controlled trials and prospective nonrandomized controlled study that compared BKP with CT for patients suffering OVCF. A random-effect model was used. Results were reported as standardized mean difference or risk ratio with 95% confidence interval. RESULTS:Twelve studies were included and there was no significant difference in total new fractures (P = .33) and adjacent fractures (P = .83) between 2 treatments. Subgroup analyses did not demonstrate significant differences in follow-up period, mean age, anti-osteoporosis therapy, and the proportion of women. CONCLUSION:Our systematic review revealed that an increased risk of fracture of vertebral bodies was not associated with BKP compared with CT.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Li HM,Zhang RJ,Gao H,Jia CY,Zhang JX,Dong FL,Shen CL

doi

10.1097/MD.0000000000012666

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

e12666

issue

40

eissn

0025-7974

issn

1536-5964

pii

00005792-201810050-00064

journal_volume

97

pub_type

杂志文章,meta分析,评审

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