Abstract:
BACKGROUND:Because of aging of population, osteoporotic vertebral compression fracture (OVCF) appears an increasing incidence rate. Conservative therapy (CT) and balloon kyphoplasty (BKP) have been used to treat OVCFs. However, an increase in new vertebral compression fractures at nontreated levels following BKP is of concern. It is still not clear whether new fractures were a result of BKP and the purpose of this meta-analysis was to evaluate the new fractures risk after BKP compared with CT. METHODS:An exhaustive literature search of PubMed, EMBASE, and the Cochrane Library was conducted to identify randomized controlled trials and prospective nonrandomized controlled study that compared BKP with CT for patients suffering OVCF. A random-effect model was used. Results were reported as standardized mean difference or risk ratio with 95% confidence interval. RESULTS:Twelve studies were included and there was no significant difference in total new fractures (P = .33) and adjacent fractures (P = .83) between 2 treatments. Subgroup analyses did not demonstrate significant differences in follow-up period, mean age, anti-osteoporosis therapy, and the proportion of women. CONCLUSION:Our systematic review revealed that an increased risk of fracture of vertebral bodies was not associated with BKP compared with CT.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Li HM,Zhang RJ,Gao H,Jia CY,Zhang JX,Dong FL,Shen CLdoi
10.1097/MD.0000000000012666subject
Has Abstractpub_date
2018-10-01 00:00:00pages
e12666issue
40eissn
0025-7974issn
1536-5964pii
00005792-201810050-00064journal_volume
97pub_type
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