Rationale and design of a randomized trial of early intensive blood pressure lowering on cerebral perfusion parameters in thrombolysed acute ischemic stroke patients.


BACKGROUND AND RATIONALE:Uncertainty persists over the optimal management of blood pressure (BP) in the early phase of acute ischemic stroke (AIS). This study aims to determine the safety and effects of intensive BP lowering on cerebral blood flow (CBF) and functional in AIS patients treated with intravenous thrombolysis. METHODS:In a randomized controlled trial, 54 thrombolysed AIS patients with a systolic BP of 160 to 180 mm Hg will be randomized to early intensive BP lowering (systolic target range 140-160 mm Hg) or guideline-based BP management (systolic range 160-180 mm Hg) during first 72-hours using primarily intravenous labetalol. We hypothesize that early intensive BP lowering will not reduce CBF by 20% and/or increase the volume of hypoperfused tissue by >20% on computed tomographic perfusion. Clinical outcome will be assessed using a dichotomized modified Rankin scale (scores 0-1 as excellent outcome vs scores 2-6 as dead or dependent) at 90 days. Other outcome would be symptomatic intracerebral hemorrhage. The trial is registered at ClinicalTrials.gov, NCT03443596. CONCLUSION:This randomized study will provide important information about the physiological effects of BP reduction on cerebral perfusion after intravenous thrombolysis in AIS.


Medicine (Baltimore)




Sharma VK,Tan BYQ,Sim MY,Kulkarni A,Seow PA,Hong CS,Du Z,Wong LYH,Chen J,Chee EYH,Ng BSM,Low Y,Ngiam NJH,Yeo LLL,Teoh HL,Paliwal PR,Rathakrishnan R,Sinha AK,Chan BPL,Butcher K,Anderson CS




Has Abstract


2018-10-01 00:00:00
















  • Combined alkaline phosphatase and phosphorus levels as a predictor of mortality in maintenance hemodialysis patients.

    abstract::Hyperphosphatemia-induced vascular calcification and higher alkaline phosphatase (ALP) levels-related high-turnover bone diseases are linked to mortality among patients with chronic kidney disease (CKD). Nonetheless, no large epidemiological study in patients with CKD has been conducted to investigate the interaction ...


    pub_type: 杂志文章


    authors: Chang JF,Feng YF,Peng YS,Hsu SP,Pai MF,Chen HY,Wu HY,Yang JY

    更新日期:2014-10-01 00:00:00

  • Interventions to improve physical performances of older people with cancer before complex medico-surgical procedures: Protocol for an umbrella review of systematic reviews and meta-analyses.

    abstract:BACKGROUND:Current demographics lead increasing older cancer patients to undergo complex medico-surgical procedures, with substantial risk of decompensations and deconditioning. The Prehabilitation & Rehabilitation in Oncology: Adaptation to Disease and Accompaniment of Patients' Trajectories (PROADAPT) project is curr...


    pub_type: 杂志文章


    authors: Falandry C,Stefani L,Andre L,Granger M,Barbavara C,Habchi H,Bourgeois C,Cure H,Passot G,Gilbert T,PROADAPT working group.

    更新日期:2020-09-25 00:00:00

  • Effect of retrograde autologous priming based on miniaturized cardiopulmonary bypass in children undergoing open heart surgery: A STROBE compliant retrospective observational study.

    abstract::To evaluate the effectiveness of retrograde autologous priming (RAP) based on miniaturized cardiopulmonary bypass (CPB) circuit in children undergoing open heart surgery.We performed a retrospective analysis of all patients (≤15 kg) who underwent open heart surgery with CPB in our center from January 1, 2017, to July ...


    pub_type: 杂志文章


    authors: Meng B,Wu K,Wang Y,Zhang S,Zhou X,Ding Y

    更新日期:2020-01-01 00:00:00

  • A multicenter, open-label, phase III study of Abcertin in Gaucher disease.

    abstract:BACKGROUND:Gaucher disease (GD) is caused by a deficiency in the lysosomal enzyme glucocerebrosidase. Enzyme replacement therapy (ERT) is recommended for clinical improvement. METHODS:The efficacy and safety of a new imiglucerase, Abcertin, were assessed in 7 Egyptian patients with treatment-naïve type 1 GD. Each pati...


    pub_type: 杂志文章,多中心研究


    authors: Lee BH,Abdalla AF,Choi JH,Beshlawy AE,Kim GH,Heo SH,Megahed AMH,Elsayed MAL,Barakat TEM,Eid KMAE,El-Tagui MH,Mahmoud MMH,Fateen E,Park JY,Yoo HW

    更新日期:2017-11-01 00:00:00

  • Breastfeeding with and without the WHO/UNICEF baby-friendly hospital initiative: A cross-sectional survey.

    abstract::The World Health Organization and United Nations Children's Fund's Baby-Friendly Hospital Initiative is aimed at the global promotion, protection and support of breastfeeding. In this study, we compared breastfeeding-related information received, knowledge and behaviours among postpartum women in Baby-Friendly Hospita...


    pub_type: 杂志文章


    authors: Marinelli A,Del Prete V,Finale E,Guala A,Pelullo CP,Attena F

    更新日期:2019-11-01 00:00:00

  • Expiratory central airway collapse - an overlooked entity?: Two case reports.

    abstract:INTRODUCTION:Expiratory central airway collapse is defined by excessive inward bulging of either tracheobronchial posterior membrane or cartilage. The former is called excessive dynamic airway collapse (EDAC), and the latter, depending on the site of collapse, tracheomalacia, bronchomalacia or tracheobronchomalacia. Du...


    pub_type: 杂志文章


    authors: Janowiak P,Rogoza K,Siemińska A,Jassem E

    更新日期:2020-10-16 00:00:00

  • Relapsing granulomatosis with polyangiitis provoked by trauma: A case report.

    abstract:RATIONALE:The precise cause of granulomatosis with polyangiitis (GPA) remains unclear. Herein we present a case of refractory GPA occurring after trauma. PATIENT CONCERNS:A 43-year-old man suffered fractures of the left orbital in an accident, and then received surgical repair. At a postoperative follow-up, he develop...


    pub_type: 杂志文章


    authors: Deng S,Xing Y,Wang H,Kong X

    更新日期:2019-01-01 00:00:00

  • Chilean Gastric Cancer Task Force: A study protocol to obtain a clinical and molecular classification of a cohort of gastric cancer patients.

    abstract::Gastric cancer (GC) is the world's second-leading cause of neoplastic mortality. Genetic alterations, response to treatments, and mortality rates are highly heterogeneous across different regions. Within Latin America, GC is the leading cause of cancer death in Chile, affecting 17.6 per 100,000 people and causing >300...


    pub_type: 临床试验,杂志文章


    authors: Owen GI,Pinto MP,Retamal IN,Fernádez MF,Cisternas B,Mondaca S,Sanchez C,Galindo H,Nervi B,Ibañez C,Acevedo F,Madrid J,Peña J,Bravo ML,Maturana MJ,Cordova-Delgado M,Romero D,de la Jara N,Torres J,Rodriguez-Fernandez

    更新日期:2018-04-01 00:00:00

  • Tuina for children with myopia: A protocol for a systematic review.

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    pub_type: 杂志文章


    authors: Rong J,Feng H,Li J,Wang M,Lu T,Zhang X,Zhuang Q,Jing F

    更新日期:2019-12-01 00:00:00

  • Successful Outflow Reconstruction to Salvage Traumatic Hepatic Vein-Caval Avulsion of a Normothermic Machine Ex-Situ Perfused Liver Graft: Case Report and Management of Organ Pool Challenges.

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    pub_type: 杂志文章


    authors: Athanasopoulos PG,Hadjittofi C,Dharmapala AD,Orti-Rodriguez RJ,Ferro A,Nasralla D,Konstantinidou SK,Malagó M

    更新日期:2016-04-01 00:00:00

  • Analysis of factors influencing the degree of detectability on diffusion-weighted MRI and diffusion background signals in patients with invasive breast cancer.

    abstract::To determine the factors influencing the degree of detectability of lesions and diffusion background signals on magnetic resonance diffusion-weighted imaging (DWI) in invasive breast cancer.Institutional review board approval was obtained and patient consent was waived. Patients with newly diagnosed invasive ductal ca...


    pub_type: 杂志文章


    authors: Hahn SY,Ko ES,Han BK,Lim Y,Gu S,Ko EY

    更新日期:2016-07-01 00:00:00

  • High Agatston Calcium Score of Intracranial Carotid Artery: A Significant Risk Factor for Cognitive Impairment.

    abstract::The effect of intracranial internal carotid artery (ICA) calcification on cognitive impairment is uncertain. Our objective was to investigate whether intracranial ICA calcification is a significant cognitive predictor for cognitive impairment. Global cognition and degrees of intracranial ICA calcification of 579 subje...


    pub_type: 杂志文章


    authors: Kao HW,Liou M,Chung HW,Liu HS,Tsai PH,Chiang SW,Chou MC,Peng GS,Huang GS,Hsu HH,Chen CY

    更新日期:2015-09-01 00:00:00

  • Erratum: Pelvic Fractures in Children Results from the German Pelvic Trauma Registry: A Cohort Study: Erratum.

    abstract::[This corrects the article DOI: 10.1097/MD.0000000000002325.]. ...


    pub_type: 已发布勘误



    更新日期:2016-05-06 00:00:00

  • Primary epiploic appendagitis as an unusual cause of acute abdominal pain in a middle-aged male: A case report.

    abstract:RATIONALE:Primary epiploic appendagitis (PEA) is a rare cause of acute abdomen caused by spontaneous torsion or venous thrombosis of epiploic appendices, it commonly manifests with acute lower quadrant pain, thus may mimic acute diverticulitis, appendicitis, or mesenteric infarction. PATIENT CONCERNS:In this case repo...


    pub_type: 杂志文章


    authors: Yang L,Jia M,Han P

    更新日期:2019-08-01 00:00:00

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    abstract:RATIONALE:Although capillary hemangiomas, common lesions involving the proliferation of small capillary vessels and a single layer of endothelial cells, can arise in any organ, they are rarely reported in the greater or lesser omentum. Here in, we report a case of capillary hemangioma arising from the lesser omentum in...


    pub_type: 杂志文章


    authors: Nagano H,Goi T,Taguchi S,Tsubaki T,Tsuchiyama T,Uematsu H,Noriki S

    更新日期:2020-01-01 00:00:00

  • Smoking and incidence of glaucoma: The SUN Cohort.

    abstract::Smoking is a serious global public health concern that has been related to many chronic diseases. However, the effect of smoking on eye disorders has been less studied. The aim of this cohort study was to assess the association between current tobacco smokers and the risk of developing glaucoma and furthermore to eval...


    pub_type: 杂志文章


    authors: Pérez-de-Arcelus M,Toledo E,Martínez-González MÁ,Martín-Calvo N,Fernández-Montero A,Moreno-Montañés J

    更新日期:2017-01-01 00:00:00

  • The effectiveness and safety of acupuncture therapy for Guillain-Barré syndrome: A systematic review and meta-analysis protocol.

    abstract:BACKGROUND:Guillain-Barré syndrome (GBS) is the most common acute paralytic neuropathy. Many clinical trials indicate acupuncture provides a good effect as a complementary therapy of Western medicine for GBS. The objective of this systematic review protocol is to provide the evidence to evaluate the effectiveness and s...


    pub_type: 杂志文章,meta分析


    authors: Fan Z,Liu B,Zhang Y,Li M,Lu T

    更新日期:2020-01-01 00:00:00

  • A 10-year follow-up study of the association between calcium channel blocker use and the risk of dementia in elderly hypertensive patients.

    abstract::Calcium channel blockers (CCBs) are widely used for reducing blood pressure of hypertensive patients. Recent reports document the beneficial effects of CCB for preventing dementia; however, the results are controversial. We aim to evaluate the risk of developing dementia among elderly hypertensive patients treated wit...


    pub_type: 杂志文章


    authors: Wu CL,Wen SH

    更新日期:2016-08-01 00:00:00

  • Doughnut sign of hepatic alveolar echinococcosis on FDG PET/CT: Clinical case report.

    abstract:RATIONALE:A characteristic metabolic finding of hepatic alveolar echinococcosis (HAE) on positron emission tomography/computed tomography (PET/CT) correlates with morphologic features on CT and magnetic resonance imaging (MRI). PATIENT CONCERNS:A young man from an endemic area was admitted to our hospital due to right...


    pub_type: 杂志文章


    authors: Shen G,Kou Y,Kuang A

    更新日期:2019-02-01 00:00:00

  • Ear mold for congenital ear malformation: A randomized controlled trial.

    abstract:BACKGROUND:Congenital auricular deformities (CAD) are prevalent worldwide. The objective of this study is to investigate the effectiveness and safety of ear molding for children with CAD at their early days. METHODS:One hundred and nighty children (under 3 days) with CAD will be included in the study. Participants wil...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Zou K,Fan Y,Jiang L,Huang J,Miao Y,Yang C,Yang M,Zhao L

    更新日期:2020-07-24 00:00:00

  • Chimeric antigen receptor-modified T-cell therapy for bone marrow and skin relapse Philadelphia chromosome-like acute lymphoblastic leukemia: A case report.

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    pub_type: 杂志文章


    authors: Yang M,Liu B,Wang Y,Liu Y,Gong X,Gong B,Xu Y,Mi Y,Wang M,Wang J

    更新日期:2020-05-01 00:00:00

  • Relationship of atopic dermatitis with stroke and myocardial infarction: A meta-analysis.

    abstract:BACKGROUND:Lots of previous reports have suggested a potential association of atopic dermatitis (AD) with stroke and myocardial infarction (MI). However, the result is still controversial, Consequently, we conducted this meta-analysis to estimate the relationship of AD with Stroke and MI. METHODS:PubMed, Embase, and W...


    pub_type: 杂志文章,meta分析


    authors: Yuan M,Cao WF,Xie XF,Zhou HY,Wu XM

    更新日期:2018-12-01 00:00:00

  • Determining the burden of the family caregivers of people with neuromuscular diseases who use a wheelchair.

    abstract::The present study provides a basic outline of the care and support that family caregivers offer to people affected by neuromuscular diseases.To determine the presence of burden in caregivers of people with neuromuscular diseases who use a wheelchair and to establish whether the presence of burden is influenced by cont...


    pub_type: 杂志文章


    authors: Pousada T,Groba B,Nieto-Riveiro L,Pazos A,Díez E,Pereira J

    更新日期:2018-06-01 00:00:00

  • Early severe coronary heart disease and ischemic heart failure in homozygous familial hypercholesterolemia: A case report.

    abstract:RATIONALE:Familial hypercholesterolemia (FH) is a common inherited cause of coronary heart disease (CHD) and premature death in an early age. Nevertheless, an ischemic heart failure (IHF) associated with FH seems to be rare, and an early diagnosis and therapy could influence the prognosis. PATIENT CONCERNS:In this 13-...


    pub_type: 杂志文章


    authors: Kuang H,Zhou X,Li L,Yi Q,Shou W,Lu T

    更新日期:2018-10-01 00:00:00

  • Accuracy of intercellular adhesion molecule-1 for diagnosing sepsis: A systematic review and meta-analysis protocol.

    abstract:BACKGROUND:Sepsis is a complex and life-threatening systemic disease. A positive blood culture is the criterion standard of diagnosis for sepsis; however, it does not produce results for 24 to 72 hours. Besides, the clinical manifestations of sepsis are variable and nonspecific. Therefore, a new diagnostic biomarker fo...


    pub_type: 杂志文章


    authors: Li XJ,Tan EL,Zhao CP,Yan J

    更新日期:2019-06-01 00:00:00

  • Excision of sebaceous cyst by intraoral approach: A case report.

    abstract:RATIONALE:Surgical removal of a sebaceous cyst is usually accomplished through an external incision, which inevitably results in a scar. Herein, we described an intraoral approach for excising sebaceous cysts located in the lip or cheek near lip commissure, to avoid a skin scar. PATIENT CONCERNS:Removal of the cyst bu...


    pub_type: 杂志文章


    authors: Chen B,Lu H,Ren C,Ma L,Hu X,Qi H,Gao Z

    更新日期:2017-12-01 00:00:00

  • Effect of high-quality nursing on alleviating depression and anxiety in patients with thyroid cancer during perioperative period: A protocol for systematic review.

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    pub_type: 杂志文章


    authors: Cui Y,Li YX

    更新日期:2020-11-06 00:00:00

  • Creatine kinase in the U.S. population: Impact of demographics, comorbidities, and body composition on the normal range.

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    pub_type: 杂志文章


    authors: George MD,McGill NK,Baker JF

    更新日期:2016-08-01 00:00:00

  • Down syndrome with primary thyroid diffuse large B-cell lymphoma and Hashimoto thyroiditis: A CARE compliant case report.

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    pub_type: 杂志文章


    authors: Wei L,Zhao N,Li Y,Zheng X,Zhang H,Zhang Z

    更新日期:2019-08-01 00:00:00

  • A multicenter retrospective analysis of the antifungal susceptibility patterns of Candida species and the predictive factors of mortality in South Korean patients with candidemia.

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    pub_type: 杂志文章,多中心研究


    authors: Jung IY,Jeong SJ,Kim YK,Kim HY,Song YG,Kim JM,Choi JY

    更新日期:2020-03-01 00:00:00