Abstract:
:To evaluate the value of lymph node status of primary tumors in predicting the prognosis of synchronous resectable metastatic colorectal cancer (mCRC).The characteristics of resectable mCRC are substantially different from other cancers, and the prognostic factors of resectable mCRC are still controversial.The data of 2007 patients with mCRC who received resection of the primary tumors and metastatic lesions synchronously were reviewed from the Surveillance, Epidemiology and End-Result database. The Kaplan-Meier method was used to evaluate the capacity of different prognostic factors. Univariate and multivariate logistic regression models were used to evaluate the relationship between the lymph node status and other factors. The mRNA profiles of primary resectable mCRC tumors were obtained by microarray at our center.The median survival times were 50, 36, 32, 27, and 19 months in the N0-stage, N1a-stage, N1b-stage, N2a-stage, and N2b-stage subgroups according to the 7th American Joint Committee on Cancer (AJCC) Tumor Lymph Node Metastasis (TNM) N-classification (P = 0.000), and 40, 29, 22, and 15 months in patients with metastatic lymph node ratio (LNR) <0.25, 0.25-0.49, 0.5-0.74, and ≥0.75 subgroups (P = 0.000). In the COX model, the 7th AJCC TNM N-stage and LNR were independent prognostic factors. The mRNA profile was not associated with lymph node involvement.Both the N-stage according to the 7th AJCC TNM staging system and LNR had the capacity to subclassify synchronous resectable mCRC with different prognoses. The lymph node might be integrated into the AJCC staging system as a diagnose-delay prognostic factor for stage IV disease.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Fu J,Jiang M,Tan Y,Yang J,Wu L,Feng L,Zheng S,Yuan Ydoi
10.1097/MD.0000000000001215subject
Has Abstractpub_date
2015-07-01 00:00:00pages
e1215issue
30eissn
0025-7974issn
1536-5964pii
00005792-201507050-00014journal_volume
94pub_type
杂志文章相关文献
MEDICINE文献大全abstract:INTRODUCTION:Polyethylene glycol (PEG) has been considered as the first recommendation for bowel preparation prior to colonoscopy. A previous meta-analysis suggested that low volume PEG may improve the acceptability of ingesting bowel preparation solution. However, several limitations impaired the power of findings fro...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000010599
更新日期:2018-04-01 00:00:00
abstract:RATIONALE:Absent pulmonary valve syndrome (APVS) is a rare congenital heart disease that is often associated with tetralogy of Fallot (TOF). Here, we report 2 cases of APVS associated with TOF diagnosed via fetal echocardiography and discuss their specific ultrasonographic characteristics. PATIENT CONCERNS:Two pregnan...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007747
更新日期:2017-09-01 00:00:00
abstract:RATIONALE:Cervical cancer primarily spreads through direct invasion or via local lymphatics, and hematogenous metastasis is infrequent. Previous reports have shown that lung, liver, and bone are the organs most frequently affected by hematogenous metastasis of cervical cancer, while skeletal muscle is very rarely invol...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000020056
更新日期:2020-05-01 00:00:00
abstract::The aim of this paper was to evaluate the activity and tolerability of oral vinorelbine in patients with advanced castration resistant prostate cancer (CRPC) who progressed after a minimum of three lines including: abiraterone acetate, docetaxel, cabazitaxel, and enzalutamide.Treatment consisted of weekly oral vinorel...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016249
更新日期:2019-06-01 00:00:00
abstract::The acyl-CoA:diacylglycerol acyltransferase (DGAT) enzymes DGAT1 and DGAT2 catalyze the final step in triglycerides biosynthesis. This study examined the relationships of baseline phenotypes and the common polymorphisms in DGAT1 and DGAT2 with the lipid responses to niacin.Lipid responses in Chinese patients with dysl...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000881
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Our study aimed to screen and explore the expression of inflammatory factors in keloid patients and to investigate how hyperbaric oxygen (HBO) therapy affects the expression levels of interleukin-12p40 (IL-12p40), macrophage inflammatory protein-1β (MIP-1β), platelet-derived growth factor-BB (PDGF-BB), and i...
journal_title:Medicine
pub_type: 临床试验,杂志文章
doi:10.1097/MD.0000000000019857
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:The efficacy and safety of oral tranexamic acid (TXA) remain controversial because of the small number of clinical studies. The aim of the present study was to compare the efficacy and safety of oral TXA with intravenous TXA in patients undergoing total hip arthroplasty and total knee arthroplasty in a syste...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000022999
更新日期:2020-10-30 00:00:00
abstract:BACKGROUND:Avulsion of the aortic valve commissure as a cause of acute aortic valve regurgitation is mostly due to trauma, infective endocarditis, or ascending aortic dissection. Nontraumatic avulsion of the aortic valve commissure is very rare. We reviewed the literature and analyzed potential risk factors of nontraum...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005053
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:With the improvement of anesthesia and surgical techniques, supraglottic device with assist ventilation under general anesthesia (GA) combined with nerve block is gradually applied to video-assisted thoracoscopic surgery. However, the safety of assist ventilation has not been fully confirmed, and a large num...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000019240
更新日期:2020-03-01 00:00:00
abstract::Prosthetic Valve Thrombosis (PVT), in spite of the advances in the valve design and the material used, remains a serious complication of mechanical cardiac valve replacement. The factors influencing the development of PVT are: thrombogenicity of the valve, hemodynamics of the transprosthetic blood flow and ineffective...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014365
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:To perform a systematic review of the effect of time interval on 2-deoxy-2-[18F] fluoro-D-glucose (18F-FDG) uptake in normal organs. METHODS:PubMed, EMBASE, Ovid, and Cochrane databases were searched to identity all potential eligible literature. The study characteristics and relevant data were extracted an...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000013122
更新日期:2018-11-01 00:00:00
abstract::Pancreatic cancer is known for its typically late presentation and poor survival rates, with overall 5-year survival of less than 5%. The role of chemotherapy alone or with radiotherapy in the management of locally advanced tumors continues to be an area of debate.We report a case of locally advanced, pancreatic adeno...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000499
更新日期:2015-02-01 00:00:00
abstract:RATIONALE:Sclerosing thymoma is an extremely rare mediastinal neoplasm; it was recognized for the first time in 1994 and to date only 15 cases have been reported. PATIENT CONCERNS:The present study report a case of a 65-year-old man who was incidentally found to have an anterior mediastinal nodule, without clinical sy...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010520
更新日期:2018-04-01 00:00:00
abstract:RATIONALE:Priapism is a common urologic emergency, but high-flow penile priapism (HFP) caused by trauma is very rare. Therefore, HFP diagnosis and treatment are still not standardized. PATIENT CONCERNS:A 29-year-old man was admitted to the urology department of our hospital on August 01, 2019, due to "persistent penil...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022618
更新日期:2020-10-09 00:00:00
abstract:RATIONALE:Hypochondroplasia (HCH) is the mildest form of chondrodysplasia characterized by disproportionate short stature, short extremities, and variable lumbar lordosis. It is caused by mutations in fibroblast growth factor receptor 3 (FGFR3) gene. Up to date, at least thirty mutations of FGFR3 gene have been found t...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000014157
更新日期:2019-01-01 00:00:00
abstract::This study is to investigate the cervical human papillomavirus (HPV) infection rate in women of Urumqi, China.The epidemiological questionnaire survey was used to study 2300 women in Urumqi with a prospective research method. The second-generation hybrid capture assay, cervical liquid-based cytology test, colposcopy, ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000013206
更新日期:2018-11-01 00:00:00
abstract::Tuberculosis (TB) disease may be transmitted to close contacts of index cases, causing physical illness. No studies have investigated the risk of developing depressive disorder among TB contacts in a TB-endemic area.Adult participants with a new diagnosis of TB contact (ICD-9-CM codes V01.1 plus chest radiographic ord...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001870
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:The relative efficacy of antihypertensive drugs/combinations is not well known. Identifying the most effective ones and the patients' characteristics associated with best performance of the drugs will improve management of hypertensive patients. OBJECTIVE:To assess the blood pressure (BP) reduction attribut...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000004071
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:B-type Raf kinase (BRAF) mutation is proved to be a critical predictive factor in papillary thyroid cancer (PTC) with aggressive characteristics. However, the association between BRAF mutation and cervical lymphatic metastasis in PTC is controversial. METHODS:We searched papers on the study of BRAF mutation...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000018917
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:The number of patients with type 2 diabetes mellitus (T2DM) is surging currently. Synbiotic as a supplement based on gut microbiota may be beneficial to improve the metabolism of T2DM. However, the results of clinical studies show that the role of synbiotic in weight management in patients with T2DM is contr...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000018197
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:The critically ill and surgical patients are at significant risk of delirium, which is associated with a high morbidity and mortality. The association between statin use and the incidence of delirium is still controversial. In this article, we will perform a systematic review and meta-analysis of published s...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000013679
更新日期:2018-12-01 00:00:00
abstract::Although facial pain expressions are considered to be the most visible pain behaviors, it is known that the association between pain intensity and facial pain expression is weak for chronic pain. The authors hypothesized that the facial pain expressiveness was altered in chronic pain and investigated it with a mental ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007990
更新日期:2017-09-01 00:00:00
abstract::Acute motor axonal neuropathy (AMAN) is a variant of Guillain-Barre syndrome. It has been reported to have no sensory symptoms and is diagnosed by typical electrophysiological findings of low-amplitude or unobtainable compound muscle action potentials with normal sensory nerve action potentials. However, the authors e...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000000392
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:No systematic review has been published in English of Dengzhanxixin (DZXX) injection for cerebral infarction. The aim of this systematic review was to assess the effects and safety of DZXX injection for cerebral infarction. METHODS:Eight databases were searched from their inception. Randomized controlled tr...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000007674
更新日期:2017-08-01 00:00:00
abstract::This study investigated the possible relationship between endocarditis and overall and individual cancer risk among study participants in Taiwan.We used data from the National Health Insurance program of Taiwan to conduct a population-based, observational, and retrospective cohort study. The case group consisted of 14...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003198
更新日期:2016-03-01 00:00:00
abstract::Most of recurrent bladder carcinoma after partial cystectomy did not cause diagnostic difficulties for urologists, because of the appearance of typical papillary in ultrasonography or cystoscopy, and could be easily confirmed by tumor biopsy. Three patients, ages from 35 to 62 years, had undergone bladder sparing trea...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000898
更新日期:2015-06-01 00:00:00
abstract:INTRODUCTION:Anti-melanoma differentiation-associated gene 5 antibody (anti-MDA5 Ab) is an autoantigen associated with dermatomyositis (DM). Anti-MDA5 Ab-positive DM patients frequently exhibit clinically amyopathic dermatomyositis (CADM), and develop rapidly progressive interstitial lung disease (RPILD). Even with ear...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000018600
更新日期:2020-01-01 00:00:00
abstract::The purpose of this study was to evaluate the effects of salvage chemotherapy on recurrent or persistent ovarian clear cell carcinoma (CCC) with the goal of identifying a more rational treatment regimen for this lethal disease.The medical records of patients with CCC were retrospectively reviewed to select patients th...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001121
更新日期:2015-07-01 00:00:00
abstract:RATIONALE:Ectopic liver tissue can develop at various sites near the liver. Ectopic hepatocellular carcinomas (HCCs) arising from ectopic liver tissue have a rare clinical incidence. A very rare case has been observed to have metastasis after operation. PATIENT CONCERNS:We report an extremely rare case with multiple m...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006747
更新日期:2017-07-01 00:00:00
abstract::Bacteremic pneumococcal pneumonia (BPP) causes considerable mortality and morbidity. We aimed to identify prognostic factors associated with mortality and major in-hospital complications in BPP.A prospective, population-based clinical registry of 1636 hospitalized adult patients (≥18 years) with BPP was established be...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005179
更新日期:2016-11-01 00:00:00