Abstract:
:The study aimed to investigate the clinical features and prognoses of patients with tuberculosis (TB) who had secondary hemophagocytic lymphohistiocytosis (HLH).Patients first presenting with fever of unknown origin, who were ultimately diagnosed with TB-associated secondary HLH, were assessed retrospectively. We summarized and analyzed clinical manifestations, laboratory examinations, diagnoses, treatments, and prognoses of patients using clinical data, outpatient follow-up, and telephone follow-up in combination with literature review.Among patients admitted to the hospital with fever of unknown origin in the past 10 years, 371 patients were diagnosed with TB. Among them, 8 cases were diagnosed as tuberculosis-associated HLH (TB-HLH). The proportion of females among TB-HLH patients was higher than the proportion of females among TB patients. Within the same time period, 227 cases met the diagnostic criteria for HLH, among which TB-HLH patients accounted for 3.52% of the cases. None of the 8 TB-HLH patients had underlying diseases, and a majority of them had short symptom durations, rapid progression, along with multisystem and multiorgan dysfunctions. Their clinical manifestations were inconsistent with the typical clinical manifestations and imaging results characteristic of TB. Compared with patients with TB in our hospital during the same period, the 8 TB-HLH patients had a higher proportion of blood-disseminated TB and tuberculous meningitis. Apart from this, the hematological damage in these patients was higher than the common clinical manifestations of TB, and they also had a high proportion of respiratory failure. All 8 TB-HLH patients received antitubercular therapy, and 6 of them were also treated for HLH. However, their morbidity and mortality were significantly higher than that for reported cases of TB-HLH cases, both domestically and abroad, which may be attributed to the fever of unknown origin.Patients with TB-HLH had poor prognoses and no specific clinical manifestations. Therefore, cases of atypical TB and severe TB should be carefully monitored to achieve early diagnosis and early intervention.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Zhang Y,Liang G,Qin H,Li Y,Zeng Xdoi
10.1097/MD.0000000000006575subject
Has Abstractpub_date
2017-04-01 00:00:00pages
e6575issue
16eissn
0025-7974issn
1536-5964pii
00005792-201704210-00031journal_volume
96pub_type
杂志文章相关文献
MEDICINE文献大全abstract::For patients with nasopharyngeal carcinoma (NPC), prognostic indicators to customize subsequent biologically conformal radiation therapy may be obtained via 2-(fluorine-18)-fluoro-2-deoxy-D-glucose (F-FDG) positron emission tomography/computed tomography (PET/CT). This retrospective study assessed the prognostic signi...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016327
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Postoperative nausea and vomiting (PONV) is a main complication of surgery, and by now, drugs cannot prevent it completely. Some meta-analyses have proved acupuncture therapy can prevent PONV. However, it is still controversial whether noninvasive acupuncture therapies are comparable with invasive ones. This...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000021544
更新日期:2020-07-31 00:00:00
abstract::The present study provides a basic outline of the care and support that family caregivers offer to people affected by neuromuscular diseases.To determine the presence of burden in caregivers of people with neuromuscular diseases who use a wheelchair and to establish whether the presence of burden is influenced by cont...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011039
更新日期:2018-06-01 00:00:00
abstract::Aspergillus tracheobronchitis (AT) is an infrequent but severe form of invasive pulmonary aspergillosis in which the fungal infection is entirely or predominantly confined to the tracheobronchial tree. We reviewed 8 cases of AT diagnosed in our tertiary care center during an 18-year period, as well as 148 cases previo...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0b013e31826c2ccf
更新日期:2012-09-01 00:00:00
abstract::Detailed characterizations of ocular biometrics and parameters of aqueous humor dynamics are lacking in primary angle closure suspect (PACS) patients. This study aims to characterize these parameters and compare them with age-matched healthy volunteers.Elderly healthy volunteers (60.6 ± 7.2 years of age, mean ± SD, n ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006096
更新日期:2017-02-01 00:00:00
abstract:RATIONALE:Primary spinal glioblastoma multiforme (GBM) is a rare clinical entity with an aggressive course and an invariably dismal prognosis. Its clinical characteristics, radiologic and pathologic findings, and treatment protocols have been discussed in a few cases. PATIENT CONCERNS:A 15-year-old female was admitted...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006634
更新日期:2017-04-01 00:00:00
abstract::The porphyrias are a group of rare metabolic disorders. The incidence and prevalence are low because the acute intermittent porphyria (AIP) is rare. Our aim was to assess the use of anthropometric and quality-of-life parameters in porphyric patients in order to identify predictor factors that might help in characteriz...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001023
更新日期:2015-07-01 00:00:00
abstract::The cerebellum has been proven to be connected to the brain network, as in the default-mode network (DMN), among healthy subjects and patients with psychiatric disorders. However, whether or not abnormal cerebellar DMN connectivity exists and what its clinical significance is among drug-naive patients with somatizatio...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004043
更新日期:2016-07-01 00:00:00
abstract::Chest injuries are common and inevitable complications of chest compressions during cardiopulmonary resuscitation (CPR). This study aimed to investigate lung parenchymal and thoracic skeletal injuries after CPR by using computed tomography (CT) and to analyze the correlation between the duration of CPR and related com...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021685
更新日期:2020-08-14 00:00:00
abstract:INTRODUCTION:Arginine is an essential amino acid that plays an important role in various body functions including cell division, wound healing, removal of ammonia, immune function, and release of hormones. Hyperargininemia, an autosomal recessive genetic disorder, is considered one of the least common urea cycle disord...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010780
更新日期:2018-05-01 00:00:00
abstract::Abnormalities in the parathyroid hormone (PTH) gene as a cause of hypoparathyroidism were evaluated by linkage analysis with DNA polymorphisms adjacent to the PTH gene in 8 families in which members were affected with familial isolated hypoparathyroidism (FIH). We found that in none of the 23 affected individuals was ...
journal_title:Medicine
pub_type: 杂志文章
doi:
更新日期:1986-03-01 00:00:00
abstract::[This corrects the article DOI: 10.1097/MD.0000000000004841.]. ...
journal_title:Medicine
pub_type: 已发布勘误
doi:10.1097/MD.0000000000006217
更新日期:2017-02-17 00:00:00
abstract::In spinal fusion surgery, total blood loss (TBL) is composed of visible blood loss from the surgical field and wound drainage, and hidden blood loss (HBL). Until now, no published studies exist reporting the effect of topical use of tranexamic acid (tTXA) on HBL in patients undergoing posterior lumbar spinal fusion su...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008233
更新日期:2017-10-01 00:00:00
abstract::This study aimed to introduce this surgical technique laparoscopic sleeve gastrectomy combined with single-anastomosis duodenal-jejunal bypass (LDJB-LSG), and to confirm this new surgical technique was safe in the treatment of type 2 diabetes mellitus (T2DM) of patients with body mass index (BMI) higher than 27.5 kg/m...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011537
更新日期:2018-08-01 00:00:00
abstract::Lateral neck radiography is often used as a screening tool in emergency departments for suspected acute epiglottitis. The qualitative radiographic signs have been mainly used. The aim of this study was to evaluate the accuracy of objective radiographic parameters to aid diagnosis of acute epiglottitis.Patients who wer...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000012256
更新日期:2018-09-01 00:00:00
abstract::Previous studies on the relationship between obesity and depression have produced conflicting results. And only a limited number of studies have been conducted in Asians, and few large-scale nationwide studies have been conducted in Korean populations.We investigated the relationship between obesity and depression in ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000009478
更新日期:2017-12-01 00:00:00
abstract:RATIONALE:According to previously published studies, treating pediatric patients with congenital pseudarthrosis of the tibia (CPT) is challenging. More effective methods are needed to treat this patient population. PATIENT CONCERNS:A 7-year-old girl with congenital pseudarthrosis of the distal tibia, previously misdia...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000013384
更新日期:2018-12-01 00:00:00
abstract::Previous studies had reported that the CDKAL1 (cyclin-dependent kinase 5 (CDK5) regulatory subunit-associated protein 1-like 1) rs10946398 C/A polymorphism associated with type 2 diabetes mellitus (T2DM) in various ethnic groups, however, inconsistent results have been obtained in studies of different populations.We p...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000021383
更新日期:2020-07-24 00:00:00
abstract:BACKGROUND:Solitary functioning kidney (SFK) is tough issue to address in clinical, mostly developed from renal artery stenosis (RAS) in adults. Although renal artery stent is widely used to help SFK patients, the efficacy of the stent is still disputable. This study is aimed at reviewing a series of SFK cases to draw ...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000004780
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Despite advances in surgical techniques in the management of the brain abscess, continuous systemic long-term antibiotics are necessary and crucial. This study was designed to evaluate the effect of intracavity administration of high-dose antibiotics on the course of antibiotic therapy. METHODS:Between 2003...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006359
更新日期:2017-05-01 00:00:00
abstract::The radial artery has been increasingly used for its favorable safety profile. However, no conclusive data are available on the optimal sheath size. In particular, it is seemingly difficult to weight both advantages and disadvantages of narrower versus larger sheaths size. Despite several studies were performed to com...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000002170
更新日期:2015-12-01 00:00:00
abstract:RATIONALE:Mucocele is a disease lined primarily by epithelium, and occurs mainly when the sinus ostium is obstructed. PATIENT CONCERNS:We report a case of a 37-year-old man who presented with painless proptosis of the right eye and diplopia. DIAGNOSES:The preoperative finding was mucocele of the ethmoid sinus. INTER...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000009353
更新日期:2017-12-01 00:00:00
abstract::Mandatory reporting rate of suspected child abuse by health care provider is relatively low in South Korea. The purpose of the study was to develop a screening tool for child abuse and evaluate the feasibility of using this screening tool in emergency department (ED) of South Korea. Injured children younger than 14 ye...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000013724
更新日期:2018-12-01 00:00:00
abstract:RATIONALE:The precise cause of granulomatosis with polyangiitis (GPA) remains unclear. Herein we present a case of refractory GPA occurring after trauma. PATIENT CONCERNS:A 43-year-old man suffered fractures of the left orbital in an accident, and then received surgical repair. At a postoperative follow-up, he develop...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014189
更新日期:2019-01-01 00:00:00
abstract::Luminal A breast cancer has a much better prognosis than other subtypes, with a low risk of local or regional recurrence. However, there is controversy around under- versus overtreatment with regard to adjuvant treatment of node-positive, luminal A breast cancer. The purpose of this study was to identify whether adjuv...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006777
更新日期:2017-06-01 00:00:00
abstract:INTRODUCTION:Although there are various therapeutic methods for the treatment of knee osteoarthritis, each has its advantages and shortcomings, and a definitive treatment method is yet to be determined. This pilot study is designed to obtain basic data for a further large-scale trial as well as provide information abou...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000021957
更新日期:2020-09-04 00:00:00
abstract::There is currently a lack of reliable, reproducible, and easily applied methods for assessing changes in liver histology in patients in the gray zone phase of chronic hepatitis B (CHB). Therefore, we aimed to develop a novel predictive scoring system to detect significant liver histological changes in these patients.A...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006465
更新日期:2017-04-01 00:00:00
abstract::Graft insertion into the anterior chamber is one of the most important procedures for successful Descemet membrane endothelial keratoplasty (DMEK). Especially in eyes with fragile zonular fibers and a shallow anterior chamber, smooth graft insertion tends to become more difficult. Ophthalmic viscoelastic devices (OVDs...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011245
更新日期:2018-06-01 00:00:00
abstract::Signet ring cell carcinoma (SRC) is a poorly differentiated cancer of the stomach. Generally, poorly differentiated cancer is believed to show poor prognosis and aggressive behavior. Recently, however, there is debate on the aggressiveness of SRC in early gastric cancer (EGC). We therefore studied postoperation biopsi...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007532
更新日期:2017-08-01 00:00:00
abstract::Information on respiratory viruses in subtropical region is limited.Incidence, mortality, and seasonality of influenza (Flu) A/B, respiratory syncytial virus (RSV), adenovirus (ADV), and parainfluenza viruses (PIV) 1/2/3 in hospitalized patients were assessed over a 15-year period (1998-2012) in Hong Kong.Male predomi...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002024
更新日期:2015-11-01 00:00:00