Abstract:
RATIONALE:Primary spinal glioblastoma multiforme (GBM) is a rare clinical entity with an aggressive course and an invariably dismal prognosis. Its clinical characteristics, radiologic and pathologic findings, and treatment protocols have been discussed in a few cases. PATIENT CONCERNS:A 15-year-old female was admitted to the neurology department with a chief complaint of progressive numbness and weakness in her left upper extremity for 3 months and neck pain for 1 month. DIAGNOSES:Spinal magnetic resonance imaging showed an intramedullary expansile mass localized between C4 and C7. The diagnosis of GBM was determined on the basis of the histopathological findings after operation. INTERVENTIONS:Laminotomy and laminoplasty between C4 and C7 were performed, and the tumor was partially resected. The patient was administered focal adjuvant radiotherapy concomitantly with oral chemotherapy following the surgery. OUTCOMES:With severe neurologic deficits at 13 months after the diagnosis, the patient expired. LESSONS:Although therapeutic options have been improving, the prognosis of the primary spinal GBM remains poor. The treatment of primary spinal GBM entered into a central registry and multiple-center cooperation is important in establishing future therapeutic strategies.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Shen CX,Wu JF,Zhao W,Cai ZW,Cai RZ,Chen CMdoi
10.1097/MD.0000000000006634subject
Has Abstractpub_date
2017-04-01 00:00:00pages
e6634issue
16eissn
0025-7974issn
1536-5964pii
00005792-201704210-00041journal_volume
96pub_type
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