Therapeutic efficacy and safety of Shexiang Baoxin Pill combined with trimetazidine in elderly patients with heart failure secondary to ischaemic cardiomyopathy: A systematic review and meta-analysis.

Abstract:

BACKGROUND:Shexiang Baoxin Pill (SBP) is one of the most commonly used traditional Chinese patent medicines for cardiovascular diseases. This systematic review was designed to provide rigorous therapeutic efficacy and safety evidence on the use of SBP combined with trimetazidine in elderly patients with heart failure (HF) secondary to ischaemic cardiomyopathy (ICM). METHODS:Relevant randomized controlled trials (RCTs) investigating the clinical efficacy of SBP combined with trimetazidine in treating ICM-associated HF were widely searched in electronic databases, including PubMed, Cochrane library, EMBASE, CBM, CNKI, VMIS, and Wanfang up to January 1, 2018. The methodological quality of each trial was assessed according to the Cochrane Reviewers' Handbook 5.0. Meta-analysis was performed by using Review Manager 5.3. RESULTS:Eighteen RCTs (N = 1532) that met the criteria were included in the review for the assessment of methodological quality. Meta-analysis showed that, when compared with conventional therapy, SBP combined with trimetazidine significantly improved the clinical efficacy and indices of cardiac function (including increasing left ventricular ejection fraction [LVEF] and 6-minute walk distance [6-MWD], decreasing left ventricular end-diastolic diameter [LVEDD] and left ventricular end-systolic diameter [LVESD]) without serious adverse reactions. CONCLUSION:This work provides evidence of the benefit of SBP combined with trimetazidine for the treatment of HF secondary to ICM. More high quality and well-designed RCTs are needed to confirm these findings.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Wen J,Ma X,Zhang L,Lu X,Yang Y,Wang J,Zhao Y

doi

10.1097/MD.0000000000013580

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

e13580

issue

51

eissn

0025-7974

issn

1536-5964

pii

00005792-201812210-00039

journal_volume

97

pub_type

杂志文章,meta分析

相关文献

MEDICINE文献大全
  • The efficacy of bilateral intervertebral foramen block for pain management in percutaneous endoscopic lumbar discectomy: A protocol for randomized controlled trial.

    abstract:BACKGROUND:Compared with open lumbar microdiscectomy, percutaneous endoscopic lumbar discectomy (PELD) has the advantages of remarkable preservation of paravertebral structures, less bleeding, shorter operation time and fewer complications, it is a common method for the treatment of lumbar disc herniation (LDH). Local ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000022693

    authors: Sang X,Shan H,Hu J,Wu M

    更新日期:2020-10-09 00:00:00

  • A comparison of tiotropium/olodaterol vs tiotropium alone in terms of treatment effect for chronic obstructive pulmonary disease: A meta-analysis.

    abstract:BACKGROUND:Combinations of long-acting bronchodilators with different mechanisms of action are recommended to improve prognosis and reduce risk of adverse events of chronic obstructive pulmonary disease (COPD). It is unclear whether the new combination therapy with long-acting muscarinic antagonist (LAMA) tiotropium (T...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,收录出版

    doi:10.1097/MD.0000000000019789

    authors: He J,Lin JT

    更新日期:2020-04-01 00:00:00

  • Goniosynechialysis combined with cataract extraction for iridoschisis: A case report.

    abstract:RATIONALE:Iridoschisis is a rare eye disease. In this case report, we described the examination and diagnosis of a case of iridoschisis accompanied by secondary glaucoma. We also observed the effects of treating the patient with a combination of goniosynechialysis and cataract removal. PATIENT CONCERN:A 67-year-old fe...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000008295

    authors: You Z,Qin Y,Li G,Shi K

    更新日期:2017-10-01 00:00:00

  • Celiac disease serology and gut microbiome following proton pump inhibitor treatment.

    abstract:BACKGROUND:Celiac disease is an autoimmune enteropathy characterized by an aberrant immune response to ingested gluten in genetically predisposed individuals. Studies have pointed to a rising prevalence of celiac disease in recent decades. Changes in diet and use of medication that may impact the gut microbiome have be...

    journal_title:Medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MD.0000000000021488

    authors: Jang S,Lebwohl B,Abrams JA,Green PHR,Freedberg DE,Alaedini A

    更新日期:2020-08-28 00:00:00

  • Characteristics and outcomes of patients hospitalized with interstitial lung diseases in Spain, 2014 to 2015.

    abstract::To assess characteristics and outcomes of patients hospitalized with interstitial lung diseases (ILD) and to analyze patient's comorbidities, procedures, and in-hospital outcomes.We identified patients hospitalized with idiopathic pulmonary fibrosis and others ILD such as hypersensitivity pneumonitis, cryptogenic orga...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000015779

    authors: Pedraza-Serrano F,Jiménez-García R,López-de-Andrés A,Hernández-Barrera V,Sánchez-Muñoz G,Puente-Maestu L,de-Miguel-Díez J

    更新日期:2019-05-01 00:00:00

  • HIV prevalence and sexual behavior among young male conscripts in the Brazilian army, 2016.

    abstract::Since 1996, the Brazilian Department of Sexually Transmitted Infections (STI), AIDS and Viral Hepatitis (Departamento de Vigilância, Prevenção e Controle das IST, do HIV, AIDS e Hepatites Virais, Secretaria de Vigilância em Saúde, Ministério da Saúde) in collaboration with the Brazilian Ministry of Defense has conduct...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000009014

    authors: Sperhacke RD,da Motta LR,Kato SK,Vanni AC,Paganella MP,Oliveira MCP,Pereira GFM,Benzaken AS

    更新日期:2018-05-01 00:00:00

  • Severity of systemic sclerosis-associated pulmonary arterial hypertension in African Americans.

    abstract::African Americans (AA) with systemic sclerosis (SSc) have a worse prognosis compared to Americans of European descent (EA). We conducted the current study to test the hypothesis that AA patients with SSc have more severe disease and poorer outcomes compared to EA patients when afflicted with pulmonary arterial hyperte...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000000032

    authors: Blanco I,Mathai S,Shafiq M,Boyce D,M Kolb T,Chami H,K Hummers L,Housten T,Chaisson N,L Zaiman A,M Wigley F,J Tedford R,A Kass D,Damico R,E Girgis R,M Hassoun P

    更新日期:2014-07-01 00:00:00

  • Chinese patent medicine (Jinlong Capsule) for gastric cancer: Protocol for a systematic review and meta-analysis.

    abstract:BACKGROUND:JLC has been widely applied as a promising adjunctive drug for GC. However, the exact effects and safety of JLC have yet to be systematically investigated. We aimed to summarize the efficacy and safety of JLC for the treatment of advanced GC through the meta-analysis, in order to provide scientific reference...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000020532

    authors: Li J,Han B,Sun G,Zheng Z,Mu Y,Chi J

    更新日期:2020-06-05 00:00:00

  • Clinicopathological features, surgical treatments, and survival outcomes of patients with small bowel adenocarcinoma.

    abstract::To date, because of their rarity, the clinicopathological features and surgical outcomes of small bowel adenocarcinomas (SBAs) have been insufficiently explored. We evaluated the clinicopathological features and long-term outcomes of patients who underwent surgery for SBA.This retrospective study (from 1999 to 2016) e...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000007713

    authors: Zhang S,Yuan W,Zhang J,Chen Y,Zheng C,Ma J,Jiang Q,Zhao Y,Xu Q,Wang C

    更新日期:2017-08-01 00:00:00

  • Computer-aided detection for prostate cancer diagnosis based on magnetic resonance imaging: Protocol for a systematic review and meta-analysis.

    abstract:BACKGROUND:Prostate cancer (PCa) is one of the most common primary malignancies in humans and the second leading cause of cancer-specific mortality among Western males. Computer-aided detection (CAD) systems have been developed for accurate and automated PCa detection and diagnosis, but the diagnostic accuracy of diffe...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000016326

    authors: Liang F,Li M,Yao L,Wang X,Liu J,Li H,Cao L,Liu S,Song Y,Song B

    更新日期:2019-07-01 00:00:00

  • Impact of CCL4 gene polymorphisms upon the progression of lung cancer in a Han Chinese cohort.

    abstract::Lung cancer is the most common malignancy in China and has a low survival rate amongst Han Chinese. The high mortality is largely attributed to late-stage diagnosis, when treatment is largely ineffective. Identification of genetic variants could potentially assist with earlier diagnosis and thus more effective treatme...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000018906

    authors: Hu W,Chien SY,Ying P,Liu PI,Su CM,Tang CH

    更新日期:2020-01-01 00:00:00

  • Therapy of anti-glomerular basement membrane antibody disease: analysis of prognostic significance of clinical, pathologic and treatment factors.

    abstract::We have compared the effect of therapy with immunosuppression alone to immunosuppression plus plasma exchange on the clinical course and rate of disappearance of antibody in 17 patients with anti-glomerular basement membrane (anti-GBM) antibody-induced renal disease. Patients receiving immunosuppression (n = 9) and th...

    journal_title:Medicine

    pub_type: 临床试验,杂志文章

    doi:10.1097/00005792-198507000-00003

    authors: Johnson JP,Moore J Jr,Austin HA 3rd,Balow JE,Antonovych TT,Wilson CB

    更新日期:1985-07-01 00:00:00

  • Prognostic Role of Neutrophil-to-Lymphocyte Ratio in Prostate Cancer: A Systematic Review and Meta-analysis.

    abstract::Inflammation is increasingly reported to be associated with the prognosis of patients with cancers. And the prognostic role of neutrophil-to-lymphocyte ratio (NLR) in patients with prostate cancer (PCa) remains inconsistent. Therefore, we conducted this systematic review and meta-analysis to obtain a more reliable ass...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MD.0000000000002544

    authors: Yin X,Xiao Y,Li F,Qi S,Yin Z,Gao J

    更新日期:2016-01-01 00:00:00

  • The effects of psychotherapy for depressed or posttraumatic stress disorder women with childhood sexual abuse history: Meta-analysis of randomized controlled trials.

    abstract:BACKGROUND:Depression and posttraumatic stress disorder (PTSD) are the most common mental disorders of women suffered from childhood sexual abuse histories. It has been widely recognized that depression and PTSD may decrease patients' quality of life. The objective of this study is conducted to explore the effects of p...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000019776

    authors: Lu JY,Tung TH,Shen SA,Huang C,Chen PS

    更新日期:2020-04-01 00:00:00

  • Risk factors for renal involvement and severe kidney disease in 2731 Chinese children with Henoch-Schönlein purpura: A retrospective study.

    abstract::To identify the risk factors for developing renal involvement and severe kidney disease in Chinese childhood Henoch-Schönlein purpura (HSP) patients.This was a retrospective study of 2731 children with HSP diagnosed between 2012 and 2015. We analyzed their demographic data, clinical manifestations, and laboratory test...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000012520

    authors: Wang K,Sun X,Cao Y,Dai L,Sun F,Yu P,Dong L

    更新日期:2018-09-01 00:00:00

  • Calcified peripancreatic lymph nodes in pancreatic and hepatic tuberculosis mimicking pancreatic malignancy: A case report and review of literature.

    abstract:RATIONALE:Tuberculosis remains a serious menace to the health of people. Isolated hepatic tuberculosis is rare and pancreatic tuberculosis is extremely rare. The preoperative diagnosis of pancreatic tuberculosis remains a great challenge. PATIENT CONCERNS:A 58-year-old Asian woman was referred to our hospital for eval...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0000000000012255

    authors: Liang X,Huang X,Yang Q,He J

    更新日期:2018-09-01 00:00:00

  • Preferences of German melanoma patients for interferon (IFN) α-2b toxicities (the DeCOG "GERMELATOX survey") versus melanoma recurrence to quantify patients' relative values for adjuvant therapy.

    abstract::Currently interferon alfa-2b (IFNα-2b) is an approved adjuvant drug for high-risk melanoma patients that leads to an improvement in disease-free survival (DFS). However, it is unclear whether it also impacts overall survival. Widespread use of adjuvant high-dose IFNα has been tempered by its significant toxicity and i...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000005375

    authors: Kaehler KC,Blome C,Forschner A,Gutzmer R,Haalck T,Heinzerling L,Kornek T,Livingstone E,Loquai C,Maul LV,Lang BM,Schadendorf D,Stade B,Terheyden P,Utikal J,Wagner T,Hauschild A,Garbe C,Augustin M

    更新日期:2016-11-01 00:00:00

  • CD34 Over-Expression is Associated With Gliomas' Higher WHO Grade.

    abstract::CD34 is a transmembrane phosphoglycoprotein that was first identified on hematopoietic stem and progenitor cells. CD34 is known as an optimum marker for microvascular density studies and it is positively stained in pathological and physiologic vessels. The use of CD34 for the prognosis, diagnosis, and treatment of neo...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MD.0000000000002830

    authors: Kong X,Guan J,Ma W,Li Y,Xing B,Yang Y,Wang Y,Gao J,Wei J,Yao Y,Xu Z,Dou W,Lian W,Su C,Ren Z,Wang R

    更新日期:2016-02-01 00:00:00

  • A good response to glucocorticoid for Henoch-Schönlein purpura with abdominal pain and gastrointestinal bleeding in an adult: A CARE case report.

    abstract:RATIONALE:Henoch-Schönlein purpura (HSP) is a small-vessel vasculitis that has been extensively studied in children, but little is known about its natural history in adults. There is no consensus regarding the treatment of glucocorticosteroids use for HSP. The efficacy of glucocorticoid for preventing from severe compl...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000018602

    authors: Yi F,Bai Z,Li Y,Xu X,Guo X,Qi X

    更新日期:2020-01-01 00:00:00

  • Ventilation during cardiopulmonary bypass for prevention of respiratory insufficiency: A meta-analysis of randomized controlled trials.

    abstract:BACKGROUND:Cardiopulmonary bypass (CPB) is necessary for most cardiac surgery, which may lead to postoperative lung injury. The objective of this paper is to systematically evaluate whether ventilation during CPB would benefit patients undergoing cardiac surgery. METHODS:We searched randomized controlled trials (RCTs)...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000006454

    authors: Chi D,Chen C,Shi Y,Wang W,Ma Y,Zhou R,Yu H,Liu B

    更新日期:2017-03-01 00:00:00

  • Comparison of 1-year clinical outcomes between prasugrel and ticagrelor versus clopidogrel in type 2 diabetes patients with acute myocardial infarction underwent successful percutaneous coronary intervention.

    abstract::Although the new oral P2Y12 inhibitors, prasugrel/ticagrelor have shown greater efficacy than clopidogrel in patients with the acute coronary syndrome, but they have not shown better efficacy in Korean patients. So we evaluated the efficacy of the prasugrel/ticagrelor in patients with myocardial infarction (MI) and di...

    journal_title:Medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MD.0000000000014833

    authors: Ahn KT,Seong SW,Choi UL,Jin SA,Kim JH,Lee JH,Choi SW,Jeong MH,Chae SC,Kim YJ,Kim CJ,Kim HS,Cho MC,Gwon HC,Jeong JO,Seong IW,Korea Acute Myocardial Infarction Registry - National Institute of Health (KAMIR-NIH) Investigato

    更新日期:2019-03-01 00:00:00

  • Delayed bilateral facet dislocation at L4-5: A case report.

    abstract:RATIONALE:Traumatic bilateral facet dislocation in the lumbar (L) spine has rarely been reported. All reported cases were presented with acute facet dislocation. However, we present the first case of delayed bilateral facet dislocation at L4-5. PATIENT CONCERNS:A 34-year-old woman presented with back pain after a head...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000012483

    authors: Park HY,Ha KY,Kim YH,Kim SI,Min HK,Oh IS,Seo JY,Chang DG,Alhazmi MA,Cho JH

    更新日期:2018-09-01 00:00:00

  • Higher hypertension prevalence, lower incidence, and aggressive treatment with decreasing mortality, cardiovascular, and cerebrovascular incidence in Taiwan from 2005 to 2010: A 2 population-based cohorts study.

    abstract::Hypertension continues to be an important public health concern because of its associated morbidity, mortality, and economic impact on society. The aims of this study are to compare the secular changes in age-stratified hypertension prevalence, incidence, co-morbidity, and 3 years of cardiovascular outcome in Taiwan i...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000022437

    authors: Liao CT,Wu PC,Shih JC,Cheng TJ,Wu WS

    更新日期:2020-09-25 00:00:00

  • A case report of pediatric neurotrophic keratopathy in pontine tegmental cap dysplasia treated with cenegermin eye drops.

    abstract:RATIONALE:To report the management of recalcitrant neurotrophic keratopathy in a pediatric patient affected by pontine tegmental cap dysplasia (PTCD) using topical human recombinant nerve growth factor (hrNGF, Cenegermin 20 μg/ml). To the best of our knowledge the present case is one of the few described in patients wi...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000020816

    authors: Fausto R,Ceccuzzi R,Micheletti E,Clerici R,Riva I,Katsanos A,Oddone F,Quaranta L

    更新日期:2020-07-24 00:00:00

  • Streptococcus pneumoniae bacteremia in patients with cancer: disease characteristics and outcomes in the era of escalating drug resistance (1998-2002).

    abstract::In the current era of multidrug-resistant organisms, the clinical spectrum of Streptococcus pneumoniae infection remains unclear, especially in immunosuppressed patients with cancer. We sought to define the characteristics of pneumococcal bacteremia in patients who were receiving care at a comprehensive cancer center....

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/01.md.0000180045.26909.29

    authors: Kumashi P,Girgawy E,Tarrand JJ,Rolston KV,Raad II,Safdar A

    更新日期:2005-09-01 00:00:00

  • Evidence for Chronic Kidney Disease-Mineral and Bone Disorder Associated With Metabolic Pathway Changes.

    abstract::Abnormalities in the levels of calcium, phosphorus, and parathyroid hormone (PTH) in serum are typical for patients with chronic kidney disease (CKD). They are used routinely to predict the onset of CKD-mineral and bone disorder (MBD). However, CKD-MBD associated with metabolic pathway imbalance is not well understood...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000001273

    authors: Wu Q,Lai X,Zhu Z,Hong Z,Dong X,Wang T,Wang H,Lou Z,Lin Q,Guo Z,Chai Y

    更新日期:2015-08-01 00:00:00

  • Case report of a congenital duodenal transverse septum causing partial obstruction.

    abstract:INTRODUCTION:Duodenal obstructions caused by congenital anatomic abnormalities are rare in adults. Several patients in whom the duodenal obstruction was caused by a congenital duodenal diaphragm have been described. The duodenal obstruction in the patient presented herein was caused by a transverse septum, which has no...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000007093

    authors: Guo X,Yu Y,Wang M,Qin R

    更新日期:2017-10-01 00:00:00

  • Utility of Red Cell Distribution Width as a Prognostic Factor in Young Breast Cancer Patients.

    abstract::The prognosis of breast cancer occurs in young women is usually poor. Red cell distribution width (RDW), 1 of many routinely examined parameters, has recently been proposed as a prognostic marker in solid tumors. The aim of our study was to assess the predictive value of RDW for survival in young women with breast can...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000003430

    authors: Huang DP,Ma RM,Xiang YQ

    更新日期:2016-04-01 00:00:00

  • Nonmedical Use of Cough Syrup Among Secondary Vocational School Students: A National Survey in China.

    abstract::Nonmedical use of cough syrup (NUCS) among secondary vocational school (SVS) students has been an increasing concern for public health in China, but no data were available. This cross-sectional study aimed to investigate the epidemiological characters of NUCS as well as its risk factors among SVS students in China.Fro...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000002969

    authors: Wu Q,Yu J,Yang C,Chen J,Yang L,Zhang H,Teng S,Li J,Yan D,Cao J,Zhao Y,Wang Z

    更新日期:2016-03-01 00:00:00

  • Gatekeeping and the utilization of community health services in Shenzhen, China: A cross-sectional study.

    abstract::To assess the effects of the gatekeeper policy implemented in Shenzhen, China, in conjunction with a labor health insurance program, on channeling patients toward community health centers (CHCs).Eight thousand patients who visited 8 CHCs in Shenzhen were surveyed between May 1, 2013 and July 28, 2013. Half of the pati...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000007719

    authors: Li W,Gan Y,Dong X,Zhou Y,Cao S,Kkandawire N,Cong Y,Sun H,Lu Z

    更新日期:2017-09-01 00:00:00