Clinicopathological features, surgical treatments, and survival outcomes of patients with small bowel adenocarcinoma.

Abstract:

:To date, because of their rarity, the clinicopathological features and surgical outcomes of small bowel adenocarcinomas (SBAs) have been insufficiently explored. We evaluated the clinicopathological features and long-term outcomes of patients who underwent surgery for SBA.This retrospective study (from 1999 to 2016) examined patients with SBA treated surgically at the China National Cancer Center/Cancer Hospital. Clinicopathological features, preoperative evaluation, surgical treatment, and outcome parameters were reviewed and analyzed.Among the 241 patients studied, pancreaticoduodenectomies were performed in 51.0%, partial resection in 24.5%, palliative bypass surgery in 23.7%, and abdominal exploration in 0.8% of the patients. Majority of the patients were diagnosed at an advanced disease stage, and the duodenum was the most common tumor site. Postoperative complications occurred in 44.4% of the patients. Median overall and progression-free survival rates were 22.0 and 13.0 months, respectively. The 5-year overall and progression-free survival rates for patients with duodenal adenocarcinoma were 30.2% and 21.7%, respectively. Duodenal adenocarcinomas, lymph node metastases, distant metastases, poor differentiation, and lymphovascular invasion were associated with poor overall survival outcomes. The 3 factors associated with progression-free survival were the degree of differentiation, lymph node metastases, and distant metastases.Surgery remains the mainstay of treatment for SBA. A poor prognosis could be owing to the site, metastasis, differentiation, and lymphovascular invasion; however, the prognosis may improve through early diagnosis and operation.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Zhang S,Yuan W,Zhang J,Chen Y,Zheng C,Ma J,Jiang Q,Zhao Y,Xu Q,Wang C

doi

10.1097/MD.0000000000007713

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

e7713

issue

31

eissn

0025-7974

issn

1536-5964

pii

00005792-201708040-00046

journal_volume

96

pub_type

杂志文章

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