Therapy of anti-glomerular basement membrane antibody disease: analysis of prognostic significance of clinical, pathologic and treatment factors.

Abstract:

:We have compared the effect of therapy with immunosuppression alone to immunosuppression plus plasma exchange on the clinical course and rate of disappearance of antibody in 17 patients with anti-glomerular basement membrane (anti-GBM) antibody-induced renal disease. Patients receiving immunosuppression (n = 9) and those receiving plasma exchange (n = 8) were similar in terms of entry clinical characteristics, pulmonary manifestations and complications associated with therapy. Rate of disappearance of anti-GBM antibody as estimated from serial estimates of antibody binding was significantly more rapid in patients receiving plasma exchange, and mean serum creatinine in these patients at end of therapy was half that of the patients receiving immunosuppression alone. Analysis of clinical and pathologic values at study entry, however, indicated that the percent of crescents on initial renal biopsy and entry serum creatinine correlated better with outcome than did therapeutic modality. Thus, though plasma exchange may offer some advantage over immunosuppression alone in the treatment of this disease, degree of pathologic involvement appears to be the major factor affecting outcome. Patients with low cresents (less than 30%) and well preserved function did well with either treatment, while patients with severe crescentic involvement and impaired glomerular filtration rate did poorly.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Johnson JP,Moore J Jr,Austin HA 3rd,Balow JE,Antonovych TT,Wilson CB

doi

10.1097/00005792-198507000-00003

subject

Has Abstract

pub_date

1985-07-01 00:00:00

pages

219-27

issue

4

eissn

0025-7974

issn

1536-5964

journal_volume

64

pub_type

临床试验,杂志文章

相关文献

MEDICINE文献大全
  • The relationship between the expression of TN and the efficiency of posterior spinal V osteotomy in patients with traumatic kyphosis.

    abstract:BACKGROUND:This study was conducted with the aim to investigate the relationship between Tetranectin (TN) and efficiency of posterior spinal V osteotomy in patients with traumatic kyphosis. METHODS:Ninety-two patients with traumatic kyphosis admitted in our hospital from February 2014 to June 2016 were included whose ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000009555

    authors: Jiang G,Zhang Y,Sun X

    更新日期:2018-02-01 00:00:00

  • Selection of Postacute Stroke Rehabilitation Facilities: A Survey of Discharge Planners From the Northeast Cerebrovascular Consortium (NECC) Region.

    abstract::The process of determining the level of care and specific postacute care facility for stroke patients has not been adequately studied. The objective of this study was to better understand the factors that influence postacute care decisions by surveying stroke discharge planners. Requests were sent to discharge planner...

    journal_title:Medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MD.0000000000003206

    authors: Magdon-Ismail Z,Sicklick A,Hedeman R,Bettger JP,Stein J

    更新日期:2016-04-01 00:00:00

  • A randomized controlled trial comparing methohexital and propofol for induction in patients receiving angiotensin axis blockade.

    abstract:BACKGROUND:Pharmacologic angiotensin axis blockade (AAB) has been associated with profound hypotension following anesthetic induction with propofol. To combat this problem, investigators have attempted to withhold angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB) preoperatively, or...

    journal_title:Medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MD.0000000000014374

    authors: Bonavia A,Verbeek T,Adhikary S,Kunselman A,Budde A,Lyn-Sue J,Mets B

    更新日期:2019-02-01 00:00:00

  • A case report of lung adenocarcinoma with polyserous effusions as the onset symptom.

    abstract:RATIONALE:Coexistence of lung adenocarcinoma and polyserous effusions is quite rare. This complexity of etiology adds difficulty to the diagnosis and is likely to cause misdiagnosis and maldiagnosis. PATIENT CONCERNS:A 43-year-old woman was admitted with symptoms of dry cough, chest suffocation, polyserous effusions, ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000007867

    authors: Han P,Yao R,Zhai D,Cheng C,Yang F,Sun S,Zhang D,Yu C

    更新日期:2017-09-01 00:00:00

  • Remission of systematic lupus erythematosus.

    abstract::The occurrence and characteristics of remissions in patients with systematic lupus erythematosus (SLE) have not been determined. We therefore studied this in a cohort of 667 patients and found that 156 patients had achieved at least 1 period of 1 year or more of treatment-free clinical remission. This represents an in...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/00005792-199603000-00005

    authors: Drenkard C,Villa AR,Garcia-Padilla C,Pérez-Vázquez ME,Alarcón-Segovia D

    更新日期:1996-03-01 00:00:00

  • The diagnostic performance of serum LIM homeobox transcription factor 1 alpha in patients with gastric cancer.

    abstract::The study was conducted to investigate the diagnostic performance of serum LIM homeobox transcription factor 1 alpha (LMX1A) in patients with gastric cancer (GC).The serum level of LMX1A in GC, benign, and healthy groups was measured using quantitative real time PCR (qRT-PCR) and compared with the student t test. The ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000015783

    authors: Li D,Li C

    更新日期:2019-05-01 00:00:00

  • Poorer prognosis in patients with advanced gastric squamous cell carcinoma compared with adenocarcinoma of the stomach: Case report.

    abstract:RATIONALE:Primary squamous cell carcinoma (SCC) of the stomach is a rare disease. The pathogenesis and prognosis of advanced SCC remains to be elucidated. The aim of the current study was to investigate the prognosis of recurrent or metastatic SCC of the stomach. PATIENT CONCERNS:A retrospective study examined the cli...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000009224

    authors: Meng Y,Zhang J,Wang H,Zhang Y,Sun R,Zhang Z,Gao F,Huang C,Zhang S

    更新日期:2017-12-01 00:00:00

  • Long-term outcome of idiopathic pulmonary hemosiderosis in children.

    abstract::We retrospectively analyzed the long-term outcome of idiopathic pulmonary hemosiderosis (IPH) in 15 children. IPH started at a mean age of 5 years, and the mean duration of follow-up was 17.2 years (range, 10-36 yr). Four patients developed immune disorders, 3 cases of rheumatoid polyarthritis or rheumatoid polyarthri...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/00005792-200009000-00005

    authors: Le Clainche L,Le Bourgeois M,Fauroux B,Forenza N,Dommergues JP,Desbois JC,Bellon G,Derelle J,Dutau G,Marguet C,Pin I,Tillie-Leblond I,Scheinmann P,De Blic J

    更新日期:2000-09-01 00:00:00

  • Is allograft a more reliable treatment option than autograft in 2-level anterior cervical discectomy and fusion with plate fixation?

    abstract::This study aimed to assess the efficacy of allograft in 2-level anterior cervical discectomy and fusion (ACDF) with plate fixation by comparing its clinical and radiological outcomes to those of autograft.Thirty five patients with femur cortical allografts and 32 patients with tricortical iliac autografts were evaluat...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000016621

    authors: Park JS,Park SJ,Lee CS,Chung SS,Park HJ

    更新日期:2019-08-01 00:00:00

  • rs1495741 as a tag single nucleotide polymorphism of N-acetyltransferase 2 acetylator phenotype associates bladder cancer risk and interacts with smoking: A systematic review and meta-analysis.

    abstract::Rs1495741 has been identified to infer N-acetyltransferase 2 (NAT2) acetylator phenotype, and to decrease the risk of bladder cancer. However, a number of studies conducted in various regions showed controversial results. To quantify the association between rs1495741 and the risk of bladder cancer and to estimate the ...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MD.0000000000004417

    authors: Ma C,Gu L,Yang M,Zhang Z,Zeng S,Song R,Xu C,Sun Y

    更新日期:2016-08-01 00:00:00

  • Gastrointestinal stromal tumor (GIST) with liver metastases: An 18-year experience from the GIST cooperation group in North China.

    abstract::Approximately 40% to 50% of gastrointestinal stromal tumor (GIST) patients will have recurrence or metastases after resection of the primary lesion, and the most common affected sites will be liver and peritoneum. Imatinib has been considered as the first-line therapy of metastatic GIST. Surgery for metastases is prop...

    journal_title:Medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MD.0000000000008240

    authors: Shi YN,Li Y,Wang LP,Wang ZH,Liang XB,Liang H,Zhang L,Li B,Fan LQ,Zhao Q,Ma ZX,Zhao XF,Zhang ZD,Liu Y,Tan BB,Wang D,Wang LL,Hao YJ,Jia N

    更新日期:2017-11-01 00:00:00

  • Hepatic outflow obstruction (Budd-Chiari syndrome). Experience with 177 patients and a review of the literature.

    abstract::Budd-Chiari syndrome (BCS) may not be as uncommon as was once believed. Our study has substantiated the existence of 2 major clinical forms. The acute syndrome is invariably associated with extensive blockage of the major hepatic veins, resulting in congestive liver cell necrosis. In a small, but significant, number o...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00005792-199401000-00003

    authors: Dilawari JB,Bambery P,Chawla Y,Kaur U,Bhusnurmath SR,Malhotra HS,Sood GK,Mitra SK,Khanna SK,Walia BS

    更新日期:1994-01-01 00:00:00

  • Topical steroids eye drops in conjunctival reactive lymphoid hyperplasia: Case report.

    abstract:RATIONALE:Conjunctival lymphoproliferative lesions constitute a significant diagnostic challenge and it is essential to exclude neoplastic lesions. Histopathological and immunohistochemical tests are very useful in establishing the correct diagnosis. Reactive lymphoid hyperplasia (RLH) is part of a spectrum of lymphocy...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000008656

    authors: Moraes BRM,Nascimento MVDD,Neto EDDS,Santo RM

    更新日期:2017-11-01 00:00:00

  • Systematic review and meta-analysis of the effect of probiotic supplementation on functional constipation in children.

    abstract:BACKGROUND:To evaluate the effect of probiotic supplementation on functional constipation in children. METHODS:We performed electronic searches in PubMed, Embase, and Cochrane Library without language restriction to identify relevant studies from the time of inception of these databases to March 2018. The relative ris...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MD.0000000000012174

    authors: Jin L,Deng L,Wu W,Wang Z,Shao W,Liu J

    更新日期:2018-09-01 00:00:00

  • Nationwide Multicenter Reference Interval Study for 28 Common Biochemical Analytes in China.

    abstract::A nationwide multicenter study was conducted in the China to explore sources of variation of reference values and establish reference intervals for 28 common biochemical analytes, as a part of the International Federation of Clinical Chemistry and Laboratory Medicine, Committee on Reference Intervals and Decision Limi...

    journal_title:Medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MD.0000000000002915

    authors: Xia L,Chen M,Liu M,Tao Z,Li S,Wang L,Cheng X,Qin X,Han J,Li P,Hou L,Yu S,Ichihara K,Qiu L

    更新日期:2016-03-01 00:00:00

  • Predictive Value of Glucose Parameters Obtained From Oral Glucose Tolerance Tests in Identifying Individuals at High Risk for the Development of Diabetes in Korean Population.

    abstract::Previous studies suggest that the future risk for type 2 diabetes is not similar among subjects in the same glucose tolerance category. In this study, we aimed to evaluate simple intuitive indices to identify subjects at high risk for future diabetes development by using 0, 30, 120 minute glucose levels obtained durin...

    journal_title:Medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/MD.0000000000003053

    authors: Yang HK,Ha HS,Rhee M,Lee JH,Park YM,Kwon HS,Yim HW,Kang MI,Lee WC,Son HY,Lee SH,Yoon KH

    更新日期:2016-03-01 00:00:00

  • EEC-LM-ADULT syndrome caused by R319H mutation in TP63 with ectrodactyly, syndactyly, and teeth anomaly: A case report.

    abstract:RATIONALE:Ectrodactyly ectodermal dysplasia-cleft lip/palate (EEC) syndrome, limb-mammary syndrome (LMS), and acro-dermato-ungual-lacrimal-tooth (ADULT) syndrome are caused by a TP63 gene disorder and have similar features. In the present article, a R319H mutation in TP63 is reported, and the correlation between genoty...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000022816

    authors: Otsuki Y,Ueda K,Nuri T,Satoh C,Maekawa R,Yoshiura KI

    更新日期:2020-10-30 00:00:00

  • Outcomes of thoracoscopy versus thoracotomy for esophageal atresia with tracheoesophageal fistula repair: A PRISMA-compliant systematic review and meta-analysis.

    abstract:BACKGROUND:A thoracoscopic approach for repair of esophageal atresia (EA) with tracheoesophageal fistula (TEF) has become a standard procedure in many pediatric surgical centers. However, whether thoracotomy or thoracoscopy offer advantages in terms of surgical outcomes is not known. METHODS:To evaluate the efficacy a...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MD.0000000000004428

    authors: Yang YF,Dong R,Zheng C,Jin Z,Chen G,Huang YL,Zheng S

    更新日期:2016-07-01 00:00:00

  • Effect of local anesthesia with lidocaine on perioperative proinflammatory cytokine levels in plasma and cerebrospinal fluid in cerebral aneurysm patients: Study protocol for a randomized clinical trial.

    abstract:BACKGROUND:Cerebral aneurysm surgery has significant mortality and morbidity rate. Inflammation plays a key role in the pathogenesis of intracranial aneurysms, their rupture, subarachnoid hemorrhage and neurologic complications. Proinflammatory cytokine level in blood and cerebrospinal fluid (CSF) is an indicator of in...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000017450

    authors: Matas M,Sotošek V,Kozmar A,Likić R,Sekulić A

    更新日期:2019-10-01 00:00:00

  • Serum Alpha-Fetoprotein Has High Specificity for the Early Detection of Hepatocellular Carcinoma After Hepatitis C Virus Eradication in Patients.

    abstract::Alpha-fetoprotein (AFP) has not played a large role in the surveillance of hepatocellular carcinoma due to inadequate sensitivity and specificity for active chronic hepatitis or cirrhosis. The aim of this study was to evaluate the diagnostic accuracy of AFP in small hepatocellular carcinomas after hepatitis C virus er...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000000901

    authors: Minami T,Tateishi R,Kondo M,Nakagomi R,Fujiwara N,Sato M,Uchino K,Enooku K,Nakagawa H,Asaoka Y,Kondo Y,Moriya K,Shiina S,Koike K

    更新日期:2015-06-01 00:00:00

  • Subtrochanteric femoral shortening osteotomy concomitantly performed with revision total hip arthroplasty: A case report.

    abstract:RATIONALE:Total hip arthroplasty (THA) concomitant with subtrochanteric femoral shortening osteotomy for Crowe type IV dysplastic hip has been reported. However, the combination of subtrochanteric femoral osteotomy and revision THA has only been mentioned in one case report. PATIENT CONCERNS:A 67-year-old female had a...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000012934

    authors: Takeda Y,Fukunishi S,Nishio S,Fujihara Y,Yoshiya S

    更新日期:2018-10-01 00:00:00

  • Usefulness of Ultrasonography for Diagnosis of Small Bowel Tumors: A Comparison Between Ultrasonography and Endoscopic Modalities.

    abstract::Ultrasonography is a standard, noninvasive modality used to evaluate patients with gastrointestinal diseases. This study assessed the usefulness of ultrasonography in the detection of small bowel tumors. This study enrolled 558 consecutive patients (295 males, 263 females; mean age 71.1 years) who underwent ultrasonog...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000001464

    authors: Fujita M,Manabe N,Honda K,Murao T,Osawa M,Kawai R,Akiyama T,Shiotani A,Haruma K,Hata J

    更新日期:2015-10-01 00:00:00

  • Use of siphon irrigation during burr-hole craniostomy to evacuate chronic subdural hematoma: A retrospective cohort comparison study.

    abstract::Burr-hole craniostomy (BHC) is a widely accepted treatment for chronic subdural hematomas (CSDHs). This study adopted siphon irrigation to evacuate CSDHs and investigated its efficacy and safety as compared with the traditional irrigation used in BHC.A retrospective cohort study was conducted at a center between Janua...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000020291

    authors: Chen S,Chen Z,Yang B,Xu T,Tu XK

    更新日期:2020-05-22 00:00:00

  • Risk factors of uveitis in ankylosing spondylitis: An observational study.

    abstract:BACKGROUND:Uveitis is the most common extra-articular manifestation in patients with ankylosing spondylitis (AS). The prevalence and characteristics of uveitis in AS have been studied in previous literatures, whereas its associated risk factors have not been clarified. Therefore, this study analyzed the risk factors of...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000004233

    authors: Sun L,Wu R,Xue Q,Wang F,Lu P

    更新日期:2016-07-01 00:00:00

  • Complete response of radioresistant brain metastases from non-small cell lung cancer with temozolomide: A case report and literature review.

    abstract:RATIONALE:Non-small cell lung cancer (NSCLC) patients with brain metastases (BMs) have been found as subjects of poor prognosis. Whole-brain radiotherapy (WBRT), surgery, and stereotactic radiosurgery, epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), or some combinations are the most commonly empl...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000023592

    authors: Yang Y,Pu Y,Dai N,Wang D,Xu M

    更新日期:2020-12-18 00:00:00

  • Predictive Significance of a New Prognostic Score for Patients With Diffuse Large B-Cell Lymphoma in the Interim-Positron Emission Tomography Findings.

    abstract::We hypothesized that the objective treatment response of patients with diffuse large B-cell lymphoma (DLBCL) was affected by many factors such as pathophysiological, biological, and pharmaceutical mechanisms. This retrospective study aimed to evaluate the predictive significance of clinical prognostic factors and inte...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000002808

    authors: Kong Y,Qu L,Li Y,Liu D,Lv X,Han J

    更新日期:2016-02-01 00:00:00

  • Massive trapezial metastasis from gastric adenocarcinoma resected and reconstructed with a vascularized scapular bone graft: A case report.

    abstract:RATIONALE:Isolated metastasis to the hand bones is very rare. Only seven cases of metastasis to the trapezium have been reported. To the best of our knowledge, this is the first report of a single metastasis to the trapezium from a gastric adenocarcinoma. PATIENT CONCERNS:A 62-year-old man presented with pain and mass...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000009294

    authors: Okamoto M,Yamazaki H,Yoshimura Y,Aoki K,Tanaka A,Kato H

    更新日期:2017-12-01 00:00:00

  • Association of Glutathione S-Transferase M1 null genotype with inflammatory bowel diseases: A systematic review and meta-analysis.

    abstract:BACKGROUND:Ulcerative colitis (UC) and Crohn disease (CD) are the 2 main types of inflammatory bowel diseases (IBDs). Several studies have been conducted to investigate the association of Glutathione S-Transferase M1 (GSTM1) null genotype with UC and CD, but the results are inconsistent. Here, we performed a meta-analy...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000017722

    authors: Zhou YJ,Zhao BL,Qian Z,Xu Y,Ding YQ

    更新日期:2019-11-01 00:00:00

  • Endometrial thickness as a predictor of the reproductive outcomes in fresh and frozen embryo transfer cycles: A retrospective cohort study of 1512 IVF cycles with morphologically good-quality blastocyst.

    abstract::To evaluate the relationship between endometrial thickness during fresh in vitro fertilization (IVF) cycles and the clinical outcomes of subsequent frozen embryo transfer (FET) cycles.FET cycles using at least one morphological good-quality blastocyst conducted between 2012 and 2013 at a university-based reproductive ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000009689

    authors: Zhang T,Li Z,Ren X,Huang B,Zhu G,Yang W,Jin L

    更新日期:2018-01-01 00:00:00

  • Corrective osteotomy with retrograde Fassier-Duval nail in an osteogenesis imperfecta patient with bilateral genu valgum: A case report.

    abstract:RATIONALE:The treatment of osteogenesis imperfecta (OI) requires a multidisciplinary approach to maximize function and reduce fracture incidence. The aim of this case report was to discuss an alternative surgical approach to stabilize a corrective osteotomy using the Fassier Duval (FD) system in an OI patient. PATIENT...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000008459

    authors: Lin TY,Yang CY,Liu SC

    更新日期:2017-11-01 00:00:00