Abstract:
:The study was conducted to investigate the diagnostic performance of serum LIM homeobox transcription factor 1 alpha (LMX1A) in patients with gastric cancer (GC).The serum level of LMX1A in GC, benign, and healthy groups was measured using quantitative real time PCR (qRT-PCR) and compared with the student t test. The associations of serum LMX1A levels with clinical parameters were analyzed with chi-square test. The diagnostic value of serum LMX1A in GC was evaluated by receiver operating characteristic (ROC) curve.The level of serum LMX1A in GC group (1.309 ± 0.553) was significantly lower than that in the benign group (2.174 ± 0.676) and healthy group (2.598 ± 0.826) (P < .01 for both). The decreased level of LMX1A was associated with large tumor size (P = .009), positive lymph node metastasis (P = .027), and advanced TNM stages (P = .002). Receiver operating characteristic (ROC) analysis demonstrated that serum LMX1A could discriminate GC patients from the healthy individuals, with the area under the curve (AUC) of 0.889 (95% confidence interval [CI] = 0.838-0.938) combining with the sensitivity and specificity of 82.68% and 82.61%. Additionally, serum LMX1A also exhibited high accuracy in discriminating between GC patients and benign gastric disease cases (AUC = 0.842, 95% CI = 0.782-0.901), with the sensitivity of 81.89% and specificity of 72.41%.Serum LMX1A may be an effective biomarker for early detection of GC.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Li D,Li Cdoi
10.1097/MD.0000000000015783subject
Has Abstractpub_date
2019-05-01 00:00:00pages
e15783issue
22eissn
0025-7974issn
1536-5964pii
00005792-201905310-00030journal_volume
98pub_type
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