当前位置： SCI文献检索 > MEDICINE期刊下所有文献 > Is allograft a more reliable treatment option than autograft in 2-level anterior cervical discectomy and fusion with plate fixation?

Is allograft a more reliable treatment option than autograft in 2-level anterior cervical discectomy and fusion with plate fixation?

Abstract：

:This study aimed to assess the efficacy of allograft in 2-level anterior cervical discectomy and fusion (ACDF) with plate fixation by comparing its clinical and radiological outcomes to those of autograft.Thirty five patients with femur cortical allografts and 32 patients with tricortical iliac autografts were evaluated. All surgeries were performed by a single senior surgeon. During routine follow-up (at 3 months, 6 months, and annually after the surgery), the fusion rate, subsidence rate, and fused segmental lordosis angle were assessed by radiologic evaluation. Clinical outcomes were assessed using the visual analog scale (VAS), neck disability index (NDI) scores, and Odom criteria. This study was conducted using the results of the 2-year postoperative follow-up.Among 67 patients, 62 (92.5%) showed successful bone fusion at 2 years postoperatively: 91.4% (32/35) in the allograft group and 93.8% (30/32) in the autograft group. The fusion rate was 37.1% (13/35) in the allograft group and 68.8% (23/32) in the autograft group at 6 months and 68.5% (24/35) in the allograft group and 93.8% (30/32) in autograft group at 1 year. Eight (72.7%) of the remaining 11 patients with allograft achieved bone fusion without any intervention at the 2-year follow-up. The fusion was achieved faster in the autograft group than in the allograft group (P = .003). There was no significant difference in the subsidence rate or change in the fused segmental lordosis angle between the 2 groups; there was also no significant difference in clinical outcomes (NDI scores, VAS scores, Odom criteria) between the 2 groups. However, the intraoperative blood loss was significantly greater in the autograft group, and the operative time was also significantly longer in the autograft group (P < .001). In the autograft group, 6 patients (18.8%) had minor complications at the donor site.In 2-level ACDF with plate fixation, the radiologic and clinical outcomes of autograft and allograft were similar at 2-year follow-up, although fusion was observed earlier in the autograft group.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Park JS,Park SJ,Lee CS,Chung SS,Park HJ

doi

10.1097/MD.0000000000016621

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

e16621

issue

eissn

0025-7974

issn

1536-5964

pii

00005792-201908090-00020

journal_volume

pub_type

杂志文章

在线工具

Is allograft a more reliable treatment option than autograft in 2-level anterior cervical discectomy and fusion with plate fixation?