Abstract:
INTRODUCTION:Henoch-Schönlein purpura nephritis (HSPN) involves the renal impairment of Henoch-Schönlein purpura and can easily relapse into life-threatening late nephropathy in severe cases. Although there is a lack of validated evidence for its effectiveness, Chinese herbal medicine (CHM) is one of the most commonly used methods in China to treat HSPN. It is thus need to report the protocol of a prospective cohort trial using CHM to investigate the effectiveness, safety and advantages for children with HSPN. METHODS AND ANALYSIS:This large, prospective, multicenter cohort study started in May 2015 in Shenyang. Six hundred children diagnosed with HSPN were recruited from 3 institutions and are followed-up every 2 to 4 weeks till May 2020. Detailed information of participants includes general information, history of treatment, physical examination, and symptoms of TCM is taken face-to-face at baseline. ETHICS AND DISSEMINATION:This study has received ethical approval from the ethics committee of institutional review board of the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine (No.2016CS(KT)-002-01). Articles summarizing the primary results and ancillary analyses will be published in peer-reviewed journals. TRIAL REGISTRATION:Clinical Trials Registration: NCT02878018.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Zhang J,Lv J,Pang S,Bai X,Yuan F,Wu Y,Jiang H,Yang G,Zhang Sdoi
10.1097/MD.0000000000011064subject
Has Abstractpub_date
2018-06-01 00:00:00pages
e11064issue
24eissn
0025-7974issn
1536-5964pii
00005792-201806150-00038journal_volume
97pub_type
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