Chinese herbal medicine for the treatment of Henoch-Schönlein purpura nephritis in children: A prospective cohort study protocol.

Abstract:

INTRODUCTION:Henoch-Schönlein purpura nephritis (HSPN) involves the renal impairment of Henoch-Schönlein purpura and can easily relapse into life-threatening late nephropathy in severe cases. Although there is a lack of validated evidence for its effectiveness, Chinese herbal medicine (CHM) is one of the most commonly used methods in China to treat HSPN. It is thus need to report the protocol of a prospective cohort trial using CHM to investigate the effectiveness, safety and advantages for children with HSPN. METHODS AND ANALYSIS:This large, prospective, multicenter cohort study started in May 2015 in Shenyang. Six hundred children diagnosed with HSPN were recruited from 3 institutions and are followed-up every 2 to 4 weeks till May 2020. Detailed information of participants includes general information, history of treatment, physical examination, and symptoms of TCM is taken face-to-face at baseline. ETHICS AND DISSEMINATION:This study has received ethical approval from the ethics committee of institutional review board of the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine (No.2016CS(KT)-002-01). Articles summarizing the primary results and ancillary analyses will be published in peer-reviewed journals. TRIAL REGISTRATION:Clinical Trials Registration: NCT02878018.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Zhang J,Lv J,Pang S,Bai X,Yuan F,Wu Y,Jiang H,Yang G,Zhang S

doi

10.1097/MD.0000000000011064

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

e11064

issue

24

eissn

0025-7974

issn

1536-5964

pii

00005792-201806150-00038

journal_volume

97

pub_type

临床试验,杂志文章,多中心研究

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