Predictive value of soluble ST-2 for changes of cardiac function and structure in breast cancer patients receiving chemotherapy.

Abstract:

:The current study was to evaluate soluble ST-2 level and left ventricular ejection fraction (LVEF) in patients with breast cancer receiving doxorubicin or trastuzumab treatment for 6 months and determine whether soluble ST-2 level can be used to predictive left ventricular function impairment.Patients who were diagnosed as having breast cancer receiving doxorubicin or trastuzumab or combined therapy were enrolled. Demographic data, prior medical history and related medical therapy, and site and stage of breast cancer information were collected from electronic health record. Fasting blood was used to detect soluble ST-2 and brain natriuretic peptide (BNP) levels before and after 6 months doxorubicin or trastuzumab therapy. Echocardiography was performed before and after 6 months of doxorubicin or trastuzumab therapy.Participants were divided into 3 groups based on tertiary soluble ST-2 level. Compared with 1st tertiary group, patients in the 3rd tertiary group had higher proportion receiving combined therapy (14.3% vs 4.7%, P < .05). Baseline soluble ST-2 level was similar across groups. After 6 months' therapy, soluble ST-2 level was significantly higher in the 3rd tertiary group. Pearson correlation analysis showed that soluble ST-2 level was positively correlated with left ventricular volume and E/e' ratio while negatively correlated with LVEF. Doxorubicin, trastuzumab, combined therapy, soluble ST-2 level, and angiotensin-converting enzyme inhibitor/angiotensin receptor blocker treatment were all independently associated with LVEF change.In breast cancer patients receiving doxorubicin or trastuzumab therapy, soluble ST-2 level can be used to predict cardiac function and structure changes.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Huang G,Zhai J,Huang X,Zheng D

doi

10.1097/MD.0000000000012447

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

e12447

issue

38

eissn

0025-7974

issn

1536-5964

pii

00005792-201809210-00078

journal_volume

97

pub_type

杂志文章

相关文献

MEDICINE文献大全
  • Impacts of 12-dose regimen for latent tuberculosis infection: Treatment completion rate and cost-effectiveness in Taiwan.

    abstract::Treatment of latent tuberculosis infection (LTBI) is essential for eradicating tuberculosis (TB). Moreover, the patient adherence is crucial in determining the effectiveness of TB control. Isoniazid given by DOTS daily for 9 months (9H) is the standard treatment for LTBI in Taiwan. However, the completion rate is low ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000004126

    authors: Huang YW,Yang SF,Yeh YP,Tsao TC,Tsao SM

    更新日期:2016-08-01 00:00:00

  • Nonfunctional pancreatic neuroendocrine tumor masked as anemia: A case report.

    abstract::After a series of clinical relevant examinations. The patient was dignosed as pancreatic tomor in the pancreatic tail accompanied with the symptom of anenmia and dizziness.Until now surgery is the best treatment strategy for pancreatic tumors.So we take a joint multiple organ removal surgery.Before surgery, the main c...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000007441

    authors: Xu B,Wang Y,Li X,Lin J

    更新日期:2017-07-01 00:00:00

  • IgG4-related disease and hypertrophic pachymeningitis.

    abstract::Hypertrophic pachymeningitis (HP) is an inflammatory condition in which the dura mater of the cranium or spine becomes thickened, leading to symptoms that result from mass effect, nerve compression, or vascular compromise. The differential diagnosis of HP includes immune-mediated conditions such as rheumatoid arthriti...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0b013e31829cce35

    authors: Wallace ZS,Carruthers MN,Khosroshahi A,Carruthers R,Shinagare S,Stemmer-Rachamimov A,Deshpande V,Stone JH

    更新日期:2013-07-01 00:00:00

  • Radiofrequency neurotomy in chronic lumbar and sacroiliac joint pain: A meta-analysis.

    abstract:BACKGROUND:Effective treatment of low back pain (LBP) originating in the lumbar and sacroiliac joints is difficult to achieve. The objective of the current study was to compare the clinical effectiveness of radiofrequency (RF) neurotomy versus conservative nonsurgical approaches for the management of chronic lumbar and...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000016230

    authors: Chen CH,Weng PW,Wu LC,Chiang YF,Chiang CJ

    更新日期:2019-06-01 00:00:00

  • Novel peroral cholangioscopy-directed lithotripsy using an ultraslim upper endoscope for refractory Mirizzi syndrome: A case report.

    abstract:RATIONALE:Mirizzi syndrome (MS) is an uncommon condition characterized by common hepatic duct (CHD) compression by an impacted gallbladder or cystic duct stones or adjacent inflammation. To date, a standardized therapeutic strategy for MS has not been established yet, owing to its complex clinical presentation. Thus, r...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000022649

    authors: Li J,Guo SJ,Zhang JC,Wang HY,Li K,Xu CS,Wang XF

    更新日期:2020-11-06 00:00:00

  • Subcutaneous Versus Submuscular Anterior Transposition of the Ulnar Nerve for Cubital Tunnel Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials and Observational Studies.

    abstract::Subcutaneous and submuscular anterior ulnar nerve transposition have been widely used in patients with cubital tunnel syndrome. However, the reliable evidence in favor of 1 of 2 surgical options on clinical improvement remains controversial. To maximize the value of the available literature, we performed a systematic ...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MD.0000000000001207

    authors: Liu CH,Wu SQ,Ke XB,Wang HL,Chen CX,Lai ZL,Zhuang ZY,Wu ZQ,Lin Q

    更新日期:2015-07-01 00:00:00

  • Assessing the relationship between the use of nonsteroidal antiinflammatory drugs and necrotizing fasciitis caused by group A streptococcus.

    abstract::Group A streptococcal (GAS) necrotizing fasciitis is a rapidly progressive soft tissue infection. Elderly and chronically ill individuals are at greatest risk, particularly when skin breakdown is present. Reports suggest that nonsteroidal antiinflammatory drugs (NSAIDs) increase the risk of developing GAS necrotizing ...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/01.md.0000085060.63483.bb

    authors: Aronoff DM,Bloch KC

    更新日期:2003-07-01 00:00:00

  • Comparison of radiological outcomes and complications between single-level and multilevel anterior cervical discectomy and fusion (ACDF) by using a polyetheretherketone (PEEK) cage-plate fusion system.

    abstract::This study aimed to compare the differences in radiological outcomes and complications between single- and multilevel anterior cervical discectomy and fusion (ACDF) by using a polyetheretherketone (PEEK) cage-plate fusion system.Fifty-seven patients who underwent ACDF via the PEEK cage-plate fusion system were enrolle...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000014277

    authors: Lee HC,Chen CH,Wu CY,Guo JH,Chen YS

    更新日期:2019-02-01 00:00:00

  • Imaging findings of intraductal tubulopapillary neoplasm (ITPN) of the pancreas: Two case reports and literature review.

    abstract:RATIONALE:Intraductal tubulopapillary neoplasm (ITPN) is a rare type of pancreatic epithelial neoplasm. We report 2 cases of ITPN and detail the imaging findings. PATIENT CONCERNS:The 1st case was a 36-year-old woman who complained of jaundice, yellow urine and diarrhea. She accepted ultrasound, computed tomography (C...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000014426

    authors: Zhang J,Ren S,Wang J,Ye D,Zhang H,Qiu W,Wang Z

    更新日期:2019-02-01 00:00:00

  • Management of Postoperative Pain in Medical Institutions in Shandong Province in China.

    abstract::The aim of the study was to investigate current situation of postoperative pain management in medical institutions in Shandong Province.A questionnaire was developed on the basis of guidelines of acute pain and pain quality assessment scale. The questionnaire was used to obtain information regarding the nature and sca...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000002690

    authors: Liu D,Ma J,Zhang Z,Yu A,Chen X,Feng C,Lei W

    更新日期:2016-02-01 00:00:00

  • Effect of mGluR7 on proliferation of human embryonic neural stem cells.

    abstract::This study is to investigate the effect of metabotropic glutamate receptor 7 (mGluR7) on the proliferation of human embryonic neural stem cells (NSCs) and its molecular mechanism.Human embryonic NSCs were isolated. The pCMV2-GV146-GFP-mGluR7 plasmid was transfected to over-express mGluR7 while mGluR7 siRNA was transfe...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000014683

    authors: Zhang J,Zhao J,Chen Y,Shi H,Huang X,Wang Y,Wang Y,Wei Y,Xue W,Han J

    更新日期:2019-03-01 00:00:00

  • A case report of Brugada-like ST-segment elevation probably due to coronary vasospasm.

    abstract:RATIONALE:Vasospastic angina is caused by sudden occlusive vasoconstriction of a segment of an epicardial artery, with transient ST-segment elevation on electrocardiography. Brugada Syndrome is an inherited arrhythmogenic cardiac disorder with a diagnostic electrocardiography characterized by coved-type ST-segment elev...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000009900

    authors: Yang L,Ma G,Yu T,Gao H,Wang Y,Wu Y

    更新日期:2018-03-01 00:00:00

  • Therapeutic efficacy and safety of Kangfuxin in combination with rabeprazole in the treatment of peptic ulcer: A systematic review and meta-analysis.

    abstract:BACKGROUND:Kangfuxin (KFX), a well-known Chinese patent medicine which extracted from Periplaneta americana, is widely used as an adjuvant in the treatment of peptic ulcers (PUs) with proton pump inhibitors (PPIs) such as rabeprazole, in China. However, no clear consensus has been reached on the efficacy for PU treatme...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000023103

    authors: Lin M,Zhang S,Zhang M,Shi J,Zhang C,Luo R,You J,Sun J,Zhang J,Gao F

    更新日期:2020-11-25 00:00:00

  • A rare case report of a saddle pulmonary embolism presenting with high grade fevers, responsive to anticoagulation.

    abstract:RATIONALE:Pulmonary embolism can manifest by a myriad of clinical symptoms. High grade fever is a rare presentation of thromboembolic phenomenon. PATIENT CONCERNS:A middle aged woman presented with high grade fevers. DIAGNOSES:Patient remained febrile despite broad spectrum antibiotics. All cultures were negative. CT...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000010002

    authors: Saad M,Shaikh DH,Adrish M

    更新日期:2018-03-01 00:00:00

  • Comparison of 3 clinical models for predicting the probability of pulmonary embolism.

    abstract::Two clinical models have been described to predict the probability of pulmonary embolism: the Canadian (or Wells) model, and the Geneva model. A third model has been developed recently at our institution (the Pisa model). We compared the performance of the 3 models in 215 consecutive patients with suspected pulmonary ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/01.md.0000158793.32512.37

    authors: Miniati M,Bottai M,Monti S

    更新日期:2005-03-01 00:00:00

  • Prevalence of Resistant Gram-Negative Bacilli in Bloodstream Infection in Febrile Neutropenia Patients Undergoing Hematopoietic Stem Cell Transplantation: A Single Center Retrospective Cohort Study.

    abstract::Bloodstream infection (BSI) is an important cause of morbidity and mortality in patients undergoing hematopoietic stem cell transplantation (HSCT). To evaluate the causative bacteria and identify risk factors for BSI associated mortality in febrile neutropenia patients undergoing HSCT, we collected the clinical and mi...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000001931

    authors: Wang L,Wang Y,Fan X,Tang W,Hu J

    更新日期:2015-11-01 00:00:00

  • Surgical treatment of pyloric stenosis caused by glyphosate poisoning: A case report.

    abstract:RATIONALE:Oral ingestion of glyphosate can induce gastrointestinal symptoms such as vomiting, abdominal pain, and hematochezia. Timely and effective treatment of pyloric stenosis caused by glyphosate poisoning is important. PATIENT CONCERNS:The patient had a poor appetite, accompanied by nausea and vomiting of a small...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000016590

    authors: Luo W,Lu T,Li F,Qian C,Zhang L,Sun M,Xu Z,Jia Y

    更新日期:2019-07-01 00:00:00

  • Dorsal Penile Nerve Block With Ropivacaine-Reduced Postoperative Catheter-Related Bladder Discomfort in Male Patients After Emergence of General Anesthesia: A Prospective, Randomized, Controlled Study.

    abstract::Catheter-related bladder discomfort (CRBD) is a distressing symptom complex after surgery, especially in male patients who have had urinary catheterization under general anesthesia. In this prospective, randomized, controlled trial, we compared dorsal penile nerve block (DPNB) with 0.33% ropivacaine with intravenous t...

    journal_title:Medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MD.0000000000003409

    authors: Li JY,Yi ML,Liao R

    更新日期:2016-04-01 00:00:00

  • Diagnostic Ability of FDG-PET/CT in the Detection of Malignant Pleural Effusion.

    abstract::We investigated the role of F-18 fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) for the differential diagnosis of malignant and benign pleural effusion. We studied 36 consecutive patients with histologically proven cancer (excluding malignant mesothelioma) who underwent FDG-PET/CT...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000001010

    authors: Nakajima R,Abe K,Sakai S

    更新日期:2015-07-01 00:00:00

  • The effectiveness of complementary manual therapies for pregnancy-related back and pelvic pain: A systematic review with meta-analysis.

    abstract:BACKGROUND:Low back pain and pelvic girth pain are common in pregnancy and women commonly utilize complementary manual therapies such as massage, spinal manipulation, chiropractic, and osteopathy to manage their symptoms. OBJECTIVE:The aim of this systematically review was to critically appraise and synthesize the bes...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MD.0000000000004723

    authors: Hall H,Cramer H,Sundberg T,Ward L,Adams J,Moore C,Sibbritt D,Lauche R

    更新日期:2016-09-01 00:00:00

  • Association of chronic kidney disease with periprocedural myocardial injury after elective stent implantation: A single center prospective cohort study.

    abstract::Coronary artery disease (CAD) is the leading cause of mortality in patients with chronic kidney disease (CKD). Patients with CKD who undergo percutaneous coronary intervention (PCI) may have more ischemic events than patients without CKD. The aim of our study was to determine the incidence of periprocedural myocardial...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000005381

    authors: Jerkic H,Letilovic T,Stipinovic M,Pocanic D,Catic J,Knotek M

    更新日期:2016-11-01 00:00:00

  • The ratio of estimated average glucose to fasting plasma glucose level as an indicator of insulin resistance in young adult diabetes: An observational study.

    abstract::At present, glycated hemoglobin (HbA1c) and glycated albumin (GA) are used to evaluate glycemic control in diabetic patients, but they cannot reflect insulin deficiency and/or insulin resistance.We investigated the feasibility of using estimated average glucose to fasting plasma glucose ratio (eAG/fPG ratio) to estima...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000022337

    authors: Guo J,Lei S,Zhou Y,Pan C

    更新日期:2020-10-02 00:00:00

  • Nationwide Multicenter Reference Interval Study for 28 Common Biochemical Analytes in China.

    abstract::A nationwide multicenter study was conducted in the China to explore sources of variation of reference values and establish reference intervals for 28 common biochemical analytes, as a part of the International Federation of Clinical Chemistry and Laboratory Medicine, Committee on Reference Intervals and Decision Limi...

    journal_title:Medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MD.0000000000002915

    authors: Xia L,Chen M,Liu M,Tao Z,Li S,Wang L,Cheng X,Qin X,Han J,Li P,Hou L,Yu S,Ichihara K,Qiu L

    更新日期:2016-03-01 00:00:00

  • Surgical treatment of acute calculous cholecystitis complicated with hepatic dysfunction.

    abstract::To evaluate the timing, feasibility, and necessity of early laparoscopic cholecystectomy (LC) in the management of patients with acute calculous cholecystitis complicated with hepatic dysfunction.The clinical data of 60 patients with acute calculous cholecystitis complicated with hepatic dysfunction treated from Janua...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000020239

    authors: Tian Y,Suo X

    更新日期:2020-06-12 00:00:00

  • Focal nodular hyperplasia on an accessory liver lobe: A case report and literature review.

    abstract:INTRODUCTION:Accessory liver lobe (ALL), an autonomous island of normal liver parenchyma, is a rare congenital anomaly that is difficult for preoperative diagnosis and often identified incidentally. It can also be accompanied with benign or malignant diseases, which is extremely rare. There are only 3 cases of focal no...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0000000000021357

    authors: Su N,Chen C,Dai Q,Wang L,Yang M,Xia Y,Jiang Y,Lv K

    更新日期:2020-07-24 00:00:00

  • Mining prognostic factors of extensive-stage small-cell lung cancer patients using nomogram model.

    abstract::This study is to establish the nomogram model and provide clinical therapy decision-making for extensive-stage small-cell lung cancer (ES-SCLC) patients with different metastatic sites using the Surveillance, Epidemiology, and End Results (SEER) Program.A total of 10,025 patients of ES-SCLC with metastasis from Januar...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000021798

    authors: Gao H,Dang Y,Qi T,Huang S,Zhang X

    更新日期:2020-08-14 00:00:00

  • Can Dynamic Contrast-Enhanced MRI (DCE-MRI) and Diffusion-Weighted MRI (DW-MRI) Evaluate Inflammation Disease: A Preliminary Study of Crohn's Disease.

    abstract::The aim of the study was to investigate diagnosis efficacy of dynamic contrast-enhanced MRI (DCE-MRI) and diffusion-weighted MRI (DW-MRI) in Crohn's disease (CD). To find out the correlations between functional MRI parameters including K, Kep, Ve, Vp, and apparent diffusion coefficient (ADC) with a serologic biomarker...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000003239

    authors: Zhu J,Zhang F,Luan Y,Cao P,Liu F,He W,Wang D

    更新日期:2016-04-01 00:00:00

  • Primary cystic and solid neuroendocrine tumor of the retroperitoneum: A case report.

    abstract:RATIONALE:Primary neuroendocrine tumors (NETs) of the retroperitoneum are extremely rare. The purpose of this case report is to highlight the unusual growth pattern and radiologic features of primary retroperitoneal NETs. PATIENT CONCERNS:A 46-year-old woman was found to have a retroperitoneal cystic and solid mass du...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000024054

    authors: Shi D,Dong GQ,Shen KR,Pan Y,Wei SM,Chen Y,Yu RS

    更新日期:2021-01-15 00:00:00

  • Effects of probucol on contrast-induced acute kidney injury in patients undergoing percutaneous coronary intervention.

    abstract:OBJECTIVE:This study was performed to explore the effects of probucol on contrast-induced acute kidney injury (CIAKI) in patients with coronary heart disease undergoing percutaneous coronary intervention (PCI). METHODS:In total, 220 patients undergoing PCI were randomly assigned to either the control group (hydration ...

    journal_title:Medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MD.0000000000016049

    authors: Wang Y,Shi Y,Xu X,Ge W,Yang S,Lu C

    更新日期:2019-06-01 00:00:00

  • Pedunculated carcinoma ex pleomorphic adenoma of the nasal cavity: A unique case report.

    abstract:BACKGROUND:A carcinoma ex pleomorphic adenoma (CXPA) is an epithelial malignancy arising in or from a benign pleomorphic salivary adenoma. The parotid gland is the most common location of CXPAs. Minor salivary gland CXPAs of the nasal cavity are exceedingly rare, with only 6 documented in the literature. METHODS AND R...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000005004

    authors: Liao PW,Chen YL,Chen JW

    更新日期:2016-09-01 00:00:00