Abstract:
:Hypertrophic pachymeningitis (HP) is an inflammatory condition in which the dura mater of the cranium or spine becomes thickened, leading to symptoms that result from mass effect, nerve compression, or vascular compromise. The differential diagnosis of HP includes immune-mediated conditions such as rheumatoid arthritis and vasculitis, malignancies, and infections. Many times, no diagnosis is reached; in such cases, the disease has been described as idiopathic HP. IgG4-related disease (IgG4-RD) is a recently described inflammatory condition known to cause tumefactive lesions at myriad anatomical locations. Both IgG4-RD and idiopathic HP share similar demographics, histopathology, and natural history. We hypothesized that IgG4-RD is a common cause of idiopathic HP.To investigate this hypothesis, we identified all pathology specimens diagnosed as noninfectious HP during 25 years at our institution. Fourteen cases had stained slides and paraffin blocks to permit review of the original hematoxylin and eosin stained slides as well as immunostaining of cell blocks. Recently published consensus guidelines describing characteristic histopathology and the necessary quantity of IgG4+ plasma cell infiltrate were used to diagnose IgG4-RD.Four cases (66.6%) that had been regarded previously as representing idiopathic HP were diagnosed as IgG4-RD; of all the reviewed cases, IgG4-RD represented 29% of cases. Of the remaining cases, 3 cases were associated with granulomatosis with polyangiitis (GPA), 2 with lymphoma, and 1 each with rheumatoid arthritis, giant cell arteritis, and sarcoidosis. Two of the cases could not be diagnosed more precisely and were classified as undifferentiated HP. Clinical history, serologic tests, cerebrospinal fluid studies, and radiology alone could not identify the cause of HP. Rather, biopsy with histopathology and immunostaining was necessary to reach an accurate diagnosis. Significant IgG4+ plasma cell infiltrates were observed in rheumatoid arthritis, granulomatosis with polyangiitis, and lymphoma, underscoring the importance of histopathology in making the diagnosis of IgG4-RD.This case series demonstrates that IgG4-RD may be the most common etiology of noninfectious HP and highlights the necessity of biopsy for accurate diagnosis.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Wallace ZS,Carruthers MN,Khosroshahi A,Carruthers R,Shinagare S,Stemmer-Rachamimov A,Deshpande V,Stone JHdoi
10.1097/MD.0b013e31829cce35subject
Has Abstractpub_date
2013-07-01 00:00:00pages
206-216issue
4eissn
0025-7974issn
1536-5964pii
00005792-201307000-00002journal_volume
92pub_type
杂志文章相关文献
MEDICINE文献大全abstract:BACKGROUND:To evaluate if splenectomy results in severely impaired immune responses against primary cytomegalovirus (CMV) infection compared to the general immunocompetent population. METHODS:We performed a systemic literature review to study CMV infections in splenectomized individuals, a special population group pre...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000017698
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Previous reports found that cinnamaldehyde has effects on anti-respiratory syncytial virus (ARSV). However, their results are still contradictory. Therefore, this study will systematically address the effects of cinnamaldehyde on ARSV. METHODS:The following electronic bibliographic databases will be retriev...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000020266
更新日期:2020-05-01 00:00:00
abstract:RATIONALE:Dislocation of the distal radioulnar joint and injury to distal forearm are commonly encountered. However, delayed diagnosis or misdiagnosis has been relatively rare due to improved diagnosis and treatment. Treatment of old dislocation of radioulnar joint is challenging due to development of secondary chronic...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010752
更新日期:2018-06-01 00:00:00
abstract::It is unclear whether the use of antibiotics is related to the efficacy of gemcitabine plus nab-paclitaxel (GnP). Therefore, we investigated the association between the use of antibiotics and efficacy of GnP.We conducted a retrospective single center study from January 2014 to December 2018 in Hokkaido University Hosp...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022250
更新日期:2020-09-25 00:00:00
abstract:RATIONALE:Fixed thoracolumbar kyphosis with spinal stenosis in adult patients with achondroplasia presents a challenging issue. We describe the first case in which spondylectomy and minimally invasive lateral access interbody arthrodesis were used for the treatment of fixed severe thoracolumbar kyphosis and lumbar spin...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008983
更新日期:2017-12-01 00:00:00
abstract::We aimed to obtain overall and regional estimates of hypertension prevalence, and to examine the pattern of this disease condition across different socio-demographic characteristics in low-and middle-income countries. We searched electronic databases from inception to August 2015. We included population-based studies ...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000001959
更新日期:2015-12-01 00:00:00
abstract::The aim of this study was to evaluate the correlation between radionuclide salivagram findings and clinical characteristics in stroke patient with swallowing difficulty.In this study, dysphagic stroke patients who had undergone both a radionuclide salivagram and videofluoroscopic swallowing study (VFSS) were included ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014977
更新日期:2019-03-01 00:00:00
abstract::Abnormalities in the parathyroid hormone (PTH) gene as a cause of hypoparathyroidism were evaluated by linkage analysis with DNA polymorphisms adjacent to the PTH gene in 8 families in which members were affected with familial isolated hypoparathyroidism (FIH). We found that in none of the 23 affected individuals was ...
journal_title:Medicine
pub_type: 杂志文章
doi:
更新日期:1986-03-01 00:00:00
abstract::Budd-Chiari syndrome (BCS) may not be as uncommon as was once believed. Our study has substantiated the existence of 2 major clinical forms. The acute syndrome is invariably associated with extensive blockage of the major hepatic veins, resulting in congestive liver cell necrosis. In a small, but significant, number o...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/00005792-199401000-00003
更新日期:1994-01-01 00:00:00
abstract::To investigate the effectiveness of dual filtration plasmapheresis (DFPP), a novel blood purification treatment, as a rapid and sustained disease-modifying therapy for active refractory rheumatoid arthritis (RA).A retrospective cohort study had been conducted. One hundred fifty three patients aged 18 years or older wi...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020966
更新日期:2020-07-10 00:00:00
abstract::To summarize the clinical features of eyeball rupture with or without orbital fracture and explore the differences between them.In all, 197 patients were observed, and the following data were recorded: sex, age, time of injury, place of injury, cause of trauma, zone of eye injury, intraocular content prolapse, surgica...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007109
更新日期:2017-06-01 00:00:00
abstract::Adenoid cystic carcinoma (ACC) is one of the most frequent malignancies of salivary glands. The objective of this study was to identify key genes and potential mechanisms during ACC samples.The gene expression profiles of GSE88804 data set were downloaded from Gene Expression Omnibus. The GSE88804 data set contained 2...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000018676
更新日期:2020-01-01 00:00:00
abstract::Subcutaneous tissue is a rare site of metastasis, accounting for only 1-2% of all lung neoplasms. Positron emission tomography (PET) using ¹⁸F-fluorodeoxyglucose (FDG) has been reported to increase the diagnostic accuracy of subcutaneous metastasis. A 58-year-old woman presented with complaints of dry coughing, in whi...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000851
更新日期:2015-05-01 00:00:00
abstract::Endotracheal tube (ETT) should be placed at the optimal level to avoid single lung ventilation or accidental extubation. This study was performed to estimate the mid-tracheal level by using surface anatomical landmarks in adult patients.Neck computed tomography images of 329 adult patients between the ages of 16 and 7...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006319
更新日期:2017-03-01 00:00:00
abstract::Calcium channel blockers (CCBs) are widely used for reducing blood pressure of hypertensive patients. Recent reports document the beneficial effects of CCB for preventing dementia; however, the results are controversial. We aim to evaluate the risk of developing dementia among elderly hypertensive patients treated wit...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004593
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Recent studies have demonstrated that coronary microcirculation dysfunction (CMVD) is closely correlated with adverse clinical outcomes. In this study, quantitative stress myocardial contrast echocardiography (MCE) was used to evaluate the CMVD and to investigate its association with the prognosis of patient...
journal_title:Medicine
pub_type: 临床试验,杂志文章
doi:10.1097/MD.0000000000015990
更新日期:2019-07-01 00:00:00
abstract::Color patterns of 3-dimensional (3D) shear wave elastography (SWE) is a promising method in differentiating tumoral nodules recently. This study was to evaluate the diagnostic accuracy of color patterns of 3D SWE in breast lesions, with special emphasis on coronal planes.A total of 198 consecutive women with 198 breas...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004877
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Traumatic brain injury (TBI) refers to head injuries that disrupt normal function of the brain. TBI commonly lead to a wide range of potential psychosocial functional deficits. Although psychosocial function after TBI is influenced by many factors, more and more evidence shows that social cognitive skills ar...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021154
更新日期:2020-07-17 00:00:00
abstract:RATIONALE:Phosphaturic mesenchymal tumor (PMT) is a new tumor entity of soft tissue and bone tumor recently accepted by the World Health Organization, which typically causes the paraneoplastic syndrome of tumor-induced osteomalacia (TIO). The majority of PMTs follow a benign clinical course and local recurrence occurs ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006750
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:To evaluate the effect of no drainage in patients who underwent thyroidectomy and neck lymph node dissection. METHODS:We followed the methodological standard expected by Cochrane. We searched the following databases by March 23, 2017: PubMed, The Cochrane Library, EMBASE via Ovid SP, and Medline via Ovid SP...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000009052
更新日期:2017-12-01 00:00:00
abstract::Risk factors for chronic kidney disease (CKD), such as hypertension, hyperglycemia, albuminuria, renal structure, and sex hormones, have been reported to have different effects on males and females. Thus, CKD progression may differ depending on sex. In addition to CKD management, treatment at earlier stages can reduce...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004203
更新日期:2016-07-01 00:00:00
abstract::Ultrasonography is a standard, noninvasive modality used to evaluate patients with gastrointestinal diseases. This study assessed the usefulness of ultrasonography in the detection of small bowel tumors. This study enrolled 558 consecutive patients (295 males, 263 females; mean age 71.1 years) who underwent ultrasonog...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001464
更新日期:2015-10-01 00:00:00
abstract::The enterococci, members of the group D streptococci and the predominant aerobic streptococci of the gastrointestinal and female genital tracts, have long been recognized as significant pathogens in infective endocarditis. Over the past 2 decades, enterococci have become increasingly important nosocomial pathogens, re...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:
更新日期:1988-07-01 00:00:00
abstract:BACKGROUND:The prognostic significance of phosphatase and tensin homolog (PTEN) in patients with breast cancer (BC) remains controversial. The aims of our meta-analysis are to evaluate its association with clinicopathological characteristics and prognostic value in patients with breast cancer. METHODS:PubMed, EMBASE, ...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000008000
更新日期:2017-09-01 00:00:00
abstract:RATIONALE:Bronchial foreign body aspiration is a critical condition that jeopardizes the respiratory function of children. Prompt diagnosis and removal of the foreign body can reduce occurrence of foreign body complications and mortality. Aspiration of spherical plastic beads is rare, and the bead is difficult to retri...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000012147
更新日期:2018-09-01 00:00:00
abstract:RATIONALE:Vascular complications of transradial percutaneous coronary intervention (PCI) are rare and usually occur at the access site below the elbow. However, vessels along the tract of the wire or catheter can be injured at any point, causing various types of bleeding complications. PATIENT CONCERNS:A 57-year-old m...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021205
更新日期:2020-07-10 00:00:00
abstract::Antiretroviral therapy (ART) and drug resistance studies worldwide have focused almost exclusively on human immunodeficiency virus type 1 (HIV-1). As a result, there is limited information on ART and drug resistance in HIV-2 patients. In Ghana, the HIV epidemic is characterized by the domination of HIV-1, with cocircu...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014313
更新日期:2019-02-01 00:00:00
abstract::Human bladder cancer (BCa) is one of the most commonly diagnosed malignancies worldwide. It has high recurrence rates and low-grade malignancy, thus representing an important public health concern. An increasing number of studies suggest that long-noncoding RNAs (lncRNAs) play important roles in various biological pro...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011887
更新日期:2018-08-01 00:00:00
abstract::To investigate the clinical efficiency of periocular triamcinolone acetonide (TA) injection for treating polypoidal choroidal vasculopathy (PCV) concurrent with hemorrhagic retinal detachment (HRD).Twenty-two cases confirmed with PCV concurrent with HRD characterized by massive subretinal hemorrhage and exudation pres...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000012464
更新日期:2018-09-01 00:00:00
abstract:RATIONALE:To report the management of recalcitrant neurotrophic keratopathy in a pediatric patient affected by pontine tegmental cap dysplasia (PTCD) using topical human recombinant nerve growth factor (hrNGF, Cenegermin 20 μg/ml). To the best of our knowledge the present case is one of the few described in patients wi...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020816
更新日期:2020-07-24 00:00:00