Abstract:
:Human bladder cancer (BCa) is one of the most commonly diagnosed malignancies worldwide. It has high recurrence rates and low-grade malignancy, thus representing an important public health concern. An increasing number of studies suggest that long-noncoding RNAs (lncRNAs) play important roles in various biological processes and disease pathologies, including cancer.We analyzed the expression profiles of lncRNA, miRNA, and mRNA, along with the clinical information of BCa patients collected from the Cancer Genome Atlas database to identify lncRNA biomarkers for prognosis. We also constructed an lncRNA-miRNA-mRNA global triple network (competitive endogenous RNA network) by bioinformational approach.This BCa lncRNA-miRNA-mRNA network consisted of 23 miRNA nodes, 52 mRNA nodes, 59 lncRNA nodes, and 365 edges. Subsequent gene ontology (GO) and pathway analyses were performed using BinGO for Cytoscape and Database for Annotation, Visualization, and Integration Discovery, respectively, highlighting important GO terms and pathways that were enriched in the network. Subnetworks were created using 3 key lncRNAs (MAGI2-AS3, ADAMTS9-AS2, and LINC00330), revealing associations with BCa-linked mRNAs and miRNAs. Finally, an analysis of significantly differentiating RNAs found 6 DElncRNAs (AC112721.1, ADAMTS9-AS1, ADAMTS9-AS2, HCG22, MYO16-AS1, and SACS-AS1), 1 DEmiRNA (miRNA-195), and 6 DEmRNAs (CCNB1, FAM129A, MAP1B, TMEM100, AIFM3, and HOXB5) that correlated with BCa patient survival.Our results provide a novel perspective from which to study the lncRNA-related ceRNA network in BCa, contributing to the development of future diagnostic biomarkers and therapeutic targets.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Zhu N,Hou J,Wu Y,Liu J,Li G,Zhao W,Ma G,Chen B,Song Ydoi
10.1097/MD.0000000000011887subject
Has Abstractpub_date
2018-08-01 00:00:00pages
e11887issue
35eissn
0025-7974issn
1536-5964pii
00005792-201808310-00012journal_volume
97pub_type
杂志文章相关文献
MEDICINE文献大全abstract::Hepatic encephalopathy (HE) is a complication associated with worst prognosis in decompensated liver cirrhosis (LC) patients. Previous studies have identified prognostic factors for HE, and recent studies reported an association between systemic inflammatory response syndrome (SIRS) and liver disease. This study aimed...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003935
更新日期:2016-06-01 00:00:00
abstract::Unplanned reoperations have not been studied extensively in pediatric patients, especially concerning risk factors. We aim to estimate the rate of unplanned reoperations and to determine the associated factors in pediatric general surgical specialties.This analysis included a retrospective case-control study of unplan...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000019982
更新日期:2020-05-01 00:00:00
abstract::High-density lipoprotein (HDL) is highly heterogeneous in its size and composition. Till now, the link of HDL subfractions to coronary risk is less clear. We aimed to investigate the associations of HDL subfractions with traditional risk factors (RFs), coronary severity, and outcomes in a cohort of nontreated patients...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002600
更新日期:2016-01-01 00:00:00
abstract::We aimed to investigate the relationship between total homocysteine (tHcy) levels in the plasma and renal function severity in patients with type 2 diabetes mellitus (T2DM) aged ≥75 years.We included 221 patients with T2DM aged ≥60 years (59 aged ≥75 years).tHcy levels among the 4 groups of patients aged ≥60 years sig...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020737
更新日期:2020-07-02 00:00:00
abstract:BACKGROUND:Hysterectomy for benign gynecologic diseases, especially dysfunctional uterine bleeding, is one of the most common gynecologic interventions. The uterus can be removed using abdominal, vaginal, laparoscopic, or robotic-assisted laparoscopic hysterectomy. In a robotic-assisted procedure, the surgeon directs t...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015974
更新日期:2019-06-01 00:00:00
abstract::This study aims to investigate major complications or symptoms of pregnant women, causes of maternal near-miss, and issues that are relevant to severe maternal disease.A retrospective analysis was performed in the "maternal individual investigation form," which included all critical maternity patients admitted to the ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011748
更新日期:2018-08-01 00:00:00
abstract::Pain is prevalent in advanced malignancies; however, some patients cannot get adequate pain relief by conservative routes of analgesic administration or experience serious side effects related to high dose of opioids. For those who have exhausted multimodal conservative analgesic, intrathecal drug delivery is an alter...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006354
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:The number of patients with type 2 diabetes mellitus (T2DM) is surging currently. Synbiotic as a supplement based on gut microbiota may be beneficial to improve the metabolism of T2DM. However, the results of clinical studies show that the role of synbiotic in weight management in patients with T2DM is contr...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000018197
更新日期:2019-12-01 00:00:00
abstract::Patients with systemic lupus erythematosus have a poor prognosis of pregnancy, since it is associated with significant maternal and fetal morbidity, including spontaneous miscarriage, pre-eclampsia, intrauterine growth restriction, fetal death and pre-term delivery. We report a case with successful pregnancy in a pati...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001531
更新日期:2015-09-01 00:00:00
abstract:RATIONALE:Hereditary diffuse leukoencephalopathy with neuroaxonal spheroids (HDLS) is a rare disease with white matter lesions of the central nervous system, and it usually has autosomal dominant inheritance. Its pathogenesis and causes are complex, and it has obvious clinical and genetic heterogeneities; also, it is c...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000015802
更新日期:2019-05-01 00:00:00
abstract:RATIONALE:Paraganglioma refers to a set of neuroendocrine tumors derived from the chromaffin cells of the adrenal diplomatic ganglion. Paragangliomas can be classified as functional or nonfunctional based on the ability to synthesize and release catecholamines. PATIENT CONCERNS:We report a 47-year-old man with a funct...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016383
更新日期:2019-07-01 00:00:00
abstract:RATIONALE:Adolescent wrist trauma can cause epiphyseal dysplasia and even distal radius deformity malunion. At present, there is no uniform treatment standard for the malunion of the distal radius of adolescents. Osteotomy and autologous bone grafting are currently one of the effective ways to treat the disease. We tre...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022535
更新日期:2020-10-02 00:00:00
abstract:OBJECTS:The present study aimed to identify the clinicopathological characteristics of colorectal cancer (CRC) with invasive micropapillary components (IMPCs) and the relationship between different amounts of micropapillary components and lymph node metastasis. METHODS:A cohort of 363 patients with CRC who underwent s...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020238
更新日期:2020-05-22 00:00:00
abstract:BACKGROUND:To verify the accuracy of serum dickkopf-1 protein (DKK-1) in the diagnosis of hepatocellular carcinoma (HCC) by an updated meta-analysis. METHODS:We searched potential eligible studies in PubMed and Embase before July 8, 2018. Sensitivity (SN), specificity (SP), positive likelihood ratio (PLR), negative li...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000016725
更新日期:2019-08-01 00:00:00
abstract::To evaluate the accuracy of contrast-enhanced whole-heart magnetic resonance coronary angiography at 3.0T for assessing significant stenosis (≥50% lumen diameter reduction) in patients with myocardial infarction, by using conventional coronary artery angiography as the reference standard, and also test the performance...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000013138
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Periodontitis is a common disease with an unclear pathological mechanism. No precise consensus has been reached to evaluate the association between the IL-10 rs1800872 (- 592, -590, -597 C>A) polymorphism and periodontal disease. Thus, we performed this meta-analysis to collect more evidence-based informatio...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000017113
更新日期:2019-10-01 00:00:00
abstract:RATIONALE:Hereditary multiple exostoses (HMEs) is an autosomal dominant skeletal disorder. PATIENT CONCERNS:Six probands of the 6 unrelated Han Chinese families were identified as having HME. These patients had exostoses at multiple sites and significantly affected joints malformation and movement. DIAGNOSES:Heredita...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015692
更新日期:2019-05-01 00:00:00
abstract::To date, because of their rarity, the clinicopathological features and surgical outcomes of small bowel adenocarcinomas (SBAs) have been insufficiently explored. We evaluated the clinicopathological features and long-term outcomes of patients who underwent surgery for SBA.This retrospective study (from 1999 to 2016) e...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007713
更新日期:2017-08-01 00:00:00
abstract::To evaluate the influence of various distributions of bone cement on the clinical efficacy of percutaneous kyphoplasty (PKP) in treating osteoporotic vertebrae compression fractures.A total of 201 OVCF patients (30 males and 171 females) who received PKP treatment in our hospital were enrolled in this study. According...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000018217
更新日期:2019-12-01 00:00:00
abstract::This article evaluates the suitability of cadavers embalmed by the saturated salt solution (SSS) method for surgical skills training (SST). SST courses using cadavers have been performed to advance a surgeon's techniques without any risk to patients. One important factor for improving SST is the suitability of specime...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000196
更新日期:2014-12-01 00:00:00
abstract:RATIONALE:Negative pressure pulmonary edema (NPPE) is a serious well-described pulmonary complication. It occurs after an intense inspiratory effort against an obstructed or closed upper airway and generates a large negative airway pressure, leading to severe pulmonary edema (transvascular fluid filtration and intersti...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000013743
更新日期:2018-12-01 00:00:00
abstract::Population aging has rapidly advanced throughout the world and the elderly accounting for out-of-hospital cardiac arrest (OHCA) has increased yearly.We identified all adults who experienced an out-of-hospital cardiac arrest in the All-Japan Utstein Registry of the Fire and Disaster Management Agency, a prospective, po...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002049
更新日期:2015-12-01 00:00:00
abstract::The worldwide incidence of Klebsiella pneumoniae liver abscess (KLA) is increasing. It is important to accurately diagnose this life-threatening disease to provide timely and appropriate treatment. Here we report the case of a 38-year-old man with acute renal failure and a tumor-like liver abscess and septic pulmonary...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003145
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Although several studies have investigated the role of psychological factors in atrial fibrillation (AF), the results are still under debate. Therefore, we performed a meta-analysis to examine the relationship between psychological factors and the risk of incident AF. METHODS:We systematically searched the ...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000019615
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Ulcerative colitis (UC) and Crohn disease (CD) are the 2 main types of inflammatory bowel diseases (IBDs). Several studies have been conducted to investigate the association of Glutathione S-Transferase M1 (GSTM1) null genotype with UC and CD, but the results are inconsistent. Here, we performed a meta-analy...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000017722
更新日期:2019-11-01 00:00:00
abstract::Many studies suggest that catalase C-262T gene polymorphism is associated with cancer risk, but with inconsistent results. This study aimed to summarize the overall association between catalase C-262T polymorphism and cancer risk. Literature search was performed in PubMed, Embase, and other databases, studies regardin...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000000679
更新日期:2015-04-01 00:00:00
abstract::Pancreatic cancer is known for its typically late presentation and poor survival rates, with overall 5-year survival of less than 5%. The role of chemotherapy alone or with radiotherapy in the management of locally advanced tumors continues to be an area of debate.We report a case of locally advanced, pancreatic adeno...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000499
更新日期:2015-02-01 00:00:00
abstract::About 77.9 million (1 in 4) American adults have high blood pressure. High blood pressure is the primary cause of left ventricular hypertrophy (LVH), which represents a strong predictor of future heart failure and cardiovascular mortality. Previous studies have shown an altered metabolic profile in hypertensive patien...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004965
更新日期:2016-11-01 00:00:00
abstract::Under the assumption of gene-environment independence, unknown/unmeasured environmental factors, irrespective of what they may be, cannot confound the genetic effects. This may lead many people to believe that genetic heterogeneity across different levels of the studied environmental exposure should only mean gene-env...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002743
更新日期:2016-03-01 00:00:00
abstract::This study aimed to explore the efficacy and toxicity of image-guided stereotactic body radiotherapy (IGSBR) by helical tomotherapy in patients with lung cancer among Chinese Han population.A total of 21 patients with stage I lung cancer were included. They received a total of 60 Gy factions IGSBR. The outcomes includ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000009243
更新日期:2018-01-01 00:00:00