Abstract:
RATIONALE:Phosphaturic mesenchymal tumor (PMT) is a new tumor entity of soft tissue and bone tumor recently accepted by the World Health Organization, which typically causes the paraneoplastic syndrome of tumor-induced osteomalacia (TIO). The majority of PMTs follow a benign clinical course and local recurrence occurs in < 10% of cases, malignant PMTs with distant organ metastasis are extremely uncommon. PATIENT CONCERNS:We reported a 41-year-old woman who was diagnosed with PMT 10 years ago with a repeated recurrence and pulmonary metastasis. DIAGNOSES:Based on clinical manifestations, MRI scan, serum biochemical indicators evaluation, followed by histopathological examination, the patient was diagnosed as malignant PMT with pulmonary metastasis. INTERVENTIONS:The patient was treated with calcium, phosphorus, and vitamin D after surgical resection and measured the serum ion concentrations every 3 months. OUTCOMES:The patient had a favorable outcome for 10 months without recurrence. LESSONS:PMTs lack of characteristic histological morphology, some recurrence cases may appear benign morphologically; the malignant PMTs are easily overlooked. Patients with PMT should be carefully evaluated and monitored, in order to early identify its malignant potential.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Qiu S,Cao LL,Qiu Y,Yan P,Li ZX,Du J,Sun LM,Zhang QFdoi
10.1097/MD.0000000000006750subject
Has Abstractpub_date
2017-04-01 00:00:00pages
e6750issue
17eissn
0025-7974issn
1536-5964pii
00005792-201704280-00049journal_volume
96pub_type
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