Abstract:
OBJECTIVE:We conducted this study to compare the efficacy and safety of entecavir and tenofovir in the treatment of treatment-naïve HBV e antigen (HBeAg)-positive patients with chronic hepatitis B (CHB) for 144 weeks. METHODS:A total of 320 treatment-naïve HBeAg-positive CHB patients who received randomly a single regimen of either entecavir capsule (ETV) (n = 160) or tenofovir disoproxil fumarate capsule (TDF) (n = 160) for 144 weeks were consecutively enrolled from 14 tertiary hospitals or university hospitals in China between January 2012 and December 2014. RESULTS:Two groups showed no difference in baseline characteristics. After 144 weeks of treatment, HBV DNA levels were similarly suppressed in both groups (ETV vs TDF; -6.6485 vs -6.692 log10IU/mL, P = .807). At the same time, both groups showed no difference in terms of the serologic and biochemical response. Of all patients, 2 dropped out due to adverse events and 5 experienced serious adverse reactions. CONCLUSION:Both capsules (ETV or TDF) were equally effective in nucleos(t)ide-naive CHB patients with a comparable side-effect profile even in a long-term of 144 weeks.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Cai D,Pan C,Yu W,Dang S,Li J,Wu S,Jiang N,Wang M,Zhang Z,Lin F,Xin S,Yang Y,Shen B,Ren Hdoi
10.1097/MD.0000000000013983subject
Has Abstractpub_date
2019-01-01 00:00:00pages
e13983issue
1eissn
0025-7974issn
1536-5964pii
00005792-201901040-00060journal_volume
98pub_type
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