Abstract:
:To study the correlation between single nucleotide polymorphism (SNP) of the 3' untranslated region (UTR) rs9722 locus in S100B and the risk of chronic heart failure (CHF), plasma levels of S100B protein as well as has-miR-340-3p in a Chinese Han population.A total of 215 patients with CHF (124 ischemic cardiomyopathy (ICM) and 91 dilated cardiomyopathy (DCM)) and 215 healthy controls were recruited to analyze the S100B rs9722 genotype by Sanger sequencing. The levels of hsa-miR-340-3p in the plasma were detected by RT-PCR, and S100B levels were detected by ELISA.The risk of CHF in S100B rs9722 locus T allele carriers was 4.24 times higher than that in those with the C allele (95% CI: 2.84-6.33, P < .001). The association of S100B rs9722 locus SNP with ICM and DCM risk was not affected by factors such as age, gender, and body mass index (BMI). The levels of plasma S100B and hsa-miR-340-3p in patients with ICM and DCM were significantly higher than those in the control group (P < .001). There was no significant difference in plasma S100B levels between patients with ICM and DCM (P > .05). Among ICM, DCM, and control subjects, TT genotype carriers had the highest levels of plasma S100B and hsa-miR-340-3p, followed by the CT genotype and TT genotype, and the difference was statistically significant (P < .05). Plasma hsa-miR-340-3p levels were positively correlated with S100B levels in the control subjects and patients with ICM and DCM.The S100B rs9722 locus SNP is associated with CHF risk in a Chinese Han population.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Chen Y,Chen X,Yao M,Chen L,Chen W,Liu Xdoi
10.1097/MD.0000000000021018subject
Has Abstractpub_date
2020-06-26 00:00:00pages
e21018issue
26eissn
0025-7974issn
1536-5964pii
00005792-202006260-00095journal_volume
99pub_type
杂志文章相关文献
MEDICINE文献大全abstract::Our goal was to evaluate the risk factors for regional recurrence in upper lip squamous cell carcinoma (SCC).A total of 109 patients with upper lip SCC were retrospectively enrolled. Clinical and pathologic information was collected and analyzed.Fifteen (13.8%) patients had a regional metastasis, 2 patients had paroti...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008270
更新日期:2017-11-01 00:00:00
abstract:RATIONALE:Heterotaxy with polysplenia is an extremely rare congenital condition resulting from abnormal arrangement of organs in the abdominal and thoracic cavities during embryologic development. When a malignancy such as pancreatic cancer develops under these conditions, surgical resection becomes particularly comple...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008599
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:One of the most common complications following autologous cranioplasty is bone flap resorption (BFR). Severe BFR can lead to revision surgery with implantation of synthetic bone flap and also necessarily lead to higher hospital expenses. This study aims to perform a meta-analysis to summarize available evide...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021035
更新日期:2020-07-10 00:00:00
abstract::Retrospective single institution observational study.The aim of the present study was to analyze the influence of early extensive posterior decompression on complications in patients with severe traumatic cervical spinal cord injury (tcSCI).Cervical SCI is associated with a high prevalence of hyponatremia and cardiopu...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021188
更新日期:2020-07-17 00:00:00
abstract::Acute cellular rejection after liver transplantation (LT) can be treated with steroid pulse therapy, but there is no ideal treatment for steroid-resistant acute rejection (SRAR). We aimed to determine the feasibility and potential complications of rabbit anti-thymocyte globulin (rATG) application to treat SRAR in live...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003711
更新日期:2016-06-01 00:00:00
abstract:INTRODUCTION:Crohn disease (CD) is a chronic relapsing systemic inflammatory disease afflicting the gastrointestinal system with a high morbidity. There has been increasing clinical interest in traditional Chinese medicine (TCM) treatment for CD. This report aims to present patient outcome of therapeutic management usi...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015148
更新日期:2019-04-01 00:00:00
abstract::In a retrospective review of 53 patients, 58 episodes of infection due to Acinetobacter calcoaceticus var. anitratus (Herellea vaginicola) were studied. Although the organism is widely distributed in nature, it is of relatively low virulence since colonization is more frequently noted than infection and since most inf...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/00005792-197703000-00001
更新日期:1977-03-01 00:00:00
abstract::The clinical symptoms of pylephlebitis caused by acute appendicitis are varied and atypical, which leads to delayed diagnosis and poor outcomes. Here, we report a case of intestinal necrosis caused by thrombophlebitis of the portomesenteric veins as a complication of acute appendicitis after appendectomy. The patient ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001033
更新日期:2015-06-01 00:00:00
abstract::The aim of this observational study was to test whether ABO blood type was a prognostic factor for pancreatic ductal adenocarcinoma (PDAC) patients and whether other risk factors could influence pancreatic cancer patients' survival. This study included 610 patients who were diagnosed as pancreatic cancer and had under...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000019413
更新日期:2020-04-01 00:00:00
abstract:RATIONALE:Congenital myasthenic syndrome (CMSs) are a group of rare genetic disorders of the neurological junction, which can result in structural or functional weakness. Here, we characterized a case of CMS in order to clarify the diagnosis and expand the understanding of it. The molecular diagnosis had implications f...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010347
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:We conducted a Pooled analysis to investigate the efficacy and safety of ureteral stent removal using an extraction string. METHODS:A systematic review was performed by using the Preferred Reporting Items for Systematic Reviews and Pooled analyses. The sources including EMBASE, MEDLINE, and the Cochrane Cont...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000017169
更新日期:2019-09-01 00:00:00
abstract:RATIONALE:Report a case of bilateral multiple retinal hamartomas (RAHs) in a patient with tuberous sclerosis complex (TSC) and introduced a new method (subthreshold micropulse laser photocoagulation) for the treatment of RAHs. PATIENT CONCERNS:A 20-year-old man with TSC complained of decreased vision and metamorphosia...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000013265
更新日期:2018-12-01 00:00:00
abstract::Medication use during pregnancy is gradually increasing; however, the safety of this practice remains largely unknown.We investigated medications with the most adverse drug reactions (ADRs) among pregnant women and the clinical features of those medications.Reports of ADRs among pregnant women were extracted from the ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015756
更新日期:2019-05-01 00:00:00
abstract::[This corrects the article DOI: 10.1097/MD.0000000000004694.]. ...
journal_title:Medicine
pub_type: 已发布勘误
doi:10.1097/01.md.0000503455.40174.9b
更新日期:2016-10-07 00:00:00
abstract:INTRODUCTION:Pial arteriovenous fistula (PAVF) is a rare intracranial vascular disease, and its presentation with a huge tumor-resembling thrombus is rarer. PATIENT CONCERNS:A 38-year-old female patient presented with a sudden left-side motor disorder and loss of consciousness. The patient was otherwise in good health...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022819
更新日期:2020-10-16 00:00:00
abstract:RATIONALE:Ovarian leiomyoma is a rare ovarian tumor that occurs in 20-65 year-old women, and is mostly misdiagnosed as malignant tumor. In most reports on this type of tumor, ovarian myoma has a benign histology. Herein,we describe a case of ovarian atypical leiomyoma. PATIENT CONCERNS:The patient is a 58-year-old wom...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000012526
更新日期:2018-10-01 00:00:00
abstract::Under the assumption of gene-environment independence, unknown/unmeasured environmental factors, irrespective of what they may be, cannot confound the genetic effects. This may lead many people to believe that genetic heterogeneity across different levels of the studied environmental exposure should only mean gene-env...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002743
更新日期:2016-03-01 00:00:00
abstract::IgG4-related disease (IgG4-RD) is a novel systemic disease entity characterized by elevated serum IgG4 and tissue infiltration of IgG4-positive plasma cells accompanied by severe fibrosis. Although recent studies demonstrated that innate immune cells including monocytes and macrophages might promote local fibrosis and...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002853
更新日期:2016-02-01 00:00:00
abstract::The objective of this study was to evaluate the association between falls and obesity using Asian body mass index (BMI) classifications. Using the data from the Korean community health survey in 2011, a total of 229,226 participants ranging from 19 to 106 years old were included in this study. The BMI groups were clas...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003130
更新日期:2016-03-01 00:00:00
abstract::This is an observational study to determine the most relevant parameter of ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for predicting recurrence in cervical cancer. Fifty-six patients with International Federation of Gynecology and Obstetrics (FIGO) stage IIB-IVA cervical can...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002992
更新日期:2016-03-01 00:00:00
abstract:RATIONALE:Splenosis is the heterotopic auto-transplantation of the splenic tissues. Gastric splenosis in a rare location mimics a gastrointestinal stromal tumor (GIST). Gastric splenosis with hemangioma has not been reported throughout the literature. PATIENT CONCERNS:We report a case of a 74-year-old schistosomiasis ...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000011461
更新日期:2018-07-01 00:00:00
abstract::The aim of our study was to compare the clinical and surgical characteristics of pregnant and nonpregnant women with surgically verified ovarian torsion, as well as the differences among 3 trimesters during pregnancy.We conducted a retrospective study of patients diagnosed with surgically proven ovarian torsion in our...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020627
更新日期:2020-06-12 00:00:00
abstract:BACKGROUND:This study aimed to investigate the safety and efficacy of the cystotome-assisted prechop phacoemulsification surgery (CAPPS) and conventional phacoemulsification surgery (CPS) in patients with IV degree nucleus cataract. METHODS:The prospective, randomized, consecutive, comparative cohort study consecutive...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000013124
更新日期:2018-11-01 00:00:00
abstract::To demonstrate the mechanisms of the curative effect of Saussurea lappa ethanol extract (SLE) against prostate cancer, we evaluated the effect of SLE on the induction of apoptosis and autophagy and investigated whether SLE-induced autophagy exerts a pro-survival or pro-apoptotic effect in lymph node carcinoma of the p...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007606
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Hypertension is one of the most common chronic diseases and an increasingly public-health challenge worldwide. Previous meta-analyses evaluated the effects of azilsartan medoxomil compared to placebo or other antihypertensive drugs in patients with hypertension. However, it is still unclear which dose of azi...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017050
更新日期:2019-09-01 00:00:00
abstract::The aim of the study was to compare differences between lymphoma and inflammation as indicated by high diffuse uptake of F-fluorodeoxyglucose (F-FDG) in the spleen, liver, and bone marrow without increased F-FDG uptake in the lymph nodes and without enlarged peripheral lymph nodes.Eighteen lymphoma patients and 14 inf...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003750
更新日期:2016-05-01 00:00:00
abstract::We aimed to evaluate the prognostic value of clinical and pathologic factors in rectal squamous cell carcinomas (SCC) and to construct a nomogram for their outcome prediction.The study cohort was selected from Surveillance, Epidemiology, and End Results (SEER) program between January 2004 and December 2013. Univariate...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017916
更新日期:2019-11-01 00:00:00
abstract:RATIONALE:Narcolepsy is a rare sleep disorder with disrupted sleep-architecture. Clinical management of narcolepsy lies dominantly on symptom-driven pharmacotherapy. The treatment role of repetitive transcranial magnetic stimulation (rTMS) for narcolepsy remains unexplored. PATIENT CONCERNS:In this paper, we present a...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008645
更新日期:2017-11-01 00:00:00
abstract::The aim of this study was to identify the risk factors associated with lymph nodes posterior to the right recurrent laryngeal nerve (LN-prRLN) metastasis in patients with papillary thyroid carcinoma (PTC).A total of 81 PTC patients who underwent total/near-total thyroidectomy with LN-prRLN dissection in the Department...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007908
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:A pathological complete response (pCR) after neoadjuvant chemotherapy (NCT) is a strong indicator of the benefit of therapy and presents an early surrogate for a favorable long-term outcome. It remains unclear whether Ki-67, a marker for tumor proliferation, can function as a predictor of the response to NCT...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000009384
更新日期:2017-12-01 00:00:00