Meta-analysis of serum lactate dehydrogenase and prognosis for osteosarcoma.

Abstract:

BACKGROUNDS:A large number of studies have reported the relationships between serum lactate dehydrogenase (LDH) and prognosis of osteosarcoma. However, the result is still controversial and no consensus has been reached. Therefore, we performed a meta-analysis to evaluate the prognostic role of serum LDH in osteosarcoma patients. METHODS:We performed the systematic computerized search for eligible articles from PubMed, Embase, and Cochrane databases until December 21, 2017. The pooled hazard ratio (HR) and 95% confidence intervals (CIs) of overall survival (OS) and event-free survival (EFS) were obtained to assess the prognostic value of serum LDH. RESULTS:A total of 18 studies with 2543 osteosarcoma patients were included. Overall, 15 studies assessed the elevated serum LDH level on OS and the pooled HR was 1.87 (95% CI = 1.58-2.20). Meanwhile, the pooled HR to evaluate the relationship between serum LDH and EFS in 9 studies was 1.78 (95% CI = 1.51-2.10). The same results were acquired when these studies were stratified by Enneking stage, geographic region, and sample size. No heterogeneity existed between these subgroups (P > .05). Begg's funnel plot and Egger's test (OS: P = .04; EFS: P = .34) showed that possible publication bias might exist in OS studies. Sensitivity analysis suggested the pooled HR was robust. CONCLUSIONS:This meta-analysis demonstrates that elevated serum LDH level is apparently associated with lower EFS rate and serum LDH could be a prognostic biomarker for osteosarcoma patients.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Fu Y,Lan T,Cai H,Lu A,Yu W

doi

10.1097/MD.0000000000010741

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

e0741

issue

19

eissn

0025-7974

issn

1536-5964

pii

00005792-201805110-00059

journal_volume

97

pub_type

杂志文章,meta分析,评审

相关文献

MEDICINE文献大全
  • Optical coherence tomographic analysis of drug-eluting in-stent restenosis at different times: A STROBE compliant study.

    abstract::The imaging characteristics of drug-eluting in-stent restenosis (ISR) at different times varied; however, the mechanism had not yet been elucidated.To analyze the imaging characteristics of drug-eluting ISR at different time points by optical coherence tomography (OCT) and investigate the cause of the stent treatment ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000012117

    authors: Feng C,Zhang P,Han B,Li X,Liu Y,Niu D,Shi Y

    更新日期:2018-08-01 00:00:00

  • Silent pulmonary thromboembolism in neurosurgery patients: Report of 2 cases and literature review.

    abstract:BACKGROUND:The requirement of postoperative bedridden and immobilization renders neurosurgical patients with higher risk of deep vein thrombosis (DVT), then more vulnerable for pulmonary thromboembolism (PTE). But silent pulmonary thromboembolism (SPTE) can be the very early stage of any typical form of PTE, its diagno...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0000000000004589

    authors: Tian R,Gao J,Chen A,Bao X,Guan J,Feng M,Li Y,Ma W,Ren Z,Wang R,Wei J

    更新日期:2016-08-01 00:00:00

  • Confirmation of the pathogenicity of a mutation p.G337C in the COL1A2 gene associated with osteogenesis imperfecta.

    abstract::Mutation analysis as the gold standard is particularly important in diagnosis of osteogenesis imperfecta (OI) and it may be preventable upon early diagnosis. In this study, we aimed to analyze the clinical and genetic materials of an OI pedigree as well as to confirm the deleterious property of the mutation.A pedigree...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000007783

    authors: Jia M,Shi R,Zhao X,Fu Z,Bai Z,Sun T,Zhao X,Wang W,Xu C,Yan F

    更新日期:2017-09-01 00:00:00

  • Deep cerebral microbleeds are associated with the severity of lacunar infarcts and hypertension: A retrospective analysis.

    abstract::Cerebral microbleeds (CMBs) and lacunar infarcts are common manifestations of cerebral small vessel disease. However, the association between the location of CMBs and lacunar infarcts is unclear. Our study aimed to clarify the relationship between the location of CMBs and lacunar infarcts.This study retrospectively an...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000011031

    authors: Gao Z,Zhai Y,Zhao X,Wang W,Wu W,Wang Z,Liu R,Wang X

    更新日期:2018-06-01 00:00:00

  • Sustained clinical response after single course of rituximab as first-line monotherapy in adult-onset asthma and periocular xanthogranulomas syndrome associated with IgG4-related disease: A case report.

    abstract:RATIONALE:IgG4-related disease (IgG4-RD) is an emerging immune-mediated disease characterized by multi-organ involvement and variable clinical behavior. PATIENT CONCERNS:We describe the case of a 50-year-old woman affected by a rare variant of IgG4-RD, characterized by eyelid xanthelasmas, adult-onset asthma and saliv...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000011143

    authors: Pomponio G,Olivari D,Mattioli M,Angeletti A,Rossetti G,Goteri G,Gabrielli A

    更新日期:2018-06-01 00:00:00

  • Case Report of Contrast-Enhanced Ultrasound Features of Primary Hepatic Neuroendocrine Tumor: A CARE-Compliant Article.

    abstract::Primary hepatic neuroendocrine tumors (PHNETs) are very rare and their clinical features and treatment outcomes are not well understood. It is difficult to reach a proper diagnosis before biopsy or resection. The aim of this study was to analyze the imaging features of PHNETs on contrast-enhanced ultrasound (CEUS). Th...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000003450

    authors: Li W,Zhuang BW,Wang Z,Liao B,Hong LY,Xu M,Lin XN,Xie XY,Lu MD,Chen LD,Wang W

    更新日期:2016-05-01 00:00:00

  • Role of the physical fitness test in risk prediction of diabetes among municipal in-service personnel in Guangxi.

    abstract::To explore the relationship between risk prediction of diabetes mellitus (DM) and different physical fitness parameters in municipal in-service personnel in Guangxi.This was a cross-sectional study conducted in China from July 2015 to December 2016. We enrolled in-service adults (20-65 year of age) from public institu...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000015842

    authors: Zhao M,Wu Z,Huang Y,Jiang Z,Mo X,Lowis H,Zhao Y,Zhang M

    更新日期:2019-05-01 00:00:00

  • Ecthyma gangrenosum, a skin manifestation of Pseudomonas aeruginosa sepsis in a previously healthy child: A case report.

    abstract:RATIONALE:Ecthyma gangrenosum (Eg) is a necrotic lesion that is mostly seen in immunocompromised patients. It reflects a severe sepsis, possibly caused by Pseudomonas aeruginosa (Pa). PATIENT CONCERNS:A healthy 3-year-old girl admitted to the Pediatric Emergency Department presented a sepsis-associated purpura with ne...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000005507

    authors: Biscaye S,Demonchy D,Afanetti M,Dupont A,Haas H,Tran A

    更新日期:2017-01-01 00:00:00

  • Influenza A with hemorrhagic shock and encephalopathy syndrome in an adult: A case report.

    abstract:INTRODUCTION:Hemorrhagic shock and encephalopathy syndrome (HSES) is a type of acute encephalopathy mainly seen in infants. It is a syndrome encompassing an onset of high fever, disturbance of consciousness, convulsion, and shock that rapidly progresses to watery diarrhea and liver and renal dysfunctions. It is extreme...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000015012

    authors: Fukuda M,Yoshida T,Moroki M,Hirayu N,Nabeta M,Nakamura A,Uzu H,Takasu O

    更新日期:2019-04-01 00:00:00

  • The value of the air bronchogram sign on CT image in the identification of different solitary pulmonary consolidation lesions.

    abstract::The aim of the present study is to investigate the value of air bronchogram sign on computed tomography (CT) image in the differential diagnosis of solitary pulmonary consolidation lesions (SPLs).A total of 105 patients (including 39 cases of lung cancer, 43 cases of tuberculosis, and 23 cases of pneumonia) with SPLs ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000011985

    authors: Qu H,Zhang W,Yang J,Jia S,Wang G

    更新日期:2018-08-01 00:00:00

  • Poikilothermia in man: pathophysiology and clinical implications.

    abstract::Poikilothermia, the inability to maintain a constant core temperature independent of ambient temperature, markedly influences both the mental and physical function of affected patients; furthermore, prolonged hypothermia can induce numerous complications. To establish the pathophysiology of thermoregulation underlying...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/00005792-199107000-00003

    authors: MacKenzie MA,Hermus AR,Wollersheim HC,Pieters GF,Smals AG,Binkhorst RA,Thien T,Kloppenborg PW

    更新日期:1991-07-01 00:00:00

  • Metastatic infectious disease and clinical outcome in Staphylococcus aureus and Streptococcus species bacteremia.

    abstract::Early detection of metastatic infection in patients with Gram-positive bacteremia is important as morbidity and mortality are higher in the presence of these foci, probably due to incomplete eradication of clinically silent foci during initial treatment. We performed a prospective study in 115 patients with Staphyloco...

    journal_title:Medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MD.0b013e31824d7ed2

    authors: Vos FJ,Kullberg BJ,Sturm PD,Krabbe PFM,van Dijk APJ,Wanten GJA,Oyen WJG,Bleeker-Rovers CP

    更新日期:2012-03-01 00:00:00

  • Use of siphon irrigation during burr-hole craniostomy to evacuate chronic subdural hematoma: A retrospective cohort comparison study.

    abstract::Burr-hole craniostomy (BHC) is a widely accepted treatment for chronic subdural hematomas (CSDHs). This study adopted siphon irrigation to evacuate CSDHs and investigated its efficacy and safety as compared with the traditional irrigation used in BHC.A retrospective cohort study was conducted at a center between Janua...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000020291

    authors: Chen S,Chen Z,Yang B,Xu T,Tu XK

    更新日期:2020-05-22 00:00:00

  • Clinical efficacy of oral immunoglobulin Y in infant rotavirus enteritis: Systematic review and meta-analysis.

    abstract:BACKGROUND:Rotavirus (RV) can cause vomiting and diarrhea in infants and children, and could be treated clinically with immunoglobulin Y (IgY), which is an immunoglobulin extracted from chicken yolk. There is no systematic evaluation of immunoglobulin in the treatment of rotavirus enteritis. Therefore, we systematicall...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000016100

    authors: Wang X,Song L,Tan W,Zhao W

    更新日期:2019-07-01 00:00:00

  • Capillary hemangioma arising from the lesser omentum in an adult: A case report.

    abstract:RATIONALE:Although capillary hemangiomas, common lesions involving the proliferation of small capillary vessels and a single layer of endothelial cells, can arise in any organ, they are rarely reported in the greater or lesser omentum. Here in, we report a case of capillary hemangioma arising from the lesser omentum in...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000018693

    authors: Nagano H,Goi T,Taguchi S,Tsubaki T,Tsuchiyama T,Uematsu H,Noriki S

    更新日期:2020-01-01 00:00:00

  • Ki-67 labeling index is a predictive marker for a pathological complete response to neoadjuvant chemotherapy in breast cancer: A meta-analysis.

    abstract:BACKGROUND:A pathological complete response (pCR) after neoadjuvant chemotherapy (NCT) is a strong indicator of the benefit of therapy and presents an early surrogate for a favorable long-term outcome. It remains unclear whether Ki-67, a marker for tumor proliferation, can function as a predictor of the response to NCT...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MD.0000000000009384

    authors: Tao M,Chen S,Zhang X,Zhou Q

    更新日期:2017-12-01 00:00:00

  • Determination of the optimal target level of proteinuria in the management of patients with glomerular diseases by using different definitions of proteinuria.

    abstract::Proteinuria is a major determinant of adverse renal outcome, and its reduction slows renal progression in glomerular diseases. However, the optimal target of proteinuria in glomerular diseases is unclear, and discrepancies in the definition of proteinuria produce ambiguous findings. Here we investigated the optimal ta...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000008154

    authors: Kee YK,Yoon CY,Kim SJ,Moon SJ,Kim CH,Park JT,Lim BJ,Chang TI,Kang EW,Kie JH,Yoo TH,Jeong HJ,Kang SW,Han SH

    更新日期:2017-11-01 00:00:00

  • Postoperative changes of liver enzymes can distinguish between biliary stricture and graft rejection after living donor liver transplantation: A longitudinal study.

    abstract::There is no known useful clinical parameter that can specifically predict a biliary stricture and differentiate it from other related complications after living donor liver transplantations (LDLT). The aims of this study were to determine whether the changes of liver enzymes can predict postoperative biliary stricture...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000006892

    authors: Woo YS,Lee KH,Lee KT,Lee JK,Kim JM,Kwon CHD,Joh JW,Kang D,Cho J

    更新日期:2017-10-01 00:00:00

  • Chinese medicine treatment of mastitis in COVID-19 patients: A protocol for systematic review.

    abstract:BACKGROUND:Assessing the effectiveness and safety of Chinese medicine for the mastitis in COVID-19 patients is the main purpose of this systematic review protocol. METHODS:The following electronic databases will be searched from inception to April 2020: MEDLINE, Ovid, EMBASE, the Cochrane Library, the Allied and Compl...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000021656

    authors: Wen D,Shi Y,Zhang X,Lv G

    更新日期:2020-08-28 00:00:00

  • Predictive Value of Glucose Parameters Obtained From Oral Glucose Tolerance Tests in Identifying Individuals at High Risk for the Development of Diabetes in Korean Population.

    abstract::Previous studies suggest that the future risk for type 2 diabetes is not similar among subjects in the same glucose tolerance category. In this study, we aimed to evaluate simple intuitive indices to identify subjects at high risk for future diabetes development by using 0, 30, 120 minute glucose levels obtained durin...

    journal_title:Medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/MD.0000000000003053

    authors: Yang HK,Ha HS,Rhee M,Lee JH,Park YM,Kwon HS,Yim HW,Kang MI,Lee WC,Son HY,Lee SH,Yoon KH

    更新日期:2016-03-01 00:00:00

  • Efficacy and safety of moxibustion in female infertility patients undergoing in vitro fertilization and embryo transfer: A systematic review protocol.

    abstract:INTRODUCTION:The purpose of this paper is to evaluate the efficacy and safety of moxibustion in infertility females/women undergoing in vitro fertilization and embryo transfer (IVF-ET). METHODS AND ANALYSIS:We will electronically search PubMed, Medline, Embase, Web of Science, the Cochrane Central Register of Controll...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000017560

    authors: Hou T,Zheng Q,Feng X,Liu Y,Wang L,Li Y

    更新日期:2019-11-01 00:00:00

  • Effect of bispectral index-guided anesthesia on consumption of anesthetics and early postoperative cognitive dysfunction after liver transplantation: An observational study.

    abstract::The objective of this study was to summarize the incidence of postoperative cognitive dysfunction (POCD) after 7days following liver transplantation (LT), and to evaluate the effectiveness of bispectral index (BIS) guided anesthetic intervention in reducing POCD. Additional serum concentrations of S100β and neuron-spe...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000007966

    authors: Cao YH,Chi P,Zhao YX,Dong XC

    更新日期:2017-09-01 00:00:00

  • Not only for melanoma. Subcutaneous pseudoprogression in lung squamous-cell carcinoma treated with nivolumab: A case report.

    abstract:RATIONALE:Pseudoprogression, that is, initial tumor growth followed by subsequent tumor regression, has been well described for immunomodulation therapy in melanoma patients. This phenomenon is not well defined in lung cancer. Nivolumab, an anti-PD-1 monoclonal antibody, was recently approved for nonsmall cell lung can...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000005951

    authors: Sarfaty M,Moore A,Dudnik E,Peled N

    更新日期:2017-01-01 00:00:00

  • Failed percutaneous kyphoplasty in treatment of stage 3 Kummell disease: A case report and literature review.

    abstract:RATIONALE:Albeit it is rare, the authors report a stage 3 Kummell disease case. It is diagnosed by dynamic thoracic magnetic resonance imaging (MRI). Because there is no established strategy on stage 3 Kummell disease, we performed percutaneous kyphoplasty at first, but unfortunately made a revision surgery to remove t...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0000000000008895

    authors: Zhang C,Wang G,Liu X,Li Y,Sun J

    更新日期:2017-11-01 00:00:00

  • Adjacent segmental degeneration following Wallis interspinous stabilization implantation: Biomechanical explanations and the value of magnetic resonance imaging.

    abstract::Adjacent segmental degeneration (ASD) is a major issue after pedicular fixation. This study examined the degeneration of the adjacent levels due to the insertion of the Wallis interspinous stabilization system compared with discectomy, using magnetic resonance imaging (MRI).Thirty-eight patients diagnosed with lumbar ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000007056

    authors: Zhou Z,Xiong W,Li L,Li F

    更新日期:2017-06-01 00:00:00

  • Complete laparoscopic cholecystectomy for a duplicated gallbladder: A case report.

    abstract:INTRODUCTION:Duplication of the gallbladder (GB) is a rare congenital abnormality occurring in 1 in 4000 to 5000 births. Three types have been reported: type I (split primordial GB), type II (2 separate GBs with their own cystic ducts), and type III (triple GBs drained by 1 to 3 separate cystic ducts). Patients with a ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000018363

    authors: Zhou DK,Huang Y,Kong Y,Ye Z,Ying LX,Wang WL

    更新日期:2020-01-01 00:00:00

  • Association of cytokine gene polymorphisms with chronic hepatitis C virus genotype 1b infection in Chinese Han population: An observational study.

    abstract::Cytokines are extensively involved in the process of hepatitis C virus (HCV) infection and take a crucial part in host immune regulation. We aimed to explore the potential correlation of cytokine single nucleotide polymorphisms (SNPs) with HCV susceptibility and response rate of interferon (IFN)-based antiviral therap...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000022362

    authors: Jing JS,Wang ZQ,Jiang YK,Zhang XY,Jiang WM

    更新日期:2020-09-18 00:00:00

  • Effect of contraindicated drugs for heart failure on hospitalization among seniors with heart failure: A nested case-control study.

    abstract::Little is known about the effect of nonsteroidal anti-inflammatory drugs (NSAIDs), thiazolidinediones (TZDs), nifedipine and nondihydropyridine calcium channel blockers (CCBs) usage on the risk of all-cause hospitalization among seniors with heart failure (HF). We assessed the risk of all-cause hospitalization associa...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000006239

    authors: Girouard C,Grégoire JP,Poirier P,Moisan J

    更新日期:2017-03-01 00:00:00

  • Orthostatic Hypotension and Mortality in Elderly Frail Patients: A Retrospective Cross-Sectional Study.

    abstract::Orthostatic hypotension (OH) is a common problem in the elderly age group, and some studies have reported an association between OH and increased mortality. We evaluated possible associations between OH and mortality in a retrospective study of frail elderly patients who came for a comprehensive geriatric assessment. ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000000977

    authors: Freud T,Punchik B,Press Y

    更新日期:2015-06-01 00:00:00

  • A systematic review of randomized controlled trials of the Wenyang Huoxue method in treating diabetic peripheral neuropathy.

    abstract:OBJECTIVE:To assess the efficacy and safety of the Wenyang Huoxue method for patients with diabetic peripheral neuropathy. METHODS:A systematic literature search was performed using 7 databases: PUBMED, EMBASE, the Chinese National Knowledge Infrastructure, Wanfang, Chinese BioMedical, and the VIP Chinese Science and ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000017618

    authors: Deng Z,Wang M,Fan YH,Huang R,Rao Y,Mai X,Liu M

    更新日期:2019-10-01 00:00:00