rs1495741 as a tag single nucleotide polymorphism of N-acetyltransferase 2 acetylator phenotype associates bladder cancer risk and interacts with smoking: A systematic review and meta-analysis.

Abstract:

:Rs1495741 has been identified to infer N-acetyltransferase 2 (NAT2) acetylator phenotype, and to decrease the risk of bladder cancer. However, a number of studies conducted in various regions showed controversial results. To quantify the association between rs1495741 and the risk of bladder cancer and to estimate the interaction effect of this genetic variant with smoking, we performed a systematic literature review and meta-analysis involving 14,815 cases and 58,282 controls from 29 studies. Our results indicates rs1495741 significantly associated with bladder cancer risk (OR = 0.85, 95% CI = 0.82-0.89, test for heterogeneity P = 0.36, I = 7.0%). And we verified this association in populations from Europe, America, and Asia. Further, our stratified meta-analysis showed rs1495741's role is typically evident only in ever smokers, which suggests its interaction with smoking. This study may provide new insight into gene-environment study on bladder cancer.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Ma C,Gu L,Yang M,Zhang Z,Zeng S,Song R,Xu C,Sun Y

doi

10.1097/MD.0000000000004417

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

e4417

issue

31

eissn

0025-7974

issn

1536-5964

pii

00005792-201608020-00046

journal_volume

95

pub_type

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