Abstract:
:Rs1495741 has been identified to infer N-acetyltransferase 2 (NAT2) acetylator phenotype, and to decrease the risk of bladder cancer. However, a number of studies conducted in various regions showed controversial results. To quantify the association between rs1495741 and the risk of bladder cancer and to estimate the interaction effect of this genetic variant with smoking, we performed a systematic literature review and meta-analysis involving 14,815 cases and 58,282 controls from 29 studies. Our results indicates rs1495741 significantly associated with bladder cancer risk (OR = 0.85, 95% CI = 0.82-0.89, test for heterogeneity P = 0.36, I = 7.0%). And we verified this association in populations from Europe, America, and Asia. Further, our stratified meta-analysis showed rs1495741's role is typically evident only in ever smokers, which suggests its interaction with smoking. This study may provide new insight into gene-environment study on bladder cancer.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Ma C,Gu L,Yang M,Zhang Z,Zeng S,Song R,Xu C,Sun Ydoi
10.1097/MD.0000000000004417subject
Has Abstractpub_date
2016-08-01 00:00:00pages
e4417issue
31eissn
0025-7974issn
1536-5964pii
00005792-201608020-00046journal_volume
95pub_type
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