Clinicopathological features and prognostic factors of young patients with surgically treated liver cancer.

Abstract:

:This article compares the clinical characteristics and prognosis of young patients in different age groups with liver cancer (LC). In this retrospective study, we searched the Surveillance, Epidemiology, and End Results population-based database and identified 2641 patients who had been diagnosed with LC between 1988 and 2005. These patients were categorized into 2 different age ranges: Group 1 (≤35 years) and Group 2 (36-45 years). Five-year cancer-specific survival (CSS) data were obtained. Kaplan-Meier methods and multivariable Cox regression models were used to analyze the long-term survival outcomes and risk factors. There were significant differences between the age groups for stage and tumor size (P < 0.001). The 5-year liver CSS rate was 20.4% and 14.5%, respectively (P < 0.001). Univariate and multivariate analysis also confirmed the difference (P < 0.001). Further analysis showed that this significant difference existed in localized, regional, and distant-stage patients. Young patients with LC of age 18 to 45 years are inherently heterogeneous. Patients aged ≤35 years have better CSS than those aged 36 to 45 years, despite exhibiting unfavorable clinicopathological characteristics.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Zhang W,Jiang R,Hou J,Sun B

doi

10.1097/MD.0000000000000684

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

e684

issue

12

eissn

0025-7974

issn

1536-5964

pii

00005792-201503040-00015

journal_volume

94

pub_type

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