Abstract:
:We aimed to elucidate the relationship between serum liver fibrosis markers (Mac-2 binding protein glycosylation isomer (M2BPGi), FIB-4 index, aspartate aminotransferase to platelet ratio index and hyaluronic acid), and skeletal muscle mass and to investigate factors linked to skeletal muscle mass loss (SMML) in patients with chronic hepatitis C (CHC, n = 277, median age = 64 years). We defined patients with psoas muscle index [PMI, sum of bilateral psoas muscle mass calculated by manual trace method at the lumber 3 level on the computed tomography images divided by height squared (cm/m)] less than 6.36 cm/m for male and 3.92 cm/m for female as those with SMML based on the recommendations in current guidelines. Receiver operating curve (ROC) analysis was performed for predicting SMML in 4 liver fibrosis markers and parameters linked to SMML were also investigated in the univariate and multivariate analyses. In terms of liver fibrosis stages, F4 was observed in 115 patients, F3 in 67, F2 in 38, F1 in 53, and F0 in 4. The median (range) PMI for male and female were 6.198 (2.999-13.698) and 4.100 (1.691-7.052) cm/m, respectively. There were 72 male patients with SMML (55.4%) and 58 female patients with SMML (39.5%) (P = .0112). In both male and female, a significant inverse correlation between PMI and levels of liver fibrosis markers was observed in all liver fibrosis markers. ROC analyses for predicting SMML revealed that FIB-4 index had the highest area under the ROC (AUC = 0.712), followed by M2BPGi (AUC = 0.692). In the multivariate analysis of factors linked to SMML, gender (P = .0003), body mass index (P < .0001), FIB-4 index (P = .0039), and M2BPGi (P = .0121) were found to be significant predictors. In conclusion, liver fibrosis markers, especially FIB-4 index, can be helpful for predicting SMML in CHC patients.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Takata R,Nishikawa H,Enomoto H,Iwata Y,Ishii A,Miyamoto Y,Ishii N,Yuri Y,Hasegawa K,Nakano C,Nishimura T,Yoh K,Aizawa N,Sakai Y,Ikeda N,Takashima T,Iijima H,Nishiguchi Sdoi
10.1097/MD.0000000000008761subject
Has Abstractpub_date
2017-12-01 00:00:00pages
e8761issue
48eissn
0025-7974issn
1536-5964pii
00005792-201712010-00030journal_volume
96pub_type
杂志文章相关文献
MEDICINE文献大全abstract::The inferior border of the femoral head (IBFH) is widely used as a landmark in femoral artery puncture during invasive coronary angiography (ICA). However, application of this technique can be challenging especially in obese patients. This study was performed to investigate the association between body mass index (BMI...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010070
更新日期:2018-03-01 00:00:00
abstract::Hyperphosphatemia-induced vascular calcification and higher alkaline phosphatase (ALP) levels-related high-turnover bone diseases are linked to mortality among patients with chronic kidney disease (CKD). Nonetheless, no large epidemiological study in patients with CKD has been conducted to investigate the interaction ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000106
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Nutrients related to serum vitamin D level were previously shown to be significantly associated with the risk of many chronic diseases. This study aimed to assess potential relationships between serum vitamin D level and otitis media (OM) risk. METHODS:PubMed, EMBASE, and Cochrane Library databases were sea...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000004739
更新日期:2016-10-01 00:00:00
abstract:INTRODUCTION:The clinical treatment is complicated for patients with placenta previa who must terminate pregnancy due to fetal malformation, death, or inevitable abortion in the second trimester. It is difficult to manage excessive bleeding during pregnancy termination; and those patients face risks of removing the ute...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022499
更新日期:2020-09-25 00:00:00
abstract:RATIONALE:Hemophagocytic lymphohistiocytosis (HLH) secondary to methicillin-resistant Staphylococcus epidermidis (MRSE)-related left-sided infectious endocarditis had never been reported before. In the last decade, daptomycin, a novel lipopeptide antibiotic, showed its excellent role in anti-Gram-positive bacteria, inc...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000009451
更新日期:2017-12-01 00:00:00
abstract:RATIONALE:The use of musculoskeletal ultrasound (MU) method in the diagnosis of shoulder pain and injury and guidance of injection and pain blocking has been established. However, the treatment of posthemiplegic shoulder pain (HSP) with MU-guided precise physical therapy has not been reported. PATIENT CONCERNS:Here, w...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000009188
更新日期:2017-12-01 00:00:00
abstract:RATIONALE:Tolosa-Hunt syndrome (THS) is rare condition characterized by painful ophthalmoplegia that usually responds well to corticosteroid. About a half of THS patients experience recurrence within intervals of months to years from initial presentation. Recurrence is more common in younger patients, and can be ipsila...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000019882
更新日期:2020-04-01 00:00:00
abstract::Curative treatments for very early-stage hepatocellular carcinoma (HCC), defined as single HCC with a maximum diameter of <2 cm in patients with well-preserved liver function, consist of surgical resection or radiofrequency ablation (RFA). In this retrospective study, we compared the efficacy of both treatments in 154...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016279
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Knee osteoarthritis (KOA) is a common chronic disorder of knee and the leading cause of pain in the elderly with an overall prevalence of 50% in people over 60 years of age. This disease is an important factor affecting the quality of life of middle-aged and elderly people, and its main symptom is knee joint...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020666
更新日期:2020-06-12 00:00:00
abstract::The prognostic implication of Barcelona Clinic Liver Cancer (BCLC) substages in Asian patients with hepatocellular carcinoma (HCC) is still obscure.The aim to this study is to compare the prognoses among HCC patients in different substages of the BCLC stage 0 and A.We enrolled 1265 treatment-naive HCC patients with BC...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001929
更新日期:2015-10-01 00:00:00
abstract::Metastatic hepatocellular carcinoma (HCC) of the right ventricle is very rare and difficult to diagnosis.A 79-year-old man who underwent right hemi-hepatectomy for HCC was admitted to our hospital for chest pain, severe dyspnea, and orthopnea. The echocardiogram showed a tumor located in the right ventricle. A biopsy ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005544
更新日期:2016-12-01 00:00:00
abstract::The aim of this study was to explore the impact of 3% hypertonic saline (HS) intragastric administration for patients who underwent upper gastrointestinal surgery.During the postoperative period, 3% HS has been suggested as a means to improve the intestinal edema and reduce gastrointestinal complications.The medical r...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006121
更新日期:2017-03-01 00:00:00
abstract::The Child-Turcotte-Pugh (CTP) score is widely used worldwide to predict outcomes across a broad spectrum of liver diseases, mainly cirrhosis. Portal hypertension and variceal bleed are significant causes of morbidity and mortality in cirrhotic patients, although the variceal status is not incorporated into the classic...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004884
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Patients with simple obesity suffer from poor quality of life, as well as high risk of hypertension, diabetes, cardiovascular, and cerebrovascular accidents. Lots of Clinical trials suggested that acupuncture is beneficial for simple obesity, and it aims to gather solid evidence in order to provide reliable ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017353
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:This study aimed to evaluate the effectiveness of continuous adductor canal block (CACB) versus continuous femoral nerve block (CFNB) in postoperative analgesia and early rehabilitation of patients with total knee arthroplasty (TKA). METHODS:The Cochrane Library, PubMed, and EMbase were systematically searc...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000018056
更新日期:2019-11-01 00:00:00
abstract::This is an observational study to determine the most relevant parameter of ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for predicting recurrence in cervical cancer. Fifty-six patients with International Federation of Gynecology and Obstetrics (FIGO) stage IIB-IVA cervical can...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002992
更新日期:2016-03-01 00:00:00
abstract::International collaboration is important in healthcare quality evaluation; however, few international comparisons of general surgery outcomes have been accomplished. Furthermore, predictive model application for risk stratification has not been internationally evaluated. The National Clinical Database (NCD) in Japan w...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002194
更新日期:2015-12-01 00:00:00
abstract::Although step counters are increasingly being used in walking programmes to promote sedentary behavior changes in adults, their effectiveness remains unknown. The aim of this meta-analysis of randomized controlled trials (RCTs) was to assess the effectiveness of step counter use in reducing sedentary time among adults...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000001412
更新日期:2015-09-01 00:00:00
abstract:RATIONALE:To report a patient with primary progressive freezing gait (PPFG) whose degeneration of corticofugal tract (CFT) from the supplementary motor area (SMA) was demonstrated using diffusion tensor tractography (DTT). PATIENT CONCERNS:A 66-year-old woman presented with a solitary symptom of a sudden transient bre...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006840
更新日期:2017-05-01 00:00:00
abstract::Progressive transformation of the germinal centers (PTGC) is a benign reaction pattern in lymph nodes. An association with Hodgkin disease (HD) has been reported and PTGC may precede, coexist, or present after the diagnosis of HD. This case report describes a patient who presented with unprovoked pulmonary embolism an...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000412
更新日期:2015-06-01 00:00:00
abstract::Adenoid cystic carcinoma (ACC) is one of the most frequent malignancies of salivary glands. The objective of this study was to identify key genes and potential mechanisms during ACC samples.The gene expression profiles of GSE88804 data set were downloaded from Gene Expression Omnibus. The GSE88804 data set contained 2...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000018676
更新日期:2020-01-01 00:00:00
abstract::Right ventricular pacing often results in prolonged QRS duration (QRSd) as the result of right ventricular stimulation, and atrial fibrillation (AF) may result. The association of pacing-induced prolonged QRSd and AF in patients with permanent pacemakers is unknown.We selected 180 consecutive patients who underwent pa...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000009839
更新日期:2018-02-01 00:00:00
abstract::We reviewed 106 patients referred to our institution for treatment of peripheral tuberculous adenitis to establish the epidemiologic, clinical, and pathologic manifestations of this disease. Tuberculous lymphadenitis occurred predominantly in young, foreign-born women a mean of 5 years after arrival in the United Stat...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/01.md.0000189090.52626.7a
更新日期:2005-11-01 00:00:00
abstract::Craniofacial abnormalities are a known obstructive sleep apnea (OSA) risk factor, but still need to be better characterized. This study investigates the relationship between mandibular width and the risk of developing OSA.We retrospectively analyzed 3D reconstructions of head and neck computed tomography (CT) scans at...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014040
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:CyclinD1 (CCND1) is a key cell cycle regulatory protein. A large number of epidemiological studies have assessed the potential correlation between the CCND1 G870A polymorphism and the risk of colorectal cancer (CRC), but their findings have been inconsistent. To obtain a more precise understanding of the ass...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000008269
更新日期:2017-10-01 00:00:00
abstract::There is a shortage of data in everyday clinical practice about the anticoagulant effects caused by the new oral anticoagulants (NOAs). Our aim was to estimate the intensity of anticoagulant activity induced by rivaroxaban 20 mg qd and dabigatran 110 mg bid among patients with nonvalvular atrial fibrillation (NV-AF).W...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003037
更新日期:2016-04-01 00:00:00
abstract::To investigate the efficacy, key technical points, and complication management of the transabdominal preperitoneal (TAPP) approach for incarcerated inguinal hernia repair. Seventy-three patients with incarcerated inguinal hernias underwent TAPP surgery in our department between Jan 2010 and Dec 2015. A retrospective r...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005686
更新日期:2016-12-01 00:00:00
abstract::Hypotonia, particularly of the masticatory and oropharyngeal muscles, is 1 of the main characteristics of Down Syndrome (DS), resulting in impaired speech, chewing and swallowing. Moreover, the complete or partial obstruction of the airways during sleep may occur due to hypotonia of the tongue, leading to snoring and ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000019904
更新日期:2020-04-01 00:00:00
abstract::Decreased level of miR-204-5p has been documented in various malignancies. However, the expression and clinical significance of miR-204-5p in hepatocellular carcinoma has not been investigated. The aim of this study is to examine the relationship between miR-204-5p expression and clinicopathological features in hepato...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000007545
更新日期:2017-07-01 00:00:00
abstract:RATIONALE:Patients with, or who develop, metastatic breast cancer have a 5-year relative survival of about 25%. Endocrine therapy clearly improves outcomes in patients with estrogen receptor-positive breast cancer. In the metastatic setting, the primary goal of treatment is to maintain long-term disease control with go...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020396
更新日期:2020-06-12 00:00:00