Remission of systematic lupus erythematosus.


:The occurrence and characteristics of remissions in patients with systematic lupus erythematosus (SLE) have not been determined. We therefore studied this in a cohort of 667 patients and found that 156 patients had achieved at least 1 period of 1 year or more of treatment-free clinical remission. This represents an incidence density of 0.028 new cases/person/year. Remission occurred within the first 2 years of disease in 62 patients. The mean duration of first remission was 4.6 years (range, 1-21 yr), and 81 patients were still in the initial remission up until cutoff time. Half of the remaining 75 patients who flared after achieving remission have not entered again in remission. Twenty-six of the 38 patients who did remained in remission, and the remaining 12 had subsequent flares and remissions. Treatment-free remission accounted for a mean of 5.8 years, corresponding to half the time of follow-up. Remission was not limited to patients with mild disease: at least 41 patients achieved remission despite renal involvement, 19 had had neuropsychiatric lupus, 15 had had thrombocytopenia, and 8 had had hemolytic anemia. We also found that the longer the time lapse between the initial manifestation and the diagnosis of SLE, the less likely it was for a patient to enter into remission. There was a continuous increase in likelihood of achieving a first remission from the beginning of disease up to 30 years of disease duration, when it reached 70%. Patients who achieved remission had increased survival, independently of the effect of other disease manifestations that cause increased mortality. We conclude that a significant proportion of patients with SLE, including those with severe organ involvement, may become symptom-free and in need of no more medication, perhaps indefinitely. Our findings support the notion that, in general, SLE is a more benign disease than previously considered.


Medicine (Baltimore)




Drenkard C,Villa AR,Garcia-Padilla C,Pérez-Vázquez ME,Alarcón-Segovia D




Has Abstract


1996-03-01 00:00:00














  • Effect of forced-air warming system in prevention of postoperative hypothermia in elderly patients: A Prospective controlled trial.

    abstract:BACKGROUND:Postoperative hypothermia in elderly patients is a well-known serious complication as it impairs wound healing, induces coagulopathy, increases the risk of blood loss, enhances oxygen consumption, and precipitates cardiac arrhythmias. We conducted this randomized controlled trial to evaluate the effect of a ...


    pub_type: 杂志文章,随机对照试验


    authors: Xu H,Xu G,Ren C,Liu L,Wei L

    更新日期:2019-05-01 00:00:00

  • Case report of a congenital duodenal transverse septum causing partial obstruction.

    abstract:INTRODUCTION:Duodenal obstructions caused by congenital anatomic abnormalities are rare in adults. Several patients in whom the duodenal obstruction was caused by a congenital duodenal diaphragm have been described. The duodenal obstruction in the patient presented herein was caused by a transverse septum, which has no...


    pub_type: 杂志文章


    authors: Guo X,Yu Y,Wang M,Qin R

    更新日期:2017-10-01 00:00:00

  • A Causal Role of Genetically Elevated Circulating Interleukin-10 in the Development of Digestive Cancers: Evidence from Mendelian Randomization Analysis Based on 29,307 Subjects.

    abstract::Recent studies have observed a high level of circulating interleukin-10 (IL-10) in patients with digestive cancers, yet whether elevated IL-10 is causally associated with digestive cancers so far remained unresolved. We therefore meta-analyzed available observational studies with Mendelian randomization method to expl...


    pub_type: 杂志文章,meta分析,评审


    authors: Niu W,Pang Q,Lin T,Wang Z,Zhang J,Tai M,Zhang L,Zhang L,Gu M,Liu C,Qu K

    更新日期:2016-02-01 00:00:00

  • Systemic lupus erythematosus in a patient with multiple system atrophy: A case report.

    abstract:RATIONALE:Multiple system atrophy is a late-onset rare neurodegenerative movement disorder which results in debilitating disease. Fever frequently ensues in the context of infections which can be associated with significant morbidity and mortality, but among alternative diagnostic possibilities neoplasms and autoimmune...


    pub_type: 杂志文章


    authors: Pilalas D,Chatzopoulos G,Kaiafa GD,Ztriva E,Spyridonakou S,Bisbinas V,Ioannidis P,Hatzitolios AI,Savopoulos C

    更新日期:2019-11-01 00:00:00

  • The correlation between recurrent risk and CYP2C19 gene polymorphisms in patients with ischemic stroke treated with clopidogrel for prevention.

    abstract:BACKGROUND:To explore the correlation between recurrent risk and CYP2C19 gene polymorphisms in patients with ischemic stroke (IS) treated with clopidogrel for prevention. METHODS:A total of 289 patients with IS treated with clopidogrel regularly were enrolled in this study, and stroke recurrence of all patients were r...


    pub_type: 杂志文章


    authors: Liu G,Yang S,Chen S

    更新日期:2020-03-01 00:00:00

  • Mean apnea-hypopnea duration (but not apnea-hypopnea index) is associated with worse hypertension in patients with obstructive sleep apnea.

    abstract::To determine which polysomnography parameters are associated with severity of hypertension.This retrospective study collected data on all patients admitted to our urban, academic center in Beijing with hypertension who had undergone polysomnograms (PSG) and were diagnosed with obstructive sleep apnea (OSA) (apnea-hypo...


    pub_type: 杂志文章


    authors: Wu H,Zhan X,Zhao M,Wei Y

    更新日期:2016-11-01 00:00:00

  • A Case Report of Churg-Strauss Syndrome Presenting With Cardiogenic Shock Treated With Extracorporeal Membrane Oxygenation.

    abstract::Churg-Strauss Syndrome (CSS) complicated with cardiogenic shock is rare. Few case reports have described successful treatment of this rare disease. However, no one has reported on the application of mechanical life support with extracorporeal membrane oxygenation (ECMO) to treat this life-threatening disease.A 36-year...


    pub_type: 杂志文章


    authors: Cui N,Su L,Wang H,Long Y,Pang C,Yang F,Liu D

    更新日期:2015-10-01 00:00:00

  • Mast Cells Comprise the Major of Interleukin 17-Producing Cells and Predict a Poor Prognosis in Hepatocellular Carcinoma.

    abstract::IL-17 and IL-17-producing cells have been found in many types of human cancers and murine models. However, the source of tumor-infiltrating IL-17 and IL-17-producing cells in HCC and the prognostic values remain poorly understood. A total of 57 HCC patients were enrolled in this study, and immunofluorescence double st...


    pub_type: 杂志文章


    authors: Tu JF,Pan HY,Ying XH,Lou J,Ji JS,Zou H

    更新日期:2016-03-01 00:00:00

  • The catalase C-262T gene polymorphism and cancer risk: a systematic review and meta-analysis.

    abstract::Many studies suggest that catalase C-262T gene polymorphism is associated with cancer risk, but with inconsistent results. This study aimed to summarize the overall association between catalase C-262T polymorphism and cancer risk. Literature search was performed in PubMed, Embase, and other databases, studies regardin...


    pub_type: 杂志文章,meta分析,评审


    authors: Shen Y,Li D,Tian P,Shen K,Zhu J,Feng M,Wan C,Yang T,Chen L,Wen F

    更新日期:2015-04-01 00:00:00

  • Tradeoff between noise reduction and inartificial visualization in a model-based iterative reconstruction algorithm on coronary computed tomography angiography.

    abstract::We aimed to evaluate the image quality performance of coronary CT angiography (CTA) under the different settings of forward-projected model-based iterative reconstruction solutions (FIRST).Thirty patients undergoing coronary CTA were included. Each image was reconstructed using filtered back projection (FBP), adaptive...


    pub_type: 杂志文章


    authors: Hirata K,Utsunomiya D,Kidoh M,Funama Y,Oda S,Yuki H,Nagayama Y,Iyama Y,Nakaura T,Sakabe D,Tsujita K,Yamashita Y

    更新日期:2018-05-01 00:00:00

  • HIV prevalence and sexual behavior among young male conscripts in the Brazilian army, 2016.

    abstract::Since 1996, the Brazilian Department of Sexually Transmitted Infections (STI), AIDS and Viral Hepatitis (Departamento de Vigilância, Prevenção e Controle das IST, do HIV, AIDS e Hepatites Virais, Secretaria de Vigilância em Saúde, Ministério da Saúde) in collaboration with the Brazilian Ministry of Defense has conduct...


    pub_type: 杂志文章


    authors: Sperhacke RD,da Motta LR,Kato SK,Vanni AC,Paganella MP,Oliveira MCP,Pereira GFM,Benzaken AS

    更新日期:2018-05-01 00:00:00

  • Prevalence and causes of visual impairment in population more than 50 years old: The Shaanxi Eye Study.

    abstract::To assess the prevalence and causes of visual impairment (VI) in the elderly Chinese rural population in Shaanxi Province.A population-based, cross-sectional study design was used to determine the extent of VI in Chinese people over the age of 50 years in Shaanxi Province. Visual acuity and best-corrected visual acuit...


    pub_type: 杂志文章


    authors: He Y,Nie A,Pei J,Ji Z,Jia J,Liu H,Wan P,Ji M,Zhang C,Zhu Y,Wang X

    更新日期:2020-05-01 00:00:00

  • Step Counter Use and Sedentary Time in Adults: A Meta-Analysis.

    abstract::Although step counters are increasingly being used in walking programmes to promote sedentary behavior changes in adults, their effectiveness remains unknown. The aim of this meta-analysis of randomized controlled trials (RCTs) was to assess the effectiveness of step counter use in reducing sedentary time among adults...


    pub_type: 杂志文章,meta分析,评审


    authors: Qiu S,Cai X,Ju C,Sun Z,Yin H,Zügel M,Otto S,Steinacker JM,Schumann U

    更新日期:2015-09-01 00:00:00

  • A case report of neurological complications owing to lately diagnosed hyperargininemia emphasizing the role of national neonatal screening policies in the kingdom of Bahrain.

    abstract:INTRODUCTION:Arginine is an essential amino acid that plays an important role in various body functions including cell division, wound healing, removal of ammonia, immune function, and release of hormones. Hyperargininemia, an autosomal recessive genetic disorder, is considered one of the least common urea cycle disord...


    pub_type: 杂志文章


    authors: Bakhiet M,AlAwadi AMI,AlHammadi MM,Ali MF,Butti N

    更新日期:2018-05-01 00:00:00

  • Impact of Age on Stent Strut Coverage and Neointimal Remodeling as Assessed by Optical Coherence Tomography.

    abstract::While older age associates with adverse percutaneous coronary intervention (PCI) outcomes, detailed information relating age to stent strut coverage and neointimal characteristics is lacking. One hundred nineteen patients with 123 sirolimus-eluting stents (SESs) were divided into 3 groups: group A (≤55 years), group B...


    pub_type: 杂志文章


    authors: Han Z,Feng L,Du H,Sun Z,Hu S,Dai J,Sun M,Xing L,Hou J,Zhang S,Yu B

    更新日期:2015-12-01 00:00:00

  • Ward nurses-focused educational intervention improves the quality of bowel preparation in inpatients undergoing colonoscopy: A CONSORT-compliant randomized controlled trial.

    abstract:BACKGROUND:Adequate bowel preparation is essential for the detection of pathological lesions during colonoscopy. However, it has been found to be inadequate in approximately 20% to 30% of colonoscopy examinations. Educational interventions focused on health staff, such as physicians and nurses, may improve the patients...


    pub_type: 杂志文章,随机对照试验


    authors: Liu A,Yan S,Wang H,Lin Y,Wu J,Fu L,Wu Q,Lu Y,Liu Y,Chen H

    更新日期:2020-09-04 00:00:00

  • Rickettsialpox: report of an outbreak and a contemporary review.

    abstract::Rickettsialpox is a mild illness characterized by the appearance of a primary eschar at the site of a mite bite followed by fever, headache, and a papulovesicular rash. It can be confused with a variety of illnesses including several other rickettsial diseases and chickenpox. R. akari, the etiologic agent, is a ricket...


    pub_type: 杂志文章


    authors: Brettman LR,Lewin S,Holzman RS,Goldman WD,Marr JS,Kechijian P,Schinella R

    更新日期:1981-09-01 00:00:00

  • The incidence risk of programmed cell death-1/programmed cell death ligand 1 inhibitor-related alopecia for cancer patients: A systematic review and meta-analysis.

    abstract:PURPOSE:To evaluate the incidence risk of programmed cell death-1/programmed cell death ligand 1 (PD-1/PD-L1) inhibitor-related alopecia for cancer patients, the meta-analysis was put into practice. METHOD:The meta-analysis was designed and put into practice according to the preferred reporting items for systematic re...


    pub_type: 杂志文章,meta分析


    authors: Li M,Huang L,Ren X,Liu L,Shi Q,Liu L,Wang X,Tian Y,Yu L,Mi F

    更新日期:2020-10-16 00:00:00

  • Examining the Association Between Quadriceps Strength and Cognitive Performance in the Elderly.

    abstract::Emerging evidences showed impaired muscle strength was prevalent in older adults with mild cognition impairment or dementia. However, little was known about the role of quadriceps strength in the cognition decline among older population. The objective of our study was to investigate the relation between quadriceps str...


    pub_type: 杂志文章


    authors: Chen WL,Peng TC,Sun YS,Yang HF,Liaw FY,Wu LW,Chang YW,Kao TW

    更新日期:2015-08-01 00:00:00

  • Stiff-person syndrome coexisting with critical illness polyneuropathy: A case report.

    abstract:RATIONALE:Stiff-person syndrome (SPS) is an uncommon neurological disorder with autoimmune features. Here, we report a 60-year-old man with SPS associated with critical illness polyneuropathy (CIP). CIP was diagnosed during an episode of acute respiratory failure secondary to muscular rigidity and spasms, which has rar...


    pub_type: 杂志文章


    authors: Cai Q,Wu C,Xu W,Liang Y,Liao S

    更新日期:2020-12-11 00:00:00

  • Systematic training program for nursing home staff based on the concept of combination of medicine and care.

    abstract::It is important to improve the training for nursing home staff in order to achieve better quality of life for the elderly.This study aimed to develop a systematic training program for nursing home staff based on the concept of combination of medicine and care.Thirty-four nursing staff from 2 representative nursing hom...


    pub_type: 杂志文章


    authors: Wang L,Chen H,Yang L,Qian C,Sun D,Sun Y

    更新日期:2020-06-12 00:00:00

  • A life-threatening case of TAFRO syndrome with dramatic response to tocilizumab, rituximab, and pulse steroids: The first case report in Latin America.

    abstract:RATIONALE:This is the report of the first case of TAFRO syndrome (Thrombocytopenia, Anasarca, myelofibrosis, Renal dysfunction, Organomegaly) in Latin America. PATIENT CONCERNS:The patient was a 61-year-old white woman of Ashkenazi Jewish descent, who presented with a history of 8 days of nausea, vomiting, and fever; ...


    pub_type: 杂志文章


    authors: José FF,Kerbauy LN,Perini GF,Blumenschein DI,Pasqualin DDC,Malheiros DMAC,Campos Neto GC,de Souza Santos FP,Piovesan R,Hamerschlak N

    更新日期:2017-03-01 00:00:00

  • Impact of statin use on cancer-specific mortality and recurrence: A meta-analysis of 60 observational studies.

    abstract::This meta-analysis mainly summarized the studies reporting an association between statin use and cancer-specific mortality and recurrence or progression of cancer patients.We systematically searched for studies about the statin used in cancer patients in electronic databases, including PubMed, Web of Science, Cochrane...


    pub_type: 杂志文章,meta分析


    authors: Yang J,Li C,Shen Y,Zhou H,Shao Y,Zhu W,Chen Y

    更新日期:2020-04-01 00:00:00

  • Recurrent Acute Liver Failure Because of Acute Hepatitis Induced by Organic Solvents: A Case Report.

    abstract::The authors present a case of recurrent acute liver failure because of occupational exposure to organic solvents. A 35-year-old man with a 3-week history of worsening jaundice and flu-like symptoms was admitted to our hospital. Viral hepatitis serology and autoimmune factors were negative. The authors considered liver...


    pub_type: 杂志文章


    authors: Ito D,Tanaka T,Akamatsu N,Ito K,Hasegawa K,Sakamoto Y,Nakagawa H,Fujinaga H,Kokudo N

    更新日期:2016-01-01 00:00:00

  • Correlation of volumetric flow rate and skin blood flow with cold intolerance in digital replantation.

    abstract::Cold intolerance is a common complication of digital replantation. The exact etiology is unclear, but it is considered to be multifactorial, including nonsurgical characteristics, vascular, and neurologic conditions. Blood flow may play a significant role in cold intolerance. This study was designed to evaluate the co...


    pub_type: 杂志文章


    authors: Zhao G,Mi J,Rui Y,Pan X,Yao Q,Qiu Y

    更新日期:2017-12-01 00:00:00

  • Clinical significance of increased cerebellar default-mode network connectivity in resting-state patients with drug-naive somatization disorder.

    abstract::The cerebellum has been proven to be connected to the brain network, as in the default-mode network (DMN), among healthy subjects and patients with psychiatric disorders. However, whether or not abnormal cerebellar DMN connectivity exists and what its clinical significance is among drug-naive patients with somatizatio...


    pub_type: 杂志文章


    authors: Wang H,Guo W,Liu F,Chen J,Wu R,Zhang Z,Yu M,Li L,Zhao J

    更新日期:2016-07-01 00:00:00

  • Primary leiomyosarcoma of the fallopian tube: A case report and literature review.

    abstract:RATIONALE:Primary leiomyosarcoma (LMS) of the fallopian tube is extremely uncommon. To the best of our knowledge, so far only 21 cases of primary fallopian tube LMS have been reported in English-language literature. No new case has been reported in the past 7 years. PATIENT CONCERNS:A 44-year-old premenopausal patient...


    pub_type: 杂志文章,评审


    authors: You D,Wang Q,Jiang W,Lin L,Yi T,Zhao L,Li M,Wang P

    更新日期:2018-04-01 00:00:00

  • Post-transplant malignancy in liver transplantation: a single center experience.

    abstract::We aim to determine the incidence of malignancy after liver transplantation (LT) compared to general population. The records of patients who received LTs at our center from October 1989 and November 2012 were retrospectively reviewed. The standardized incidence ratio (SIR) of cancer in the patients was compared to gen...


    pub_type: 杂志文章


    authors: Hsiao CY,Lee PH,Ho CM,Wu YM,Ho MC,Hu RH

    更新日期:2014-12-01 00:00:00

  • Migrated foreign body liver abscess: illustrative case report, systematic review, and proposed diagnostic algorithm.

    abstract::Pyogenic liver abscess is a severe condition and a therapeutic challenge. Treatment failure may be due to an unrecognized ingested foreign body that migrated from the gastrointestinal tract. There has recently been a marked increase in the number of reported cases of this condition, but initial misdiagnosis as cryptog...


    pub_type: 杂志文章,评审


    authors: Leggieri N,Marques-Vidal P,Cerwenka H,Denys A,Dorta G,Moutardier V,Raoult D

    更新日期:2010-03-01 00:00:00

  • Late puerperal hemorrhage of a patient with Klippel-Trenaunay syndrome: A case report.

    abstract:INTRODUCTION:The Klippel-Trenaunay syndrome (KTS) is a rare congenital disorder. The obstetric course of women with KTS varies. Complications include bleeding, disseminated intravascular coagulation (DIC), thromboembolic events, etc. PATIENT CONCERNS:: Here, we report a case of late puerperal hemorrhage of a Chinese pu...


    pub_type: 杂志文章


    authors: Zhang J,Wang K,Mei J

    更新日期:2019-12-01 00:00:00