Systematic review and meta-analysis of the effect of probiotic supplementation on functional constipation in children.


BACKGROUND:To evaluate the effect of probiotic supplementation on functional constipation in children. METHODS:We performed electronic searches in PubMed, Embase, and Cochrane Library without language restriction to identify relevant studies from the time of inception of these databases to March 2018. The relative risk or weighted mean difference was calculated to evaluate the treatment effect of probiotics using random-effects model. RESULTS:We included 4 trials reporting data on 382 children with functional constipation. Overall, there were no significant differences in treatment success (P = .697), spontaneous bowel movements per week (P = .571), fecal soiling episodes per week (P = .642), straining at defecation (P = .408), use of lactulose (P = .238), use of laxatives (P = .190), fecal incontinence (P = .139), pain during defecation (P = .410), flatulence (P = .109), and adverse events (P = .979) between probiotics and placebo. Further, the use of probiotics was associated with lower frequency of glycerin enema use (weighted mean difference -2.40, P = .004) and abdominal pain (weighted mean difference -4.80, P < .001). CONCLUSION:The findings of this study suggested that the use of probiotics was associated with significant improvement in glycerin enema use and abdominal pain but did not affect the treatment success and other function indices.


Medicine (Baltimore)




Jin L,Deng L,Wu W,Wang Z,Shao W,Liu J




Has Abstract


2018-09-01 00:00:00
















  • The relationship between the expression of TN and the efficiency of posterior spinal V osteotomy in patients with traumatic kyphosis.

    abstract:BACKGROUND:This study was conducted with the aim to investigate the relationship between Tetranectin (TN) and efficiency of posterior spinal V osteotomy in patients with traumatic kyphosis. METHODS:Ninety-two patients with traumatic kyphosis admitted in our hospital from February 2014 to June 2016 were included whose ...


    pub_type: 杂志文章


    authors: Jiang G,Zhang Y,Sun X

    更新日期:2018-02-01 00:00:00

  • Does adding variceal status to the Child-Turcotte-Pugh score improve its performance in predicting mortality in cirrhosis?

    abstract::The Child-Turcotte-Pugh (CTP) score is widely used worldwide to predict outcomes across a broad spectrum of liver diseases, mainly cirrhosis. Portal hypertension and variceal bleed are significant causes of morbidity and mortality in cirrhotic patients, although the variceal status is not incorporated into the classic...


    pub_type: 杂志文章


    authors: Fan X,Wen M,Shen Y,Wang W,Yang X,Yang L

    更新日期:2016-09-01 00:00:00

  • Does metaphyseal cement augmentation in fracture management influence the adjacent subchondral bone and joint cartilage?: an in vivo study in sheep stifle joints.

    abstract::Augmentation of implants with polymethylmethacrylate (PMMA) bone cement in osteoporotic fractures is a promising approach to increase implant purchase. Side effects of PMMA for the metaphyseal bone, particularly for the adjacent subchondral bone plate and joint cartilage, have not yet been studied. The following exper...


    pub_type: 杂志文章


    authors: Goetzen M,Hofmann-Fliri L,Arens D,Zeiter S,Stadelmann V,Nehrbass D,Richards RG,Blauth M

    更新日期:2015-01-01 00:00:00

  • A new CO2 laser technique for the treatment of pediatric hypertrophic burn scars: An observational study.

    abstract::Treatment of hypertrophic scars arising as a result of thermal burns in children is still a big problem. The results of the treatment are not satisfactory for patients and parents, and new methods of treatment are still investigated.We present the use of one of the most modern carbon dioxide (CO2) lasers (Lumenis Enco...


    pub_type: 杂志文章


    authors: Żądkowski T,Nachulewicz P,Mazgaj M,Woźniak M,Cielecki C,Wieczorek AP,Beń-Skowronek I

    更新日期:2016-10-01 00:00:00

  • Utility of Red Cell Distribution Width as a Prognostic Factor in Young Breast Cancer Patients.

    abstract::The prognosis of breast cancer occurs in young women is usually poor. Red cell distribution width (RDW), 1 of many routinely examined parameters, has recently been proposed as a prognostic marker in solid tumors. The aim of our study was to assess the predictive value of RDW for survival in young women with breast can...


    pub_type: 杂志文章


    authors: Huang DP,Ma RM,Xiang YQ

    更新日期:2016-04-01 00:00:00

  • Proposal of a multidimensional strategic-management dashboard for use in a rehabilitation respiratory unit.

    abstract::Health information systems are the core support to decision-making in health organizations. Economic and clinical managements often function separately, while a governance system for quality and safety functions with quality checks and performance accountability, could improve efficiency. The aims of this study were, ...


    pub_type: 杂志文章


    authors: Vitacca M,Vitacca M

    更新日期:2019-05-01 00:00:00

  • Anterior tibial artery occlusion post total knee arthroplasty: A case report.

    abstract:RATIONALE:Total knee arthroplasty (TKA) is a globally well-accepted surgery because of its good outcome and safety. Although TKA-associated arterial injuries occur, postoperative anterior tibial artery (ATA) occlusion has not been reported yet. Herein, we present a case of ATA occlusion after TKA. PATIENT CONCERNS:A 4...


    pub_type: 杂志文章


    authors: Li X,Song Y,Wang J

    更新日期:2019-07-01 00:00:00

  • Which is the better timing between embolization and surgery for hypervascular spinal tumors, the same day or the next day?: A retrospective comparative study.

    abstract::Previous series presented the timing between embolization and surgery in a wide range on the basis of their experience rather than supportive data. And comparative studies were limited to small samples. In addition, there is no study publishing the timing by considering both safety and efficacy of embolization. The ai...


    pub_type: 杂志文章


    authors: Tang B,Ji T,Guo W,Tang X,Jin L,Dong S,Xie L

    更新日期:2018-06-01 00:00:00

  • Chlorhexidine bathing for the prevention of colonization and infection with multidrug-resistant microorganisms in a hematopoietic stem cell transplantation unit over a 9-year period: Impact on chlorhexidine susceptibility.

    abstract::Health care associated infections (HAIs) are currently among the major challenges to the care of hematopoietic stem cell transplantation (HSCT) patients. The objective of the present study was to evaluate the impact of 2% chlorhexidine (CHG) bathing on the incidence of colonization and infection with vancomycin-resist...


    pub_type: 杂志文章


    authors: Mendes ET,Ranzani OT,Marchi AP,Silva MTD,Filho JUA,Alves T,Guimarães T,Levin AS,Costa SF

    更新日期:2016-11-01 00:00:00

  • A systematic review and network meta-analysis protocol of neoadjuvant treatments for patients with gastric cancer.

    abstract:BACKGROUND:National Comprehensive Cancer Network (NCCN) guidelines recommend surgery, chemotherapy, and radiation therapy for gastric cancer patients. Neoadjuvant treatments as the administration of therapeutic agents before a main treatment gained in more and more attention. However, the role of neoadjuvant treatments...


    pub_type: 杂志文章,meta分析


    authors: Long B,Yu ZY,Li Q,Du HR,Wang ZJ,Zhan H,Jiao ZY

    更新日期:2018-04-01 00:00:00

  • Association of the CDKAL1 polymorphism rs10946398 with type 2 diabetes mellitus in adults: A meta-analysis.

    abstract::Previous studies had reported that the CDKAL1 (cyclin-dependent kinase 5 (CDK5) regulatory subunit-associated protein 1-like 1) rs10946398 C/A polymorphism associated with type 2 diabetes mellitus (T2DM) in various ethnic groups, however, inconsistent results have been obtained in studies of different populations.We p...


    pub_type: 杂志文章,meta分析


    authors: Liu X,Liang J,Geng H,Xu W,Teng F,Yang M

    更新日期:2020-07-24 00:00:00

  • Acute Splenic Infarction at an Academic General Hospital Over 10 Years: Presentation, Etiology, and Outcome.

    abstract::Few case series provide a current, comprehensive, and detailed description of splenic infarction (SI), an uncommon condition.Retrospective chart review complemented by imaging evaluation and patient follow-up.All adult patients with a confirmed diagnosis of acute SI discharged over 10 years from a single academic cent...


    pub_type: 杂志文章


    authors: Schattner A,Adi M,Kitroser E,Klepfish A

    更新日期:2015-09-01 00:00:00

  • A 14-year literature survey on spine-related clinical research output by orthopedic surgeons from mainland China.

    abstract:BACKGROUND:In recent years, China is increasingly playing an active role in various fields of biomedical research. Many bibliometric studies have provided valuable insights to different fields of clinical studies. However, similar evaluation on spine surgery-related clinical research is still limited. We herein aimed t...


    pub_type: 杂志文章,meta分析,评审


    authors: Si G,Liu X,Xu N,Yu M,Liu X

    更新日期:2018-08-01 00:00:00

  • Antiglomerular basement membrane antibody-mediated glomerulonephritis and Goodpasture's syndrome.

    abstract::The originally dismal prognosis associated with anti-GBM Ab-mediated GN and Goodpasture's syndrome may be changing as we recognize a broader spectrum of disease, improve general supportive care, and improve specific treatment. Immunosuppressive therapy, if started early in the course of disease, may prevent or allow r...


    pub_type: 杂志文章


    authors: Briggs WA,Johnson JP,Teichman S,Yeager HC,Wilson CB

    更新日期:1979-09-01 00:00:00

  • Applicability of ultrasonography for detection of marginal sinus placenta previa.

    abstract:ABSTRACT:This study aimed to examine whether marginal sinus placenta previa, defined as when the marginal sinus just reaches the internal cervical os and placental parenchyma might be >2 cm from the internal cervical os, can be diagnosed using ultrasonography (US). We identified the placenta previa cases that underwent...


    pub_type: 杂志文章


    authors: Ishibashi H,Miyamoto M,Shinmoto H,Soga S,Iwahashi H,Kakimoto S,Matsuura H,Sakamoto T,Hada T,Suzuki R,Takano M

    更新日期:2021-01-08 00:00:00

  • Ventriculoperitoneal shunt malfunction due to chronic cholecystitis: A case report.

    abstract:RATIONALE:Ventriculoperitoneal shunt (VPS) is the most common treatment for idiopathic normal pressure hydrocephalus, a subtype of hydrocephalus characterized by gait disturbance, dementia, and urinary incontinence. However, while the malfunction of VPS is reported at a high rate, the involvement of chronic cholecystit...


    pub_type: 杂志文章


    authors: Yu Q,Lou C,Feng T,Liu Y

    更新日期:2020-06-19 00:00:00

  • Concomitant severe influenza and cryptococcal infections: A case report and literature review.

    abstract::Concomitant influenza and cryptococcal infections are rare. Herein, we describe an unusual case of an avian influenza A (H7N9) infection with several severe mixed bacterial infections and systemic super-infection with Cryptococcus neoformans presenting as ventilator-associated pneumonia (VAP) and bloodstream infection...


    pub_type: 杂志文章,评审


    authors: Huang J,Li H,Lan C,Zou S,Zhang H,Wang X,Weng H

    更新日期:2019-05-01 00:00:00

  • Efficacy and Safety of Zoledronic Acid and Pamidronate Disodium in the Treatment of Malignant Skeletal Metastasis: A Meta-Analysis.

    abstract::Solid tumors frequently metastasize to bone. Two bisphosphonates have been investigated for bone metastases including pamidronate disodium and zoledronic acid.By searching the PubMed, Embase, Wanfang, and China National Knowledge Infrastructure (CNKI) databases, we conducted a meta-analysis to determine the efficacy a...


    pub_type: 杂志文章,meta分析


    authors: Yang L,Du S

    更新日期:2015-10-01 00:00:00

  • Allograft hemorrhage as a manifestation of carbapenem-resistant Klebsiella pneumonia infection in kidney transplant recipients: Case series.

    abstract:RATIONALE:Carbapenem-resistant Klebsiella pneumonia (CRKP) infections have been a concerning threat, especially in organ transplant patients with very high mortality. Allograft hemorrhage associated with CRKP infection has never been described. PATIENT CONCERNS:A total of 6 recipients tested positive for CRKP were ide...


    pub_type: 杂志文章


    authors: Wang Z,Qian Y,Bai H,Yang J,Li X

    更新日期:2020-03-01 00:00:00

  • Efficacy and safety of low dose aspirin and magnesium sulfate in the treatment of pregnancy induced hypertension: A protocol for systematic review and meta-analysis.

    abstract:BACKGROUND:Magnesium sulfate combined with low-dose aspirin can significantly reduce adverse reactions and effectively lower blood pressure in patients with pregnancy induced hypertension, but the overall efficacy and safety of the combination of drugs are not clear. The purpose of this study was to evaluate the effica...


    pub_type: 杂志文章


    authors: He G,Chen Y,Chen M,He G,Liu X

    更新日期:2020-11-13 00:00:00

  • Triglyceride glucose-body mass index is effective in identifying nonalcoholic fatty liver disease in nonobese subjects.

    abstract::Nonalcoholic fatty liver disease (NAFLD) is an increasingly common condition that is highly correlated with obesity; however, it is not uncommon among nonobese individuals. Triglyceride (TG) and glucose index combined with body mass index (TyG-BMI) has been proposed as a favorable marker of insulin resistance. We soug...


    pub_type: 杂志文章


    authors: Zhang S,Du T,Li M,Jia J,Lu H,Lin X,Yu X

    更新日期:2017-06-01 00:00:00

  • Rickettsialpox: report of an outbreak and a contemporary review.

    abstract::Rickettsialpox is a mild illness characterized by the appearance of a primary eschar at the site of a mite bite followed by fever, headache, and a papulovesicular rash. It can be confused with a variety of illnesses including several other rickettsial diseases and chickenpox. R. akari, the etiologic agent, is a ricket...


    pub_type: 杂志文章


    authors: Brettman LR,Lewin S,Holzman RS,Goldman WD,Marr JS,Kechijian P,Schinella R

    更新日期:1981-09-01 00:00:00

  • Group A streptococcal bacteremia. A 10-year prospective study.

    abstract::In this paper we present a prospective evaluation of 100 patients with Group A Streptococcal (GAS) bacteremia evaluated in our hospital over a 10-year period. Sixty-two patients were intravenous drug users (IVDU); all but 1 of these had an obvious cutaneous portal of entry related to the injection of illicit drugs. Tw...


    pub_type: 杂志文章,评审


    authors: Bernaldo de Quirós JC,Moreno S,Cercenado E,Diaz D,Berenguer J,Miralles P,Catalán P,Bouza E

    更新日期:1997-07-01 00:00:00

  • Are spiritual interventions beneficial to patients with cancer?: A meta-analysis of randomized controlled trials following PRISMA.

    abstract:BACKGROUND:In addition to the physical burden, the quality of life and survival in patients with cancer may also be reduced because of psychological distress, such as spiritual crisis, anxiety, and depression. Many studies have verified that spirituality could reduce anxiety and depression and improve quality of life a...


    pub_type: 杂志文章,meta分析,评审


    authors: Xing L,Guo X,Bai L,Qian J,Chen J

    更新日期:2018-08-01 00:00:00

  • Diagnostic Accuracy of Procalcitonin in Bacterial Meningitis Versus Nonbacterial Meningitis: A Systematic Review and Meta-Analysis.

    abstract::Several studies have investigated the diagnostic accuracy of procalcitonin (PCT) levels in blood or cerebrospinal fluid (CSF) in bacterial meningitis (BM), but the results were heterogeneous. The aim of the present study was to ascertain the diagnostic accuracy of PCT as a marker for BM detection. A systematic search ...


    pub_type: 杂志文章,meta分析,评审


    authors: Wei TT,Hu ZD,Qin BD,Ma N,Tang QQ,Wang LL,Zhou L,Zhong RQ

    更新日期:2016-03-01 00:00:00

  • Using a Web-Based Approach to Assess Test-Retest Reliability of the "Hypertension Self-Care Profile" Tool in an Asian Population: A Validation Study.

    abstract::Essential hypertension often requires affected patients to self-manage their condition most of the time. Besides seeking regular medical review of their life-long condition to detect vascular complications, patients have to maintain healthy lifestyles in between physician consultations via diet and physical activity, ...


    pub_type: 杂志文章


    authors: Koh YLE,Lua YHA,Hong L,Bong HSS,Yeo LSJ,Tsang LPM,Ong KZ,Wong SWS,Tan NC

    更新日期:2016-03-01 00:00:00

  • Borderline tuberculoid leprosy mimicking sarcoidosis: A case report.

    abstract:INTRODUCTION:Leprosy is a chronic infectious granulomas disease caused by Mycobacterium leprae that can manifest as a wide variety of immunological and clinical features. CASE SUMMARY:Here, we describe the case of a woman with clinical characteristics of borderline tuberculoid (BT) leprosy that manifested as 3 asymmet...


    pub_type: 杂志文章


    authors: Liu J,Wen Y,Xing Y,Wang S

    更新日期:2018-08-01 00:00:00

  • Risk factors of uveitis in ankylosing spondylitis: An observational study.

    abstract:BACKGROUND:Uveitis is the most common extra-articular manifestation in patients with ankylosing spondylitis (AS). The prevalence and characteristics of uveitis in AS have been studied in previous literatures, whereas its associated risk factors have not been clarified. Therefore, this study analyzed the risk factors of...


    pub_type: 杂志文章


    authors: Sun L,Wu R,Xue Q,Wang F,Lu P

    更新日期:2016-07-01 00:00:00

  • Effects of core strength training combined with Tai Chi Chuan for the musculoskeletal system and cardiopulmonary function in older adults: A study protocol for a randomized controlled trial.

    abstract:BACKGROUND:According to the national census, China has gradually become an aging society; moreover, aging has become an irreversible worldwide trend in the twenty-first century. Aging can lead to decreased physical function, mobility, cardiopulmonary function and quality of life (QOL). The feasibility and benefits of c...


    pub_type: 杂志文章,随机对照试验


    authors: Jia X,Jiang C,Tao J,Li Y,Zhou Y,Chen LD

    更新日期:2018-08-01 00:00:00

  • Traumatic intradural ruptured lumbar disc with a spinal compression fracture: A case report.

    abstract:RATIONALE:We present a rare case of a traumatic intradural ruptured disc associated with a mild vertebral body compression fracture along with a review of the relevant medical literature. An intradural ruptured disc often occurs due to chronic degenerative diseases and is rarely due to trauma. It can cause irreversible...


    pub_type: 杂志文章


    authors: Lee G,Han MS,Lee SK,Moon B,Lee JK

    更新日期:2020-02-01 00:00:00