Bisphenol A and hormone-associated cancers: current progress and perspectives.

Abstract:

:Bisphenol A (BPA), a carbon-based synthetic compound, exhibits hormone-like properties and is present ubiquitously in the environment and in human tissues due to its widespread use and biological accumulation. BPA can mimic estrogen to interact with estrogen receptors α and β, leading to changes in cell proliferation, apoptosis, or migration and thereby, contributing to cancer development and progression. At the genetic level, BPA has been shown to be involved in multiple oncogenic signaling pathways, such as the STAT3, MAPK, and PI3K/AKT pathways. Moreover, BPA may also interact with other steroid receptors (such as androgen receptor) and plays a role in prostate cancer development. This review summarizes the current literature regarding human exposure to BPA, the endocrine-disrupting effects of BPA, and the role of BPA in hormone-associated cancers of the breast, ovary, and prostate.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Gao H,Yang BJ,Li N,Feng LM,Shi XY,Zhao WH,Liu SJ

doi

10.1097/MD.0000000000000211

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

e211

issue

1

eissn

0025-7974

issn

1536-5964

pii

00005792-201501010-00006

journal_volume

94

pub_type

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