Prophylaxis of ibuprofen in acute mountain sickness: A protocol for systematic review and meta-analysis.

Abstract:

BACKGROUND:Acute mountain sickness (AMS) is the effect when people accessing high altitude in a short period of time. As a cyclooxygenase (COX) inhibitor, ibuprofen could alleviate the symptoms of AMS. However, whether it can prevent AMS or not is still controversial. It is necessary to perform a meta-analysis to evaluate the role of ibuprofen in AMS prophylaxis. METHODS:PubMed, EMBASE, Medline, ISI Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI) will be searched for the relevant published studies that explored the value of ibuprofen in AMS prophylaxis from inception to October 2020. The data will be independently extracted by 2 researchers. Risk of bias will be evaluated based on Cochrane risk of bias assessment tool. Heterogeneity among the included studies will be evaluated by χ and I values. The meta-analysis was conducted by RevMan software version 5.3. RESULTS:This study will evaluate the role of ibuprofen in AMS prophylaxis. CONCLUSION:This study will summarize the current evidence of ibuprofen in AMS prophylaxis, which could further guide the recommendation in prevention of AMS.Open Science Framework (OSF) registration number: October 8, 2020. osf.io/n3mjt.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Yi H,Wang K,Gan X,Li L,Zhang Q,Xiang J,Yuan X,Zhang Y,Wang Y

doi

10.1097/MD.0000000000023233

subject

Has Abstract

pub_date

2020-11-13 00:00:00

pages

e23233

issue

46

eissn

0025-7974

issn

1536-5964

pii

00005792-202011130-00078

journal_volume

99

pub_type

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