Abstract:
:Presently noninvasive methods were employed to the diagnosis of nonalcoholic fatty liver disease (NAFLD), including fatty liver index (FLI), hepatic steatosis index (HSI), product of fasting triglyceride and glucose levels (TyG), and single nucleotide polymorphism (SNP), whereas the accuracy of those indexes need to be improved. Our study aimed to investigate the feasibility of a new index comprehensive index (CI), consisting of 6 serum biomarkers and anthropometric parameters through multivariate logistic regression analysis, to the earlier detection of NAFLD, and the diagnostic value of 5 SNPs (S1: rs2854116 of apolipoprotein C3 [APOC3], S2: rs4149267 of ATP-binding cassette transporter [ABCA1], S3: rs13702 of lipoprotein lipase [LPL], S4: rs738409 of protein 3 [patatin-like phospholipase domain containing protein 3 (PNPLA3)], S5: rs780094 of glucokinase regulatory protein gene [GCKR]) for NAFLD were also explored. Area under the receiver operating characteristic curves (AUROC) and Youden index (YI) were calculated to assess the diagnostic value. The AUROC of CI was higher than FLI, HSI, and TyG (CI: 0.897, FLI: 0.873, HSI: 0.855, TyG: 0.793). Therefore, CI might be a better index for the diagnosis of NAFLD. Although there had no statistical significance (P = .123), the AUROC and YI were increased when CI combined with rs2854116 (S1) (AUROC = 0.902, YI = 0.6844). The combination of CI with S1 showed even better diagnostic accuracy than CI, which suggests the potential value of rs2854116 for the diagnosis of NAFLD.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Yang H,Chen G,Song C,Li D,Ma Q,Chen G,Li Xdoi
10.1097/MD.0000000000010272subject
Has Abstractpub_date
2018-03-01 00:00:00pages
e0272issue
13eissn
0025-7974issn
1536-5964pii
00005792-201803300-00063journal_volume
97pub_type
杂志文章相关文献
MEDICINE文献大全abstract::Osteoarthritis (OA) is the most common form of arthritis in older individuals and is among the most prevalent and disabling chronic conditions worldwide.We conducted a meta-analysis to determine the efficacy and safety of celecoxib, a cyclooxygenase-2 (COX-2) inhibitor in the treatment of osteoarthritis. Studies were ...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000003585
更新日期:2016-05-01 00:00:00
abstract:RATIONALE:Patients with, or who develop, metastatic breast cancer have a 5-year relative survival of about 25%. Endocrine therapy clearly improves outcomes in patients with estrogen receptor-positive breast cancer. In the metastatic setting, the primary goal of treatment is to maintain long-term disease control with go...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020396
更新日期:2020-06-12 00:00:00
abstract::This study aimed to introduce this surgical technique laparoscopic sleeve gastrectomy combined with single-anastomosis duodenal-jejunal bypass (LDJB-LSG), and to confirm this new surgical technique was safe in the treatment of type 2 diabetes mellitus (T2DM) of patients with body mass index (BMI) higher than 27.5 kg/m...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011537
更新日期:2018-08-01 00:00:00
abstract::In a review of endocarditis caused by fastidious, slow-growing gram-negative rods, similarities in the spectrum of disease overshadow differences among cases grouped by specific organisms. Cardiobacterium hominis, Actinobacillus actinomycetemcomitans and Haemophilus species usually seed previously damaged cardiac valv...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/00005792-197903000-00003
更新日期:1979-03-01 00:00:00
abstract:RATIONALE:Managing the health of vulnerable groups is an important component of health care. Given the long-term burden of radiation-release incidents among those exposed, managing the health of vulnerable groups following a nuclear disaster is very important. However, there is limited information available concerning ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017989
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:Auricular acupressure has been used for treating obesity, but inconsistent outcomes have been reported. Moreover, systematic reviews and meta-analyses have seldom addressed the effects of auricular acupressure and duration of treatment in overweight/obese individuals. This study reviewed research articles on...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000016144
更新日期:2019-06-01 00:00:00
abstract::Taking into consideration the progress in cancer treatment, an increase in the number of adult survivors of childhood cancer is expected. These survivors will have received treatment that predisposes them to late morbidity and increased risk of early mortality. The aim of this single-center retrospective cohort study ...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000014921
更新日期:2019-03-01 00:00:00
abstract::Information on respiratory viruses in subtropical region is limited.Incidence, mortality, and seasonality of influenza (Flu) A/B, respiratory syncytial virus (RSV), adenovirus (ADV), and parainfluenza viruses (PIV) 1/2/3 in hospitalized patients were assessed over a 15-year period (1998-2012) in Hong Kong.Male predomi...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002024
更新日期:2015-11-01 00:00:00
abstract::Emerging evidences showed impaired muscle strength was prevalent in older adults with mild cognition impairment or dementia. However, little was known about the role of quadriceps strength in the cognition decline among older population. The objective of our study was to investigate the relation between quadriceps str...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001335
更新日期:2015-08-01 00:00:00
abstract::The aim of this study was to investigate whether histogram analysis in diffusion-weighted (DW) magnetic resonance imaging (MRI) can help differentiate pancreatic adenocarcinomas from neuroendocrine tumors.Sixty-four patients with histologically confirmed 53 pancreatic adenocarcinomas or 19 neuroendocrine tumors underw...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002574
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Adequate bowel preparation is essential for the detection of pathological lesions during colonoscopy. However, it has been found to be inadequate in approximately 20% to 30% of colonoscopy examinations. Educational interventions focused on health staff, such as physicians and nurses, may improve the patients...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000020976
更新日期:2020-09-04 00:00:00
abstract::Severe community-acquired pneumonia (CAP) requiring admission to an intensive care unit (ICU) has been inadequately studied. We compared characteristics and outcomes of patients with CAP who were admitted to the ICU with those of patients managed on the ward. Of the 3675 patients hospitalized with CAP, 374 (10%) were ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0b013e3180421c16
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND:The critically ill and surgical patients are at significant risk of delirium, which is associated with a high morbidity and mortality. The association between statin use and the incidence of delirium is still controversial. In this article, we will perform a systematic review and meta-analysis of published s...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000013679
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Positional change affects the cuff pressure of an endotracheal tube (ETT) in treacheally intubated patients. We compared the cuff pressure of a TaperGuard ETT and a cylindrical ETT after lateral rotation of head during middle ear surgery. METHODS:Fifty-two patients aged 18-70 years underwent a tympanomastoi...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000006257
更新日期:2017-03-01 00:00:00
abstract::The objective of this study was to assess whether preoperative breast magnetic resonance imaging (MRI) combined with conventional breast imaging techniques decreases the rates of margin involvement and reexcision.Data on patients who underwent surgery for primary operable breast cancer were obtained from the Changhua ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003810
更新日期:2016-05-01 00:00:00
abstract::Massive blood transfusion (MBT) is a relatively common complication of cardiac surgery, which is independently associated with severe postoperative adverse events. However, the value of using rapid thrombotomography (r-TEG) to predict MBT in perioperative period of cardiac surgery has not been explored. This study aim...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021833
更新日期:2020-09-11 00:00:00
abstract::The gradient monotonicity of existing tumor, node, metastases staging systems for colorectal cancer is unsatisfactory. Our proposed T-plus staging system strengthens weighting of the T stage. In this study, applicability of the T-plus staging system was verified with data of a Chinese colorectal cancer center.Records ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002711
更新日期:2016-02-01 00:00:00
abstract:RATIONALE:Invasive moles occur in the fertile period, with about 95% occurring after previous mole removal and the remaining 5% occurring after several other pregnancies. PATIENT CONCERNS:A 27-year-old patient developed a rare invasive mole two months after a missed abortion. DIAGNOSES:A transvaginal ultrasound scan ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017565
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1) inhibitors are immune therapies that have shown great promise in the treatment of multiple cancers. However, immune-related adverse events of PD-1 and PD-L1 inhibitors may limit their use in non-small cell lung cancer (NSCLC). Given the rising n...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021613
更新日期:2020-08-07 00:00:00
abstract:BACKGROUND:The digestive tract malignancies are a series of malignant tumor with high morbidity and mortality. Traditional Chinese medicine (TCM) combined with chemotherapy drugs interventions have been applied for the treatment of malignant tumors in Asian countries for dacades. This study aimed to assess the effectiv...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000019480
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:The surgical pleth index (SPI) is proposed for titration of analgesic drugs during general anesthesia. Several reports have investigated the effect of SPI on the consumption of opioids including remifentanil, fentanyl, and sufentanil during anesthesia, but there are no reports about oxycodone. We aimed to in...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000004743
更新日期:2016-08-01 00:00:00
abstract::Human bladder cancer (BCa) is one of the most commonly diagnosed malignancies worldwide. It has high recurrence rates and low-grade malignancy, thus representing an important public health concern. An increasing number of studies suggest that long-noncoding RNAs (lncRNAs) play important roles in various biological pro...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011887
更新日期:2018-08-01 00:00:00
abstract::Thyroid cancer (TC) is the most common malignancy of the endocrine system. The relationship between iodine intake and TC risk is controversial always. We aim to figure out the relationship between iodine intake and TC using meta-analysis. Literature research in MEDLINE, Embase, China National Knowledge Infrastructure,...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000006734
更新日期:2017-05-01 00:00:00
abstract::Acute kidney injury requiring dialysis (AKI-D) treatment has significantly increased in incidence over the years, with more than 400 new cases per million population/y, 2/3 of which concern noncritically ill patients. In these patients, there are little data on mortality or on information of care organization and its ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004277
更新日期:2016-07-01 00:00:00
abstract::In view of the forthcoming long-acting antiretrovirals, measures should be taken to prevent the selection of HIV drug resistance mutations. All subjects who had been switched to boosted protease inhibitors plus maraviroc (bPIs/MVC) with baseline HIV-1 RNA >50 copies/mL between June, 2014, and April, 2015, were retrosp...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005728
更新日期:2017-02-01 00:00:00
abstract:RATIONALE:Sodium valproate (VPA) and lamotrigine (LTG) are widely used antiepileptic drugs, disabling postural, and action tremors after using LTG with VPA were reported in 1993. However, in this study, we describe a patient in whom disabling resting-type tremor induced by 2-year use of VPA and LTG. PATIENT CONCERNS:A...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008711
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Interest in the anesthetic use of xenon, a noble gas, has waxed and waned for decades, and the clinical effects of xenon are still debated. We performed a meta-analysis to compare the clinical efficacy of xenon with that of propofol. METHODS:Electronic searches were performed through December 2017 using var...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000010758
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Femoral nerve block (FNB) is considered the preferred analgesia after anterior cruciate ligament reconstruction (ACLR), but leads to weakness in the quadriceps muscles. Adductor canal block (ACB) is a new sensory block technique that effectively relieves postoperative pain while preserving quadriceps strengt...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020776
更新日期:2020-07-10 00:00:00
abstract:RATIONALE:Recurrent laryngeal nerve block is an uncommon complication that can occur after an interscalene brachial plexus block (ISB), which may lead to vocal cord palsy or paresis. However, if the recurrent laryngeal nerve is blocked in patients with a preexisting contralateral vocal cord palsy following neck surgery...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006598
更新日期:2017-04-01 00:00:00
abstract::While salmonellosis is often considered to affect primarily the gastrointestinal tract, infection at other sites may occur, producing characteristic clinical syndromes. We reviewed cases from our institutions and the literature on focal manifestations of salmonella infections. In the past, most extra-intestinal salmon...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/00005792-198709000-00003
更新日期:1987-09-01 00:00:00