Targeting the rheumatoid arthritis synovial fibroblast via cyclin dependent kinase inhibition: An early phase trial.

abstract：BACKGROUND:This randomized controlled trial (RCT) aimed to compare the clinical outcomes of thoracolumbar burst fractures (TLBFs) treated with open reduction and internal fixation via the posterior paraspinal muscle approach (PPMA) and the post-middle approach (PA). METHODS:Patients with a traumatic single-level TLBFs...

journal_title：Medicine

authors： Chang W,Zhang D,Liu W,Lian X,Jiao Z,Chen W

更新日期：2018-06-01 00:00:00

abstract：:Blood pressure (BP) control is the most established practice for preventing the progression and complications of chronic kidney disease (CKD). We examined the influence of BP patterns on target organ damage in hypertensive patients with CKD by using long-term follow-up data of the APrODiTe-2 study.We collected 5 years...

journal_title：Medicine

authors： Cha RH,Lee H,Lee JP,Kim YS,Kim SG

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Previous studies have demonstrated that single-nucleotide polymorphisms (SNPs) in miRNAs are related to the susceptibility to brain tumors, but the conclusions remain controversial. This study was to perform a meta-analysis to re-assess the associations between miRNA SNPs and brain tumor risk. METHODS:Relev...

journal_title：Medicine

authors： Gao F,Zhu Y

更新日期：2019-08-01 00:00:00

abstract：:The aim of this study was to assess the levels of self-perceived burden (SPB) and self-management behavior in elderly stroke survivors during the first 3 months after acute stroke, and to explore the correlation between them.A total of 203 consecutive hospitalized elderly patients diagnosed with stroke were recruited....

journal_title：Medicine

authors： Ren XR,Wei YY,Su XN,Hua Y,Shao P,Xiao T,Wang J,Ni CP,Guo HX

更新日期：2020-10-30 00:00:00

abstract：RATIONALE:West syndrome (WS) is an age-dependent epileptic encephalopathy that is characterized by intractable epileptic seizures, hypsarrhythmia, and observed through electroencephalogram (EEG) and significant neurodevelopmental regression. The spontaneous remission of epileptic seizure is clinically rare and has not ...

journal_title：Medicine

authors： Li H,Wang B,Shan L,Du L,Jia F

更新日期：2019-07-01 00:00:00

abstract：:Our aim is to determine the sufficiency, accuracy, and safety of ultrasound-guided percutaneous needle core biopsy of renal masses in Chinese patients.Patients who had undergone ultrasound-guided needle core renal mass biopsy from June 2012 to June 2016 at West China Hospital, China were retrospectively reviewed. The ...

journal_title：Medicine

authors： Wang X,Lv Y,Xu Z,Aniu M,Qiu Y,Wei B,Li X,Wei Q,Dong Q,Lin T

更新日期：2018-03-01 00:00:00

abstract：RATIONALE:Linear nevus sebaceous syndrome (LNSS) is a rare neurocutaneous syndrome, characterized by nevus sebaceous,central nervous system (CNS), ocular and skeletal abnormalities. The present study describes KRAS somatic mosaic mutation in a case of LNSS with lymphatic malformations (LMs). PATIENT CONCERNS:A 4-month...

journal_title：Medicine

authors： Lihua J,Feng G,Shanshan M,Jialu X,Kewen J

更新日期：2017-11-01 00:00:00

abstract：:The importance of bedside assistants has been well established in various robotic procedures. However, the effect of assistants on the surgical outcomes of thyroid surgery remains unclear. We investigated the effects of a dedicated robot assistant (DRA) in robotic thyroidectomy. We also evaluated the learning curve of...

journal_title：Medicine

authors： Kwon H

更新日期：2020-09-04 00:00:00

abstract：BACKGROUND:Studies showed the controversial results about the effect of common genetic polymorphisms on the atrial fibrillation (AF) recurrence. We performed the systematic review and meta-analysis to qualify the association between common genetic polymorphisms and AF recurrence. METHODS:Articles were systematically r...

journal_title：Medicine

authors： Jiang T,Wang YN,Qu Q,Qi TT,Chen YD,Qu J

更新日期：2019-06-01 00:00:00

abstract：:Endothelial dysfunction and chronic inflammatory process are prevalent in patients with end-stage renal disease (ESRD) on maintenance hemodialysis (HD). The aim of this study was to evaluate the acute and short-term effects of online hemodiafiltration (OL-HDF) versus conventional HD on endothelial function and inflamm...

journal_title：Medicine

authors： Jia P,Jin W,Teng J,Zhang H,Zou J,Liu Z,Shen B,Cao X,Ding X

更新日期：2016-04-01 00:00:00

abstract：:The aim of this study was to study the ability of the genotype to predict impairment and disability in hospitalized ischemic stroke (IS) patients after hospital discharge and 6 months after the onset of stroke symptoms.A total of 786 patients with a first IS were enrolled. Apolipoprotein E (ApoE) polymorphism was exam...

journal_title：Medicine

authors： Zhang Y,Liu S,Yue W,Shi Z,Guan Y,Li M,Ji Y,Li X

更新日期：2017-12-01 00:00:00

abstract：:Vitamin D deficiency has been associated with several adverse outcomes mainly in the outpatient setting. The objective of this study was to examine the prevalence of vitamin D deficiency and its association with risk of adverse clinical outcomes in a large prospective cohort of medical inpatients.We collected clinical...

journal_title：Medicine

authors： Graedel L,Merker M,Felder S,Kutz A,Haubitz S,Faessler L,Kaeslin M,Huber A,Mueller B,Schuetz P

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVE:DNA methylation is the earliest and most studied epigenetic modification in cancer. The literature reported that the abnormal methylation level of multiple genes was associated with poor prognosis in ovarian cancer. However, due to a small sample size, the results reported in the literature vary widely. In th...

journal_title：Medicine

authors： Feng LY,Chen CX,Li L

更新日期：2019-02-01 00:00:00

abstract：:Hypertension continues to be an important public health concern because of its associated morbidity, mortality, and economic impact on society. The aims of this study are to compare the secular changes in age-stratified hypertension prevalence, incidence, co-morbidity, and 3 years of cardiovascular outcome in Taiwan i...

journal_title：Medicine

authors： Liao CT,Wu PC,Shih JC,Cheng TJ,Wu WS

更新日期：2020-09-25 00:00:00

abstract：BACKGROUND:Since the COVID-19 outbreak in 2020, more than 20 million people worldwide have been diagnosed with COVID-19, and all health care workers are looking for ways to improve the cure rate of the disease. As an important method of rehabilitation therapy, exercise therapy has been proved to improve the level of hu...

journal_title：Medicine

authors： Qiu G,Ji Y,Tan Y,He B,Tan C,Wang Z,Gao H

更新日期：2020-12-18 00:00:00

abstract：RATIONALE:Chronic thromboembolic pulmonary hypertension (CTEPH) is rare in children and determining the underlying etiologies is essential for treatment. Venous thromboembolism, a well-known complication in nephrotic syndrome (NS), always occurrs during the treatment in course of the disease. However, CTEPH as the firs...

journal_title：Medicine

authors： Ma F,Zhou K,Hua Y,Liu X,Duan H,Li Y,Wang C

更新日期：2018-10-01 00:00:00

abstract：:[This corrects the article DOI: 10.1097/MD.0000000000004251.]. ...

journal_title：Medicine

authors：

更新日期：2016-12-09 00:00:00

abstract：:Recurrent angina (RA) has an important influence on health status of patients after percutaneous coronary intervention (PCI). This study aimed to retrospectively investigate the effect of multiple clinical factors on both short-term and long-term development of RA.A total of 398 ST-segment elevation myocardial infarct...

journal_title：Medicine

authors： Zhang J,Liu C,Pan C,Bai M,Zhang J,Peng Y,Zheng D,Zhang Z

更新日期：2016-10-01 00:00:00

abstract：:Hydatid cysts are most frequently localized within the liver and lungs, although they can also be found in highly vascularized tissues such as the brain, muscle, heart, pancreas, adrenal, and thyroid glands.A 65-year-old female patient was admitted to our clinic with complaints of a progressively growing mass that was...

journal_title：Medicine

authors： Eken H,Isik A,Balci G,Firat D,Cimen O,Soyturk M

更新日期：2016-03-01 00:00:00

abstract：:Stroke is one of the most common causes of physical disability, and early, intensive, and repetitive rehabilitation exercises are crucial to the recovery of stroke survivors. Unfortunately, research shows that only one third of stroke patients actually perform recommended exercises at home, because of the repetitive a...

journal_title：Medicine

authors： Hung YX,Huang PC,Chen KT,Chu WC

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:To investigate the efficacy and advantage of combining situ-morcellation with continuous-fill-mattress suture compared with conventional morcellation and suture in laparoscopic myomectomy. METHODS:One hundred sixteen patients who underwent laparoscopic myomectomy from March 2014 to October 2016. INTERVENTI...

journal_title：Medicine

authors： Li B,Zhang S,Ma N,Jiao Y,Zhou Y,Ni S,Han X,Liu X,Ouyang L

更新日期：2017-08-01 00:00:00

abstract：:This study is to investigate the methylation status of multiple tumor suppressor 1 (p16), secreted glycoprotein 2 (SLIT2), scavenger receptor class A, member 5 putative (SCARA5), and human runt-related transcription factor 3 (Runx3) genes in the peripheral blood of hepatocellular carcinoma (HCC).This is a case-control...

journal_title：Medicine

authors： Sun G,Zhang C,Feng M,Liu W,Xie H,Qin Q,Zhao E,Wan L

更新日期：2017-10-01 00:00:00

abstract：:To evaluate the value of lymph node status of primary tumors in predicting the prognosis of synchronous resectable metastatic colorectal cancer (mCRC).The characteristics of resectable mCRC are substantially different from other cancers, and the prognostic factors of resectable mCRC are still controversial.The data of...

journal_title：Medicine

authors： Fu J,Jiang M,Tan Y,Yang J,Wu L,Feng L,Zheng S,Yuan Y

更新日期：2015-07-01 00:00:00

abstract：:[This corrects the article DOI: 10.1097/MD.0000000000002532.]. ...

journal_title：Medicine

authors：

更新日期：2016-08-26 00:00:00

abstract：:Extra-cardiac abdominal complications are common in left-side infective endocarditis (LS-IE). The aim of this work was to study whether patients with LS-IE presenting splenic, renal, or liver (SRL) involvement seen in abdominal computed tomography (CT) had different clinical features, therapeutic plans, and outcome th...

journal_title：Medicine

authors： Parra JA,Hernández L,Muñoz P,Blanco G,Rodríguez-Álvarez R,Vilar DR,de Alarcón A,Goenaga MA,Moreno M,Fariñas MC,Spanish Collaboration on Endocarditis-Grupo de Apoyo al Manejo de la Endocarditis Infecciosa en España (GAMES).

更新日期：2018-08-01 00:00:00

abstract：INTRODUCTION:Smoking is well-known to increase cancer risk, particularly risk of lung cancer, and negatively affects efficacy of cancer treatment. However, recent evidence suggests that among cancer patients, paradoxically, smokers respond to treatment better than non-smokers. We propose to conduct a focused review and...

journal_title：Medicine

authors： Wang L,Feng H,Li J,Liu F,Liu Q,Ji J,Postlethwaite A,Gu W,Shan B

更新日期：2020-09-18 00:00:00

abstract：:The present study investigated the effectiveness of a Carisolv III + 0.5% sodium hypochlorite (NaOCl)-based root canal irrigant for smear layer removal.Forty maxillary incisors were randomly divided into 4 groups (n = 10 per group). The canals in group A (experimental) were prepared with 0.5% NaOCl, and Carisolv III a...

journal_title：Medicine

authors： Wu D,Ma YZ,Jia J,Xin BC,Wang DS,Sun DG,Wang LX

更新日期：2020-05-29 00:00:00

abstract：:Increased prevalence of metabolic syndrome was found in patients with schizophrenia. Brain-derived neurotrophic factor (BDNF) was involved in energy metabolism and the pathophysiology of schizophrenia, but differently in males and females. We aimed to investigate the serum BDNF levels in patients with schizophrenia wi...

journal_title：Medicine

authors： Lin CC,Hung YY,Tsai MC,Huang TL

更新日期：2017-06-01 00:00:00

abstract：:Acute lymphoblastic leukemia (ALL) is the most frequent pediatric malignancy. The chemotherapy for ALL is associated with a profound secondary immune deficiency.We evaluated the number and phenotype of natural killer (NK) cells at diagnosis, after the intensive chemotherapy and following the completion of the entire t...

journal_title：Medicine

authors： Koltan S,Debski R,Koltan A,Grzesk E,Tejza B,Eljaszewicz A,Gackowska L,Kubicka M,Kolodziej B,Kurylo-Rafinska B,Kubiszewska I,Wiese M,Januszewska M,Michalkiewicz J,Wysocki M,Styczynski J,Grzesk G

更新日期：2015-12-01 00:00:00

abstract：:This study investigated the prevalence of smoking, alcohol consumption, and physical activity in cancer survivors and examined the sociodemographic factors affecting these health-related behaviors.We used data from the 4th and 5th Korean National Health and Nutrition Examination Survey conducted between 2007 and 2012,...

journal_title：Medicine

authors： Park B,Kong SY,Kim J,Kim Y,Park IH,Jung SY,Lee ES

更新日期：2015-08-01 00:00:00