Abstract:
RATIONALE:West syndrome (WS) is an age-dependent epileptic encephalopathy that is characterized by intractable epileptic seizures, hypsarrhythmia, and observed through electroencephalogram (EEG) and significant neurodevelopmental regression. The spontaneous remission of epileptic seizure is clinically rare and has not previously been reported in a Chinese infant. Herein, we reported a Chinese infant with WS whose seizures disappeared following a human herpesvirus 7 (HHV-7) infection. PATIENT CONCERNS:The male Chinese infant was born at the gestational age of 36 weeks with a birth weight of 1.65 kg and an Apgar score of 7 at the first minute. At the age of 6 months, the infant developed seizures that manifested as flexor spasms with trunk involvement and mental regression. DIAGNOSIS:Brain magnetic resonance imaging revealed leukomalacia of the posterior horn and a reduction in the size of the periventricular of the bilateral ventricle and the corpus callosum. An EEG revealed hypsarrhythmia and typical spasm seizures. Therefore, the infant was diagnosed with symptomatic WS. INTERVENTIONS:The infant was treated with adequate vitamin B6 intravenous drip and oral treatment with topiramate and levetiracetam. OUTCOMES:The observed seizures disappeared spontaneously 40 days after onset, without any changes in the anti-epileptic drug treatment, following a febrile rash due to a HHV-7 infection. LESSONS:Spontaneous remission of epileptic seizures can occur following viral infection of HHV-7 in children with WS. The mechanism behind this spontaneous remission warrants further research.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Li H,Wang B,Shan L,Du L,Jia Fdoi
10.1097/MD.0000000000016441subject
Has Abstractpub_date
2019-07-01 00:00:00pages
e16441issue
28eissn
0025-7974issn
1536-5964pii
00005792-201907120-00083journal_volume
98pub_type
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