Abstract:
RATIONALE:Chronic thromboembolic pulmonary hypertension (CTEPH) is rare in children and determining the underlying etiologies is essential for treatment. Venous thromboembolism, a well-known complication in nephrotic syndrome (NS), always occurrs during the treatment in course of the disease. However, CTEPH as the first manifestation of NS has not been reported till now. PATIENT CONCERNS:A 12-year-old boy initially complained of hemoptysis, cough and shortness of breath with exertion, any symptoms regarding NS such as edema were not presented. Due to the identification of P2 enhancement, liver enlargement (2 cm below the rib) and jugular vein distension, pulmonary hypertension (PH) was firstly suspected and ultimately confirmed by detection of enlargement of right atrium (RA) and right ventricle (RV) enlargement (RA = 45mm, RV = 30mm), mild tricuspid valve regurgitation (TR) and elevation of pulmonary arterial pressure (63 mmHg) on echocardiogram. In order to search the underlying causes of PH, series of targeted laboratory evaluation and imaging were conducted, and pulmonary arterial embolism (PE) in inferior lobes of double lungs was found on chest contrast-enhanced computed tomography. DIAGNOSIS:NS was unexpectedly discovered by detection of lower serum albumin level (24.4 g/L), severe proteinuria (+++, 4.62 g/24 h) when we were searching for the predisposing factors causing thromboembolism. INTERVENTIONS AND OUTCOMES:After treatment of NS, the symptom regarding shortness of breath with exertion gradually became less apparent and was relieved one month later. Proteinuria and microscopic hematuria also disappeared. Encouragingly, RA and RV dilation, and the pulmonary arterial pressure almost returned to a normal range half a year later, with alleviation of MR. LESSONS:CTEPH can occur rarely in children and NS is an important predisposing factor. PE could be the first manifestation of NS. When pediatricians encounter children with PE or CTEPH, NS as the underlying etiology should be considered. Except for renal venous thrombosis, the possibility of PE needs to be paid more attention in children with NS.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Ma F,Zhou K,Hua Y,Liu X,Duan H,Li Y,Wang Cdoi
10.1097/MD.0000000000012349subject
Has Abstractpub_date
2018-10-01 00:00:00pages
e12349issue
41eissn
0025-7974issn
1536-5964pii
00005792-201810120-00012journal_volume
97pub_type
杂志文章相关文献
MEDICINE文献大全abstract::Determination of Fuhrman grade (FG) on biopsies of renal masses is relatively inaccurate, being prone to underestimating the true grade as ascertained from surgical specimens. This study evaluated whether anatomical features of tumors could predict tumor upgrading between core biopsies and surgical specimens. We prosp...
journal_title:Medicine
pub_type: 临床试验,杂志文章
doi:10.1097/MD.0000000000000581
更新日期:2015-02-01 00:00:00
abstract::The aim of our study was to determine whether combinations of ultrasound echocardiography (UCG) and electrocardiography (EKG) parameters correlated with the functional status of ischemic cardiomyopathy (ICM) patients according to the New York Heart Association (NYHA) classification system.We assessed 536 elderly Chine...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007071
更新日期:2017-06-01 00:00:00
abstract:RATIONALE:Tailgut cysts are a type of very rare congenital polycystic lesions that are always located posterior to the rectum and anterior to the sacrum. The symptoms of tailgut cysts are nonspecific and misleading. Therefore, a full understanding of the characteristics of tailgut cysts is important for their diagnosis...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014448
更新日期:2019-02-01 00:00:00
abstract::The enterococci, members of the group D streptococci and the predominant aerobic streptococci of the gastrointestinal and female genital tracts, have long been recognized as significant pathogens in infective endocarditis. Over the past 2 decades, enterococci have become increasingly important nosocomial pathogens, re...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:
更新日期:1988-07-01 00:00:00
abstract::Pyogenic liver abscess is a severe condition and a therapeutic challenge. Treatment failure may be due to an unrecognized ingested foreign body that migrated from the gastrointestinal tract. There has recently been a marked increase in the number of reported cases of this condition, but initial misdiagnosis as cryptog...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0b013e3181d41c38
更新日期:2010-03-01 00:00:00
abstract::Chest injuries are common and inevitable complications of chest compressions during cardiopulmonary resuscitation (CPR). This study aimed to investigate lung parenchymal and thoracic skeletal injuries after CPR by using computed tomography (CT) and to analyze the correlation between the duration of CPR and related com...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021685
更新日期:2020-08-14 00:00:00
abstract::The clinical significance of ineffective esophageal motility (IEM) together with multiple rapid swallow (MRS) has not been yet evaluated in the Chicago Classification v3.0. This study evaluated the adjunctive role of MRS in IEM and determined the criteria of abnormal MRS to maximize the utility of IEM. We analyzed 186...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001669
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:To assess the efficacy and safety of tranexamic acid (TA) in reducing blood loss and lowering transfusion needs for patients undergoing caesarean section (CS) or vaginal delivery (VD). METHODS:An electronic literature search of PubMed, EMBASE, OVID, Cochrane library, Scopus, Central, and Clinical trials.gov...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000005653
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:Dyslipidemia is a major risk factor for the development of cardiovascular disease. Both statins and omega-3 fatty acids demonstrate beneficial effects on lipid concentrations. The goal was to evaluate the safety and efficacy of combination therapy with statins and omega-3 fatty acids. METHODS:We performed a ...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000013593
更新日期:2018-12-01 00:00:00
abstract::Metabolic and respiratory acid-base disorders occur as single and mixed entities. When induced perturbations in PCO2, HCO3(-), pH, and serum electrolytes are interpreted in the light of sound physiologic principles, even the most complicated mixed disorders may be easily diagnosed. The pathophysiology underlying the s...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/00005792-198005000-00001
更新日期:1980-05-01 00:00:00
abstract:BACKGROUND:Myasthenia gravis (MG) is a progressive autoimmune disease that occurs as a result of the failure of neuromuscular transmission and is characterized by muscle weakness. There has been evidence on the correlations between the genetic predisposition of cytotoxic T lymphocyte and the antigen-4 (CTLA-4) and MG. ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010620
更新日期:2018-05-01 00:00:00
abstract:RATIONALE:Primary diffuse large B-cell lymphoma of the chest wall is extremely rare. A majority of the pleural lymphomas develop in patients with chronic tuberculous pyothorax. The underlying mechanism might be attributed to the sustained stimulation of chronic inflammation. Surgery followed by adjuvant chemotherapy ca...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000013291
更新日期:2018-11-01 00:00:00
abstract::This case series investigated the efficacy and optimal dose of Escherichia coli-derived bone morphogenetic protein-2 (E.BMP-2) as a bone graft substitute for additional posterolateral spinal fusion, accompanying interbody fusion procedures, for treating lumbar degenerative spinal stenosis. This study focused on the op...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020477
更新日期:2020-06-12 00:00:00
abstract:RATIONALE:Heterotaxy with polysplenia is an extremely rare congenital condition resulting from abnormal arrangement of organs in the abdominal and thoracic cavities during embryologic development. When a malignancy such as pancreatic cancer develops under these conditions, surgical resection becomes particularly comple...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008599
更新日期:2017-12-01 00:00:00
abstract::Although the outcome of renal transplantation in patients with systemic lupus erythematosus (SLE) has been studied, there are few reports about the outcome of patients with systemic sclerosis who have undergone renal transplantation. We retrospectively collected data from the United Network for Organ Sharing (UNOS) Sc...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/00005792-199911000-00003
更新日期:1999-11-01 00:00:00
abstract::Elevated serum homocysteine has been shown to be a risk factor for hypertension, cardiovascular disease (CVD), and type-2 diabetes mellitus (T2DM).We characterized the relationships between the serum levels of homocysteine, folic acid, and vitamins D2, D3, and B12 in patients with T2DM, CVD, and hypertension in Shangh...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002652
更新日期:2016-02-01 00:00:00
abstract::Fetuin-A is a protein with various biological functions. It plays a role in insulin resistance and arterial calcium deposition. Thyroid dysfunction may affect energy expenditure, glucose metabolism, and the risk of cardiovascular diseases. In the present study, we compared the serum fetuin-A concentrations in hyperthy...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000013254
更新日期:2018-11-01 00:00:00
abstract::Cirrhosis and idiopathic portal hypertension (IPH) are 2 major diseases showing portal hypertension. However, characteristics and outcomes of IPH with ascites have not yet been determined. The aim of the study was to examine the influence of ascites on the long-term clinical course of IPH.This observational study comp...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001056
更新日期:2015-07-01 00:00:00
abstract::Data from preclinical studies suggest that ursodeoxycholic acid (UDCA) has a chemopreventive effect on colorectal cancer (CRC) development, but no large observational study has examined this possibility. The aim of this study was to investigate the association of UDCA use with CRC risk in a nationwide population-based...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002980
更新日期:2016-03-01 00:00:00
abstract:RATIONALE:Hemolymphangioma is a rare developmental defect of combined vasal and lymphatic vasculature. It is very rare that hemolymphangioma affects the bones and bladder simultaneously, and this condition has never been reported in PubMed. PATIENT CONCERNS:A 12-year-old male has a history of hospitalization for recur...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015213
更新日期:2019-04-01 00:00:00
abstract::Subcutaneous tissue is a rare site of metastasis, accounting for only 1-2% of all lung neoplasms. Positron emission tomography (PET) using ¹⁸F-fluorodeoxyglucose (FDG) has been reported to increase the diagnostic accuracy of subcutaneous metastasis. A 58-year-old woman presented with complaints of dry coughing, in whi...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000851
更新日期:2015-05-01 00:00:00
abstract::To examine the characteristics and short-term outcome of perioperative myocardial infarction (PMI), a single-center retrospective study was carried out. The electronic medical records of 278,939 patients aged 45 years or older who underwent non-cardiac surgery at Renji Hospital from January 2003 to December 2015 were ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016929
更新日期:2019-08-01 00:00:00
abstract::Intra-arterial chemotherapy (IAC) has become an essential technique for the management of advanced intraocular retinoblastoma (RB). In this study, the aim of this article is to describe the clinical results and the short-term complications of IAC performed in our hospital.We retrospectively analyzed patients with newl...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000012676
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Well-developed coronary collateral circulation usually results in fewer infarct size, improved cardiac function, and fewer mortality. Traditional coronary risk factors (diabetes, hypertension, and smoking) have some effects on coronary collateral circulation. However, the association between these risk facto...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000010417
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:As the prevalence of total hip arthroplasty (THA) is increasing, it is usually associated with considerable blood loss. Tranexamic acid (TXA) has been reported to reduce perioperative blood loss in hip joint arthroplasty. But the best route of TXA administration continues to be controversial. So, we conducte...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000005573
更新日期:2016-12-01 00:00:00
abstract::Aberrant glycosylated IgA1 molecules, mainly galactose-deficient IgA1 (Gd-IgA1), are important causal factors in IgA nephropathy; however, the underlying mechanism for the production of aberrantly glycosylated IgA1 is unknown. A recent genome-wide association study identified a novel IgAN susceptibility gene, TNFSF13,...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003099
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Number of studies have been performed to evaluate the relationship between the cytotoxic T-lymphocyte associated antigen-4 (CTLA-4) gene variant rs5742909 polymorphism and cervical cancer risk, but the sample size was small and the results were conflicting. This meta-analysis was conducted to comprehensively...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000019433
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Tuberculosis (TB) is the leading cause of health complications and death among human with immunodeficiency virus (HIV) infection. When TB develops during pregnancy or the early postpartum period, it is associated with negative maternal, pregnancy, and fetus and infant outcome, including premature birth, low ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000023089
更新日期:2020-11-20 00:00:00
abstract::A number of studies have reported on treatment outcomes of coronary stenting (PCI) for multivessel coronary artery diseases (MVD), and compared them with the conventional coronary artery bypass grafting (CABG). However, the clinical outcomes of robot-assisted CABG (R-CABG) in comparison with PCI in MVD patients have n...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017202
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:The aim of the study was to evaluate the diagnostic accuracy of cervical elastography in predicting preterm delivery (PTD). METHODS:We searched the PubMed, EMBASE, and Cochrane databases to identify relevant studies that applied ultrasound (US) elastography to assess cervical stiffness and predict PTD. All ...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000016449
更新日期:2019-07-01 00:00:00