Hypermethylation of tumor suppressor genes is a risk factor for poor prognosis in ovarian cancer: A meta-analysis.

abstract：RATIONALE:The treatment of metastatic melanoma has been revolutionized in the past decade because of the development of immunotherapies and targeted therapies. Despite these developments, there is still an unmet clinical need for more advanced combination therapies for the subset of patients who remain resistant to imm...

journal_title：Medicine

authors： Abdou Y,Kapoor A,Hamad L,Ernstoff MS

更新日期：2019-11-01 00:00:00

abstract：:Carotid intima-media thickness (IMT) has been one widely used index of early carotid atherosclerosis. We speculated that the influence of blood pressure variability (BPV) on early carotid atherosclerosis may be varied by the location of the carotid artery and diabetes history. Thus, the goal of this study was to evalu...

journal_title：Medicine

authors： Wu D,Li C,Chen Y,Xiong H,Tian X,Wu W,Huang W,Zhang YT,Zhang H

更新日期：2016-06-01 00:00:00

abstract：:HBV (hepatitis B virus) genotyping is important in determining the clinical manifestation of disease and treatment response, particularly, in patients with low viral loads. Also, sensitive detection of HBV antiviral drug resistance mutations is essential for monitoring therapy response.Asensitive direct sequencing met...

journal_title：Medicine

authors： Tong Y,Liu B,Liu H,Zheng H,Gu J,Liu H,Lin M,Ding Y,Song C,Li Y

更新日期：2016-08-01 00:00:00

abstract：RATIONALE:Low-grade fibromyxoid sarcoma (LGFMS) is a pathological type of fibrosing fibrosarcoma that appears as a distinctive soft tissue masse with bland histological features. It is mostly located in the deep soft tissues of the extremities. Computed tomography (CT) plays an important role in diagnosing fibrosing fi...

journal_title：Medicine

authors： Wang G,Zhao Z,Wei J,Yang J

更新日期：2017-12-01 00:00:00

abstract：:Early risk stratification is crucial for appropriate management using invasive strategies in non-ST elevation myocardial infarction (NSTEMI), and electrocardiography (ECG) has been widely used for risk stratification. However, ECG findings in NSTEMI vary, and there is a need to define the clinical characteristics and ...

journal_title：Medicine

authors： Jin ES,Park CB,Kim DH,Hwang HJ,Cho JM,Sohn IS,Kim CJ

更新日期：2016-09-01 00:00:00

abstract：:The early prediction of atherosclerosis (AS) is important in the management of obstructive sleep apnea patients (OSA). MicroRNA (miRNA) plays a vital role in the evolution of OSA and AS. Its differential expression may therefore serve as a diagnostic and prognostic biomarker of AS in OSA. The aim of this study was to ...

journal_title：Medicine

authors： Li K,Chen Z,Qin Y,Wei Y

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Alopecia areata (AA) is a common, inflammatory, nonscarring type of hair loss that is characterized by depression, anxiety and social isolation. In recent years, Plum-blossom needle plus Chinese herbal medicine has gradually shown its clinical advantages and been more and more widely used in China. Whereas, ...

journal_title：Medicine

authors： Tang G,Xiong J,Fan Q,Guo H,Zhou X,Zhu S,Zhong Z,Chen J,Lu L

更新日期：2020-10-09 00:00:00

abstract：:To investigate the diurnal variations of the ocular blood flow in healthy eyes using laser speckle flowgraphy (LSFG), and to determine the relationship of the diurnal variations between the ocular blood flow and other ocular parameters.This prospective cross-sectional study was conducted at Nagoya University Hospital....

journal_title：Medicine

authors： Iwase T,Yamamoto K,Ra E,Murotani K,Matsui S,Terasaki H

更新日期：2015-02-01 00:00:00

abstract：:Oral contraceptives (OCs) following induced abortion offer a reliable method to avoid repeated abortion. However, limited data exist supporting the effective use of OCs postabortion. We conducted this systematic review and meta-analysis in the present study reported immediate administration of OCs or combined OCs post...

journal_title：Medicine

authors： Che Y,Liu X,Zhang B,Cheng L

更新日期：2016-07-01 00:00:00

abstract：:Primary squamous cell carcinoma (SCC) of liver is rare, and its prognosis is extremely poor. This study aims at reviewing the clinical data of all pathologically diagnosed liver cancer in our institute, and discussing the clinical presentation, diagnosis, treatment, and prognosis of our cases of SCC and the literature...

journal_title：Medicine

authors： Zhang XF,Du ZQ,Liu XM,Lv Y

更新日期：2015-07-01 00:00:00

abstract：RATIONALE:Subacute combined degeneration (SCD) is a disease caused by decreased vitamin B12 intake or metabolic disorders. It is more common in the elderly and rarely seen in children. Here, we report 2 pediatric cases of SCD in late-onset cobalamin C (CblC) deficiency. PATIENT CONCERNS:The patients complained of unst...

journal_title：Medicine

authors： Cui J,Wang Y,Zhang H,Cui X,Wang L,Zheng H

更新日期：2019-09-01 00:00:00

abstract：:Human and animal research indicates that exposure to early life adversity increases stress sensitivity later in life. While behavioral markers of adversity-induced stress sensitivity have been suggested, physiological markers remain to be elucidated. It is known that trapezius muscle activity increases during stressfu...

journal_title：Medicine

authors： Luijcks R,Vossen CJ,Roggeveen S,van Os J,Hermens HJ,Lousberg R

更新日期：2016-09-01 00:00:00

abstract：:Transient receptor potential vanilloid-1 (TRPV1) receptor and proteinase-activated receptor 2 (PAR2) have been implicated in the mechanism of acid-induced inflammation in gastroesophageal reflux disease (GERD). We aimed to evaluate TRPV1 and PAR2 mRNA expression levels in the GERD patients and their relationship with ...

journal_title：Medicine

authors： Kim JJ,Kim N,Choi YJ,Kim JS,Jung HC

更新日期：2016-08-01 00:00:00

abstract：:Activated nuclear factor-κB (NF-κB) is associated with the pathogenesis of numerous cancers, such as gastric cancer (GC). Genetic polymorphisms in the genomic region containing nuclear factor-κB1 (NFKB1) have a plausible role in modulating the risk of GC. To identify markers contributing to the genetic susceptibility ...

journal_title：Medicine

authors： Hua T,Qinsheng W,Xuxia W,Shuguang Z,Ming Q,Zhenxiong L,Jingjie W

更新日期：2014-12-01 00:00:00

abstract：:Hand, foot, and mouth disease (HFMD), caused by enteroviruses, is an acute contagious disease in children. Some severe infections caused by human enterovirus 71 (HEV71) lead to rapid death in children with acute heart failure (HF). N-terminal probrain natriuretic peptide (NT-proBNP) is an important indicator of HF; ho...

journal_title：Medicine

authors： Li S,Xiao Z,Li L,Hu B,Zhou Z,Yi S,Luo J,Xie L,Nie B,Mo L,Wang S

更新日期：2018-09-01 00:00:00

abstract：INTRODUCTION:The clinical treatment is complicated for patients with placenta previa who must terminate pregnancy due to fetal malformation, death, or inevitable abortion in the second trimester. It is difficult to manage excessive bleeding during pregnancy termination; and those patients face risks of removing the ute...

journal_title：Medicine

authors： Su C,Chen D

更新日期：2020-09-25 00:00:00

abstract：BACKGROUND:Gaucher disease (GD) is caused by a deficiency in the lysosomal enzyme glucocerebrosidase. Enzyme replacement therapy (ERT) is recommended for clinical improvement. METHODS:The efficacy and safety of a new imiglucerase, Abcertin, were assessed in 7 Egyptian patients with treatment-naïve type 1 GD. Each pati...

journal_title：Medicine

authors： Lee BH,Abdalla AF,Choi JH,Beshlawy AE,Kim GH,Heo SH,Megahed AMH,Elsayed MAL,Barakat TEM,Eid KMAE,El-Tagui MH,Mahmoud MMH,Fateen E,Park JY,Yoo HW

更新日期：2017-11-01 00:00:00

abstract：:The evaluation of the electrically induced bulbocavernosus reflex (BCR) using electromyography (EMG) is a useful tool for evaluating the integrity of sacral spinal segments 2 to 4, and that of their afferent and efferent connections in the urogenital region. In the current retrospective study, the value of this techni...

journal_title：Medicine

authors： Lee DG,Kwak SG,Chang MC

更新日期：2017-05-01 00:00:00

abstract：:Soft-tissue defects overlying the Achilles tendon are common complications after bicycle or motorcycle spoke injuries in children and usually require surgical management by various flaps. There is no apparent consensus on the optimal choice of flaps for these injuries. We designed a novel step-advanced rectangular fla...

journal_title：Medicine

authors： Zhang Y,Liu Y,Tian S,Song L,Peng A

更新日期：2019-10-01 00:00:00

abstract：:Immune-checkpoint inhibitor (ICI) efficacy in patients with non-small cell lung cancer (NSCLC) harboring molecular alterations remains poorly elucidated. This study was undertaken to determine ICI efficacy against epidermal growth-factor receptor (EGFR)/anaplastic lymphoma kinase (ALK)/c-ros oncogene 1 (ROS1)-mutated ...

journal_title：Medicine

authors： Bylicki O,Guisier F,Monnet I,Doubre H,Gervais R,Janicot H,Perol M,Fournel P,Lamy R,Auliac JB,Chouaid C

更新日期：2020-01-01 00:00:00

abstract：:The aim of the study was to review the distribution, current trends, and microbiological characteristics of bacterial pathogens isolated from dacryocystitis patients in China during the last 15 years.This is a retrospective multiple-center noncomparative case series. The medical records of 15,452 consecutive patients ...

journal_title：Medicine

authors： Chen L,Fu T,Gu H,Jie Y,Sun Z,Jiang D,Yu J,Zhu X,Xu J,Hong J

更新日期：2018-06-01 00:00:00

abstract：:There is still debate on whether high uric acid increases bone mineral density (BMD) against osteoporotic fracture or bone resorption caused by gout inflammation. This study aimed to evaluate whether gout offers a protective effect on bone health or not. We conducted a nationwide population-based retrospective cohort ...

journal_title：Medicine

authors： Tzeng HE,Lin CC,Wang IK,Huang PH,Tsai CH

更新日期：2016-08-01 00:00:00

abstract：:Hypertension should be best managed under primary care settings. This study aimed to compare, between Shanghai and Shenzhen, the perceived quality of primary care in terms of accessibility, continuity, co-ordination, and comprehensiveness among hypertensive patients.A cross-sectional study was conducted in Shanghai an...

journal_title：Medicine

authors： Li H,Wei X,Wong MC,Wong SY,Yang N,Griffiths SM

更新日期：2015-08-01 00:00:00

abstract：:Dysphagia can occur among patients receiving medical care despite having no history of neurologic disease. The current study aimed to investigate factors contributing to airway invasion among non-neurologically ill patients with dysphagia.This retrospective study included 52 non-neurologically ill patients who complai...

journal_title：Medicine

authors： Kim KL,Park GY,Kwon DR,Kwon DY,Kwak SG,Cho HK

更新日期：2020-11-06 00:00:00

abstract：RATIONALE:Extracorporeal membrane oxygenation (ECMO) can deliver effective respiratory and circulatory maintenance to organ donors, improve organ function, and shorten warm ischemic time before harvesting. However, ECMO-supported brain-dead donors (DBDs) still have a high risk of acute kidney injury related to decrease...

journal_title：Medicine

authors： Chiang PJ,Tang SH,Li CC,Chou MH,Lin YC,Wu ST

更新日期：2018-06-01 00:00:00

abstract：:In this study, we evaluate the efficacy of short-course radiotherapy (SCRT) versus long-course radiotherapy (LCRT) in the treatment of metastatic spinal cord compression (MSCC).PubMed, EMBASE, and Web of Science were searched up to April 2015. Relevant data were extracted based on inclusion and exclusion criteria. Met...

journal_title：Medicine

authors： Qu S,Meng HL,Liang ZG,Zhu XD,Li L,Chen LX,Zhou ZR

更新日期：2015-10-01 00:00:00

abstract：:To determine which polysomnography parameters are associated with severity of hypertension.This retrospective study collected data on all patients admitted to our urban, academic center in Beijing with hypertension who had undergone polysomnograms (PSG) and were diagnosed with obstructive sleep apnea (OSA) (apnea-hypo...

journal_title：Medicine

authors： Wu H,Zhan X,Zhao M,Wei Y

更新日期：2016-11-01 00:00:00

abstract：:Nuclear factor-κB-inducing kinase (NIK) is a new regulator of nuclear factor-κB signaling, which plays an important role in tumorigenesis. This study aimed to examine the expression of NIK in gastric cancer and investigate its clinical significance.Tumor issues were collected from 80 gastric cancer patients who receiv...

journal_title：Medicine

authors： Teng H,Xue L,Wang Y,Ding X,Li J

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:Systematically review and Grading of Recommendations Assessment, Development, and Evaluation (GRADE) studies on prophylactic negative pressure wound therapy (pNPWT) to prevent surgical site infections (SSIs). INTRODUCTION:pNPWT has been suggested as a new method to prevent wound complications, specifically S...

journal_title：Medicine

authors： De Vries FEE,Wallert ED,Solomkin JS,Allegranzi B,Egger M,Dellinger EP,Boermeester MA

更新日期：2016-09-01 00:00:00

abstract：:Tuberculosis (TB) disease may be transmitted to close contacts of index cases, causing physical illness. No studies have investigated the risk of developing depressive disorder among TB contacts in a TB-endemic area.Adult participants with a new diagnosis of TB contact (ICD-9-CM codes V01.1 plus chest radiographic ord...

journal_title：Medicine

authors： Pan SW,Yen YF,Feng JY,Su VY,Kou YR,Su WJ

更新日期：2015-10-01 00:00:00