Comparison of Short-Course Radiotherapy Versus Long-Course Radiotherapy for Treatment of Metastatic Spinal Cord Compression: A Systematic Review and Meta-Analysis.


:In this study, we evaluate the efficacy of short-course radiotherapy (SCRT) versus long-course radiotherapy (LCRT) in the treatment of metastatic spinal cord compression (MSCC).PubMed, EMBASE, and Web of Science were searched up to April 2015. Relevant data were extracted based on inclusion and exclusion criteria. Methodological quality of randomized controlled trial (RCT) was evaluated using modified Jadad scale; non-RCT was evaluated using Newcastle-Ottawa Scale. Meta-analysis was performed using RevMan 5.3 software.Fourteen studies with 2239 patients were included. Results of meta-analysis showed that there were no significant differences between SCRT and long-course radiotherapy LCRT in 6-month overall survival rate (risk ratio [RR] = 0.97, 95% confidence interval [CI] 0.88, 1.07, P = 0.55), 1-year overall survival rate (RR = 0.94, 95% CI 0.85, 1.04, P = 0.22), motor function improvement (RR = 0.96, 95% CI 0.81, 1.13, P = 0.63), no change on motor function (RR = 0.98, 95% CI (0.88, 1.09), P = 0.74], and deterioration on motor function (RR = 0.96, 95% CI 0.71, 1.31, P = 0.78). Compared with SCRT, LCRT significantly increased 6-month local control rate (RR = 0.87, 95% CI 0.80, 0.95, P = 0.002), 1-year local control rate (RR = 0.83, 95% CI 0.71, 0.97, P = 0.02), and 2-year local control rate (RR = 0.83, 95% CI 0.79, 0.87, P < 0.00001).Both LCRT and SCRT provided similar survival rates and functional outcome, but LCRT showed better local control rates than SCRT. However, considering low cost and good patient's compliance, SCRT may be a better choice.


Medicine (Baltimore)




Qu S,Meng HL,Liang ZG,Zhu XD,Li L,Chen LX,Zhou ZR




Has Abstract


2015-10-01 00:00:00
















  • Biomechanical effect of bone resorption of the spinous process after single-segment interspinous dynamic stabilization device implantation: A finite element analysis.

    abstract::This study aims to explore the influence of bone resorption of the spinous process after single-segment interspinous process device (IPD) implantation on the biomechanics of the lumbar spine.The 3D finite element model of the lumbar spine (L3-L5) was modified, and 2 models that simulated the presence and absence of bo...


    pub_type: 杂志文章


    authors: Zhu ZQ,Duan S,Wang KF,Liu HY,Xu S,Liu CJ

    更新日期:2018-07-01 00:00:00

  • Applicability of the masseter muscle as a nutritional biomarker.

    abstract::Nutritional assessment is feasible with computed tomography anthropometry. The abdominal muscle at the L3 vertebra is a well-known nutritional biomarker for predicting the prognosis of various diseases, especially sarcopenia. However, studies on nutritional assessment of the brain using computed tomography are still s...


    pub_type: 杂志文章


    authors: Hwang Y,Lee YH,Cho DH,Kim M,Lee DS,Cho HJ

    更新日期:2020-02-01 00:00:00

  • Early diagnosis and follow-up of chronic active Epstein-Barr-virus-associated cardiovascular complications with cardiovascular magnetic resonance imaging: A case report.

    abstract:INTRODUCTION:Chronic active Epstein-Barr virus (EBV) infection (CAEBV) is characterized as chronic or recurrent mononucleosis-like symptoms and elevated EBV deoxyribonucleic acid (EBV-DNA) copies. Cardiovascular complications have high morbidity and mortality. The treatment regimen for CAEBV has not been established ye...


    pub_type: 杂志文章,评审


    authors: Jiang S,Li X,Cao J,Wu D,Kong L,Lin L,Jin Z,An J,Wang Y

    更新日期:2016-08-01 00:00:00

  • Negative pressure wound therapy combined with skin grafting improves surgical wound healing in the perianal area.

    abstract::Management of large tissue defects resulting from local wide resection of perianal is a clinical challenge for surgeons. The aim of the present study was to investigate the efficacy of negative pressure wound therapy (NPWT) following skin grafting on perianal surgical wound healing.Included in this study were 12 patie...


    pub_type: 杂志文章


    authors: Jia-Zi S,Xiao Z,Jun-Hui L,Chun-Yu X,Hong-da B

    更新日期:2016-08-01 00:00:00

  • Poorer prognosis in patients with advanced gastric squamous cell carcinoma compared with adenocarcinoma of the stomach: Case report.

    abstract:RATIONALE:Primary squamous cell carcinoma (SCC) of the stomach is a rare disease. The pathogenesis and prognosis of advanced SCC remains to be elucidated. The aim of the current study was to investigate the prognosis of recurrent or metastatic SCC of the stomach. PATIENT CONCERNS:A retrospective study examined the cli...


    pub_type: 杂志文章


    authors: Meng Y,Zhang J,Wang H,Zhang Y,Sun R,Zhang Z,Gao F,Huang C,Zhang S

    更新日期:2017-12-01 00:00:00

  • D-Dimer Can Serve as a Prognostic and Predictive Biomarker for Metastatic Gastric Cancer Treated by Chemotherapy.

    abstract::Systemic activation of hemostasis and thrombosis has been implicated in tumor progression and metastasis. D-dimer has been used as an indicator for the thrombosis. Here, we investigated the role of the activation of coagulation in patients with metastatic gastric cancer by measuring D-dimer level.We conducted an obser...


    pub_type: 杂志文章


    authors: Go SI,Lee MJ,Lee WS,Choi HJ,Lee US,Kim RB,Kang MH,Kim HG,Lee GW,Kang JH,Lee JH,Kim SJ

    更新日期:2015-07-01 00:00:00

  • Sex-specific association of monocyte count to high-density lipoprotein ratio with SYNTAX score in patients with suspected stable coronary artery disease.

    abstract::Recently, the monocyte count to high-density lipoprotein cholesterol ratio (MHR) was found to be associated with the SYNTAX score in patients with both stable coronary artery disease (CAD) and acute coronary syndrome (ACS). The MHR was significantly higher in male patients. However, the sex-specific association of MHR...


    pub_type: 杂志文章


    authors: Xu W,Guan H,Gao D,Pan J,Wang Z,Alam M,Lian J,Zhou J

    更新日期:2019-10-01 00:00:00

  • Long-term results of irrigated bipolar radiofrequency ablation in patients with recurrent arrhythmia after failed unipolar ablation.

    abstract:INTRODUCTION:The RF ablation of ventricular tachycardia (VT) or atrial flutter (AFl) can be unsuccessful due to lack of lesion transmurality. Bipolar ablation (BA) is more successful than unipolar ablation (UA). The purpose of our study was to investigate the long-term effect of BA ablation in patients after failed UA....


    pub_type: 杂志文章


    authors: Baszko A,Kochman K,Królak T,Kałmucki P,Telec W,Ożegowski S,Szyszka A

    更新日期:2020-05-22 00:00:00

  • Parotid ductal stenosis after facial cosmetic surgery (2 case reports).

    abstract:RATIONALE:Facial cosmetic surgery sometimes causes complications involving surrounding tissues. In particular, parotid damage may cause fibrous tissue formation, ductal stenosis, and obstruct salivary flow. Affected patients usually complain of symptoms such as pain and swelling. PATIENT CONCERNS:The authors report 2 ...


    pub_type: 杂志文章


    authors: Choi JS,Kim YM,Lim JY

    更新日期:2019-04-01 00:00:00

  • A strobe multicenter descriptive study of 55 infectious aortitis.

    abstract::Infectious aortitis (IA) is a rare and severe disease. The treatment classically associates open surgery with prolonged antibiotic therapy. This study aimed to describe clinical characteristics, medical and surgical supports in a large and current series of IA.We conducted a retrospective multicenter study of native a...


    pub_type: 杂志文章,多中心研究


    authors: Journeau L,de la Chapelle M,Guimard T,Ferfar Y,Saadoun D,Mahé I,Castier Y,Montravers P,Lescure X,Van Gysel D,Asseray N,Lascarrou JB,Ngohou C,Vandamme YM,Connault J,Cepoy PD,Brochard J,Goueffic Y,Pistorius MA,Boutoil

    更新日期:2020-10-02 00:00:00

  • The association between rs12885713 polymorphism in CALM1 and risk of osteoarthritis: A meta-analysis of case-control studies.

    abstract:OBJECTIVE:The single nucleotide polymorphism (SNP) rs12885713 of calmodulin 1 gene (CALM1) has been reported to involve in the etiology of osteoarthritis (OA) in several association studies with limited sample size and conflicting results. The purpose of the present systematic review and meta-analysis was to evaluate a...


    pub_type: 杂志文章,meta分析,评审


    authors: Shi J,Gao ST,Lv ZT,Sheng WB,Kang H

    更新日期:2018-09-01 00:00:00

  • CHRNE compound heterozygous mutations in congenital myasthenic syndrome: A case report.

    abstract:RATIONALE:Congenital myasthenic syndrome (CMSs) are a group of rare genetic disorders of the neurological junction, which can result in structural or functional weakness. Here, we characterized a case of CMS in order to clarify the diagnosis and expand the understanding of it. The molecular diagnosis had implications f...


    pub_type: 杂志文章


    authors: Yang K,Cheng H,Yuan F,Meng L,Yin R,Zhang Y,Wang S,Wang C,Lu Y,Xi J,Lu Q,Chen Y

    更新日期:2018-04-01 00:00:00

  • Successful treatment of sudden sensorineural hearing loss by means of pharmacotherapy combined with early hyperbaric oxygen therapy: Case report.

    abstract:RATIONALE:According to the World Health Organization reports, adult-onset hearing loss is the 15th leading cause of burden of disease, and is projected to move up to 7th by the year 2030, especially in high-income countries. Sudden sensorineural hearing loss is considered by otologists as a true otologic emergency. The...


    pub_type: 杂志文章


    authors: Olex-Zarychta D

    更新日期:2017-12-01 00:00:00

  • Recurrence of anti-MDA5 antibody-positive clinically amyopathic dermatomyositis after long-term remission: A case report.

    abstract:RATIONALE:Among all dermatomyositis (DM) patients, antimelanoma differentiation-associated gene 5 antibody (anti-MDA5 Ab) positive patients have significantly poor short-term mortality, whereas they experience less relapses over the long term after the remission. We report the case of a patient with anti-MDA5 Ab-positi...


    pub_type: 杂志文章


    authors: Endo Y,Koga T,Ishida M,Fujita Y,Tsuji S,Takatani A,Shimizu T,Sumiyoshi R,Igawa T,Umeda M,Fukui S,Nishino A,Kawashiri SY,Iwamoto N,Ichinose K,Tamai M,Nakamura H,Origuchi T,Kuwana M,Hosono Y,Mimori T,Kawakami A

    更新日期:2018-06-01 00:00:00

  • The relationship between HER2 overexpression and angiogenesis in gastric cancer.

    abstract::In gastric cancer, HER2 protein overexpression is considered to be conducive to the higher proliferation activity of the tumor cells. Tumor formation is associated with angiogenesis in order to secure an abundant supply of oxygen and glucose to cancer cells. The aim of the study was to assess if HER2 overexpression is...


    pub_type: 杂志文章


    authors: Ciesielski M,Szajewski M,Pęksa R,Lewandowska MA,Zieliński J,Walczak J,Szefel J,Kruszewski WJ

    更新日期:2018-10-01 00:00:00

  • Aldehyde dehydrogenase 1 as a predictor of the neoadjuvant chemotherapy response in breast cancer: A meta-analysis.

    abstract:BACKGROUND:Many reports suggest that aldehyde dehydrogenase 1 (ALDH1) expression is associated with poorer neoadjuvant chemotherapy (NAC) response in patients with breast cancer; however, the prognostic value of this enzyme in cancer has yet to be confirmed. Therefore, we conducted a meta-analysis of related studies to...


    pub_type: 杂志文章,meta分析,评审


    authors: Li J,Zhang B,Yang YF,Jin J,Liu YH

    更新日期:2018-08-01 00:00:00

  • Bioinformatics analysis to identify the critical genes, microRNAs and long noncoding RNAs in melanoma.

    abstract::Melanoma, which is usually induced by ultraviolet light exposure and the following DNA damage, is the most dangerous skin cancer. The purpose of the present study was to screen key molecules involved in melanoma.Microarray data of E-MTAB-1862 were downloaded from the ArrayExpress database, which included 21 primary me...


    pub_type: 杂志文章


    authors: Zhang Q,Wang Y,Liang J,Tian Y,Zhang Y,Tao K

    更新日期:2017-07-01 00:00:00

  • Management of iatrogenic renal arteriovenous fistula and renal arterial pseudoaneurysm by transarterial embolization: A single center analysis and outcomes.

    abstract::The purpose of this study was to evaluate the efficacy and safety of transarterial embolization (TAE) for iatrogenic renal arterial pseudoaneurysm and arteriovenous fistula at our center.Our retrospective analysis included 27 patients who received TAE for iatrogenic renal arterial pseudoaneurysm and arteriovenous fist...


    pub_type: 杂志文章


    authors: Guo H,Wang C,Yang M,Tong X,Wang J,Guan H,Song L,Zou Y

    更新日期:2017-10-01 00:00:00

  • Seasonal variations of severe hypoglycemia in patients with type 1 diabetes mellitus, type 2 diabetes mellitus, and non-diabetes mellitus: clinical analysis of 578 hypoglycemia cases.

    abstract::Blood glucose control in patients with diabetes mellitus (DM) is reportedly influenced by the seasons, with hemoglobin A1c (HbA1c) levels decreasing in the summer or warm season and increasing in the winter or cold season. In addition, several studies have shown that sepsis is also associated with the seasons. Althoug...


    pub_type: 杂志文章


    authors: Tsujimoto T,Yamamoto-Honda R,Kajio H,Kishimoto M,Noto H,Hachiya R,Kimura A,Kakei M,Noda M

    更新日期:2014-11-01 00:00:00

  • Sonography-guided trigger point injections in abdominal myofascial pain syndrome.

    abstract::Even though chronic abdominal pain is 1 of the most common reasons for hospital visits, diagnostic testing is often time-consuming and treatment is inadequate. Abdominal myofascial pain syndrome (AMPS) is usually not included as a differential diagnosis, but it should be considered in cases of chronic abdominal pain. ...


    pub_type: 杂志文章


    authors: Rhim HC,Cha JH,Cha J,Kim DH

    更新日期:2020-12-04 00:00:00

  • Transphyseal anterior cruciate ligament reconstruction in adolescents with substantial remaining growth causes temporary growth arrest resulting in subclinical leg-length discrepancy.

    abstract::The purpose of the present study was to investigate the characteristics of growth disturbances in patients with remaining growth after transphyseal anterior cruciate ligament (ACL) reconstruction who were confirmed to have no definite postoperative physeal abnormalities on magnetic resonance imaging (MRI).Forty adoles...


    pub_type: 杂志文章


    authors: Jeon JY,Lee J,Kang MS

    更新日期:2019-06-01 00:00:00

  • Approach to diagnosis of factitious disorder with unexplained hemoptysis: A case report.

    abstract:RATIONALE:Hemoptysis or hematemesis is a common clinical symptom in adults, but is unusually to be observed in children. Hemoptysis can occur with circulatory diseases, injuries, several types of systemic diseases, or systemic factors including factitious disorder (FD), which is difficult to be diagnosed. Here, we repo...


    pub_type: 杂志文章


    authors: Yue P,Zhou K,Hua Y,Fang J,Li Y

    更新日期:2019-02-01 00:00:00

  • Successful treatment of a critically ill patient with acute respiratory distress syndrome from COVID-19 using mechanical ventilation strategy with low levels of positive end-expiratory pressure: A CARE-compliant case report.

    abstract:INTRODUCTION:Acute respiratory distress syndrome (ARDS) secondary to COVID-19 is different from the ARDS caused by other infections. Conventional mechanical ventilation strategies using high levels of PEEP may not be beneficial and can even be harmful to patient with ARDS from COVID-19. So the ventilation strategies sh...


    pub_type: 杂志文章


    authors: Guo WG,Fang B,Xian YS,Yu ZH,Zhou LX

    更新日期:2020-12-04 00:00:00

  • Bioinformatic analysis of the pathogenic mechanism of talaromyces marneffei infection.

    abstract:BACKGROUND:Talaromyces marneffei (T marneffei), known as a significant pathogen in patients with AIDS in Southeast Asia, is a dimorphic fungus, which can cause deadly systematic infection in immunocompromised hosts. What is more, the dimorphic phase transition has been reported as a conspicuous process linked with viru...


    pub_type: 杂志文章


    authors: Cen J,Chen J,Qiu Y,Zeng W,Zhang J

    更新日期:2020-11-25 00:00:00

  • The effect of care intervention for obese patients with type II diabetes.

    abstract::The incidence of type II diabetes mellitus (T2DM) is increasing worldwide and affecting the quality of people's life. This study was designed to evaluate the effect of care intervention on body weight and glycemic parameters in obese T2DM patients.One hundred twenty-six obese T2DM cases were randomly divided into 2 gr...


    pub_type: 杂志文章,随机对照试验


    authors: Jiang X,Fan X,Wu R,Geng F,Hu C

    更新日期:2017-10-01 00:00:00

  • Diagnosis and treatment of gastrointestinal stromal tumor extending to prostate: A case report and literature review.

    abstract:RATIONALE:Gastrointestinal stromal tumor (GIST) is the neoplasm of gastrointestinal tract. PATIENT CONCERNS:The patient complained about the retention of urinary. DIAGNOSES:GIST. INTERVENTIONS:radical prostatectomy and the imatinib therapy. OUTCOMES:No recurrence and metastasis have been found during a 14-month fol...


    pub_type: 杂志文章


    authors: Xu H,Liu C,Chen Y,Gu M,Cai Z,Chen Q,Wang Z

    更新日期:2016-11-01 00:00:00

  • Thoracolumbar traumatic nucleus pulposus sequestration combined with a slight flexion distraction fracture: A rare case report and literature review.

    abstract:RATIONALE:Traumatic nucleus pulposus sequestration (TNPS) usually occurs concurrently with severe destruction of bone. TNPS combined with a slight thoracolumbar flexion- distraction fracture, triggering a disastrous nerve injury, has rarely been reported. Due to the atypical radiologic manifestations, such a patient ca...


    pub_type: 杂志文章


    authors: Yin R,Chang P,Zhu Q,Cheng F,Zhao B,Gu R,Zhang BY

    更新日期:2018-06-01 00:00:00

  • Emphysematous prostatic abscess due to candidiasis: A case report and review of the literature.

    abstract:RATIONALE:The emphysematous prostatic abscess is a rare but potentially life-threatening clinical condition. The early diagnosis is difficult due to nonspecific symptoms. PATIENT CONCERNS:A 72-year-old man with poorly controlled diabetes mellitus was admitted to hospital because of dysuria and acute urine retention. H...


    pub_type: 杂志文章,评审


    authors: Li Z,Wen J,Zhang N

    更新日期:2020-02-01 00:00:00

  • Volume-Based F-18 FDG PET/CT Imaging Markers Provide Supplemental Prognostic Information to Histologic Grading in Patients With High-Grade Bone or Soft Tissue Sarcoma.

    abstract::The aim of the study is to assess the prognostic value of different volume-based calculations of tumor metabolic activity in the initial assessment of patients with high-grade bone sarcomas (BS) and soft tissue sarcomas (STS) using F-18 FDG PET/CT.A single-site, retrospective study from 2002 to 2012 including 92 patie...


    pub_type: 杂志文章


    authors: Andersen KF,Fuglo HM,Rasmussen SH,Petersen MM,Loft A

    更新日期:2015-12-01 00:00:00

  • Comparison of Direct Anterior and Lateral Approaches in Total Hip Arthroplasty: A Systematic Review and Meta-Analysis (PRISMA).

    abstract::The direct anterior approach (DAA) to total hip arthroplasty has been promoted as a minimally invasive alternative to the lateral approach, which we sought to verify by systematically reviewing and meta-analyzing the literature comparing clinical, radiographic, and surgical outcomes. Two reviewers independently search...


    pub_type: 杂志文章,meta分析,评审


    authors: Yue C,Kang P,Pei F

    更新日期:2015-12-01 00:00:00