Comparison of Short-Course Radiotherapy Versus Long-Course Radiotherapy for Treatment of Metastatic Spinal Cord Compression: A Systematic Review and Meta-Analysis.


:In this study, we evaluate the efficacy of short-course radiotherapy (SCRT) versus long-course radiotherapy (LCRT) in the treatment of metastatic spinal cord compression (MSCC).PubMed, EMBASE, and Web of Science were searched up to April 2015. Relevant data were extracted based on inclusion and exclusion criteria. Methodological quality of randomized controlled trial (RCT) was evaluated using modified Jadad scale; non-RCT was evaluated using Newcastle-Ottawa Scale. Meta-analysis was performed using RevMan 5.3 software.Fourteen studies with 2239 patients were included. Results of meta-analysis showed that there were no significant differences between SCRT and long-course radiotherapy LCRT in 6-month overall survival rate (risk ratio [RR] = 0.97, 95% confidence interval [CI] 0.88, 1.07, P = 0.55), 1-year overall survival rate (RR = 0.94, 95% CI 0.85, 1.04, P = 0.22), motor function improvement (RR = 0.96, 95% CI 0.81, 1.13, P = 0.63), no change on motor function (RR = 0.98, 95% CI (0.88, 1.09), P = 0.74], and deterioration on motor function (RR = 0.96, 95% CI 0.71, 1.31, P = 0.78). Compared with SCRT, LCRT significantly increased 6-month local control rate (RR = 0.87, 95% CI 0.80, 0.95, P = 0.002), 1-year local control rate (RR = 0.83, 95% CI 0.71, 0.97, P = 0.02), and 2-year local control rate (RR = 0.83, 95% CI 0.79, 0.87, P < 0.00001).Both LCRT and SCRT provided similar survival rates and functional outcome, but LCRT showed better local control rates than SCRT. However, considering low cost and good patient's compliance, SCRT may be a better choice.


Medicine (Baltimore)




Qu S,Meng HL,Liang ZG,Zhu XD,Li L,Chen LX,Zhou ZR




Has Abstract


2015-10-01 00:00:00
















  • Influence of gum-chewing on postoperative bowel activity after laparoscopic surgery for gastric cancer: A randomized controlled trial.

    abstract:BACKGROUND:In some studies, gum-chewing was demonstrated to have a beneficial effect on resumption of bowel function; however, other contradictory findings in other studies refute the effects of gum-chewing on peristaltic movements and digestive system stimulation. In addition, most previous studies were after colorect...


    pub_type: 杂志文章,随机对照试验


    authors: Ge B,Zhao H,Lin R,Wang J,Chen Q,Liu L,Huang Q

    更新日期:2017-03-01 00:00:00

  • Identification of novel biomarkers correlated with prostate cancer progression by an integrated bioinformatic analysis.

    abstract::Prostate cancer (PCa) is a highly aggressive malignant tumor and the biological mechanisms underlying its progression remain unclear.We performed weighted gene co-expression network analysis in PCa dataset from the Cancer Genome Atlas database to identify the key module and key genes related to the progression of PCa....


    pub_type: 杂志文章


    authors: Ma Z,Wang J,Ding L,Chen Y

    更新日期:2020-07-10 00:00:00

  • Predictors of lymph nodes posterior to the right recurrent laryngeal nerve metastasis in patients with papillary thyroid carcinoma: A retrospective study.

    abstract::The aim of this study was to identify the risk factors associated with lymph nodes posterior to the right recurrent laryngeal nerve (LN-prRLN) metastasis in patients with papillary thyroid carcinoma (PTC).A total of 81 PTC patients who underwent total/near-total thyroidectomy with LN-prRLN dissection in the Department...


    pub_type: 杂志文章


    authors: Yuan J,Li J,Chen X,Zhong Z,Chen Z,Yin Y,Du J,Cong S,Wu Z

    更新日期:2017-09-01 00:00:00

  • Non-pharmacological interventions for patients with dementia: A protocol for a systematic review and meta-analysis.

    abstract:BACKGROUND:This protocol for a systematic review describes the methods that will be used to evaluate the efficacy and safety of non-pharmacological interventions for patients with dementia. METHODS:We will search ALOIS, the specialized register of the Cochrane Dementia and Cognitive Improvement Group (CDCIG), without ...


    pub_type: 杂志文章,meta分析


    authors: Lee GE,Kim JY,Jung JH,Kang HW,Jung IC

    更新日期:2019-09-01 00:00:00

  • Effect of acupuncture on in vitro fertilization: An updated systematic review and data mining protocol.

    abstract:BACKGROUND:Although many patients try to seek acupuncture to improve in vitro fertilization (IVF) outcomes, evidence regarding its efficacy and acupoints characters are lacking. The aim of this protocol is to evaluate the effectiveness and safety, as well as the acupoints characteristics of acupuncture in the treatment...


    pub_type: 杂志文章


    authors: Wang X,Lin H,Chen M,Wang J,Jin Y

    更新日期:2018-06-01 00:00:00

  • Coinfection with cryptococcus and aspergillus in an immunocompetent adult: A case report.

    abstract:RATIONALE:Aspergillus and Cryptococcus exposure can cause serious secondary infections in human lungs, especially in immunocompromised patients or in conjunction with a chronic disease caused by low disease resistance. Primary invasive fungal infections are clinically rare; therefore, coexistence of 2 fungi at an infec...


    pub_type: 杂志文章


    authors: Wang Q,Wang Z,Hao Y,Li W,Xin T,Chen M,Gao P

    更新日期:2018-09-01 00:00:00

  • X-linked hypophosphatemia: a clinical, biochemical, and histopathologic assessment of morbidity in adults.

    abstract::Research and management of XLH have concentrated on the disease in childhood, and the natural history and morbidity of XLH in adult life are thus poorly understood. We have studied 22 adults (6 men) with XLH to clarify these aspects of this most common inherited form of rickets and osteomalacia. Most study participant...


    pub_type: 杂志文章


    authors: Reid IR,Hardy DC,Murphy WA,Teitelbaum SL,Bergfeld MA,Whyte MP

    更新日期:1989-11-01 00:00:00

  • Effect of auriculotherapy on chronic low back pain: A protocol for systematic review and meta-analysis.

    abstract:BACKGROUND:Chronic low back pain (CLBP) is a clinically common and recurrent disease. However, many trials have shown that auriculotherapy (AT) can effectively treat CLBP. There are currently no systematic reviews of this therapy. The plan aims to evaluate the effectiveness and safety of this treatment in patients with...


    pub_type: 杂志文章


    authors: Zhang G,Zhang L,Deng Y,Shen Y,Wang X,Yu Y

    更新日期:2020-04-01 00:00:00

  • Correlation analysis and clinical significance of CA125, HE4, DDI, and FDP in type II epithelial ovarian cancer.

    abstract::Ovarian cancer is one of the common female malignant tumors. The early diagnosis and treatment of ovarian cancer has been a research hotspot. Therefore, we aimed to investigate the correlations between the levels of carbohydrate antigen 125 (CA125), human epididymis protein 4 (HE4), D-dimer (DDI), and fibrinogen degra...


    pub_type: 杂志文章


    authors: Qiao L,Chen X,Xi X,Chen X,Zhang P,Dong H,Wu X,Chen X

    更新日期:2020-12-04 00:00:00

  • Salivary alpha-amylase, salivary cortisol, and anxiety during a youth taekwondo championship: An observational study.

    abstract::The aim of this study was to assess the stress-related responses and the coach's capability to match perceived efforts of youth athletes during a taekwondo championship.Using a cross-sectional study design, salivary cortisol (sC) and alpha-amylase (sAA) were measured in 6 males and 3 females young (11.0 ± 0.9 years) a...


    pub_type: 杂志文章


    authors: Capranica L,Condello G,Tornello F,Iona T,Chiodo S,Valenzano A,De Rosas M,Messina G,Tessitore A,Cibelli G

    更新日期:2017-07-01 00:00:00

  • Peritoneal epithelioid angiosarcoma: A case report.

    abstract:INTRODUCTION:Peritoneal angiosarcoma is an extremely rare sarcoma (0.01287% incidence per 100,000) with an aggressive course and a poor prognosis. In this case, the manifestation of peritoneal angiosarcoma was ascites, which caused difficulty in early diagnosis and the diagnosis of peritoneal angiosarcoma, was made onl...


    pub_type: 杂志文章


    authors: Chen WJ,Wu IC,Wu CC,Yu FJ

    更新日期:2018-09-01 00:00:00

  • Treatment for acute flares of gout: A protocol for systematic review.

    abstract:INTRODUCTION:The current evidence confirms the effectiveness and safety of several drug interventions in the treatment of acute flares of gout, however, the most preferred drugs are still unclear. We, therefore, seek to conduct a network meta-analysis that can systematically compare non-steroidal anti-inflammatory drug...


    pub_type: 杂志文章


    authors: Tang H,Xu G,Zheng Q,Cheng Y,Zheng H,Li J,Yin Z,Liang F,Chen J

    更新日期:2020-04-01 00:00:00

  • Five known tagging DLL3 SNPs are not associated with congenital scoliosis: A case-control association study in a Chinese Han population.

    abstract::Genetic etiology hypothesis is widely accepted in the development of congenital scoliosis (CS). The delta-like 3 (DLL3) gene, a member of the Notch signaling pathway, was implicated to contribute to human CS. In this study, a case-control association study was conducted to determine the association of single nucleotid...


    pub_type: 杂志文章


    authors: Yang Y,Wang BQ,Wu ZH,Zhang HY,Qiu GX,Shen JX,Zhang JG,Zhao Y,Wang YP,Fei Q

    更新日期:2016-07-01 00:00:00

  • Extralobar pulmonary sequestration with elevated serum neuron-specific enolase: A case report and review of the literature.

    abstract:RATIONALE:Pulmonary sequestration (PS) presenting with elevated serum tumor markers is rare, and it might be misdiagnosed as malignancy. PATIENT CONCERNS:A 26-year-old asymptomatic male patient was admitted because the x-ray showed an intrathoracic lesion. Meanwhile, the serum neuron-specific enolase (NSE) was elevate...


    pub_type: 杂志文章,评审


    authors: Kong FW,Wang WM,Gong L,Wu W,Zhang M

    更新日期:2020-10-02 00:00:00

  • Overall prevalence of human parvovirus B19 among blood donors in mainland China: A PRISMA-compliant meta-analysis.

    abstract:BACKGROUND:Human parvovirus B19 (B19V) infection exhibits a broad range of clinical outcomes. Blood transfusion is a common route of B19V transmission. However, information about the overall prevalence of B19V infection and B19V genotypes among blood donors in mainland China is lacking. METHODS:This meta-analysis was ...


    pub_type: 杂志文章,meta分析


    authors: Li X,Lin Z,Liu J,Tang Y,Yuan X,Li N,Lin Z,Chen Y,Liu A

    更新日期:2020-04-01 00:00:00

  • A systematic review and meta-analysis including GRADE qualification of the risk of surgical site infections after prophylactic negative pressure wound therapy compared with conventional dressings in clean and contaminated surgery.

    abstract:OBJECTIVE:Systematically review and Grading of Recommendations Assessment, Development, and Evaluation (GRADE) studies on prophylactic negative pressure wound therapy (pNPWT) to prevent surgical site infections (SSIs). INTRODUCTION:pNPWT has been suggested as a new method to prevent wound complications, specifically S...


    pub_type: 杂志文章,meta分析,评审


    authors: De Vries FEE,Wallert ED,Solomkin JS,Allegranzi B,Egger M,Dellinger EP,Boermeester MA

    更新日期:2016-09-01 00:00:00

  • Chlorhexidine bathing for the prevention of colonization and infection with multidrug-resistant microorganisms in a hematopoietic stem cell transplantation unit over a 9-year period: Impact on chlorhexidine susceptibility.

    abstract::Health care associated infections (HAIs) are currently among the major challenges to the care of hematopoietic stem cell transplantation (HSCT) patients. The objective of the present study was to evaluate the impact of 2% chlorhexidine (CHG) bathing on the incidence of colonization and infection with vancomycin-resist...


    pub_type: 杂志文章


    authors: Mendes ET,Ranzani OT,Marchi AP,Silva MTD,Filho JUA,Alves T,Guimarães T,Levin AS,Costa SF

    更新日期:2016-11-01 00:00:00

  • Ultrasound follow-up of spontaneous tears of the plantar fascia treated with conservative therapies: Two case reports.

    abstract:RATIONALE:The plantar fascia (PF) is an important anatomical structure that stabilizes the longitudinal arch of the foot. While plantar fasciitis is a common pathology affecting the foot, tears of the PF are uncommon injuries characterized by acute pain in the plantar aspect of the foot. The main purpose of this paper ...


    pub_type: 杂志文章


    authors: Cocco G,Ricci V,Boccatonda A,Abate M,Guagnano MT,Schiavone C

    更新日期:2019-12-01 00:00:00

  • Feasibility of measuring urethral pressure during female midurethral slings: Case report.

    abstract:RATIONALE:Stress urinary incontinence (SUI) refers to the involuntary leakage of urine when abdominal pressure increases. Midurethral slings (MUS) have become the main surgical method for treating SUI, but no quantitative standard for the degree of sling tightness during operation exists. We achieved this quantitative ...


    pub_type: 杂志文章


    authors: Meng LF,Wang M,Zhang W,Liu XD,Zhang YG

    更新日期:2020-07-10 00:00:00

  • Case report: A non-obstructive azoospermia patient with heat shock factor-2 mutation.

    abstract:RATIONALE:Infertility is a common medical condition that affects nearly 15% of the world population. Non-obstructive azoospermia (NOA) is one of the most severe forms of male infertility. Some common structural variants, single nucleotide polymorphisms (SNPs), and genetic factors were reported to be associated with NOA...


    pub_type: 杂志文章


    authors: Zhao H,Zhang H,Xi Q,Li L,Zhu H,Hu X,Liu R

    更新日期:2020-07-31 00:00:00

  • Anterior tibial artery occlusion post total knee arthroplasty: A case report.

    abstract:RATIONALE:Total knee arthroplasty (TKA) is a globally well-accepted surgery because of its good outcome and safety. Although TKA-associated arterial injuries occur, postoperative anterior tibial artery (ATA) occlusion has not been reported yet. Herein, we present a case of ATA occlusion after TKA. PATIENT CONCERNS:A 4...


    pub_type: 杂志文章


    authors: Li X,Song Y,Wang J

    更新日期:2019-07-01 00:00:00

  • TACE plus percutaneous chemotherapy-lipiodol treatment of unresectable pedunculated hepatocellular carcinoma.

    abstract::Pedunculated hepatocellular carcinoma (P-HCC) is rare type of HCC. The study aimed to evaluate the clinical features and outcomes of unresectable P-HCC treated with transcatheter arterial chemoembolization (TACE) and percutaneous chemotherapeutic agents lipiodol emulsion (CALE) injection. The clinical features and out...


    pub_type: 杂志文章


    authors: Huang D,Chen Y,Chen S,Zeng Q,Zhao J,Wu R,Li Y

    更新日期:2017-07-01 00:00:00

  • Hemangioblastoma arising from duramater: Case report.

    abstract:RATIONALE:Hemangioblastoma (HB) is a benign tumor that is typically located in the subtentorial region of the brain. HB that originates from dura mater is extremely rare. PATIENT CONCERNS:Herein, we reported a single case of a patient who presented with dizziness and headache lasting for 1 year that progressively aggr...


    pub_type: 杂志文章


    authors: Bian B,Zhang B,Zhou H,Tian J,Wang Z,Wang J

    更新日期:2019-11-01 00:00:00

  • A randomized controlled trial comparing methohexital and propofol for induction in patients receiving angiotensin axis blockade.

    abstract:BACKGROUND:Pharmacologic angiotensin axis blockade (AAB) has been associated with profound hypotension following anesthetic induction with propofol. To combat this problem, investigators have attempted to withhold angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB) preoperatively, or...


    pub_type: 杂志文章,随机对照试验


    authors: Bonavia A,Verbeek T,Adhikary S,Kunselman A,Budde A,Lyn-Sue J,Mets B

    更新日期:2019-02-01 00:00:00

  • Effects of flavopiridol on critical regulation pathways of CD133high/CD44high lung cancer stem cells.

    abstract:BACKGROUND:Flavopiridol a semisynthetic flavone that inhibits cyclin-dependent kinases (CDKs) and has growth-inhibitory activity and induces a blockade of cell-cycle progression at G1-phase and apoptosis in numerous human tumor cell lines and is currently under investigation in phase II clinical trials. Cancer stem cel...


    pub_type: 杂志文章


    authors: Bozok Cetintas V,Acikgoz E,Yigitturk G,Demir K,Oktem G,Tezcanli Kaymaz B,Oltulu F,Aktug H

    更新日期:2016-10-01 00:00:00

  • Rapid thrombelastography predicts perioperative massive blood transfusion in patients undergoing coronary artery bypass grafting: A retrospective study.

    abstract::Massive blood transfusion (MBT) is a relatively common complication of cardiac surgery, which is independently associated with severe postoperative adverse events. However, the value of using rapid thrombotomography (r-TEG) to predict MBT in perioperative period of cardiac surgery has not been explored. This study aim...


    pub_type: 杂志文章


    authors: Lin C,Fu Y,Huang S,Zhou S,Shen C

    更新日期:2020-09-11 00:00:00

  • Predicting outcome of repair of medial meniscus posterior root tear with early osteoarthritis using bone single-photon emission computed tomography/computed tomography.

    abstract::Repair of medial meniscus posterior root tear (MMPRT) is considered as an effective early intervention strategy for osteoarthritis. We aimed at evaluating whether or not single-photon emission computed tomography/computed tomography (SPECT/CT) could predict the treatment outcome.Eleven patients with MMPRT who underwen...


    pub_type: 杂志文章


    authors: Whi W,Park JY,Choi H,Paeng JC,Cheon GJ,Kang KW,Lee DS,Han HS

    更新日期:2020-07-02 00:00:00

  • Chinese herbal products and the reduction of risk of breast cancer among females with type 2 diabetes in Taiwan: A case-control study.

    abstract::Women with type 2 diabetes have a higher risk of developing breast cancer. In Taiwan, traditional Chinese medicine is widely used to treat diabetes; however, its precise influence has not been empirically tested.The objective of the case-control study is to estimate the effect on the risk of breast cancer of using tra...


    pub_type: 杂志文章


    authors: Wu CT,Tsai YT,Lin JG,Fu SL,Lai JN

    更新日期:2018-08-01 00:00:00

  • Prognostic Value of the Sum of Metabolic Tumor Volume of Primary Tumor and Lymph Nodes Using 18F-FDG PET/CT in Patients With Cervical Cancer.

    abstract::This is an observational study to determine the most relevant parameter of ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for predicting recurrence in cervical cancer. Fifty-six patients with International Federation of Gynecology and Obstetrics (FIGO) stage IIB-IVA cervical can...


    pub_type: 杂志文章


    authors: Hong JH,Min KJ,Lee JK,So KA,Jung US,Kim S,Eo JS

    更新日期:2016-03-01 00:00:00

  • Sex Differences in the Morphine-Sparing Effects of Intraoperative Dexmedetomidine in Patient-Controlled Analgesia Following General Anesthesia: A Consort-Prospective, Randomized, Controlled Clinical Trial.

    abstract::Previous studies have reported that intraoperative dexmedetomidine has morphine-sparing effects in patient-controlled analgesia (PCA). The present study was designed to investigate the possible sex differences in the morphine-sparing effects of intraoperative dexmedetomidine following general anesthesia. A total of 22...


    pub_type: 杂志文章,随机对照试验


    authors: Li YY,Ge DJ,Li JY,Qi B

    更新日期:2016-05-01 00:00:00