The role of IL22 polymorphisms on liver cirrhosis in patients with hepatitis B virus: A case control study.

Abstract:

AIMS:Interleukin(IL)-22 plays an important role in promoting liver regeneration and repair, but its role in chronic HBV-related liver diseasesis not clear. The goal of this study was to evaluate associations between eight IL22 single nucleotide polymorphisms (SNPs) and the development of chronic HBV cirrhosis and HBV-related HCC within a Chinese Han population. METHODS:We investigated associations between single nucleotide polymorphisms (SNPs) in the IL22 gene (rs1026788, rs2227472, rs2227491, rs2227485, rs1179249, rs2046068,rs2227473, and rs7314777) and the risk of HBV-related chronic liver diseases within a Han population in Northeast China. A total of 649 participants were included in the study, including 103 patients with CHB, 264 patients with LC, and 282 patients with HCC. The odds ratios (OR) and corresponding 95% confidence intervals (CI) were calculated using chi-square test. Haplotype analysis was conducted by haploview software. RESULTS:Genotype and allele distributions of SNPs rs1179249 and rs2227472 differed between LC and CHB groups (both P < 0.05).The G alleles of SNP rs2227491 and rs1026788 were more frequent in the LC group than in the CHB group (P = 0.046, P = 0.041 respectively). A IL22 haplotype consisting of the minor alleles of SNP rs1179249 and the major alleles of seven other SNPs occurred less frequently in the LC and HCC groups than in the CHB group (28.2%, 33.94%, and 37.86%, respectively, P < 0.05). Moreover, there were no significant associations between smoking or drinking and IL22 SNPs on the risk of HCC (P > 0.05). CONCLUSION:IL22 genetic variations were associated with chronic HBV infection progression, especially in the HBV-LC group. The IL22 genetic variations may help clinicians initiate the correct treatment strategy at the CHB stage.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Gao YH,Li QQ,Wang CG,Sun J,Wang XM,Li YJ,He XT,Xu HQ,Niu JQ

doi

10.1097/MD.0000000000017867

subject

Has Abstract

pub_date

2019-11-01 00:00:00

pages

e17867

issue

44

eissn

0025-7974

issn

1536-5964

pii

00005792-201911010-00140

journal_volume

98

pub_type

杂志文章

相关文献

MEDICINE文献大全
  • Th17/Treg imbalance in patients with severe acute pancreatitis: Attenuated by high-volume hemofiltration treatment.

    abstract:BACKGROUND:To investigate the effect of high-volume hemofiltration (HVHF) on Th17/Treg imbalance in patients with severe acute pancreatitis (SAP). METHODS:Forty-two patients with SAP were randomly received 24 hours of continuous HVHF (n = 21) or without HVHF (n = 21). At day 28, all 42 patients were divided into survi...

    journal_title:Medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MD.0000000000021491

    authors: Guo J,Li Z,Tang D,Zhang J

    更新日期:2020-07-31 00:00:00

  • Migration inhibitory factor in spinal tuberculosis: -173G/C polymorphisms, and transcript and protein levels in a northern province of China.

    abstract::The aim of this study was to elucidate the possible association between migration inhibitory factor (MIF)-173G/C gene polymorphisms and transcript and plasma levels of MIF in spinal tuberculosis (TB) patients. Clinical data were collected from 254 spinal TB patients and 262 healthy controls participating in the study....

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000021331

    authors: Wang J,Sheng B,Li X,Sun J,Shi L,Wei W,Wang G,Cao X

    更新日期:2020-07-24 00:00:00

  • Trends in Outcomes for Out-of-Hospital Cardiac Arrest by Age in Japan: An Observational Study.

    abstract::Population aging has rapidly advanced throughout the world and the elderly accounting for out-of-hospital cardiac arrest (OHCA) has increased yearly.We identified all adults who experienced an out-of-hospital cardiac arrest in the All-Japan Utstein Registry of the Fire and Disaster Management Agency, a prospective, po...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000002049

    authors: Fukuda T,Ohashi-Fukuda N,Matsubara T,Doi K,Kitsuta Y,Nakajima S,Yahagi N

    更新日期:2015-12-01 00:00:00

  • Integrative network analysis identifies an immune-based prognostic signature as the determinant for the mesenchymal subtype in epithelial ovarian cancer.

    abstract:BACKGROUND:Epithelial ovarian cancer (EOC) has been classified into four molecular subtypes, of which the mesenchymal subtype has the poorest survival. Our goal is to develop an immune-based prognostic signature by incorporating molecular subtypes for EOC patients. METHODS:The gene expression profiles of EOC samples w...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000022549

    authors: Sheng M,Tong H,Lu X,Shanshan N,Zhang X,Reddy BA,Shu P

    更新日期:2020-10-09 00:00:00

  • Sensitivity and Specificity of a Novel Approach to Confirm the Depth of the Endotracheal Tube: A Pilot Study.

    abstract::This study aimed to explore the sensitivity and specificity an approach to confirm the depth of the endotracheal tube. It was a prospective, diagnostic study (Registration number: chiCTR-TRC-14005170) conducted in the Department of Anesthesiology of West China Hospital. A total of 100 patients underwent general anesth...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000001460

    authors: Li Y,Xie Y,Hu B,Wang J,Song H,Wei X

    更新日期:2015-08-01 00:00:00

  • Methodology of dose calculation for external beam radiation combined with high dose rate brachytherapy in the era of 3-dimensional treatment planning system.

    abstract::Intracavitary application of brachytherapy (BT) sources followed by external beam radiation is essential for the local treatment of carcinoma of the cervix, postate, and nasopharynx. Dose distribution of external beam radiation plus BT can be challenging for the planning system because of their dose calculation by 2 d...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000020760

    authors: Wang F,Jiang C,Liu T,Sun Q,Ye Z,Shi K,Wu P,Qin W,Fu Z,Jiang Y

    更新日期:2020-07-17 00:00:00

  • Infections with Acinetobacter calcoaceticus (Herellea vaginicola): clinical and laboratory studies.

    abstract::In a retrospective review of 53 patients, 58 episodes of infection due to Acinetobacter calcoaceticus var. anitratus (Herellea vaginicola) were studied. Although the organism is widely distributed in nature, it is of relatively low virulence since colonization is more frequently noted than infection and since most inf...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/00005792-197703000-00001

    authors: Glew RH,Moellering RC Jr,Kunz LJ

    更新日期:1977-03-01 00:00:00

  • Comparison of clinical outcomes between cystotome-assisted prechop phacoemulsification surgery and conventional phacoemulsification surgery for hard nucleus cataracts: A CONSORT-compliant article.

    abstract:BACKGROUND:This study aimed to investigate the safety and efficacy of the cystotome-assisted prechop phacoemulsification surgery (CAPPS) and conventional phacoemulsification surgery (CPS) in patients with IV degree nucleus cataract. METHODS:The prospective, randomized, consecutive, comparative cohort study consecutive...

    journal_title:Medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MD.0000000000013124

    authors: Li X,He Y,Su T,Tian Y,Wang Y,Xia X,Song W

    更新日期:2018-11-01 00:00:00

  • Analysis of cervical human papillomavirus infection in 2300 women in Urumqi, China.

    abstract::This study is to investigate the cervical human papillomavirus (HPV) infection rate in women of Urumqi, China.The epidemiological questionnaire survey was used to study 2300 women in Urumqi with a prospective research method. The second-generation hybrid capture assay, cervical liquid-based cytology test, colposcopy, ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000013206

    authors: Yao L,Yuan M,Yuan J,Zhou P,Mei L,Cheng J

    更新日期:2018-11-01 00:00:00

  • Electro-acupuncture attenuates inflammatory responses and intraabdominal pressure in septic patients: A randomized controlled trial.

    abstract:BACKGROUND:A pathological increase in intraabdominal pressure (IAP) and inflammatory responses have negative effects on splanchnic, respiratory, cardiovascular, renal, and neurological function in septic patients with intestinal dysfunction. Electro-acupuncture (EA) has been evidenced to have a bidirectional neuron-end...

    journal_title:Medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MD.0000000000010555

    authors: Meng JB,Jiao YN,Xu XJ,Lai ZZ,Zhang G,Ji CL,Hu MH

    更新日期:2018-04-01 00:00:00

  • Erratum: Association of Lifestyle-Related Comorbidities With Periodontitis: A Nationwide Cohort Study in Korea: Erratum.

    abstract::[This corrects the article DOI: 10.1097/MD.0000000000001567.]. ...

    journal_title:Medicine

    pub_type: 已发布勘误

    doi:10.1097/01.md.0000479543.97836.5d

    authors:

    更新日期:2016-01-15 00:00:00

  • Aldosterone and renin in cardiac patients referred for catheterization.

    abstract::Little is known regarding alterations of the renin-angiotensin system in patients referred for cardiac catheterization. Here, we measured plasma levels of active renin and aldosterone in patients referred for cardiac catheterization in order to determine the prevalence of elevated renin, aldosterone, and the aldostero...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000007282

    authors: Erne P,Müller A,Rossi GP,Seifert B,Stehlin F,Redondo M,Bauer PT,Kobza R,Resink TJ,Radovanovic D

    更新日期:2017-06-01 00:00:00

  • Breastfeeding with and without the WHO/UNICEF baby-friendly hospital initiative: A cross-sectional survey.

    abstract::The World Health Organization and United Nations Children's Fund's Baby-Friendly Hospital Initiative is aimed at the global promotion, protection and support of breastfeeding. In this study, we compared breastfeeding-related information received, knowledge and behaviours among postpartum women in Baby-Friendly Hospita...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000017737

    authors: Marinelli A,Del Prete V,Finale E,Guala A,Pelullo CP,Attena F

    更新日期:2019-11-01 00:00:00

  • The value of eZIS analysis of Tc-99m ECD SPECT on identifying cerebellar hypoperfusion in a patient with superficial siderosis: A case report.

    abstract:INTRODUCTION:Brain perfusion single photon computed tomography (SPECT) is a functional imaging modality and has been widely utilized in evaluation of various kinds of neurological disorders. Easy z-score imaging system (eZIS) is a computer-assisted statistical analysis, based on the comparison with age-classified ethyl...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000005416

    authors: Wei CY,Chen TY,Shih I,Chiu PY,Hung GU,Matsuda H

    更新日期:2016-11-01 00:00:00

  • Quality of life in patients who undergo conventional or robotic-assisted total laparoscopic hysterectomy: Protocol for a systematic review of randomized controlled trials.

    abstract:BACKGROUND:Hysterectomy for benign gynecologic diseases, especially dysfunctional uterine bleeding, is one of the most common gynecologic interventions. The uterus can be removed using abdominal, vaginal, laparoscopic, or robotic-assisted laparoscopic hysterectomy. In a robotic-assisted procedure, the surgeon directs t...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000015974

    authors: Rodrigues RC,Rodrigues MRK,Freitas NO,Rudge MVC,Lima SAM

    更新日期:2019-06-01 00:00:00

  • Clinical analysis of hyperkalemia after esophagectomy: A case report.

    abstract:RATIONALE:The occurrence of hyperkalemia after esophagectomy is clinically rare. Patients who underwent esophagectomy often have a serum potassium level due to perioperative reduced intake, fluids loss, consumption and other reasons. These patients often require the artificial administration of potassium. Rapid fluid l...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000008966

    authors: Chen Q,Zhang WG,Chen SC

    更新日期:2017-12-01 00:00:00

  • Long-term results of irrigated bipolar radiofrequency ablation in patients with recurrent arrhythmia after failed unipolar ablation.

    abstract:INTRODUCTION:The RF ablation of ventricular tachycardia (VT) or atrial flutter (AFl) can be unsuccessful due to lack of lesion transmurality. Bipolar ablation (BA) is more successful than unipolar ablation (UA). The purpose of our study was to investigate the long-term effect of BA ablation in patients after failed UA....

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000019970

    authors: Baszko A,Kochman K,Królak T,Kałmucki P,Telec W,Ożegowski S,Szyszka A

    更新日期:2020-05-22 00:00:00

  • QTc prolongation and torsades de pointes due to a coadministration of fluoxetine and amiodarone in a patient with implantable cardioverter-defibrillator: Case report and review of the literature.

    abstract:RATIONALE:Drug-induced prolongation of the corrected QT interval (QTc) may lead to serious and potentially life-threatening ventricular tachyarrhythmia, such as torsades de pointes (Tdp), which is worthy of clinical attention. Here, we report 1 case of Tdp after a coadministration of fluoxetine and amiodarone. PATIENT...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0000000000009071

    authors: Wei A,Peng J,Gu Z,Li J

    更新日期:2017-12-01 00:00:00

  • A case report of Brugada-like ST-segment elevation probably due to coronary vasospasm.

    abstract:RATIONALE:Vasospastic angina is caused by sudden occlusive vasoconstriction of a segment of an epicardial artery, with transient ST-segment elevation on electrocardiography. Brugada Syndrome is an inherited arrhythmogenic cardiac disorder with a diagnostic electrocardiography characterized by coved-type ST-segment elev...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000009900

    authors: Yang L,Ma G,Yu T,Gao H,Wang Y,Wu Y

    更新日期:2018-03-01 00:00:00

  • Percutaneous transforaminal endoscopic decompression for the treatment of intraspinal tophaceous gout: A case report.

    abstract:RATIONALE:Intraspinal tophaceous gout is relatively rare condition presenting with major clinical manifestations, such as spinal cord or nerve roots compressions (radiculopathy). It is usually difficult to differentiate intraspinal tophaceous gout, lumbar disc herniation, stenosis of spinal canal, ossification of ligam...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000020125

    authors: Chen X,Xu G,Hu Q,Zhao T,Bi Q,Huang Y,Shao H,Zhang J

    更新日期:2020-05-22 00:00:00

  • Prognostic significance of serum procalcitonin in patients with unresectable hepatocellular carcinoma treated with transcatheter arterial chemoembolization: A retrospective analysis of 509 cases.

    abstract::Although procalcitonin (PCT) is a valid marker for early diagnosis of bacterial infections, its accuracy in hepatocellular carcinoma (HCC) patients is unknown. The aim of this study was to investigate the prognostic significance of PCT in patients with unresectable HCC treated with transcatheter arterial chemoemboliza...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000007438

    authors: Shen H,Zheng S,Chen R,Jin X,Xu X,Jing C,Lin J,Zhang J,Zhang M,Zhang L,Xie X,Guo K,Ren Z,Lin S,Zhang B

    更新日期:2017-07-01 00:00:00

  • A prospective, randomized and controlled study of interscalene brachial plexus block for arthroscopic shoulder surgery: A comparison of C5 and conventional approach, a CONSORT-compliant article.

    abstract:BACKGROUND:The shoulder area is mainly innervated with the C5 and C6 nerve roots, and interscalene brachial plexus block (ISB) is widely used for postoperative analgesia after shoulder surgery. However, it is associated with adverse effects, such as numbness and weakness in the blocked arm due to an unwanted block of t...

    journal_title:Medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MD.0000000000004921

    authors: Shin HJ,Na HS,Oh AY,Hwang JW,Kim BG,Park HP,Jeon YT,Min SW,Ryu JH

    更新日期:2016-09-01 00:00:00

  • Extra-intestinal manifestations of salmonella infections.

    abstract::While salmonellosis is often considered to affect primarily the gastrointestinal tract, infection at other sites may occur, producing characteristic clinical syndromes. We reviewed cases from our institutions and the literature on focal manifestations of salmonella infections. In the past, most extra-intestinal salmon...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/00005792-198709000-00003

    authors: Cohen JI,Bartlett JA,Corey GR

    更新日期:1987-09-01 00:00:00

  • A study on the paraspinal muscle surface electromyography in acute nonspecific lower back pain.

    abstract::Aim of this study was to determine if surface electromyography (sEMG) could provide objective data in monitoring the alteration of signal amplitude of myoelectric activity of the paraspinal muscles in the patients with acute nonspecific lower back pain (ANLBP), and to explore the correlation between sEMG data and symp...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000016904

    authors: Qiao J,Zhang SL,Zhang J,Feng D

    更新日期:2019-08-01 00:00:00

  • Necessity of harvesting at least 25 lymph nodes in patients with stage N2-N3 resectable gastric cancer: a 10-year, single-institution cohort study.

    abstract::A minimum of 15 lymph nodes (LNs) has been recommended as an adequate number for radical gastrectomy for gastric cancer (GC). This study aimed to investigate whether the harvesting of at least 25 LNs was a better criterion for stage N2-3 GC based on the 10-year experience of a high-volume hospital. A total of 1363 pat...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000000620

    authors: Chen HN,Chen XZ,Zhang WH,Chen XL,Yang K,Liu JP,Zhang B,Chen ZX,Chen JP,Zhou ZG,Hu JK

    更新日期:2015-03-01 00:00:00

  • Management and outcomes of spinal epidural hematoma during vertebroplasty: Case series.

    abstract:RATIONALE:Spinal cord injury (SCI) is one of the common complications of spinal surgery. There is no definite treatment and time of decompression for spinal cord induced by epidural hematoma during vertebroplasty. PATIENT CONCERNS:A total of 6 patients with SCI during vertebroplasty were included in our research. All ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000010732

    authors: Fang M,Zhou J,Yang D,He Y,Xu Y,Liu X,Zeng Y

    更新日期:2018-05-01 00:00:00

  • Surgical treatment of acute calculous cholecystitis complicated with hepatic dysfunction.

    abstract::To evaluate the timing, feasibility, and necessity of early laparoscopic cholecystectomy (LC) in the management of patients with acute calculous cholecystitis complicated with hepatic dysfunction.The clinical data of 60 patients with acute calculous cholecystitis complicated with hepatic dysfunction treated from Janua...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000020239

    authors: Tian Y,Suo X

    更新日期:2020-06-12 00:00:00

  • Acute eosinophilic pneumonia. A summary of 15 cases and review of the literature.

    abstract::Idiopathic acute eosinophilic pneumonia (AEP) is an acute febrile illness that may be mistaken for an infectious pneumonia. Patients are often young and otherwise healthy. Clues to considering this disorder in a differential diagnosis include the acuity and severity of the clinical presentation and an initial chest X-...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00005792-199611000-00004

    authors: Pope-Harman AL,Davis WB,Allen ED,Christoforidis AJ,Allen JN

    更新日期:1996-11-01 00:00:00

  • Severe Infection With Avian Influenza A Virus is Associated With Delayed Immune Recovery in Survivors.

    abstract::Human infection with avian influenza A virus (H7N9) is a concern because of the mortality rate. Previously, we characterized immunological responses during active infection with it and reported evidence of impaired antigen-presenting capability, particularly in severely affected individuals. Here we describe an invest...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000002606

    authors: Chen J,Cui G,Lu C,Ding Y,Gao H,Zhu Y,Wei Y,Wang L,Uede T,Li L,Diao H

    更新日期:2016-02-01 00:00:00

  • Differences of bleedings after percutaneous coronary intervention using femoral closure and radial compression devices.

    abstract::Bleedings represent most relevant complications being correlated with significant rates of adverse clinical outcomes in patients undergoing percutaneous coronary intervention (PCI). To reduce bleeding and improve prognosis various types of vascular closure devices (VCD) are frequently applied. This study aims to compa...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000015501

    authors: Kim SH,Behnes M,Baron S,Shchetynska-Marinova T,Tekinsoy M,Mashayekhi K,Hoffmann U,Borggrefe M,Akin I

    更新日期:2019-05-01 00:00:00