Abstract:
BACKGROUND:To investigate the effect of high-volume hemofiltration (HVHF) on Th17/Treg imbalance in patients with severe acute pancreatitis (SAP). METHODS:Forty-two patients with SAP were randomly received 24 hours of continuous HVHF (n = 21) or without HVHF (n = 21). At day 28, all 42 patients were divided into survival group (n = 32) and non-survival group (n = 10). Venous blood samples collected at 0, 6, 12, and 24 hours during HVHF treatment (or equivalent time in non-HVHF group) were assessed by flow cytometry to detect Th17 and Treg cells. Concentrations of IL-6, IL-17, IL-10, and TGF-β1 were detected by enzyme-linked immunosorbent assay. RESULTS:Th17%, Treg%, Th17/Treg, and levels of related cytokines were significantly higher in SAP patients than healthy controls (P < .05), and these changes were more pronounced in SAP patients with multiple organ failure than those with single organ failure (P < .05). After HVHF treatment, Th17%, Treg%, Th17/Treg, IL-6, IL-17, and IL-10 significantly reduced (P < .05), while there were no significant changes in non-HVHF group (P > .05). In addition, acute physiology and chronic health evaluation II and sequential organ failure assessment scores decreased markedly after HVHF treatment. Baselines of Th17%, Treg%, Th17/Treg, and related cytokines were significantly higher in non-survival group than survival group. Both acute physiology and chronic health evaluation I score and IL-6 level were positively correlated with Th17% before and after HVHF treatment (P < .01). CONCLUSIONS:Th17/Treg imbalance is present in SAP and may be correlated with its severity and prognosis. HVHF effectively attenuates the Th17/Treg imbalance in SAP patients. The beneficial effect of HVHF on Th17/Treg imbalance is possibly associated with removing excess inflammatory mediators.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Guo J,Li Z,Tang D,Zhang Jdoi
10.1097/MD.0000000000021491subject
Has Abstractpub_date
2020-07-31 00:00:00pages
e21491issue
31eissn
0025-7974issn
1536-5964pii
00005792-202007310-00110journal_volume
99pub_type
杂志文章,随机对照试验相关文献
MEDICINE文献大全abstract::Carbamazepine (CBZ) is a widely used antiepileptic drug with large interindividual variability in serum concentrations. Previous studies found that CYP3A5*3 (rs776746), UGT2B7*2 (802C>T), and UGT2B7*3 (211G>T) variants could change the enzymes' activity, which may influence drug concentrations. Our study aims to inves...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011662
更新日期:2018-07-01 00:00:00
abstract:INTRODUCTION:Purpuric drug eruption (PDE) is an uncommon, clinically distinct side effect of epidermal growth factor receptor (EGFR) inhibitors. PATIENT CONCERNS:Unlike acneiform eruption, which arises from hair follicles mainly in the head and neck area, PDE starts from xerosis cutis, primarily in the lower extremiti...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000018112
更新日期:2019-11-01 00:00:00
abstract::Apolipoprotein E (APOE) gene has been implicated as one of the genes susceptible to temporal lobe epilepsy (TLE), but the association is inconsistent. We carried out a study to investigate the association of APOEε4 allele with a subtype of TLE-nonlesional mesial temporal lobe epilepsy (NLMTLE) in Han Chinese people.T ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002894
更新日期:2016-03-01 00:00:00
abstract::Although supraclavicular brachial plexus block (SCBPB) was repopularized by the introduction of ultrasound, its usefulness in shoulder surgery has not been widely reported. The objective of this study was to compare motor and sensory blockades, the incidence of side effects, and intraoperative opioid analgesic require...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000001726
更新日期:2015-10-01 00:00:00
abstract::After successful introduction of anti-Haemophilus influenzae (Hi) serotype b vaccination program in Poland, invasive non-b or nontypeable H. influenzae infections have been reported more frequently alike in other countries all over the world. In this paper, we report 2 cases of H. influenzae serotype f (Hif) meningiti...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002671
更新日期:2016-02-01 00:00:00
abstract:INTRODUCTION:Thrombosis is the most common complication of thrombocytosis, which can be particularly damaging to reattached digits. We present a guideline about digital replantation when thrombocytosis is expected. CASE PRESENTATION:We report a case of an 18-year-old man who sustained a traumatic amputation of two fin...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010951
更新日期:2018-06-01 00:00:00
abstract:RATIONALE:Total knee arthroplasty (TKA) is a globally well-accepted surgery because of its good outcome and safety. Although TKA-associated arterial injuries occur, postoperative anterior tibial artery (ATA) occlusion has not been reported yet. Herein, we present a case of ATA occlusion after TKA. PATIENT CONCERNS:A 4...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000016503
更新日期:2019-07-01 00:00:00
abstract::Little was known about the effects of acupuncture on stroke recurrence. The aim of this study is to investigate whether ischemic stroke patients receiving acupuncture treatment have a decreased risk of stroke recurrence. A retrospective cohort study of 30,058 newly diagnosed cases of ischemic stroke in 2000 to 2004 wa...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001572
更新日期:2015-09-01 00:00:00
abstract:INTRODUCTION:Although there are various therapeutic methods for the treatment of knee osteoarthritis, each has its advantages and shortcomings, and a definitive treatment method is yet to be determined. This pilot study is designed to obtain basic data for a further large-scale trial as well as provide information abou...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000021957
更新日期:2020-09-04 00:00:00
abstract:OBJECTIVES:The primary objective of this study was to investigate whether dexmedetomidine could potentiate the analgesic efficacy of ropivacaine, when added to ropivacaine for wound infiltration in patients undergoing open gastrectomy. METHODS:Fifty patients scheduled for open gastrectomy were divided into 2 equal gro...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000007950
更新日期:2017-09-01 00:00:00
abstract::Consistency between back pain intensity and degenerative changes on magnetic resonance imaging (MRI) of the lumbar spine is poor. This study aimed to show whether tender point (TP) examination, used as a test for diffuse central sensitization, may add valuable information to clinical assessment of patients with low ba...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022198
更新日期:2020-09-18 00:00:00
abstract::The aim of our study was to compare the clinical and surgical characteristics of pregnant and nonpregnant women with surgically verified ovarian torsion, as well as the differences among 3 trimesters during pregnancy.We conducted a retrospective study of patients diagnosed with surgically proven ovarian torsion in our...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020627
更新日期:2020-06-12 00:00:00
abstract:INTRODUCTION:Intramuscular hemangioma (IMH) is a rare congenital soft tissue tumor. Here, we report a case of IMH patient who had undergone several surgeries and other treatments that were all ineffective before he visited us. CLINICAL FINDINGS:This IMH patient was a 16-yearold male who was born with a tumor of unknow...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005939
更新日期:2017-01-01 00:00:00
abstract::The recurrence rate for acute appendicitis treated nonoperatively varies between studies. Few studies have adequately evaluated the management of these patients when appendicitis recurs. We aimed to explore the recurrence rate and management of patients with acute appendicitis that were first treated nonoperatively.We...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003159
更新日期:2016-03-01 00:00:00
abstract:INTRODUCTION:Most of the patients with bladder genital tract fistula recover with surgical treatment. In the present study, we aimed to assess conservative treatment strategies for bladder genital tract fistula. PATIENT CONCERNS:We reviewed 3 cases with bladder genital tract fistula who underwent treatment at our hosp...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000021430
更新日期:2020-07-31 00:00:00
abstract:BACKGROUND:A pathological increase in intraabdominal pressure (IAP) and inflammatory responses have negative effects on splanchnic, respiratory, cardiovascular, renal, and neurological function in septic patients with intestinal dysfunction. Electro-acupuncture (EA) has been evidenced to have a bidirectional neuron-end...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000010555
更新日期:2018-04-01 00:00:00
abstract::Several risk factors for pancreatic fistula had been widely reported, but there was no research focusing on the exocrine output of remnant gland.During the study period of January 2015 to September 2016, 82 patients accepted pancreaticoduodenectomy (PD, end-to-end dunking pancreaticojejunostomy with internal stent tub...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008451
更新日期:2017-11-01 00:00:00
abstract::When the sensory block level (SBL) is ≥T5 or T4, a high incidence of hypotension occurs in parturients after spinal anesthesia. A rapidly ascending SBL is another risk factor for spinal anesthesia-induced hypotension. However, the relationship between the ascension rate of the SBL and spinal anesthesia-induced hypoten...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007184
更新日期:2017-06-01 00:00:00
abstract::Fetuin-A is a protein with various biological functions. It plays a role in insulin resistance and arterial calcium deposition. Thyroid dysfunction may affect energy expenditure, glucose metabolism, and the risk of cardiovascular diseases. In the present study, we compared the serum fetuin-A concentrations in hyperthy...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000013254
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Shexiang Baoxin Pills (SBP) is widely used for the treatment of unstable angina pectoris (UAP) in China. However, the clinical evidence on the efficacy of SBP for the treatment of UAP is not well concluded. METHODS:Seven electronic databases will be searched for eligible studies: MEDLINE, EMBASE, The Cochra...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017119
更新日期:2019-09-01 00:00:00
abstract::The purpose of this study was to perform a meta-analysis on the efficacy of ibandronate by evaluating the effect sizes of different dosing regimens.Major electronic databases were searched from 1985 to February 2015. A random effects meta-analysis was performed in STATA.Data from 34 studies (13,639 patients) were incl...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000001007
更新日期:2015-07-01 00:00:00
abstract:RATIONALE:Nd:YAG laser-induced macular holes (MHs) feature more extensive anatomical defects and worse functional outcomes than idiopathic MHs. Although new treatment options for large refractory MHs have been suggested, the current literature on Nd:YAG laser-induced MHs suggests only conventional pars plana vitrectomy...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000018185
更新日期:2019-11-01 00:00:00
abstract::Transient global amnesia is now considered a very rare complication of cerebral angiography. Various etiological mechanisms have been suggested to account for this complication, but no consensus has been reached yet. This case report documents one of the few reported cases of cerebral angiography-related transient glo...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003590
更新日期:2016-05-01 00:00:00
abstract::IL-17 and IL-17-producing cells have been found in many types of human cancers and murine models. However, the source of tumor-infiltrating IL-17 and IL-17-producing cells in HCC and the prognostic values remain poorly understood. A total of 57 HCC patients were enrolled in this study, and immunofluorescence double st...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003220
更新日期:2016-03-01 00:00:00
abstract::Our study questioned whether the outcome of postoperative early oral feeding is different from traditional postoperative feeding in children with Hirschsprung's disease who underwent transanal endorectal pull-through.This was an observational and comparative study. Patients were allocated into 2 groups. Age, gender, f...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014829
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:A thoracoscopic approach for repair of esophageal atresia (EA) with tracheoesophageal fistula (TEF) has become a standard procedure in many pediatric surgical centers. However, whether thoracotomy or thoracoscopy offer advantages in terms of surgical outcomes is not known. METHODS:To evaluate the efficacy a...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000004428
更新日期:2016-07-01 00:00:00
abstract::We aimed to elucidate the relationship between serum liver fibrosis markers (Mac-2 binding protein glycosylation isomer (M2BPGi), FIB-4 index, aspartate aminotransferase to platelet ratio index and hyaluronic acid), and skeletal muscle mass and to investigate factors linked to skeletal muscle mass loss (SMML) in patie...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008761
更新日期:2017-12-01 00:00:00
abstract::Lipoprotein-associated phospholipase A2 (Lp-PLA2) probably plays an important role in the development of acute coronary syndrome (ACS). However, alterations of Lp-PLA2 levels during ACS and its association with cardiovascular outcome are unclear. Our aim was to investigate the change in Lp-PLA2 and its association wit...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011517
更新日期:2018-07-01 00:00:00
abstract::This study evaluated the clinical outcome of endoscopic submucosal dissection (ESD) in minute submucosa (SM) invasion or undifferentiated early gastric cancer (EGC) and analyzed factors related to local recurrence after ESD.We retrospectively reviewed the chart of EGC patients, who underwent ESD at our tertiary hospit...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006710
更新日期:2017-04-01 00:00:00
abstract::Based on the source of the embolus, septic pulmonary embolism (SPE) can be classified as cardiac, peripheral endogenous, or exogenous. Cardiac SPEs are the most common.We conducted a retrospective analysis of 20 patients with cardiac SPE hospitalized between 1991 and 2013 at a Chinese tertiary referral hospital.The st...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003846
更新日期:2016-06-01 00:00:00