Epidermal growth factor receptor (EGFR) inhibitor induced purpuric drug eruption: Three case reports.

Abstract:

INTRODUCTION:Purpuric drug eruption (PDE) is an uncommon, clinically distinct side effect of epidermal growth factor receptor (EGFR) inhibitors. PATIENT CONCERNS:Unlike acneiform eruption, which arises from hair follicles mainly in the head and neck area, PDE starts from xerosis cutis, primarily in the lower extremities and is not associated with hair follicles. Herein, we report 3 cases of 3 patients who had received EGFR inhibitor and were hospitalized for PDE later. The cases were characterized by painful late-onset palpable purpura with identifiable bacterial pathogens. DIAGNOSIS:The patients were diagnosed with characteristic clinical presentations, that is, late onset, PDE locations mainly in the lower extremities, nonfollicular centricity, and laboratory findings with identifiable bacterial pathogens. INTERVENTIONS:Systemic antibiotics and intensive moisturizer application were prescribed. OUTCOMES:All the patients were successfully treated within 6 to 9 days without discontinuation of EGFR inhibitors. CONCLUSION:Systemic antibiotics, topical emollient, and skin barrier repair should be included in the treatment regimens for PDE.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Fang SY,Wu CS,Liu YS,Wei KC

doi

10.1097/MD.0000000000018112

subject

Has Abstract

pub_date

2019-11-01 00:00:00

pages

e18112

issue

47

eissn

0025-7974

issn

1536-5964

pii

00005792-201911220-00081

journal_volume

98

pub_type

杂志文章

相关文献

MEDICINE文献大全
  • Meta-analysis of serum lactate dehydrogenase and prognosis for osteosarcoma.

    abstract:BACKGROUNDS:A large number of studies have reported the relationships between serum lactate dehydrogenase (LDH) and prognosis of osteosarcoma. However, the result is still controversial and no consensus has been reached. Therefore, we performed a meta-analysis to evaluate the prognostic role of serum LDH in osteosarcom...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MD.0000000000010741

    authors: Fu Y,Lan T,Cai H,Lu A,Yu W

    更新日期:2018-05-01 00:00:00

  • Opioid analgesics are the leading cause of adverse drug reactions in the obstetric population in South Korea.

    abstract::Medication use during pregnancy is gradually increasing; however, the safety of this practice remains largely unknown.We investigated medications with the most adverse drug reactions (ADRs) among pregnant women and the clinical features of those medications.Reports of ADRs among pregnant women were extracted from the ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000015756

    authors: Choi SK,Kim YH,Kim SM,Wie JH,Lee DG,Kwon JY,Song JH,Lee SJ,Park IY

    更新日期:2019-05-01 00:00:00

  • Retrospective comparison of fludarabine in combination with intermediate-dose cytarabine versus high-dose cytarabine as consolidation therapies for acute myeloid leukemia.

    abstract::This retrospective study compared efficacy and safety of fludarabine combined with intermediate-dose cytarabine (FA regimen) versus high-dose cytarabine (HiDAC regimen) as consolidation therapy in acute myeloid leukemia (AML) patients who achieved complete remission. Disease-free survival (DFS) and overall survival (O...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000000134

    authors: Zhang W,Ding Y,Wu H,Chen Y,Lu H,Chen C,Fu J,Wang W,Liang A,Zou S

    更新日期:2014-12-01 00:00:00

  • Current trends in health coaching for chronic conditions: A systematic review and meta-analysis of randomized controlled trials.

    abstract:BACKGROUND:Chronic conditions are placing a serious burden on individuals as well as the health care system. Health coaching (HC) has emerged as a promising approach that can support effective lifestyle interventions for chronic conditions. However, until now there is no particularly comprehensive systematic review of ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000021080

    authors: Yang J,Bauer BA,Lindeen SA,Perlman AI,Abu Dabrh AM,Boehmer KR,Salinas M,Cutshall SM

    更新日期:2020-07-24 00:00:00

  • Retrospective clinical analysis of 320 cases of microvascular decompression for hemifacial spasm.

    abstract::To investigate effects of microvascular decompression (MVD) surgical treatment on hemifacial spasm.A retrospective analysis of 320 adult patients (95 male cases, 29.7% and 225 female cases, 70.3%) with hemifacial spasm treated by surgery was conducted between February 2007 to June 2016, with an average age of 49.3 yea...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000011825

    authors: Li Z,Gao J,Wang T,Li Y

    更新日期:2018-10-01 00:00:00

  • Durable remission in a patient of mixed phenotype acute leukemia with Philadelphia chromosome-positive treated with nilotinib and lenalidomide: A case report.

    abstract:RATIONALE:Philadelphia chromosome-positive mixed phenotype acute leukemia (Ph+ MPAL) is a rare type of leukemia with poor prognosis. Tyrosine kinase inhibitors (TKIs) in combination with chemotherapy have significantly improved its remission rate. However, relapse remains the major obstacle to achieve long survival. Le...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000010294

    authors: Lai B,Mu Q,Zhu H,Wang Y,Zhang Y,Xu K,Sheng L,Ouyang G

    更新日期:2018-04-01 00:00:00

  • Localized amyloidosis of the genitourinary tract: report of 5 new cases and review of the literature.

    abstract::Primary localized amyloidosis of the genitourinary tract is a rare entity characterized by small pseudotumors localized in the renal pelvis, ureters, or bladder. Amyloid fibrils are derived from immunoglobulin light chains, but no systemic plasma cell proliferation is detected. The clinical and radiologic features mim...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0b013e31821cbdab

    authors: Monge M,Chauveau D,Cordonnier C,Noël LH,Presne C,Makdassi R,Jauréguy M,Lecaque C,Renou M,Grünfeld JP,Choukroun G

    更新日期:2011-05-01 00:00:00

  • Straight sinus dural arteriovenous fistula presenting with reversible parkinsonism: A case report and literature review.

    abstract:RATIONALE:A dural arteriovenous fistula (DAVF) refers to an abnormal direct connection between an intracranial artery and a dural venous sinus. A DAVF presenting with parkinsonism is rare, and is therefore easily misdiagnosed. Therefore, early consideration of DAVF in the differential diagnosis of reversible parkinsoni...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000009005

    authors: Pu J,Si X,Ye R,Zhang B

    更新日期:2017-12-01 00:00:00

  • Epileptiform EEG discharges and sevoflurane in children: Protocol of a systematic review and meta-analysis.

    abstract:BACKGROUND:Epileptiform discharges in electroencephalogram (EEG) have been frequently reported in children undergoing sevoflurane mask induction. However, the incidence, characteristics and risk factors of these epileptiform patterns during sevoflurane anesthesia in children are poorly understood. The aim of this study...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000017401

    authors: Miao M,Xu Y,Cong X,Zhang L,Zhang J

    更新日期:2019-10-01 00:00:00

  • A meta-analysis of the effects of probiotics and synbiotics in children with acute diarrhea.

    abstract:OBJECTIVE:This meta-analysis assessed the effectiveness of probiotics and synbiotics for acute diarrhea (AD) in children and investigated probiotic formulations, types of interventions, and country factors. METHODS:Randomized, double-blind, placebo-controlled trials evaluating the effects of probiotics or synbiotics o...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000016618

    authors: Yang B,Lu P,Li MX,Cai XL,Xiong WY,Hou HJ,Ha XQ

    更新日期:2019-09-01 00:00:00

  • Effects of somatostatin/octreotide treatment in neonates with congenital chylothorax.

    abstract::The influence of somatostatin/octreotide treatment on outcomes of neonates with congenital chylothorax remains controversial. We retrospectively reviewed our experience with somatostatin/octreotide therapy in neonates with this very rare disease.Fourteen neonates with congenital chylothorax who were treated with somat...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000007594

    authors: Yin R,Zhang R,Wang J,Yuan L,Hu L,Jiang S,Chen C,Cao Y

    更新日期:2017-07-01 00:00:00

  • Diffusion tensor imaging for evaluating perianal fistula: Feasibility study.

    abstract::To explore the feasibility of using diffusion tensor imaging (DTI) in the diagnosis of anal fistula and evaluating its activity.Thirty-four patients with perianal fistulas were examined with DTI on a 3.0 T magnetic resonance imaging (MRI) before undergoing surgery. Based on the surgery requirement and preoperative exa...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000011570

    authors: Wang Y,Gu C,Huo Y,Han W,Yu J,Ding C,Zhao X,Meng Y,Li C

    更新日期:2018-07-01 00:00:00

  • The prevalence of heterotopic ossification among patients after cervical artificial disc replacement: A systematic review and meta-analysis.

    abstract:BACKGROUND:Prevalence estimates of heterotopic ossification (HO) following cervical artificial disc replacement (ADR) varied widely in previous studies. We conducted a systematic review and meta-analysis to summarize its point prevalence. METHODS:Electronic searches of PubMed, Web of Science, Embase, and Cochrane Libr...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MD.0000000000007163

    authors: Kong L,Ma Q,Meng F,Cao J,Yu K,Shen Y

    更新日期:2017-06-01 00:00:00

  • A retrospective study of transcutaneous vagus nerve stimulation for poststroke epilepsy.

    abstract:BACKGROUND:This study assessed the effect transcutaneous vagus nerve stimulation (TVNS) for poststroke epilepsy (PSE). METHODS:Fifty-two patients with PSE were included in this study. Twenty-seven patients received TVNS, 30 minutes each session, once daily, twice weekly for a total of 4 weeks; and were assigned to the...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000011625

    authors: Song GF,Wang HY,Wu CJ,Li X,Yang FY

    更新日期:2018-08-01 00:00:00

  • PD-1/PD-L1 pathway activation restores the imbalance of Th1/Th2 and treg/Th17 cells subtypes in immune thrombocytopenic purpura patients.

    abstract::This study aims to investigate the changes of cytokines and the effect of programmed death ligand 1 (PD-L1) signaling pathway on T cell function in patients with immune thrombocytopenic purpura (ITP).Totally, 40 untreated ITP patients were recruited and 30 healthy people were recruited as the healthy control. Then who...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000017608

    authors: Wu D,Liu Y,Pang N,Sun M,Wang X,Haridia Y,Zhao F,Qin Y,Fan W,Guo X,Ding J

    更新日期:2019-10-01 00:00:00

  • Delayed bilateral facet dislocation at L4-5: A case report.

    abstract:RATIONALE:Traumatic bilateral facet dislocation in the lumbar (L) spine has rarely been reported. All reported cases were presented with acute facet dislocation. However, we present the first case of delayed bilateral facet dislocation at L4-5. PATIENT CONCERNS:A 34-year-old woman presented with back pain after a head...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000012483

    authors: Park HY,Ha KY,Kim YH,Kim SI,Min HK,Oh IS,Seo JY,Chang DG,Alhazmi MA,Cho JH

    更新日期:2018-09-01 00:00:00

  • Efficacy and safety of Danhong injection on endothelial function and inflammatory factors after the percutaneous coronary intervention for coronary heart disease: A protocol of systematic review and meta-analysis of randomized controlled trials.

    abstract:BACKGROUND:To systematically review the effects of Danhong injection on endothelial function and inflammatory factors after the percutaneous coronary intervention (PCI) for coronary heart disease (CHD) and to provide a basis for further research. METHODS:Through computer retrieval, including PubMed, Embase, the Cochra...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000020783

    authors: Li S,Duan S,Ning Y,Zhang H,Zheng Q

    更新日期:2020-07-02 00:00:00

  • Erratum: Association of Genetic Polymorphisms on VEGFA and VEGFR2 With Risk of Coronary Heart Disease: Erratum.

    abstract::[This corrects the article DOI: 10.1097/MD.0000000000003413.]. ...

    journal_title:Medicine

    pub_type: 已发布勘误

    doi:10.1097/01.md.0000484496.43819.1a

    authors:

    更新日期:2016-08-19 00:00:00

  • Cost-effectiveness analysis of neonatal screening of critical congenital heart defects in China.

    abstract:BACKGROUND:Pulse oximetry screening is a highly accurate tool for the early detection of critical congenital heart disease (CCHD) in newborn infants. As the technique is simple, noninvasive, and inexpensive, it has potentially significant benefits for developing countries. The aim of this study is to provide informatio...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000008683

    authors: Tobe RG,Martin GR,Li F,Moriichi A,Wu B,Mori R

    更新日期:2017-11-01 00:00:00

  • To predict sufentanil requirement for postoperative pain control using a real-time method: A prospective observational cohort study.

    abstract::Preoperative identification of individual sensitivity to opioid analgesics could improve the quality of postoperative analgesia. We explored the feasibility and utility of a real-time assessment of sufentanil sensitivity in predicting postoperative analgesic requirement.Our primary study included 111 patients who unde...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000003915

    authors: Zhang Y,Duan G,Guo S,Ying Y,Huang P,Zhang M,Li N,Zhang X

    更新日期:2016-06-01 00:00:00

  • Extramedullary relapse of leukemia after allogeneic hematopoietic stem cell transplantation: A retrospective study.

    abstract::Extramedullary relapse (EMR) rarely occurs after allogeneic hematopoietic stem cell transplantation (HSCT) in leukemia. This study was to investigate the clinical characteristics of EMR.We retrospectively investigated 316 consecutive patients undergoing HSCT for acute leukemia or chronic myeloid leukemia (CML) at 2 in...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000015584

    authors: Xie N,Zhou J,Zhang Y,Yu F,Song Y

    更新日期:2019-05-01 00:00:00

  • A Causal Role of Genetically Elevated Circulating Interleukin-10 in the Development of Digestive Cancers: Evidence from Mendelian Randomization Analysis Based on 29,307 Subjects.

    abstract::Recent studies have observed a high level of circulating interleukin-10 (IL-10) in patients with digestive cancers, yet whether elevated IL-10 is causally associated with digestive cancers so far remained unresolved. We therefore meta-analyzed available observational studies with Mendelian randomization method to expl...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MD.0000000000002799

    authors: Niu W,Pang Q,Lin T,Wang Z,Zhang J,Tai M,Zhang L,Zhang L,Gu M,Liu C,Qu K

    更新日期:2016-02-01 00:00:00

  • Elevated Th22 cells and related cytokines in patients with epithelial ovarian cancer.

    abstract::This study is conducted to investigate the involvement of T-helper (Th) cells and regulatory T cells in epithelial ovarian cancer (EOC).The percentages of Th22, Th17, Th1, and regulatory T cells in the peripheral blood of EOC patients, benign ovarian epithelial neoplasm (BOEN) patients, and healthy control (HC) were e...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000008359

    authors: Wang T,Zhang Z,Xing H,Wang L,Zhang G,Yu N,Wang J,Guo W,Jiang J

    更新日期:2017-10-01 00:00:00

  • Gluteal, abdominal, and thoracic multiple impalement injuries: A case report on management of a complex polytrauma.

    abstract:RATIONALE:Historically, traumatic injuries include penetrating and blunt lesions. Impalement injury represents one of the rarest and potentially dramatic forms of penetrating trauma. If patient reaches hospital alive and is hemodynamically stable, there is a good chance that patient overcomes the traumatic event. Howev...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000015824

    authors: Ugoletti L,Zizzo M,Castro Ruiz C,Pavesi E,Biolchini F,Annessi V

    更新日期:2019-05-01 00:00:00

  • Outcome in noncritically ill patients with acute kidney injury requiring dialysis: Effects of differing medical staffs and organizations.

    abstract::Acute kidney injury requiring dialysis (AKI-D) treatment has significantly increased in incidence over the years, with more than 400 new cases per million population/y, 2/3 of which concern noncritically ill patients. In these patients, there are little data on mortality or on information of care organization and its ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000004277

    authors: Fagugli RM,Patera F,Battistoni S,Tripepi G

    更新日期:2016-07-01 00:00:00

  • Chronic obstructive pulmonary disease is independently associated with hypertension in men: A survey design analysis using nationwide survey data.

    abstract::Although studies have shown that chronic obstructive pulmonary disease (COPD) and hypertension are linked as comorbidities, it remains unclear whether COPD is independently associated with the risk of hypertension or is caused by common risk factors such as age and smoking. The objective of this study was to investiga...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000006826

    authors: Kim SH,Park JH,Lee JK,Heo EY,Kim DK,Chung HS

    更新日期:2017-05-01 00:00:00

  • Development and internal validation of a novel model and markers to identify the candidates for lymph node metastasis in patients with prostate cancer.

    abstract:BACKGROUND:High-grade prostate cancer (PCa) has a poor prognosis, and up to 15% of patients worldwide experience lymph node invasion (LNI). To further improve the prediction lymph node invasion in prostate cancer, we adopted risk scores of the genes expression based on the nomogram in guidelines. METHODS:We analyzed c...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000016534

    authors: Cao HM,Wan Z,Wu Y,Wang HY,Guan C

    更新日期:2019-07-01 00:00:00

  • Correlation of ultrasound features and the Risk of Ovarian Malignancy Algorithm score for different histopathological subtypes of benign adnexal masses.

    abstract::Ovarian masses are one of the most frequently identified entities in gynecological practice. Early differential diagnosis is a key factor in the medical management of each patient. Transvaginal ultrasound along with additional preoperative testing, such as serum cancer antigen 125 (CA-125) levels and the Risk of Ovari...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000011762

    authors: Ionescu CA,Matei A,Navolan D,Dimitriu M,Bohâltea R,Neacsu A,Ilinca C,Ples L

    更新日期:2018-08-01 00:00:00

  • Treatment of herpes labialis by photodynamic therapy: Study protocol clinical trial (SPIRIT compliant).

    abstract:BACKGROUND:Lesions of herpes labialis are caused by the herpes simplex virus type 1 and cause pain and aesthetic compromise. It is characterized by the formation of small vesicles that coalesce and rupture forming extremely painful ulcers, that evolve to crusts, dry desquamations until their complete remission. Current...

    journal_title:Medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MD.0000000000019500

    authors: La Selva A,Negreiros RM,Bezerra DT,Rosa EP,Pavesi VCS,Navarro RS,Bello-Silva MS,Ramalho KM,Aranha ACC,Braz-Silva PH,Fernandes KPS,Bussadori SK,Horliana ACRT

    更新日期:2020-03-01 00:00:00

  • Milk and yogurt intake and breast cancer risk: A meta-analysis.

    abstract::Different patterns of milk and breast cancer rates across countries suggest that several components of milk could affect breast cancer risk. However, the components of diet are complex including milk that could potentially influence risk. Some milk products such as whole milk and cheese have a high fat content which m...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000014900

    authors: Chen L,Li M,Li H

    更新日期:2019-03-01 00:00:00