Abstract:
INTRODUCTION:Purpuric drug eruption (PDE) is an uncommon, clinically distinct side effect of epidermal growth factor receptor (EGFR) inhibitors. PATIENT CONCERNS:Unlike acneiform eruption, which arises from hair follicles mainly in the head and neck area, PDE starts from xerosis cutis, primarily in the lower extremities and is not associated with hair follicles. Herein, we report 3 cases of 3 patients who had received EGFR inhibitor and were hospitalized for PDE later. The cases were characterized by painful late-onset palpable purpura with identifiable bacterial pathogens. DIAGNOSIS:The patients were diagnosed with characteristic clinical presentations, that is, late onset, PDE locations mainly in the lower extremities, nonfollicular centricity, and laboratory findings with identifiable bacterial pathogens. INTERVENTIONS:Systemic antibiotics and intensive moisturizer application were prescribed. OUTCOMES:All the patients were successfully treated within 6 to 9 days without discontinuation of EGFR inhibitors. CONCLUSION:Systemic antibiotics, topical emollient, and skin barrier repair should be included in the treatment regimens for PDE.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Fang SY,Wu CS,Liu YS,Wei KCdoi
10.1097/MD.0000000000018112subject
Has Abstractpub_date
2019-11-01 00:00:00pages
e18112issue
47eissn
0025-7974issn
1536-5964pii
00005792-201911220-00081journal_volume
98pub_type
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