Abstract:
:This study is conducted to investigate the involvement of T-helper (Th) cells and regulatory T cells in epithelial ovarian cancer (EOC).The percentages of Th22, Th17, Th1, and regulatory T cells in the peripheral blood of EOC patients, benign ovarian epithelial neoplasm (BOEN) patients, and healthy control (HC) were examined by flow cytometry. Enzyme-linked immunosorbent assay was used to determine serum levels of interleukin (IL)-22, IL-17, interferon-γ (IFN-γ), and tumor necrosis factor-α (TNF-α).Th22 and Th17 were significantly increased in EOC patients. The plasma concentrations of IL-22 and TNF-α were significantly elevated in EOC patients compared with BOEN patients and HC. In EOC patients, there was an increased trend of Th22, IL-22, and TNF-α in stage III-IV patients compared with stage I-II patients. A positive correlation was seen among Th22, Th17, and Th1 cells in EOC patients. Similarly, positive correlations were detected between Th22 cells and IL-22 or TNF-α and between Th1 cells and interferon-γ (IFN-γ) in EOC patients. Besides, no significant difference was found in Th1 cells and regulatory T cells among EOC and BOEN patients and HC.There is a higher circulating frequency of Th22, Th17 cells, IL-22, and TNF-α concentration in EOC patients, which may conjointly participate in the pathogenesis and growth of EOC.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Wang T,Zhang Z,Xing H,Wang L,Zhang G,Yu N,Wang J,Guo W,Jiang Jdoi
10.1097/MD.0000000000008359subject
Has Abstractpub_date
2017-10-01 00:00:00pages
e8359issue
43eissn
0025-7974issn
1536-5964pii
00005792-201710270-00047journal_volume
96pub_type
杂志文章相关文献
MEDICINE文献大全abstract:BACKGROUND:Effective treatment of low back pain (LBP) originating in the lumbar and sacroiliac joints is difficult to achieve. The objective of the current study was to compare the clinical effectiveness of radiofrequency (RF) neurotomy versus conservative nonsurgical approaches for the management of chronic lumbar and...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000016230
更新日期:2019-06-01 00:00:00
abstract::The neoadjuvant chemotherapy (NAC) is the gold standard initial treatment of the locally advanced breast cancer (LABC). However, the reliability of methods that used to assess response the NAC is still controversial. In this study, patients with LABC who underwent NAC were evaluated retrospectively. The assessment of ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000023538
更新日期:2020-12-04 00:00:00
abstract:RATIONALE:Gorham-Stout syndrome in the spine is extremely rare, and there is no standard curative management thus far. The objective of this article is to report a very rare case of Gorham-Stout syndrome of the lumbar and sacral spine with chylothorax and chyloperitoneum successfully treated by combination of vertebrop...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000011555
更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:The neutrophil-to-lymphocyte ratio (NLR) has been reported to possess significant prognostic value in multiple types of cancer. We conducted a meta-analysis to evaluate the prognostic value of pretreatment NLR in soft tissue sarcoma (STS). METHODS:A systematic literature search through April 2018 was conduc...
journal_title:Medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MD.0000000000012176
更新日期:2018-09-01 00:00:00
abstract::The aim of this study was to investigate the usefulness of titanium mesh cage as an interlaminar spacer combined with nitinol shape memory loop fixation in patients with atlantoaxial instability.From April 2009 to March 2017, among the patients with atlantoaxial instability, a total of 30 patients were treated by niti...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000008022
更新日期:2017-09-01 00:00:00
abstract:INTRODUCTION:Falls are a serious concern for wheelchair and scooter users with multiple sclerosis (MS). Approximately, 75% of the population reports at least one fall in a 6-month period and nearly half report frequent falls. Falls can result in physical injuries and contribute to activity curtailment. Despite the nega...
journal_title:Medicine
pub_type: 杂志文章,多中心研究
doi:10.1097/MD.0000000000015418
更新日期:2019-05-01 00:00:00
abstract::We aimed to evaluate the image quality performance of coronary CT angiography (CTA) under the different settings of forward-projected model-based iterative reconstruction solutions (FIRST).Thirty patients undergoing coronary CTA were included. Each image was reconstructed using filtered back projection (FBP), adaptive...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010810
更新日期:2018-05-01 00:00:00
abstract::Significant unprotected left main (LM) coronary artery disease is frequently associated with severe multivessel disease and increased mortality and morbidity compared with non-LM coronary artery disease. This study compared the clinical outcomes of patients with LM disease who received percutaneous coronary interventi...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000009778
更新日期:2018-02-01 00:00:00
abstract::Aspergillus tracheobronchitis (AT) is an infrequent but severe form of invasive pulmonary aspergillosis in which the fungal infection is entirely or predominantly confined to the tracheobronchial tree. We reviewed 8 cases of AT diagnosed in our tertiary care center during an 18-year period, as well as 148 cases previo...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0b013e31826c2ccf
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Uveitis is the most common extra-articular manifestation in patients with ankylosing spondylitis (AS). The prevalence and characteristics of uveitis in AS have been studied in previous literatures, whereas its associated risk factors have not been clarified. Therefore, this study analyzed the risk factors of...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004233
更新日期:2016-07-01 00:00:00
abstract::Population aging has rapidly advanced throughout the world and the elderly accounting for out-of-hospital cardiac arrest (OHCA) has increased yearly.We identified all adults who experienced an out-of-hospital cardiac arrest in the All-Japan Utstein Registry of the Fire and Disaster Management Agency, a prospective, po...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002049
更新日期:2015-12-01 00:00:00
abstract::In gastric cancer, HER2 protein overexpression is considered to be conducive to the higher proliferation activity of the tumor cells. Tumor formation is associated with angiogenesis in order to secure an abundant supply of oxygen and glucose to cancer cells. The aim of the study was to assess if HER2 overexpression is...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000012854
更新日期:2018-10-01 00:00:00
abstract::The aim of the present study was to assess the effect of Endostar and temozolomide or dacarbazine plus 5-fluorouracil (5-FU) in patients with advanced pancreatic neuroendocrine tumors (pNETs).Phase II study of 14 patients with locally advanced or metastatic well-differentiated pNETs treated between April 2013 and Sept...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000012750
更新日期:2018-11-01 00:00:00
abstract::Vitamin D deficiency has been associated with several adverse outcomes mainly in the outpatient setting. The objective of this study was to examine the prevalence of vitamin D deficiency and its association with risk of adverse clinical outcomes in a large prospective cohort of medical inpatients.We collected clinical...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003533
更新日期:2016-05-01 00:00:00
abstract::The purpose of this study is to confirm and complement previous data regarding an association between gastroesophageal reflux disease and appendectomy.The Korean National Health Insurance Service-National Sample Cohort includes data from people ≥ 20 years old collected from 2002 to 2013. A total of 13,484 participants...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000013700
更新日期:2018-12-01 00:00:00
abstract::Necrotizing autoimmune myopathy (NAM) is a group of acquired myopathies characterized by prominent myofiber necrosis with little or no muscle inflammation. Recently, researchers identified autoantibodies (aAb) against 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) in patients with NAM, especially in statin-ex...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000028
更新日期:2014-05-01 00:00:00
abstract::Osteogenesis imperfecta (OI) is a hereditary connective tissue disorder that leads to bone weakness and deformities, especially in the spine, which can lead to poor outcomes.The aim of this study was to find patterns and risk factors in spinal deformities in patients with OI.In a retrospective study, 70 patients with ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001841
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Myasthenia gravis (MG) is a progressive autoimmune disease that occurs as a result of the failure of neuromuscular transmission and is characterized by muscle weakness. There has been evidence on the correlations between the genetic predisposition of cytotoxic T lymphocyte and the antigen-4 (CTLA-4) and MG. ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010620
更新日期:2018-05-01 00:00:00
abstract::[This corrects the article DOI: 10.1097/MD.0000000000001654.]. ...
journal_title:Medicine
pub_type: 已发布勘误
doi:10.1097/01.md.0000479947.63919.bc
更新日期:2016-01-22 00:00:00
abstract::The objective of this work is to verify the relationship between the self-perception of health and the self-concept of physical appearance in adolescents, in order to check their influence on the physical activity they perform with the aim of preventing chronic illnesses. To this end, an observational, cross-sectional...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020884
更新日期:2020-07-10 00:00:00
abstract:BACKGROUND:This study was conducted with the aim to investigate the relationship between Tetranectin (TN) and efficiency of posterior spinal V osteotomy in patients with traumatic kyphosis. METHODS:Ninety-two patients with traumatic kyphosis admitted in our hospital from February 2014 to June 2016 were included whose ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000009555
更新日期:2018-02-01 00:00:00
abstract::There is a lack of clear guidance for the prophylactic use of anticoagulants for patients undergoing laparoscopic adjustable gastric banding (LAGB) surgery.This study aimed to evaluate the risk of venous thromboembolism (VTE), prophylactic use of enoxaparin and clinical outcomes in patients undergoing primary and revi...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020174
更新日期:2020-05-01 00:00:00
abstract:PURPOSE:Neovascular glaucoma (NVG) is a severe secondary glaucoma with uncontrolled intraocular pressure that leads to serious eye pain and vision loss. Presently, the therapeutic strategies for NVG are diverse, but the therapeutic effects are still not ideal. We performed a network analysis to assess the effect of mul...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000009897
更新日期:2018-04-01 00:00:00
abstract::Cystoscopic technique is the current common method of retrieving double J ureteral stent in most pediatric urological centers. In this study, we evaluated the feasibility and efficacy of a novel noncystoscopic method to remove retained ureteral stents in pediatric patients.We reviewed all medical records from a total ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000009540
更新日期:2018-01-01 00:00:00
abstract:RATIONALE:Myoepithelial carcinoma mainly occurs in the salivary glands, but myoepithelial carcinoma of the lung is extremely rare neoplasm whose biological behavior and clinical course still remain to be fully elucidated. Although considered as low-grade carcinoma, these tumors have a high rate of recurrence or distant...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000010049
更新日期:2018-03-01 00:00:00
abstract::Spondyloarthritis may be increasingly present in older patients as life expectancy increases. We investigated clinical differences between early-onset and late-onset spondyloarthritis in Japan.We retrospectively reviewed 114 patients consecutively diagnosed with spondyloarthritis. The clinical course of each patient w...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014431
更新日期:2019-02-01 00:00:00
abstract:PURPOSE:To evaluate the incidence risk of programmed cell death-1/programmed cell death ligand 1 (PD-1/PD-L1) inhibitor-related alopecia for cancer patients, the meta-analysis was put into practice. METHOD:The meta-analysis was designed and put into practice according to the preferred reporting items for systematic re...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000022555
更新日期:2020-10-16 00:00:00
abstract::This study aims to investigate the value of the ABCD score combined with the position of the offending vessel stenosis in predicting the risk of transient ischemic attack (TIA) to develop into cerebral infarction.The ABCD score and head magnetic resonance imaging + magnetic resonance angiography (MRA) results of 192 p...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000015081
更新日期:2019-04-01 00:00:00
abstract::Familial Mediterranean fever (FMF) is a febrile disease characterized by acute, spontaneously resolving episodes of fever and pain caused by serosal inflammation and associated with mutations in the FMF gene, MEFV. Prophylaxis is maintained with colchicine. To our knowledge, no study has yet shown an association betwe...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0b013e31815be056
更新日期:2007-11-01 00:00:00
abstract::When the sensory block level (SBL) is ≥T5 or T4, a high incidence of hypotension occurs in parturients after spinal anesthesia. A rapidly ascending SBL is another risk factor for spinal anesthesia-induced hypotension. However, the relationship between the ascension rate of the SBL and spinal anesthesia-induced hypoten...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000007184
更新日期:2017-06-01 00:00:00