Retrospective comparison of fludarabine in combination with intermediate-dose cytarabine versus high-dose cytarabine as consolidation therapies for acute myeloid leukemia.

Abstract:

:This retrospective study compared efficacy and safety of fludarabine combined with intermediate-dose cytarabine (FA regimen) versus high-dose cytarabine (HiDAC regimen) as consolidation therapy in acute myeloid leukemia (AML) patients who achieved complete remission. Disease-free survival (DFS) and overall survival (OS) based on age (≥ 60, <60 years) and cytogenetics were evaluated from data between January 2005 and March 2013. Total 82 patients (FA, n = 45; HiDAC, n = 37; 14-65 years) were evaluated. Five-year DFS was 32.0% and 36.2% for FA and HiDAC groups, respectively (P = 0.729), and 5-year OS was 39.5% and 47.8% (P = 0.568), respectively. Among older patients (≥ 60 years), 3-year DFS was 26.0% for FA group and 12.5% for HiDAC group (P = 0.032), and 3-year OS was 34.6% and 12.5%, respectively (P = 0.026). In FA group, hematological toxicities were significantly lower. FA regimen was as effective as HiDAC regimen in patients with good/intermediate cytogenetics and significantly improved DFS and OS in older patients.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Zhang W,Ding Y,Wu H,Chen Y,Lu H,Chen C,Fu J,Wang W,Liang A,Zou S

doi

10.1097/MD.0000000000000134

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

e134

issue

27

eissn

0025-7974

issn

1536-5964

pii

00005792-201412020-00004

journal_volume

93

pub_type

杂志文章

相关文献

MEDICINE文献大全