Abstract:
RATIONALE:Unilateral manifestation of lymphedema during everolimus therapy has been described only rarely, mostly in transplant recipients. PATIENT CONCERNS:We report the first case of a patient who developed unilateral abdominal lymphedema, during a short period of everolimus treatment for renal cancer. DIAGNOSIS:The abdominal asymmetry occurred only on the right side of the abdomen, neither ultrasound nor CT scan detected ascites but showed enlargement of the abdominal wall. The Naranjo Adverse Drug Reaction Probability scale was evaluated, in this case, a score of 6 indicated a probable adverse reaction to everolimus. INTERVENTIONS:Discontinuation of everolimus therapy led to immediate alleviation and reduction of the lymphedema, with worsening once again after initiating retreatment with everolimus at a reduced dose. OUTCOMES:The patient's lymphedema recovered after discontinuation of everolimus. LESSONS:This rare case demonstrates the importance of the selection of mammalian target of rapamycin inhibitors using caution, especially for patients with a high risk of developing lymphedema.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Halamkova J,Kazda T,Adamkova-Krakorova D,Rybnickova S,Kiss I,Demlova Rdoi
10.1097/MD.0000000000022634subject
Has Abstractpub_date
2020-10-16 00:00:00pages
e22634issue
42eissn
0025-7974issn
1536-5964pii
00005792-202010160-00033journal_volume
99pub_type
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