Abstract:
RATIONALE:Chimeric antigen receptor-modified T-cell (CART) therapy has revolutionized the treatment of patients with relapsed or refractory B-cell acute lymphoblastic leukemia (ALL). However, the capacity of CART therapy has not yet been fully elucidated. PATIENT CONCERNS:An 18-year-old Chinese male patient presented with multiple firm masses on the skin all over his body following regular chemotherapy. DIAGNOSES:Bone marrow smear and skin biopsy confirmed that it was a bone marrow and skin relapse from the initial B-cell ALL. INTERVENTIONS:CD19 CART-cell therapy was performed to manage the bone marrow and skin of the relapsed B-cell ALL. OUTCOMES:During CART-cell therapy, cytokine release syndrome and central nervous encephalopathy occurred. Eventually, the lesions disappeared, and the bone marrow and skin tested minimal residual disease (MRD) negative. The patient achieved complete remission (CR). Fourteen days after testing MRD negative, he received allogeneic hematopoietic stem-cell transplantation and has remained disease free to date. LESSONS:The CR of this patient with leukemia cutis demonstrated that CART exhibited efficacy in this case. While further research is still required, this treatment could potentially be used as a therapy for skin leukemia, lymphoma, and other primary skin cancers.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Yang M,Liu B,Wang Y,Liu Y,Gong X,Gong B,Xu Y,Mi Y,Wang M,Wang Jdoi
10.1097/MD.0000000000018639subject
Has Abstractpub_date
2020-05-01 00:00:00pages
e18639issue
18eissn
0025-7974issn
1536-5964pii
00005792-202005010-00002journal_volume
99pub_type
杂志文章相关文献
MEDICINE文献大全abstract:BACKGROUND:Coronavirus disease 2019 (COVID-19) is a global pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). There is no specific cure for this disease, and the clinical management mainly depends on supportive treatment. Traditional Chinese medicines (CHM) is widely used in treating C...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020157
更新日期:2020-05-29 00:00:00
abstract::We present 2 cases of the Lemierre syndrome (also called postanginal septicemia), along with 36 other cases from a review of recent literature. A review of the literature during the preantibiotic era is also included. This disease is caused by an acute oropharyngeal infection with secondary thrombophlebitis of the int...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:
更新日期:1989-03-01 00:00:00
abstract::To investigate the costs associated with postoperative complications following rectal resection.Rectal resection is a major surgical procedure that carries a significant risk of complications. The occurrence of complications following surgery has both health and financial consequences. There are very few studies that ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020089
更新日期:2020-05-01 00:00:00
abstract::The purpose of this study was to develop and validate a finite element (FE) model to predict vertebral bone strength in vitro using multidetector computed tomography (MDCT) images in multiple myeloma (MM) patients, to serve as a complementing tool to assess fracture risk. In addition, it also aims to differentiate MM ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005825
更新日期:2017-01-01 00:00:00
abstract::About 77.9 million (1 in 4) American adults have high blood pressure. High blood pressure is the primary cause of left ventricular hypertrophy (LVH), which represents a strong predictor of future heart failure and cardiovascular mortality. Previous studies have shown an altered metabolic profile in hypertensive patien...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004965
更新日期:2016-11-01 00:00:00
abstract:RATIONALE:Chronic thromboembolic pulmonary hypertension (CTEPH) is rare in children and determining the underlying etiologies is essential for treatment. Venous thromboembolism, a well-known complication in nephrotic syndrome (NS), always occurrs during the treatment in course of the disease. However, CTEPH as the firs...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000012349
更新日期:2018-10-01 00:00:00
abstract:RATIONALE:Ectopic variceal bleeding is a rare (2-5%) but fatal gastrointestinal bleed in patients with portal hypertension. Patients with ectopic variceal bleeding manifest melena, hematochezia, or hematemesis, which require urgent managements. Definitive therapeutic modalities of ectopic varices are not yet standardiz...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005860
更新日期:2017-01-01 00:00:00
abstract::While older age associates with adverse percutaneous coronary intervention (PCI) outcomes, detailed information relating age to stent strut coverage and neointimal characteristics is lacking. One hundred nineteen patients with 123 sirolimus-eluting stents (SESs) were divided into 3 groups: group A (≤55 years), group B...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002246
更新日期:2015-12-01 00:00:00
abstract::The role of cancer stem cell (CSC) markers in differentiation of hepatocellular carcinoma (HCC) remains uncertain. We conducted a meta-analysis to first investigate the association between expression of CSC markers (CD133, CD90, CD44, and EpCAM) and poor differentiation of HCC, and second, to determine if these CSC ma...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000001306
更新日期:2015-08-01 00:00:00
abstract::Olfactory outcomes as well as oronasal postoperative complications of transsphenoidal pituitary surgery have not been well studied. The objective of this study was to investigate nasal symptoms including olfactory function as well as quality of life following transsphenoidal pituitary surgery. The study is designed as...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000000465
更新日期:2015-01-01 00:00:00
abstract::The incidence of acute myocarditis complicated with ventricular tachycardia (VT) is unknown. This study aimed to investigate the association between myocarditis and the incidence of VT and mortality. We also aimed to determine the independent predictors that increased the VT risk in those patients. From 2000 to 2004, ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000006633
更新日期:2017-05-01 00:00:00
abstract::Cerebral edema is a frequent and serious complication in traumatic brain injury (TBI) patients. The objective is to study the effect of dexamethasone in patients with brain contusions, and to assess its effect on the vasogenic component of the pericontusional edema.Prospective-observational study to quantify, using ma...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022879
更新日期:2020-10-23 00:00:00
abstract::Human T lymphotropic virus type 1 (HTLV-I) is a retrovirus which is prevalent in southern Japan, the Caribbean Basin, and Africa. Recent seroprevalence studies in the United States suggest that there are about 50,000 infected individuals. The identification of 5 individuals with HTLV-I-associated leukemia/lymphoma ref...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/00005792-198811000-00004
更新日期:1988-11-01 00:00:00
abstract::Nutritional assessment is feasible with computed tomography anthropometry. The abdominal muscle at the L3 vertebra is a well-known nutritional biomarker for predicting the prognosis of various diseases, especially sarcopenia. However, studies on nutritional assessment of the brain using computed tomography are still s...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000019069
更新日期:2020-02-01 00:00:00
abstract::The clinical symptoms of pylephlebitis caused by acute appendicitis are varied and atypical, which leads to delayed diagnosis and poor outcomes. Here, we report a case of intestinal necrosis caused by thrombophlebitis of the portomesenteric veins as a complication of acute appendicitis after appendectomy. The patient ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001033
更新日期:2015-06-01 00:00:00
abstract:RATIONALE:Multiple primary malignancies can occur in the same organ or in multiple organs or systems. Likewise, they can occur simultaneously or successively. Based on the timing of the diagnosis, they are classified as multiple synchronous (i.e., concurrent) or metachronous (i.e., successive) primary malignancies. The...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011107
更新日期:2018-06-01 00:00:00
abstract::To evaluate the efficacy and safety of high viscosity bone cement in the percutaneous vertebroplasty (PVP) for treatment of single-level osteoporotic vertebral compression fractures.Eighty patients were enrolled in this study. All patients were received PVP, and they were divided into 2 groups according to the viscosi...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020515
更新日期:2020-06-05 00:00:00
abstract:RATIONALE:A dural arteriovenous fistula (DAVF) refers to an abnormal direct connection between an intracranial artery and a dural venous sinus. A DAVF presenting with parkinsonism is rare, and is therefore easily misdiagnosed. Therefore, early consideration of DAVF in the differential diagnosis of reversible parkinsoni...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000009005
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:The activation of the Notch signaling pathway has been shown to play an important role in diabetic nephropathy (DN) development. Besides, Notch-1 is a target gene in miR-34a. However, the regulation of the podocyte lesions involved in DN by miR-34a has not been identified. METHODS:This study utilized miR-34...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005050
更新日期:2016-11-01 00:00:00
abstract::Several studies have reported the relationship between alcoholic liver disease (ALD) and carotid intima-media thickness (CIMT). Few studies, however, have investigated the causes of CIMT thickening in patients with ALD. The authors explored the causes of CIMT thickening in patients with ALD. The authors enrolled 152 p...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001087
更新日期:2015-07-01 00:00:00
abstract::Familial Mediterranean Fever is a rare disease which usually begins in childhood and occurs primarily among persons of Mediterranean ancestry. It is characterized by short, self-limited, febrile episodes that may occur alone or with inflammation of serosal surfaces. Some individuals may exhibit an erysipilas-like eryt...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:
更新日期:1980-01-01 00:00:00
abstract::Primary hepatic neuroendocrine tumors (PHNETs) are very rare and their clinical features and treatment outcomes are not well understood. It is difficult to reach a proper diagnosis before biopsy or resection. The aim of this study was to analyze the imaging features of PHNETs on contrast-enhanced ultrasound (CEUS). Th...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003450
更新日期:2016-05-01 00:00:00
abstract::The connection between Helicobacter pylori (Hp) infection and eye diseases has been increasingly reported in the literature and in active research. The implication of this bacterium in chronic eye diseases, such as blepharitis, glaucoma, central serous chorioretinopathy and others, has been hypothesized. Although the ...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000000216
更新日期:2014-12-01 00:00:00
abstract:RATIONALE:Primary leiomyosarcoma (LMS) of the fallopian tube is extremely uncommon. To the best of our knowledge, so far only 21 cases of primary fallopian tube LMS have been reported in English-language literature. No new case has been reported in the past 7 years. PATIENT CONCERNS:A 44-year-old premenopausal patient...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000010536
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Plate fixation and intramedullary nail/Knowles pin fixation methods are commonly used to treat displaced midshaft clavicle fractures. However, the differences between these 2 methods are unclear. OBJECTIVE:This meta-analysis aimed to compare plate fixation and intramedullary nail/Knowles pin fixation for di...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000022284
更新日期:2020-09-25 00:00:00
abstract::Scrub typhus is caused by Orientia tsutsugamushi. Any delay in diagnosis can result in delayed treatment and severe complications, including secondary hemophagocytic lymphohistiocytosis, which is rare but potentially fatal.In this paper, the authors present 3 cases of secondary hemophagocytic lymphohistiocytosis assoc...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/MD.0000000000002928
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Benign prostatic hyperplasia (BPH) is a medical condition that affects the quality of life by causing lower urinary tract symptoms (LUTS) in 40% to 70% of men aged ≥60 years. Medication treatment is primarily recommended for patients with BPH if their symptom score based on the International Prostate Symptom...
journal_title:Medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/MD.0000000000019678
更新日期:2020-04-01 00:00:00
abstract::The aim of this study was to identify the prevalence of proximal junctional kyphosis (PJK) in degenerative lumbar scoliosis (DLS) following long instrumented posterior spinal fusion, and to search for predictable risk factors for the progression of junctional kyphosis.In total 98 DLS patients with a minimum 2-year fol...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000004443
更新日期:2016-08-01 00:00:00
abstract::The mixed convolution kernel alters his properties geographically according to the depicted organ structure, especially for the lung. Therefore, we compared the image quality of the mixed convolution kernel to standard soft and hard kernel reconstructions for different organ structures in thoracic computed tomography ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005309
更新日期:2016-11-01 00:00:00
abstract::To assess the hypothesis if tocilizumab (TCZ) is effective on disease activity, and also its effect in fatigue and other clinical and psychological disease-related factors in patients with rheumatoid arthritis (RA) treated with TCZ.A 24-week, multicenter, prospective, observational study in patients with moderate to s...
journal_title:Medicine
pub_type: 杂志文章,多中心研究
doi:10.1097/MD.0000000000015947
更新日期:2019-06-01 00:00:00