Abstract:
BACKGROUND:Cardiopulmonary bypass (CPB) is necessary for most cardiac surgery, which may lead to postoperative lung injury. The objective of this paper is to systematically evaluate whether ventilation during CPB would benefit patients undergoing cardiac surgery. METHODS:We searched randomized controlled trials (RCTs) through PubMed, Embase, and Cochrane Library from inception to October 2016. Eligible studies compared clinical outcomes of ventilation versus nonventilation during CPB in patients undergoing cardiac surgery. The primary outcome includes oxygenation index (PaO2/FiO2 ratio) or alveolar to arterial oxygen tension difference (AaDO2) immediately after weaning from bypass. The secondary outcomes include postoperative pulmonary complications (PPCs), shunt fraction (Qs/Qt), hospital stay, and AaDO2 4 hours after CPB. RESULTS:Seventeen trials with 1162 patients were included in this meta-analysis. Ventilation during CPB significantly increased post-CPB PaO2/FiO2 ratio (mean difference [MD] = 21.84; 95% confidence interval [CI] = 1.30 to 42.37; P = 0.04; I = 75%) and reduced post-CPB AaDO2 (MD = -50.17; 95% CI = -71.36 to -28.99; P <0.00001; I = 74%). Qs/Qt immediately after weaning from CPB showed a significant difference between groups (MD = -3.24; 95% CI = -4.48 to -2.01; P <0.00001; I = 0%). Incidence of PPCs (odds ratio [OR] = 0.79; 95% CI = 0.42 to 1.48; P = 0.46; I = 37%) and hospital stay (MD = 0.09; 95% CI = -23 to 0.41; P = 0.58; I = 37%) did not differ significantly between groups. CONCLUSION:Ventilation during CPB might improve post-CPB oxygenation and gas exchange in patients who underwent cardiac surgery. However, there is no sufficient evidence to show that ventilation during CPB could influence long-term prognosis of these patients. The beneficial effects of ventilation during CPB are requisite to be evaluated in powerful and well-designed RCTs.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Chi D,Chen C,Shi Y,Wang W,Ma Y,Zhou R,Yu H,Liu Bdoi
10.1097/MD.0000000000006454subject
Has Abstractpub_date
2017-03-01 00:00:00pages
e6454issue
12eissn
0025-7974issn
1536-5964pii
00005792-201703240-00063journal_volume
96pub_type
杂志文章,meta分析相关文献
MEDICINE文献大全abstract:RATIONALE:Football players are at high risk for lower extremity injuries because they turn on an axis of rotation, turn while decelerating, and repeatedly jump and land. One of the most common sites of injury is the knee. PATIENT CONCERNS:A 25-year-old amateur university football player with pain in the knee medial ar...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010973
更新日期:2018-06-01 00:00:00
abstract::Thyrotoxic periodic paralysis (TPP) is characterized by the presence of muscle paralysis, hypokalemia, and hyperthyroidism. We report the case of a young man with paralysis of the lower extremities, severe hypokalemia, and concurrent hyperthyroidism. TPP was suspected; therefore, treatment consisting of judicious pota...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000001689
更新日期:2015-09-01 00:00:00
abstract::Solid tumors frequently metastasize to bone. Two bisphosphonates have been investigated for bone metastases including pamidronate disodium and zoledronic acid.By searching the PubMed, Embase, Wanfang, and China National Knowledge Infrastructure (CNKI) databases, we conducted a meta-analysis to determine the efficacy a...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000001822
更新日期:2015-10-01 00:00:00
abstract:RATIONALE:Phlegmonous gastritis is a rare bacterial infection of the gastric wall with high mortality. However, diagnosis of phlegmonous gastritis is difficult and standard treatment remains unestablished. PATIENT CONCERNS:We report a 33-year-old male patient with mixed-phenotype acute leukemia who developed acute phl...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017777
更新日期:2019-11-01 00:00:00
abstract::Diabetes mellitus (DM) is a common complication of chronic pancreatitis (CP) and increases the mortality. The identification of risk factors for DM development may contribute to the early detection and potential risk reduction of DM in patients with CP.Patients with CP admitted to Changhai Hospital (Shanghai, China) f...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003251
更新日期:2016-04-01 00:00:00
abstract::Alanine transaminase (ALT) abnormalities are common in chronic hepatitis B (CHB) carriers during postpartum period. Disturbances in cytokines are considered to be associated with hepatitis Flares. There are limited data on cytokines changes in HBeAg positive patients with ALT abnormalities.This is an observational stu...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000017969
更新日期:2019-11-01 00:00:00
abstract:RATIONALE:According to the World Health Organization reports, adult-onset hearing loss is the 15th leading cause of burden of disease, and is projected to move up to 7th by the year 2030, especially in high-income countries. Sudden sensorineural hearing loss is considered by otologists as a true otologic emergency. The...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000009397
更新日期:2017-12-01 00:00:00
abstract:RATIONALE:Undifferentiated carcinoma with osteoclast-like giant cells (UC-OGCs) of the pancreas is an extremely rare and aggressive pancreatic malignancy. To our knowledge, the computed tomography (CT) findings of this disease have rarely been analyzed. PATIENT CONCERNS:A 65-year-old man who experienced weight loss of...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000013516
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:Auricular acupressure has been used for treating obesity, but inconsistent outcomes have been reported. Moreover, systematic reviews and meta-analyses have seldom addressed the effects of auricular acupressure and duration of treatment in overweight/obese individuals. This study reviewed research articles on...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000016144
更新日期:2019-06-01 00:00:00
abstract:RATIONALE:Advanced ovarian malignancies are associated with poor overall survival; thus, patients often turn to alternative treatments, despite the controversy surrounding their use. Mistletoe extract has been commonly used as complementary medicine to treat patients with cancer for several decades, and has proven bene...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014536
更新日期:2019-02-01 00:00:00
abstract::The endoscopic endonasal transsphenoidal approach (EETA) is the primary treatment for growth hormone (GH) adenoma. This study aimed to investigate the outcomes of EETA in 33 patients with GH-secreting pituitary adenoma (PA).Thirty-three patients who underwent EETA in Eighth People's Hospital of Shenzhen between Januar...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000019855
更新日期:2020-05-01 00:00:00
abstract::To explore the efficacy, and safety of the intensive conditioning regimen consisting of cladribine, cytarabine (Ara-C), and granulocyte colony-stimulating factor (G-CSF) plus modified busulfan (Bu) combined with cytoxan (Cy) (BuCy), prior to allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients wi...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010228
更新日期:2018-04-01 00:00:00
abstract::Budd-Chiari syndrome (BCS) may not be as uncommon as was once believed. Our study has substantiated the existence of 2 major clinical forms. The acute syndrome is invariably associated with extensive blockage of the major hepatic veins, resulting in congestive liver cell necrosis. In a small, but significant, number o...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/00005792-199401000-00003
更新日期:1994-01-01 00:00:00
abstract::Dysphagia can occur among patients receiving medical care despite having no history of neurologic disease. The current study aimed to investigate factors contributing to airway invasion among non-neurologically ill patients with dysphagia.This retrospective study included 52 non-neurologically ill patients who complai...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000022977
更新日期:2020-11-06 00:00:00
abstract::Rapidly progressive glomerulonephritis (RPGN) is mainly caused by anti-glomerular basement membrane (GBM) antibody-mediated glomerulonephritis, immune-complex or anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides and leads to rapid loss of renal function. Detection of ANCA and autoantibodies (autoAbs)...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000005225
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Rotavirus infection is the main cause of severe dehydration enteritis in children under 5 years old. It gives rise to malnutrition and even death in children even though there were rotavirus vaccines. However, there is no effective anti-virus drugs for rotavirus, supporting treatments are used in the clinics...
journal_title:Medicine
pub_type: 杂志文章,meta分析
doi:10.1097/MD.0000000000023376
更新日期:2020-12-04 00:00:00
abstract:BACKGROUND:Parkinson disease (PD) is a progressive neuromuscular disease associated with bradykinesia, tremor, and postural instability. We aimed to compare outcomes and complications of total hip arthroplasty (THA) between patients with PD and those without. METHODS:A single institution retrospective cohort from 2000...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020018
更新日期:2020-05-01 00:00:00
abstract::Stroke is one of the most common causes of physical disability, and early, intensive, and repetitive rehabilitation exercises are crucial to the recovery of stroke survivors. Unfortunately, research shows that only one third of stroke patients actually perform recommended exercises at home, because of the repetitive a...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000003032
更新日期:2016-03-01 00:00:00
abstract::[This corrects the article DOI: 10.1097/MD.0000000000004694.]. ...
journal_title:Medicine
pub_type: 已发布勘误
doi:10.1097/01.md.0000503455.40174.9b
更新日期:2016-10-07 00:00:00
abstract:RATIONALE:Hyponatremia occurs frequently in the hospital setting and may be attributable to a host of etiologies. Drugs are frequently implicated. Trimethoprim-sulfamethoxazole (TMP/SMX) represents a well-recognized pharmacologic precipitant of drug-induced hyponatremia, with several reports extant in the retrievable l...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020746
更新日期:2020-08-14 00:00:00
abstract::This study used Taiwan's National Health Insurance medical claims to investigate the predictors for operative modes chosen by early-stage breast cancer patients; as well as to assess whether operative modes are associated with risk of mood disorder. We included 36,377 patients with breast cancer who received surgery b...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002510
更新日期:2016-01-01 00:00:00
abstract::Graft insertion into the anterior chamber is one of the most important procedures for successful Descemet membrane endothelial keratoplasty (DMEK). Especially in eyes with fragile zonular fibers and a shallow anterior chamber, smooth graft insertion tends to become more difficult. Ophthalmic viscoelastic devices (OVDs...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000011245
更新日期:2018-06-01 00:00:00
abstract::This prospective study investigated the relationship between 2 inosine triphosphatase (ITPA) polymorphisms (rs7270101 and rs1127354) and the efficacy of ribavirin-based antiviral therapy in hepatitis C virus (HCV)-infected Chinese patients.A total of 906 patients diagnosed with chronic hepatitis C receiving pegylated ...
journal_title:Medicine
pub_type: 杂志文章,多中心研究
doi:10.1097/MD.0000000000007554
更新日期:2017-07-01 00:00:00
abstract:RATIONALE:Paradoxical embolism (PE) is an important cause of cryptogenic stroke, particularly in young patients, which usually have a relation with an unexpected route in circulation. Here we report a rare case of cryptogenic stroke carried 2 uncommon malformations. PATIENT CONCERNS:A 48-year-old female experienced do...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000019507
更新日期:2020-04-01 00:00:00
abstract::The health effects of short-term exposure to air pollutants on respiratory deaths and its modifiers such as meteorological indexes have been widely investigated. However, most of the previous studies are limited to single pollutants or total respiratory deaths, and their findings are inconsistent.To comprehensively ex...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000014694
更新日期:2019-03-01 00:00:00
abstract::Previous studies on the relationship between obesity and depression have produced conflicting results. And only a limited number of studies have been conducted in Asians, and few large-scale nationwide studies have been conducted in Korean populations.We investigated the relationship between obesity and depression in ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000009478
更新日期:2017-12-01 00:00:00
abstract::To investigate the costs associated with postoperative complications following rectal resection.Rectal resection is a major surgical procedure that carries a significant risk of complications. The occurrence of complications following surgery has both health and financial consequences. There are very few studies that ...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000020089
更新日期:2020-05-01 00:00:00
abstract::It has been suggested by the first voxel-based morphometry investigation that betel quid dependence (BQD) individuals are presented with brain structural changes in previous reports, and there may be a neurobiological basis for BQD individuals related to an increased risk of executive dysfunction and disinhibition, su...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000002638
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Chronic pelvic inflammation disease (PID) is a difficult-to-treat gynecological disorder with complex etiologies. Acupuncture has been applied widely for treating chronic pelvic inflammation or chronic pelvic pain symptoms in China. The aim of this review is to undertake a systematic review to estimate the e...
journal_title:Medicine
pub_type: 杂志文章
doi:10.1097/MD.0000000000010225
更新日期:2018-03-01 00:00:00
abstract::Eighteen cases of mesothelioma, 7 benign and 11 malignant, were analyzed retrospectively. There were 5 females with benign tumors and 10 males with the malignant variety. The mean age was 59 years in the benign group and 55 years in those with malignant tumors. Exposure to asbestos was documented in one benign and fiv...
journal_title:Medicine
pub_type: 杂志文章,评审
doi:10.1097/00005792-197603000-00004
更新日期:1976-03-01 00:00:00